Unravelling the molecular biology of HIV.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Unravelling the molecular biology of HIV.

Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:20 (abstract no. TPI-5). Unique Identifier : AIDSLINE ASHM5/94348936
Rosenberg M; SmithKline Beecham Pharmaceuticals, King of Prussia, PA; 19406-0939.

Abstract: HIV is a genetically complex retrovirus which can integrate into the genome of its human host and thereby remain hidden from immune surveillance or replicate slowly to achieve its chronic infection process. The advent of the recombinant DNA technologies have allowed identification, molecular dissection and characterisation of many aspects of the virus, including its structure, life cycle and interaction with the human host. The emerging picture remains a daunting one. The virus uses intricate mechanisms to regulate its growth, genetic diversity and deceptive interaction and eventual destruction of the host. Although a molecular description of HIV has certainly revealed many vital features of the virus and has helped to identify those which might serve as a focus of certain control strategies, the present picture still falls short of revealing the full dimensions of the challenge presented by AIDS.

Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*MICROBIOLOGY Human HIV/*GENETICS/IMMUNOLOGY HIV Infections/IMMUNOLOGY/*MICROBIOLOGY Molecular Biology Virus Replication/GENETICS/IMMUNOLOGY ABSTRACT
941230
M94C4291

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