Progressive multifocal leucoencephalopathy--the Fairfield Hospital experience.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Progressive multifocal leucoencephalopathy--the Fairfield Hospital experience.

Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:30 (abstract no. TC8). Unique Identifier : AIDSLINE ASHM5/94348953
Marshall C; Jennens I; Fairfield Hospital, Vic.

Abstract: Progressive multifocal leucoencephalopathy (PML) is a cerebral infection caused by JC virus occurring in immunocompromised people. It has been well described in transplant recipients requiring immunosuppressive therapy and more recently in people immunosuppressed with human immunodeficiency virus (HIV). PML is estimated to occur in 1% of persons with AIDS. Fairfield Infectious Diseases Hospital has treated 716 people with Category IV disease or AIDS. PML has been diagnosed in 12 of these patients. We conducted a search of hospital records to determine the clinical features of patients with HIV infection and PML. As opposed to transplant recipients where PML is multifocal, PML complicating HIV infection presented with distinct neurological deficits with unifocal lesions on brain imaging on 8 occasions. All patients were homosexual males. Median CD4 count at presentation was 45 (range 10-330), and in 9/12 patients PML was their AIDS defining illness. Median survival following a diagnosis/presentation was 2 months (range 0.5-6 months). Three patients received treatment with IV Ara C, but treatment did not appear to improve neurological deficits or prolong survival.

Keywords: AIDS Dementia Complex/*DIAGNOSIS/IMMUNOLOGY/MORTALITY CD4-Positive T-Lymphocytes/IMMUNOLOGY Follow-Up Studies Human Leukocyte Count Leukoencephalopathy, Progressive Multifocal/*DIAGNOSIS/IMMUNOLOGY/ MORTALITY Neurologic Examination Polyomavirus hominis 2 Survival Rate ABSTRACT
941230
M94C4274

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