Resistant fungal infections in AIDS--an emerging problem. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Resistant fungal infections in AIDS--an emerging problem.

Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:28 (abstract no. TC6). Unique Identifier : AIDSLINE ASHM5/94348950
Woolley I; Fuller A; Franklin C; Hale C; Vujovic O; Russell P; Spelman D; Spicer WJ; Department of Microbiology and Infectious Diseases, Alfred; Hospital, Prahran.

Abstract: 1. CANDIDIASIS. We discuss 3 patients who developed severe symptomatic oral candidiasis. Clinical resistance to ketoconazole and fluconazole occurred over time, necessitating the use of intravenous amphotericin in two patients. Disc sensitivity testing of their isolates with Neosensitabs confirmed the resistance. 2. CRYPTOCOCCOSIS. We discuss one patient with cryptococcaemia and not meningitis treated with fluconazole who relapsed months later. Disc sensitivity testing of the isolate with Neosensitabs revealed the cryptococcus was initially intermediate and later became resistant to fluconazole. He is now being treated with itraconazole. Fungal resistance is clearly an emerging problem in AIDS patients. We find there is good correlation with our disc sensitivity testing and clinical outcome.
Keywords: Amphotericin B/*ADMINISTRATION & DOSAGE AIDS-Related Opportunistic Infections/*DRUG THERAPY Candidiasis, Oral/*DRUG THERAPY Cryptococcosis/*DRUG THERAPY Drug Resistance, Microbial Drug Therapy, Combination Fluconazole/*ADMINISTRATION & DOSAGE Fungemia/*DRUG THERAPY Human Infusions, Intravenous Itraconazole/*ADMINISTRATION & DOSAGE Ketoconazole/*ADMINISTRATION & DOSAGE ABSTRACTKWDamphotericinb/KWDadministration&dosageaids-relatedopportunisticinfections/KWDdrugtherapycandidiasis,oral/KWDdrugtherapycryptococcosis/KWDdrugtherapydrugresistance,microbialdrugtherapy,combinationfluconazole/KWDadministration&dosagefungemia/KWDdrugtherapyhumaninfusions,intravenousitraconazole/KWDadministration&dosageketoconazole/KWDadministration&dosageabstract
941230
M94C4277

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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