Reduced anti-Mycobacterium tuberculosis antibody response in tuberculosis patients with acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Reduced anti-Mycobacterium tuberculosis antibody response in tuberculosis patients with acquired immunodeficiency syndrome.

Braz J Med Biol Res. 1992;25(6):611-8. Unique Identifier : AIDSLINE MED/94100908
Figueiredo JF; Machado AA; Departamento de Clinica Medica, Faculdade de Medicina de; Ribeirao Preto, Universidade de Sao Paulo, Brasil.

Abstract: 1. When the sera of patients with tuberculosis were tested for anti-Mycobacterium tuberculosis IgG using an indirect ELISA, the test was positive for 94.1% of the samples from patients not having AIDS (N = 51), but for only 37.5% of the samples from patients with AIDS (N = 16). 2. False-positive results were obtained for 7.3% of patients not infected with HIV (N = 96) and for 4.7% of patients infected with HIV (N = 64). 3. In most serum samples obtained from patients with tuberculosis and AIDS after the beginning of specific treatment there was a reduction of the ELISA absorbance at 490 nm with time. 4. These results indicate that serological tests for the detection of anti-M. tuberculosis IgG in patients with AIDS are of limited value for the diagnosis of tuberculosis, most likely as a consequence of the underlying immune defect of the patients.
Keywords: Adult Antibodies, Bacterial/*BLOOD Antigens, Bacterial/DIAGNOSTIC USE/ISOLATION & PURIF AIDS-Related Opportunistic Infections/*DIAGNOSIS Comparative Study Enzyme-Linked Immunosorbent Assay/METHODS False Positive Reactions Female Human IgG/BLOOD Male Mycobacterium tuberculosis/*IMMUNOLOGY Sensitivity and Specificity Support, Non-U.S. Gov't Tuberculosis, Pulmonary/*DIAGNOSIS JOURNAL ARTICLEKWDadultantibodies,bacterial/KWDbloodantigens,bacterial/diagnosticuse/isolation&purifaids-relatedopportunisticinfections/KWDdiagnosiscomparativestudyenzyme-linkedimmunosorbentassay/methodsfalsepositivereactionsfemalehumanigg/bloodmalemycobacteriumtuberculosis/KWDimmunologysensitivityandspecificitysupport,non-uKWDsKWDgov'ttuberculosis,pulmonary/KWDdiagnosisjournalarticle
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