1993

Counselling challenges of early HIV intervention. [videorecording]: [New York, N.Y.] : Burroughs Wellcome, c1992 1 videocassette : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9300897A
The:Treatment of HIV & AIDS with Chinese herbs. [videorecording]: Portland, Or. : I.T.M., 1992 1 videocassette (45 min.) : sd., col. ; 1/2 in (Health care for all ; no. 102) Unique Identifier : AIDSLINE AV/9300921A; Dharmananda S
Mycobacterium avium Complex in AIDS. [videorecording]: Secaucus, N.J. : Network for Continuing Medical Education, 1993 1 videocassette (35 min.) : sd., col. ; 1/2 in. + 1 booklet (NCME telecourse ; no. 641) Unique Identifier : AIDSLINE AV/9300908A; Cohn DL; Mycobacterium avium complex (MAC) is the most common opportunistic infection in persons with AIDS. Once thought of as an ultimately fatal complication, it can now be managed with various combinations of drugs.
HIV infection : neurologic complications. [videorecording]: [Oakland, Calif.] : Kaiser Foundation Health Plan, c1993 1 videocassette (54 min.) : sd., col. ; 1/2 in. + 1 guide (Medicine in the nineties) Unique Identifier : AIDSLINE AV/9300934A; Wolfe E
[AIDS : acquired immune deficiency syndrome.] 2. Aufl.: Munchen : Zuckschwerdt, 1985 vii, 187 p. : ill Unique Identifier : AIDSLINE CAT/9311977; Helm EB
Guide to public health practice : HTLV-III antibody testing and community approaches : recommendations from a consensus conference.: Kensington, Md. : Association of State and Territorial Health Officials Foundation, [1985] vii, 27 p (Publication ; no. 85 (Oct. 1985)) Unique Identifier : AIDSLINE CAT/9312432
AIDS and mental health.: [Pleasant Hill, Calif.] : Diablo Valley College, [1987] x, 382 p. : ill., ports Unique Identifier : AIDSLINE CAT/9311975; Daley J
AIDS, what is now known.: [Pleasant Hill, Calif.] : Diablo Valley College, [1987] 1 v. (various pagings) : ill., ports Unique Identifier : AIDSLINE CAT/9312339; Daley J
Facts about AIDS : acquired immune deficiency syndrome : an annotated hand searched bibliography and Infotrac data base file.: [Pleasant Hill, Calif.] : Diablo Valley College, [1987] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9312415; Daley J
A:community response to AIDS.: Dallas, Tex. : Halcyon Press, 1988 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9311935
New York City strategic plan for AIDS.: [New York : City of New York, 1988] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9312541
Reducing the impact of AIDS and other STDs.: [Adelaide, S. Aust.?] : Public and Environmental Health Division, South Australian Health Commission, [1988?] 34 p. : ill (Bulletin ; no. 2) Unique Identifier : AIDSLINE CAT/9312594; Hart G
Report. No. 1-no. 3.: Syndrome [Washington, D.C. : The Commission, 1989-1990 3 v Unique Identifier : AIDSLINE CAT/9313322
AIDS : a guide to the law.: London ; New York : Tavistock/Routledge, 1990 xiv, 192 p. : ill Unique Identifier : AIDSLINE CAT/9311498; Harris D; Haigh R
Research priorities : behavioural research : World Health Organization, Global Programme on AIDS : meeting on research priorities regarding women and AIDS, WHO, Geneva, 19-20 November 1990.: [Canberra] : Australian National University, [1990] 9 p (Health Transition working paper ; no. 6 (1990)) Unique Identifier : AIDSLINE CAT/9311836; Caldwell P
HIV infection and AIDS : a report to Congress on the USAID program for prevention and control.: Washington, D.C. : U.S. Agency for International Development, [1990] 64 p. : ill Unique Identifier : AIDSLINE CAT/9312799
HIV infection : prevention and care : a report of the NCNR Priority Expert Panel on HIV Infection.: Bethesda, Md. : U.S. Dept. of Health and Human Services, U.S. Public Health Service, National Institutes of Health, National Center for Nursing Research, 1990 x, 61 p. : ill (National nursing research agenda ; 2) Unique Identifier : AIDSLINE CAT/9312800
