Localization of Mycobacterium avium-intracellulare within a skin lesion of bacillary angiomatosis in a patient with AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Localization of Mycobacterium avium-intracellulare within a skin lesion of bacillary angiomatosis in a patient with AIDS.

Diagn Mol Pathol. 1992 Sep;1(3):212-6. Unique Identifier : AIDSLINE MED/94115766
Sagerman PM; Relman DA; Niroomand F; Niedt GW; Department of Pathology, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021.

Abstract: We report a 39-year-old man who had AIDS and who presented with an unusual cutaneous vascular lesion, which was clinically thought to be Kaposi's sarcoma. Histologically, the lesion was characterized by capillary proliferation and a mixed inflammatory infiltrate that included numerous histiocytes. The lesion was found to contain slender intracellular acid-fast bacilli, as well as plump extracellular Warthin-Starry-positive bacilli. The acid-fast bacilli were confirmed to be Mycobacterium avium-intracellulare by subsequent positive blood cultures for this organism. To further investigate the lesion, polymerase chain reaction DNA amplification and sequencing was performed, and the lesion was found to contain DNA sequences identical to those previously established for the agent of bacillary angiomatosis. The lesion is thought to represent a lesion of bacillary angiomatosis with secondary involvement by M. avium-intracellulare.
Keywords: Adult Angiomatosis, Bacillary/*COMPLICATIONS/*DIAGNOSIS/MICROBIOLOGY AIDS-Related Opportunistic Infections/*DIAGNOSIS/MICROBIOLOGY/ PATHOLOGY Case Report Gram-Negative Bacteria/GENETICS/ISOLATION & PURIF Human Male Mycobacterium avium Complex/GENETICS/ISOLATION & PURIF Mycobacterium avium-intracellulare Infection/*COMPLICATIONS/ *DIAGNOSIS/MICROBIOLOGY Polymerase Chain Reaction RNA, Bacterial/GENETICS/ISOLATION & PURIF Skin Diseases, Bacterial/COMPLICATIONS/*DIAGNOSIS/MICROBIOLOGY JOURNAL ARTICLEKWDadultangiomatosis,bacillary/KWDcomplications/KWDdiagnosis/microbiologyaids-relatedopportunisticinfections/KWDdiagnosis/microbiology/pathologycasereportgram-negativebacteria/genetics/isolation&purifhumanmalemycobacteriumaviumcomplex/genetics/isolation&purifmycobacteriumavium-intracellulareinfection/KWDcomplications/KWDdiagnosis/microbiologypolymerasechainreactionrna,bacterial/genetics/isolation&purifskindiseases,bacterial/complications/KWDdiagnosis/microbiologyjournalarticle
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M9440857

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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