Antibodies to M. genitalium in patients with AIDS and patients attending sexual transmitted diseases clinics.

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Antibodies to M. genitalium in patients with AIDS and patients attending sexual transmitted diseases clinics.

Abstr Gen Meet Am Soc Microbiol. 1993;93:165 (abstract no. G-18). Unique Identifier : AIDSLINE ASM93/93291790
Wang R; Grandinetti T; Tully J; Davies C; Wear D; Shih J; Lo SC; Armed Forces Inst. of Pathol., Wash. D.C.

Abstract: Mycoplasma genitalium is a fastidious Mollicute originally isolated from the urethra of two homosexual men with nongonococcal urethritis. The prevalence of M. genitalium infection in humans is not known due to the difficulties of culture isolation from various clinical specimens. We have studied 1333 serum samples from various patient groups for M. genitalium-specific antibodies by ELISA using lipid-associated membrane proteins (LAMPS) as antigens. Antibodies to LAMPS from M. genitalium show little cross reactivity to LAMPS from M. pneumoniae. Antibodies to M. genitalium was detected in 150 of 341 (44.0%) patients with AIDS, and 41 of 127 (32.3%) HIV-infected asymptomatic patients. In contrast, only 21 of 381 (5.5%) HIV-negative healthy blood donors and 5 of 144 (3.5%) patients with malignant diseases tested positive. In this study, we found 126 of 340 (37.1%) HIV-negative patients attending sexually transmitted disease clinics have positive antibodies. The positive antibody reactivity was mainly directed against six LAMPS of M. genitalium as determined by Western blot. The results suggest M. genitalium is a sexually transmitted mycoplasma.

Keywords: Antibodies, Bacterial/*BLOOD AIDS-Related Opportunistic Infections/BLOOD/*DIAGNOSIS/ MICROBIOLOGY Blood Donors Blotting, Western Community Health Services Homosexuality Human HIV Infections/BLOOD/*COMPLICATIONS/MICROBIOLOGY HIV Seropositivity/BLOOD Mycoplasma/IMMUNOLOGY/*ISOLATION & PURIF Mycoplasma Infections/BLOOD/*DIAGNOSIS/TRANSMISSION Reference Values Sexually Transmitted Diseases/PREVENTION & CONTROL/TRANSMISSION ABSTRACT
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M9391181

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