The:Costs and financing of care for AIDS patients : results of a cohort study in Los Angeles.: Santa Monica, CA : Rand, [1990] xi, 24 p (A Rand note ; N-3060-HCFA) Unique Identifier : AIDSLINE CAT/9313075; Pascal AH
[AIDES : solidaires.]: Paris : Editions du cerf, 1991 710 p (L'Histoire a vif, ISSN 0299-2833) Unique Identifier : AIDSLINE CAT/9311495; Hirsch E
AIDS in Australia : reconstructing the epidemic from 1980 to 1990 and predicting future trends in HIV disease.: Canberra, ACT, Australia : National Centre for Epidemiology and Population Health, Australian National University, c1991 32 p. : ill (Working paper, ISSN 1033-1557 ; no. 29 (Dec. 1991)) Unique Identifier : AIDSLINE CAT/9311497; Solomon PJ
AIDS, philosophy and beyond : philosophical dilemmas of a modern pandemic.: Aldershot, Hants, England ; Brookfield, USA : Avebury, c1991 vi, 341 p (Avebury series in philosophy) Unique Identifier : AIDSLINE CAT/9311500; Smith JW
Blood donation and human immunodeficiency virus infection : do new and regular donors present different risks?.: Canberra, A.C.T., Australia : National Centre for Epidemiology and Population Health, Australian National University, [1991] 17 p (Working paper, ISSN 1033-1557 ; no. 27 (Dec. 1991)) Unique Identifier : AIDSLINE CAT/9311515; Jones ME
Underreaction to AIDS in sub-Saharan Africa.: [Canberra] : Australian National University, [1991] 21 p (Health Transition working paper ; no. 9 (1991)) Unique Identifier : AIDSLINE CAT/9311904; Caldwell JC
[Infoscopie Alsace : bulletin trimestriel d'information sur la sante publique.] No 1 (mars 1991)-: Strasbourg : D.D.A.S.S. du Bas-Rhin ; Colmar : D.D.A.S.S. du Haut-Rhin, [1991- v. : ill Unique Identifier : AIDSLINE CAT/9312087
Longitudinal studies of HIV infection in intravenous drug users : methodological issues in natural history research.: Rockville, MD : U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse ; Washington, D.C. : For sale by the Supt. of Docs., U.S. G.P.O., 1991 iv, 153 p. : ill (Research monograph ; 109) Unique Identifier : AIDSLINE CAT/9312127; Hartsock P; Genser SG
[El:SIDA en el derecho penal de la Republica Dominicana.] 1. ed.: Santo Domingo, Republica Dominicana : Editora Corripio, 1991 99 p. : port Unique Identifier : AIDSLINE CAT/9312259; Yepez Suncar LS
Marijuana & AIDS : pot, politics & PWAs in America.: Washington, D.C. : Galen Press, c1991 iii, 183 p. : ill Unique Identifier : AIDSLINE CAT/9312507; Randall RC
World AIDS day features.: [Geneva?] : World Health Organization Global Programme on AIDS, v Unique Identifier : AIDSLINE CAT/9312664
Oklahoma STD/HIV update.: Oklahoma City, Okla. : STD/HIV Division, Epidemiology Service, Oklahoma State Dept. of Health, v. : ill Unique Identifier : AIDSLINE CAT/9312870
Accessions list of the WHO/SPC Information Exchange for the Prevention of AIDS and STD in the Pacific = Recentes adjonctions a la base de donnees Centre OMS/CPS d'echange de documentation pour la prevention du sida et des MST en Oceanie.: in the Pacific [Noumea, New Caledonia] : The Centre, v Unique Identifier : AIDSLINE CAT/9313002
As real as it gets : the life of a hospital at the center of the AIDS epidemic.: New York : Carol Pub. Group, c1992 xv, 255 p Unique Identifier : AIDSLINE CAT/9311476; Pogash C
AIDS impact assessment : modelling and scenario analysis.: Amsterdam ; New York : Elsevier, 1992 xxiii, 319 p. : ill Unique Identifier : AIDSLINE CAT/9311496; Jager JC; Ruitenberg EJ
AIDS/HIV infection : recommendations for health care practices and public policy.: Chicago : American Hospital Association, c1992 17 p Unique Identifier : AIDSLINE CAT/9311499
HIV/AIDS and infection control in dentistry : a self-study course for dental professionals.: [Hollywood, Fla.] : Current Concept Seminars, c1992 45 p Unique Identifier : AIDSLINE CAT/9311656
London International atlas of AIDS.: Oxford, UK ; Cambridge, Mass., USA : Blackwell Publishers, 1992 1 atlas (430 p.) : ill (Blackwell reference) Unique Identifier : AIDSLINE CAT/9311692; Smallman-Raynor M; Cliff AD; Haggett P
Living HIV : a publication of the National Association of People with AIDS. Vol. 1, no. 1 (fall 1992)-: Washington, D.C. : NAPWA, [1992- v. : ill Unique Identifier : AIDSLINE CAT/9312126
Homosexuality and medicine, health, and science.: New York : Garland, 1992 xxi, 335 p. : ill (Studies in homosexuality ; v. 9) Unique Identifier : AIDSLINE CAT/9312453; Dynes WR; Donaldson S
New Jersey Women and AIDS Network news : NJWAN news.: New Brunswick, N.J. : The Network, v Unique Identifier : AIDSLINE CAT/9312540
Tanzania : AIDS assessment and planning study.: Washington, D.C. : World Bank, c1992 xxxviii, 161 p. : ill (A World Bank country study, ISSN 0253-2123) Unique Identifier : AIDSLINE CAT/9312627
Working with women and AIDS : medical, social, and counselling issues.: London ; New York : Tavistock/Routledge, 1992 xiv, 153 p. : ill Unique Identifier : AIDSLINE CAT/9312663; Bury J; Morrison V; McLachlan S
World AIDS day newsletter.: [Geneva, Switzerland] : World Health Organization Global Programme on AIDS, v Unique Identifier : AIDSLINE CAT/9312665
AIDS in Africa : a manual for physicians.: Geneva : World Health Organization, 1992 viii, 125 p. : ill Unique Identifier : AIDSLINE CAT/9312708; Piot P
Caring for a loved one with AIDS : the experiences of families, lovers, and friends.: Seattle : Published for the University of Washington School of Nursing by the University of Washington Press, c1992 vii, 64 p. : ill Unique Identifier : AIDSLINE CAT/9312730; Brown MA; Powell-Cope GM; Utterback LK
Counselling drug users about HIV and AIDS.: Oxford ; Boston : Blackwell Scientific Publications, 1992 xiii, 204 p Unique Identifier : AIDSLINE CAT/9312745; Mulleady G
Report on testing for AIDS.: Toronto, Ont., Canada : The Commission, 1992 xi, 114 p Unique Identifier : AIDSLINE CAT/9313320
The:Source.: Berkeley, CA : AIA National Resource Center, [1992- v. : ports Unique Identifier : AIDSLINE CAT/9313353
Bad blood : the Tuskegee syphilis experiment. New and expanded ed.: New York : Free Press ; Toronto : Maxwell Macmillan Canada ; New York : Maxwell McMillan International, c1993 xv, 297 p. : ill., ports Unique Identifier : AIDSLINE CAT/9311503; Jones JH
[AIDS in Psychiatrie und Neurologie.]: Koln : Deutscher Arzte-Verlag, 1993 268 p. : ill Unique Identifier : AIDSLINE CAT/9311976; Peters UH
Drugs of abuse, immunity, and AIDS.: New York : Plenum Press, c1993 xiv, 286 p. : ill (Advances in experimental medicine and biology ; v. 335) Unique Identifier : AIDSLINE CAT/9312392; Friedman H; Klein TW; Specter S
The:AIDS directory : an essential guide to the 1500 leaders in research, services, policy, advocacy, and funding. 1st ed. (1993)-: Washington, D.C. : Buraff Publications, c1993- v Unique Identifier : AIDSLINE CAT/9313031
Transcending AIDS : nurses and HIV patients in New York City.: Philadelphia : University of Pennsylvania Press, c1994 viii, 199 p (Studies in health, illness, and caregiving) Unique Identifier : AIDSLINE CAT/9312949; McGarrahan P
Fear and AIDS/HIV : empathy and communication.: New York : Delmar Publishers, c1994 xiv, 136 p (Realnursing series) Unique Identifier : AIDSLINE CAT/9313113; Lego S
Questions & answers on AIDS. 2nd ed.: Los Angeles, Calif. : PMIC, c1994 xxiv, 208 p. : Unique Identifier : AIDSLINE CAT/9313313; Frumkin LR; Leonard JM
Man, medicine & microbe : the science of AIDS & long-term survival.: Las Colinas, Tex. : Monument Press, 1994 xi, 179 p. : port (The Politics of AIDS ; v. 6) Unique Identifier : AIDSLINE CAT/9312837; Dickerson NA
HIV infection : a primary care approach. 2nd ed.: Waltham, MA : Pub. Division of the Massachusetts Medical Society, c1994 64 p Unique Identifier : AIDSLINE CAT/9312460; Hecht FM; Soloway B; Cotton DJ; Friedland GH
American cancer society textbook of clinical oncology.: American Cancer Society Textbook of Clinical Oncology. Holleb AI, Fink DJ and Murphy GP, eds. Atlanta, GA, American Cancer Society, 717 p., 1991.. Unique Identifier : AIDSLINE ICDB/93690819; Anonymous; No affiliation given; In the time since publication of this text s predecessor (Clinical Oncology: A Multidisciplinary Approach), the body of knowledge relative to cancer has grown so dramatically that this new, more comprehensive text for medical students and physicians involved in oncology was created to address not only the pathology, e
Pathogenesis of avian nephroblastoma induced by MAV-2(O).: Diss Abstr Int [B]; 52(9):4582 1992. Unique Identifier : AIDSLINE ICDB/93682290; Aidarous HM; Colorado State Univ.; Inoculation of B14 strain embryos at 10 days of incubation with the subgroup B myeloblastosis associated virus, MAV-2(O), results in a massive nephroblastoma by 12 wk of age. The purpose of this dissertation was to examine the possible factors that modulate tumor cell phenotype in avian nephroblastomas. The origin of
High-dose zidovudine (AZT) in patients with treated myelodysplastic syndromes (MDS), and relapsed or refractory AML: a preliminary report (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 34:A1184 1993. Unique Identifier : AIDSLINE ICDB/93692157; Silverman LR; Roboz J; Demakos EP; Holland JF; Derald H. Ruttenberg Cancer Center, Dept. of Neoplastic Diseases,; Mount Sinai Sch. of Medicine, New York, NY 10029; AZT , a chain terminator of DNA synthesis with myelosuppressive effects in patients (pts) with AIDS, can inhibit the growth and induce the differentiation of HL-60 leukemia cells in vitro (Proc AACR 30:53, 1989). In a feasibility study, AZT was adminis
AIDS-related lymphomas: NCI drug discovery efforts (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 34:A2600 1993. Unique Identifier : AIDSLINE ICDB/93693533; Skehan P; Williamson K; Giavazzi R; Malspeis L; Camalier R; Grever M; NCI-FCRDC, Frederick, MD 21701; B-cell lymphomas are a major cause of death in long-term AIDS survivors. The NCI has established an in vitro subpanel of human lymphoma lines to identify new chemotherapeutic agents with antilymphoma selectivity. Agents referred from the NCI in vitro anticancer drug screen are tested in vitro against 10 human B-cell l
Towards optimal anti-Tac antibody dosing in the presence of antigenemia in adult T-cell leukemia-lymphoma (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 34:A2849 1993. Unique Identifier : AIDSLINE ICDB/93693792; Junghans RP; Goldman CK; Carrasquillo J; Reynolds J; Nelson DL; Waldmann TA; New England Deaconess Hosp., Boston, MA 02215; Circulating antigen may interfere with antibody therapy by binding to antibody and reducing access to cellular targets. Patients with Tac+ leukemias and varying levels of circulating antigen (soluble Tac) were infused with anti-Tac antibody for therapy and imaging (Tac=IL2 receptor-alpha). With high soluble Tac levels
Deoxycytidine kinase and drug resistance in cancer and AIDS (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 34:565-6 1993. Unique Identifier : AIDSLINE ICDB/93694303; Mitchell BS; Ayscue LH; Dept. of Pharmacology, Univ. of North Carolina, Chapel Hill, NC; 27599; Deoxycytidine kinase (dCK) catalyzes the phosphorylation of 2 -deoxyadenosine, 2 -deoxyguanosine, and 2 -deoxycytidine to their corresponding 2 -deoxynucleoside monophosphates and is also required for the phosphorylation of a variety of clinically useful nucleoside analogs including cytosine arabinoside (araC), 2 ,3 -
Phosphorodithioate oligodeoxynucleotide analogs as inhibitors of HIV-1 reverse transcriptase and viral replication.: Diss Abstr Int [B]; 52(9):4710 1992. Unique Identifier : AIDSLINE ICDB/93682297; Marshall WS; Univ. of Colorado at Boulder; Phosphorodithioate DNA is a nucleic acid analog which contains internucleotide phosphodiester groups having sulfur at the two nonlinking positions. We have synthesized a number of dithioate oligodeoxynucleotide analogs and examined the potential anti-HIV activity of these derivatives. Oligodeoxycytidine analogs exhibi
Fatal seronegative human ehrlichiosis in a patient with human immunodeficiency virus disease.: Abstr Gen Meet Am Soc Microbiol. 1993;93:110 (abstract no. D-87). Unique Identifier : AIDSLINE ASM93/93291786; Paddock C; Suchard D; Hadley WK; Kerschmann R; Grumbach K; Dawson J; Dumler JS; Anderson B; Sims K; Herndier B; San Francisco General Hospital, CA.; The first confirmed case of disease due to Ehrlichia chaffeensis occurring in a patient with human immunodeficiency virus type 1 (HIV-1) is reported. A 42 year-old Arkansas woman with HIV-1 disease (CD4 lymphocyte count = 64 cells per cmm) died of pulmonary hemorrhage approximately 2 weeks following acute onset of a f
Evaluation of the new Baxter MicroScan Automated Probe Analyzer for detection of HIV in clinical samples.: Abstr Gen Meet Am Soc Microbiol. 1993;93:134 (abstract no. D220). Unique Identifier : AIDSLINE ASM93/93291787; Bush C; Sherman D; Donovan R; Peterson R; Godsey J; Henry Ford Hospital, Detroit, MI.; A major limitation in the use of PCR in the clinical laboratory is the detection and quantitation of the amplified product. The limitations to current technology include the use of radioactive labels, labor intensive procedures, long time to results and lack of automation. This study applied the MicroScan Automated Pr
Quantitative polymerase chain reaction for HIV is modulated by primer and target sequence.: Abstr Gen Meet Am Soc Microbiol. 1993;93:134 (abstract no. D-219). Unique Identifier : AIDSLINE ASM93/93291788; Byrne BC; Baltazar MC; Baxter JD; UMDNJ/RWJ Med. Sch., Camden.; PCR provides one measure of proviral load in HIV-infected patients. Results are frequently and conveniently expressed as copy number where the patient sample PCR signal is measured against and interpreted through signals from PCR of standard concentrations of control proviral genomes. Copy number calculations provide
Hepatitis B vaccine acceptance in HIV infected patients.: Abstr Gen Meet Am Soc Microbiol. 1993;93:159 (abstract no. E-94). Unique Identifier : AIDSLINE ASM93/93291789; Cobian L; Mayer C; Villanueva L; Sinnott J; Ganguly R; University of South Florida, Tampa.; Human immunodeficiency virus (HIV) infected patients are at high risk of acquiring hepatitis B virus (HBV) infection and also of developing carrier state. Despite these risks, there exists little information regarding HIV patients knowledge of HBV infection and their acceptance of HBV vaccine. A questionnaire was dev
Antibodies to M. genitalium in patients with AIDS and patients attending sexual transmitted diseases clinics.: Abstr Gen Meet Am Soc Microbiol. 1993;93:165 (abstract no. G-18). Unique Identifier : AIDSLINE ASM93/93291790; Wang R; Grandinetti T; Tully J; Davies C; Wear D; Shih J; Lo SC; Armed Forces Inst. of Pathol., Wash. D.C.; Mycoplasma genitalium is a fastidious Mollicute originally isolated from the urethra of two homosexual men with nongonococcal urethritis. The prevalence of M. genitalium infection in humans is not known due to the difficulties of culture isolation from various clinical specimens. We have studied 1333 serum samples fro
Isolation of Mycoplasma species from bronchoalveolar lavage of HIV and non-HIV patients.: Abstr Gen Meet Am Soc Microbiol. 1993;93:165 (abstract no. G-16). Unique Identifier : AIDSLINE ASM93/93291791; Teel L; Finelli M; Johnson S; Henry M. Jackson Foundation for the Advancement of Military; Medicine, Walter Reed Army Medical Center, Washington, D.C.; From March, 1991 through March, 1992, 94 consecutive bronchoalveolar lavages (BAL) performed for diagnosis of suspected infectious pulmonary disease were cultured for mycoplasma as part of the routine microbiological workup. Polymerase chain reaction (PCR) specific for Mycoplasma fermentans was also performed on 89 of
Seroconversion following Mycoplasma penetrans infection in patients with AIDS.: Abstr Gen Meet Am Soc Microbiol. 1993;93:165 (abstract no. G-17). Unique Identifier : AIDSLINE ASM93/93291792; Wang R; Grandinetti T; Melcher G; Hendrix C; Hayes M; Shih J; Lo SC; Armed Forces Inst. of Pathol., Wash, D.C.; Mycoplasma penetrans, a new species of human mycoplasma isolated from patients with AIDS, has a unique tip-like structure and displays prominent pathobiological properties associated with virulence. All 6 clinical isolates share extensive antigenic similarity and DNA homology. We have studied serial serum samples from
The MCR (mycoplasmal cell reactivity), a new concept in cellular infectivity: application as amplification factor for in vitro diagnosis purpose.: Abstr Gen Meet Am Soc Microbiol. 1993;93:165 (abstract no. G-19). Unique Identifier : AIDSLINE ASM93/93291793; Pautrat G; Regis R; Julia F; Dombrecht S; Escarguel C; Papierok G; International Mycoplasma (Groupe STAGO), ZAC de Signes, France.; Mycoplasma has been implied as cofactor in AIDS (MONTAGNIER and lo Groups). We tested different species of Mycoplasma (M. hominis, U. urealyticum, M. orale, M. salivarium, M. fermentans, M. pirium, M. genitalium, etc) on in vitro cellular permissive systems for infectious agents of urogenital and pulmonary tracts (res
AIDS-associated mycoplasmas and antibiotic susceptibilities.: Abstr Gen Meet Am Soc Microbiol. 1993;93:166 (abstract no. G-21). Unique Identifier : AIDSLINE ASM93/93291794; Poulin SA; Perkins RE; Kundsin RB; Brigham and Women's Hospital, Boston, MA.; Because mycoplasmas may be a cofactor in the progression of HIV infection to AIDS, their susceptibilities to antibiotics need to be understood for appropriate therapy. The mycoplasmas studied were: Mycoplasma penetrans; Mycoplasma fermentans, var. incognitus; two strains of Mycoplasma fermentans isolated from AIDS pat
The effect of antimycobacterial treatment on survival of AIDS patients with disseminated Mycobacterium avium complex infection (DMAC).: Abstr Gen Meet Am Soc Microbiol. 1993;93:174 (abstract no. U-35). Unique Identifier : AIDSLINE ASM93/93291795; Otte J; Rimland D; Ivester K; Atlanta Veterans Affairs Medical Center (AVAMC), GA.; DMAC has become the most common bacterial infection in later stages of AIDS. In order to assess the impact of DMAC, with or without specific therapy, on survival we retrospectively reviewed all patients with AIDS seen at AVAMC between 1981 and 1992. Treatment for DMAC was first used in 1989; since that time treatment
Novel, rapid test system to determine mycobacterial antibiotic susceptibility.: Abstr Gen Meet Am Soc Microbiol. 1993;93:175 (abstract no. U-36). Unique Identifier : AIDSLINE ASM93/93291796; Toneguzzo F; Stottmeier K; Brecher S; One Cell Systems, Inc., Cambridge, MA.; Infection of HIV positive individuals with strains of multi-drug resistant tuberculosis (MDRTB) has emerged as a serious and potentially explosive public health problem. These mycobacterial strains, which are essentially untreatable, pose a major threat to HIV infected individuals, health care workers, and ultimately
Detection of 28 and 65 kDa proteins in Mycobacterium avium-intracellulare complex-infected human macrophages.: Abstr Gen Meet Am Soc Microbiol. 1993;93:180 (abstract no. U-66). Unique Identifier : AIDSLINE ASM93/93291797; Ippoliti F; Fattorini L; Damiani G; Santoro C; Arizzi M; Xiao Y; Orefici G; La Sapienza University, Rome, Italy.; Organisms belonging to Mycobacterium avium-intracellulare complex (MAC) are the most common bacterial pathogens isolated from acquired immunodeficiency syndrome (AIDS)-patients. MAC are usually present within tissue macrophages where they proliferate with little evidence of inflammatory response. To investigate if mem
