Modelling the HIV-1 infection cycle. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Modelling the HIV-1 infection cycle.

Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:112 (poster no. 73). Unique Identifier : AIDSLINE ASHM5/94348932
Deacon N; McPhee D; Newnham J; Linger H; AIDS Molecular Biology Unit, Monash University.

Abstract: We have developed a computational tool for biological research to study the replication strategy of the human immunodeficiency virus. This model incorporates a formal model using Petri Nets and scientific citations. In the development of the formal model we have uncovered some facets of the replication strategy that warrant further investigation due to the incompleteness of current knowledge. A detailed understanding of the replication strategy allows better definition of steps that might be amenable to novel antiviral development. Modelling this strategy on the computer facilitates formulating and testing hypotheses at a theoretical level and organising the burgeoning HIV literature within the structure of this easily interpreted model. Application of this to modelling roles for the HIV auxiliary proteins revealed details of Tat, Rev and Nef functions yet to be resolved.
Keywords: *Computer Simulation Gene Expression Regulation, Viral/PHYSIOLOGY Genes, nef/GENETICS Genes, rev/GENETICS Genes, tat/GENETICS Human HIV Infections/*MICROBIOLOGY HIV-1/GENETICS/*PHYSIOLOGY Models, Genetic Virus Replication/GENETICS/*PHYSIOLOGY ABSTRACTKWDcomputersimulationgeneexpressionregulation,viral/physiologygenes,nef/geneticsgenes,rev/geneticsgenes,tat/geneticshumanhivinfections/KWDmicrobiologyhiv-1/genetics/KWDphysiologymodels,geneticvirusreplication/genetics/KWDphysiologyabstract
941230
M94C4295

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1994. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1994. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .