Human B cell interleukin 10.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Human B cell interleukin 10.

Leuk Lymphoma. 1994 Jan;12(3-4):205-10. Unique Identifier : AIDSLINE MED/94220947
Benjamin D; Park CD; Sharma V; Division of Hematology and Oncology, Arthur G. James Cancer; Hospital and Research Institute, Columbus, Ohio 43210.

Abstract: Interleukin 10 (IL-10) is a novel lymphokine which exhibits strong DNA and amino acid sequence homology to BCRF1, an open reading frame in the Epstein-Barr virus genome. Using a wide panel of EBV positive and EBV negative cell lines, it has been shown that EBV positive B cell lines derived from patients with AIDS and Burkitt's lymphoma (AABCL) secrete large quantities of B cell IL-10, compared with EBV-positive B cell lines obtained from patients with undifferentiated lymphomas of Burkitt's and non-Burkitt's types. In contrast, EBV-negative B cell lines do not express IL-10 by Northern blot analysis, ELISA or even PCR. B cell IL-10 is confined to a narrow window in the B cell differentiation pathway, and whereas IL-10 expression is detected in mature and preplasmacytic stages, none of the pro-B, pre-B, or myeloma cell lines produce IL-10. EBV exerts direct effect on the production of B cell IL-10, and purified tonsillar B cells infected with EBV were triggered to secrete IL-10. The large amount of IL-10 secreted by B cells derived from AIDS-related lymphomas suggests that HIV-1 also exerts direct effect on IL-10 secretion. B cell IL-10 may function as autocrine growth factor for B cell lymphomas, and both IL-10 and BCRF1 seem to be involved in the pathophysiology of non-Hodgkin's lymphomas.

Keywords: Amino Acid Sequence B-Lymphocyte Subsets/IMMUNOLOGY B-Lymphocytes/*IMMUNOLOGY Burkitt's Lymphoma/IMMUNOLOGY Cell Line Comparative Study Herpesvirus 4, Human/GENETICS Human HIV-1/IMMUNOLOGY Interleukin-10/*BIOSYNTHESIS/GENETICS Lymphoma, AIDS-Related/IMMUNOLOGY Polymerase Chain Reaction Sequence Homology, Amino Acid Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Viral Proteins/GENETICS JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
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M9480751

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