Suppression of lymphocyte proliferation by Mycobacterium avium complex in HIV infected and normal healthy individuals.

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Suppression of lymphocyte proliferation by Mycobacterium avium complex in HIV infected and normal healthy individuals.

Abstr Gen Meet Am Soc Microbiol. 1993;93:180 (abstract no. U-67). Unique Identifier : AIDSLINE ASM93/93291798
Ghassemi M; Reddy MV; Gangadharam PR; Andersen B; Novak R; University of Illinois, Chicago.

Abstract: Disseminated Mycobacterium avium complex (MAC) infection is the common opportunistic infection in AIDS patients. MAC forms several isogenic colonial variants, smooth transparent (ST) colonial variant, most frequently isolated from AIDS patients, smooth opaque (SO) and rough opaque (RO) variants, commonly found in the environment. These variants differ in their modulation of host immunological functions. We have studied the effect of ST, SO, and RO sonicate antigens on the proliferation of peripheral blood mononuclear cells in normal (n = 6) as well as HIV infected patients (n = 12) with different stages of disease. All the three antigens at a concentration of 29 to 32 micrograms/ml caused suppression of PHA-induced proliferation. Of the three, SO antigen was consistently more suppressive than ST and RO antigens. The mean percent suppression for ST, SO, and RO was 37.7 +/- 6.9, 66.0 +/- 3.5, 43.5 +/- 9.5 respectively. The degree of suppression was not significantly different in HIV infected patients and normal controls. There was no correlation between different stages of the disease and percent suppression of proliferation. However, in patients with absolute CD4+ T cell count < 50, the proliferation response was minimal. From this study we conclude that the MAC antigens interfere with the lymphocyte function, and the SO isogenic variant of MAC is more effective in this respect.

Keywords: Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Antigens, Bacterial/*IMMUNOLOGY Antigens, CD/IMMUNOLOGY Antigens, CD4/IMMUNOLOGY Comparative Study Human HIV Infections/*MICROBIOLOGY *Immunosuppression *Lymphocyte Transformation Mycobacterium avium Complex/*IMMUNOLOGY Reference Values T-Lymphocyte Subsets/IMMUNOLOGY ABSTRACT
930930
M9391173

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