AIDS-related lymphomas: NCI drug discovery efforts (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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AIDS-related lymphomas: NCI drug discovery efforts (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 34:A2600 1993. Unique Identifier : AIDSLINE ICDB/93693533
Skehan P; Williamson K; Giavazzi R; Malspeis L; Camalier R; Grever M; NCI-FCRDC, Frederick, MD 21701

Abstract: B-cell lymphomas are a major cause of death in long-term AIDS survivors. The NCI has established an in vitro subpanel of human lymphoma lines to identify new chemotherapeutic agents with antilymphoma selectivity. Agents referred from the NCI in vitro anticancer drug screen are tested in vitro against 10 human B-cell lymphoma lines using a new propidium iodide fluorescence assay to quantitate cellular responsiveness. Over 450 agents have been evaluated to date. Lymphoma-selective agents are tested for in vitro growth recovery over a 60-day period, then evaluated in vivo against xenografts grown in SCID mice. Lead compounds have emerged with novel chemical structures.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Drug Screening Assays, Antitumor Human Lymphoma, B-Cell/COMPLICATIONS/*DRUG THERAPY Spectrometry, Fluorescence Tumor Cells, Cultured ABSTRACTKWDacquiredimmunodeficiencysyndrome/KWDcomplicationsdrugscreeningassays,antitumorhumanlymphoma,b-cell/complications/KWDdrugtherapyspectrometry,fluorescencetumorcells,culturedabstract
930930
M9391189

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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