[In vitro studies of possible transmission of human immunodeficiency virus (HIV) by allogeneic cartilage transplants] NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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[In vitro studies of possible transmission of human immunodeficiency virus (HIV) by allogeneic cartilage transplants]

Laryngorhinootologie. 1993 Oct;72(10):473-7. Unique Identifier : AIDSLINE MED/94092277
Bujia J; Meyer H; Kim C; Hammer C; Wilmes E; Gurtler L; HNO-Klinik und Poliklinik, Ludwig-Maximilians-Universitat; Munchen.

Abstract: With the increasing prevalence of the human immunodeficiency virus (HIV), the possibility of a transmission of HIV via allogenic transplants has increased. To assess the risk of transferring HIV with allogenic cartilage grafts we investigated the susceptibility of chondrocytes to the virus. Our results indicate the absence of the HIV receptor (CD-4-molecule) on chondrocytes by immunohistochemistry and FACS analyses. Furthermore cultures from chondrocytes and high doses of HIV-1 did not show an active replication. Hence, we conclude that normal cartilage cells cannot be infected by HIV. This means that the risk of HIV transmission by cartilage allografts is very low if no contaminating tissues like blood, perichondrium and calcifications etc. are present.
Keywords: Antigens, CD4/ANALYSIS Cartilage/MICROBIOLOGY/*TRANSPLANTATION Cells, Cultured English Abstract Fluorescent Antibody Technique Human HIV Infections/MICROBIOLOGY/*TRANSMISSION Immunoenzyme Techniques Otorhinolaryngologic Diseases/*SURGERY Rhinoplasty Transplantation, Homologous JOURNAL ARTICLEKWDantigens,cd4/analysiscartilage/microbiology/KWDtransplantationcells,culturedenglishabstractfluorescentantibodytechniquehumanhivinfections/microbiology/KWDtransmissionimmunoenzymetechniquesotorhinolaryngologicdiseases/KWDsurgeryrhinoplastytransplantation,homologousjournalarticle
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M9440854

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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