p24 antigenemia in HIV-infected pediatric patients: comparison with virus culture. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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p24 antigenemia in HIV-infected pediatric patients: comparison with virus culture.

Abstr Gen Meet Am Soc Microbiol. 1993;93:434 (abstract no. T-14). Unique Identifier : AIDSLINE ASM93/93291811
Paul M; Pahwa S; North Shore Univ. Hosp.-Cornell Univ. Med. Col., Manhasset, N.Y.

Abstract: Sera (52) from 28 HIV-infected children (CDC class, P2), aged, 0.8-106 months, were examined for HIV p24 antigen (Coulter), without (Cont) and with, acid hydrolysis (AH) treatment. Virus isolation was attempted in corresponding plasma and PBMC of the same patients. Results show: 1. No difference in positivity rates for p24 antigen (AH or Cont) in specimens from infants up to 6 months old. 2. A persistence of p24 Ag by AH in all age groups, compared with a progressive decline without. 3. Equal sensitivity of plasma and PBMC in cultures from infants up to 12 months old; and a steady reduction in positive plasma cultures in those over 12 months. 4. No difference in PBMC isolation rate at any age. Additionally, comparative samples from uninfected children (CDC, P3) were negative by all tests. Our results indicate (1) a persistence of p24 Ag at all ages and (2), that our observed reduced isolation rate for plasma in older infants may be due to immune complex formation.
Keywords: Age Factors Child Child, Preschool Comparative Study Human HIV/*PHYSIOLOGY HIV Core Protein p24/*BLOOD HIV Infections/*BLOOD/DIAGNOSIS Infant Infant, Newborn Monocytes/MICROBIOLOGY ABSTRACTKWDagefactorschildchild,preschoolcomparativestudyhumanhiv/KWDphysiologyhivcoreproteinp24/KWDbloodhivinfections/KWDblood/diagnosisinfantinfant,newbornmonocytes/microbiologyabstract
930930
M9391160

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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