Pathologic findings in disseminated Mycobacterium genavense infection.

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Pathologic findings in disseminated Mycobacterium genavense infection.

Abstr Gen Meet Am Soc Microbiol. 1993;93:185 (abstract no. U-94). Unique Identifier : AIDSLINE ASM93/93291803
Wilson M; Seilstad K; Bessesen M; Cohn D; Winter S; Department of Health & Hospitals, Denver, CO.

Abstract: M. genavense is a newly-described mycobacterium that causes opportunistic infections in patients with AIDS. Of 4 patients with M. genavense infection who have been evaluated and treated at our institution, pathological material from 2 has been available for examination. Patient #1, a 29 year-old male, underwent biopsy of an enlarged cervical lymph node; the node was effaced by macrophages filled with acid-fast bacilli (AFB). Small foci of acute inflammation were present within the node. A bone marrow biopsy also showed AFB. At autopsy, massive mesenteric and para-aortic lymphadenopathy was present; the nodes were widely necrotic and/or fibrotic, with large numbers of AFB in the necrotic areas. Viable areas contained few or no AFB. Routine mycobacterial cultures of premortem lymph node and post-mortem lymph node, liver, and lung showed no or delayed growth but limited growth occurred in BACTEC TB 12B vials. Patient #2, a 35 year-old male, also had massive mesenteric lymphadenopathy; biopsy of one lymph node showed effacement of the architecture by macrophages filled with AFB. Liver biopsy taken at the same time showed AFB in Kupffer cells. Again, limited growth occurred in BACTEC TB 12B vials. Acid-fast stain of tissue taken from both patients and from mycobacteria grown in BACTEC TB 12B vials revealed short (< or = 1 micron) beaded mycobacteria. The mycobacteria were identified by PCR using 16S rRNA primers as M. genavense. We suggest that a presumptive tissue identification of M. genavense infection can be made by 1) characteristic tissue reaction, 2) size and morphology of the AFB, and 3) delayed or no growth on routine media with limited growth in BACTEC TB 12B vials.

Keywords: Adult Autopsy Case Report Human Liver/MICROBIOLOGY/PATHOLOGY Lung/MICROBIOLOGY/PATHOLOGY Lymph Nodes/MICROBIOLOGY/PATHOLOGY Male Mycobacterium/GROWTH & DEVELOPMENT/ISOLATION & PURIF Mycobacterium Infections/*PATHOLOGY Staining ABSTRACT
930930
M9391168

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1993. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1993. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .