Clinical and radiologic features of lung cancer in HIV infected patients. (Meeting abstract).

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Clinical and radiologic features of lung cancer in HIV infected patients. (Meeting abstract).

Proc Annu Meet Am Soc Clin Oncol; 13:A16 1994. Unique Identifier : AIDSLINE ICDB/94600013
Belani CP; Elder K; White CS; Haramati LH; Karp J; Mason A; Hussain A; University of Maryland, Baltimore

Abstract: The clinical spectrum of lung cancer (LC) occurring in HIV-infected patients (pts) remains undefined. We report a series of 23 pts who developed HIV infection that antedated the development of LC by 0-60 mo. The M:F ratio in this group was 19:4. The breakdown of risk factors for HIV included: homosexuality (3 pts), iv drug abuse (18 pts), and both (2 pts). The median age was 41 yr (range 32-61); all had history of smoking (7.5 to 40 pack yr). Mean CD4 count in 13 of the 23 pts was 213 (range 71-380). Disease was either locally advanced or metastatic at presentation, with sites of involvement (in addition to lung) being brain (6), liver (3), bone (7), pleural effusion (3), peritoneum (1), adrenal (1). Histologically 20 had adenocarcinoma and 3 squamous cell cancer. The presenting radiologic findings of tumor included hilar or central mass (10 pts), peripheral nodule (4 pts), peripheral mass greater than 3 cm (5 pts), pleural thickening only (4 pts). Of the 20 pts with adenocarcinoma, the primary lesion was central in 9, peripheral in 7 and not clearly visible in 4. Management included palliative RT to whole brain (5 pts), palliative chest RT (5 pts), definitive chest RT (2 pts), chemotherapy (4 pts) and supportive care (7 pts). Only 1 pt survived greater than 1 yr after LC diagnosis, and the median survival was 5 mo. In conclusion: (1) LC manifests in an advanced stage and at a relatively young age in HIV infected pts. (2) Adenocarcinoma is the most common histological type and usually is present in a central location in the chest.

Keywords: Adenocarcinoma/PATHOLOGY/RADIOGRAPHY/THERAPY Adult Carcinoma, Squamous Cell/PATHOLOGY/RADIOGRAPHY/THERAPY Combined Modality Therapy Female Follow-Up Studies Human HIV Infections/PATHOLOGY/*RADIOGRAPHY/THERAPY Lung Neoplasms/PATHOLOGY/*RADIOGRAPHY/THERAPY Male Middle Age Neoplasm Staging Palliative Care ABSTRACT
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M9480774

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