Cytokine dysregulation associated with the course of HIV infection.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Cytokine dysregulation associated with the course of HIV infection.

Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:104 (poster no. 58). Unique Identifier : AIDSLINE ASHM5/94348918
Fan J; Bass H; Nguyen T; Fahey JL; National Centre for HIV Virology Research, Institute of Medical; and Veterinary Science, Adelaide, South Australia.

Abstract: By using quantitative RT-PCR, elevated levels of IFN gamma mRNA and lowered IL-2 mRNA were found in PBMC of HIV-seropositive men with CD4 T cells over 500/mm3 (mean:647/mm3) while IL-4 and IL-10 mRNAs did not change significantly. Men whose CD4 levels fell more than 200/mm3 in the two following years showed further changes in lymphokine mRNA levels. Furthermore, changes in cytokine gene expression were markedly different in CD4 and CD8 T cells from HIV-seropositive men. On a per cell basis, mRNA levels of IFN gamma, IL-10 and TNF alpha increased approximately three times in CD4 T cells isolated from HIV seropositive subjects (p < 0.05) while IL-2 gene expression showed no significant change. Cytokine production in CD8 T cells, however, changed little following HIV infection. After stimulation of PBMC with PHA, PWM, and rIL-2; IL-2 and IL-2R were found lower, but IL-10 and TNF alpha found higher in seropositive subjects as compared to seronegative individuals. Cytokines play a central role in the performance and regulation of the human immune system. The altered balance of cytokine production is likely to contribute to the immune dysfunction in HIV-infection.

Keywords: Cytokines/*GENETICS CD4-CD8 Ratio CD4-Positive T-Lymphocytes/IMMUNOLOGY Gene Expression Regulation, Viral/PHYSIOLOGY Human HIV Infections/GENETICS/*IMMUNOLOGY HIV Seronegativity/GENETICS/IMMUNOLOGY Interferon Type II/GENETICS Interleukin-10/GENETICS Interleukin-2/GENETICS Interleukin-4/GENETICS Leukocyte Count RNA, Messenger/GENETICS ABSTRACT
941230
M94C4309

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