Response of dermal epidemic Kaposi's sarcoma to concomitant topical 5-fluorouracil and radiation therapy: results of a pilot study (Meeting abstract).

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Response of dermal epidemic Kaposi's sarcoma to concomitant topical 5-fluorouracil and radiation therapy: results of a pilot study (Meeting abstract).

American Radium Society's 75th Annual Meeting. April 24-28, 1993, Aruba, p. 35, 1993.. Unique Identifier : AIDSLINE ICDB/94698272
Williams PS; Mun C; Dept. of Radiation Oncology, Moses Div., Montefiore Medical; Center, Bronx, NY

Abstract: Epidemic Kaposi's sarcoma is the most common cancer associated with HIV infection. Since its recognition in 1981, several treatment regimens have evolved, but there is no consensus approach to treatment. These approaches to treatment have produced differing results and varying expectations. This pilot study found that combining bid topical 5-fluorouracil treatment with 24 Gy external beam radiotherapy (RT) produced a significantly greater CR rate (p=0.016) and a significantly shorter time to CR (p=0.016) than lesions treated concurrently with RT alone. The concomitant treatment produced 100% CR at 1 month vs 0% for the RT alone group (n=6). There were no treatment failures in the concomitant treatment group at 6 months vs 60% failure in the RT alone group (n=5). These results are compared to the reported results in the literature.

Keywords: Combined Modality Therapy Fluorouracil/*THERAPEUTIC USE Human Pilot Projects Sarcoma, Kaposi's/*DRUG THERAPY/*RADIOTHERAPY Skin Neoplasms/*DRUG THERAPY/*RADIOTHERAPY Treatment Failure ABSTRACT
940430
M9440913

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1994. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1994. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .