The pathological diagnosis of specific inflammatory myopathies. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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The pathological diagnosis of specific inflammatory myopathies.

Brain Pathol. 1992 Jan;2(1):13-9. Unique Identifier : AIDSLINE MED/94093804
Carpenter S; Karpati G; Department of Neurology, Neurosurgery, McGill University,; Montreal, Quebec, Canada.

Abstract: Pathological diagnosis of dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM) should be possible in almost all cases when an appropriately involved muscle is biopsied. DM shows characteristic patterns of muscle fiber damage and capillary damage. Lymphocytes and macrophages are seen in PM and IBM partially invading non-necrotic fibers. IBM is also characterized by rimmed vacuoles with membranous whorls, characteristic masses of filaments in cytoplasm and sometimes in nuclei, and grouped atrophic fibers. Muscle fiber damage in PM is more variable. Inflammatory myopathy can be associated with HTLV-1 and HIV infection. In the latter a strong resemblance to PM is reported. Separate, still less well characterized forms of inflammatory myopathy occur in young children.
Keywords: Atrophy Child, Preschool Dermatomyositis/*PATHOLOGY Human HIV Infections/PATHOLOGY HTLV-I Infections/PATHOLOGY Inflammation Microscopy, Electron Muscles/*PATHOLOGY/ULTRASTRUCTURE Myositis/*PATHOLOGY Necrosis Polymyositis/*PATHOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDatrophychild,preschooldermatomyositis/KWDpathologyhumanhivinfections/pathologyhtlv-iinfections/pathologyinflammationmicroscopy,electronmuscles/KWDpathology/ultrastructuremyositis/KWDpathologynecrosispolymyositis/KWDpathologyjournalarticlereviewreview,tutorial
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Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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