Suppression of lymphocyte proliferation by Mycobacterium avium complex in HIV infected and normal healthy individuals.: Abstr Gen Meet Am Soc Microbiol. 1993;93:180 (abstract no. U-67). Unique Identifier : AIDSLINE ASM93/93291798; Ghassemi M; Reddy MV; Gangadharam PR; Andersen B; Novak R; University of Illinois, Chicago.; Disseminated Mycobacterium avium complex (MAC) infection is the common opportunistic infection in AIDS patients. MAC forms several isogenic colonial variants, smooth transparent (ST) colonial variant, most frequently isolated from AIDS patients, smooth opaque (SO) and rough opaque (RO) variants, commonly found in the
T cell mitogenesis-inhibitory activity of phospholipid fraction of M. intracellulare.: Abstr Gen Meet Am Soc Microbiol. 1993;93:180 (abstract no. U-68). Unique Identifier : AIDSLINE ASM93/93291799; Tomioka H; Saito H; Shimane Medical University, Izumo, Japan.; Previously, phospholipid (PL) and polar mycoside fractions of M. avium complex (MAC) were found to have immunosuppressive activity against ConA-induced T cell mitogenesis. In this study, we investigated the immunosuppressive mechanism of action of the PL fraction, which was prepared by serial extractions with acetone,
Intestinal macrophages (MO) can be activated to kill intracellular Mycobacterium avium complex (MAC) but have differentiated ability to produce cytokines.: Abstr Gen Meet Am Soc Microbiol. 1993;93:181 (abstract no. U-69). Unique Identifier : AIDSLINE ASM93/93291800; Hsu N; Young L; Bermudez LE; Kuzell Institute, San Francisco, CA.; Current evidence suggest that the gut is the main portal of entry of MAC infection in AIDS patients. Bacterial invasion of the intestinal mucosa presumably occurs throughout the M cells where they come in contact with immuno-competent cells such as MO, T and B lymphocytes. As mucosal MO are the first line of defense,
Isolation and characterization of Mycobacterium avium isolates from African water samples.: Abstr Gen Meet Am Soc Microbiol. 1993;93:182 (abstract no. U-79). Unique Identifier : AIDSLINE ASM93/93291801; Eaton T; Falkinham JO; Von Reyn CF; Waddell R; Gilks CF; Brindle RJ; VPI&SU, Blacksburg 24061-0406.; Mycobacterium avium and Mycobacterium intracellulare (M. avium complex, MAC) are opportunistic human pathogens whose source of infection is the environment. Though disseminated MAC infection occurs in as many as 25% of United States AIDS patients, the prevalence of disseminated MAC inf
Mycobacterium tuberculosis bacteremia at Cook County Hospital: a 30-month experience.: Abstr Gen Meet Am Soc Microbiol. 1993;93:183 (abstract no. U-82). Unique Identifier : AIDSLINE ASM93/93291802; Fernandez J; Pulvirenti J; Wurtz R; Panovic S; Kocka F; Cook County Hospital-Rush Medical College, Chicago, IL.; Patients with Mycobacterium tuberculosis (MTb) bacteremia are not well described. Over a 30-month period, Cook County Hospital had 497 patients with documented MTb, 68 of these had mycobacterial blood cultures done, 14 were positive. MTb constituted 21% of all mycobacterial bacteremias. All 14 were HIV-positive with a
Pathologic findings in disseminated Mycobacterium genavense infection.: Abstr Gen Meet Am Soc Microbiol. 1993;93:185 (abstract no. U-94). Unique Identifier : AIDSLINE ASM93/93291803; Wilson M; Seilstad K; Bessesen M; Cohn D; Winter S; Department of Health & Hospitals, Denver, CO.; M. genavense is a newly-described mycobacterium that causes opportunistic infections in patients with AIDS. Of 4 patients with M. genavense infection who have been evaluated and treated at our institution, pathological material from 2 has been available for examination. Patient #1, a 29 year-old male, underwent biopsy
Physical mapping of nine genes to the chromosome of rat Pneumocystis carinii.: Abstr Gen Meet Am Soc Microbiol. 1993;93:194 (abstract no. H-24). Unique Identifier : AIDSLINE ASM93/93291804; Dykstra CC; Fletcher LD; Berger LC; Tidwell RR; Dept. of Pathology, Univ. of North Carolina, Chapel Hill.; Despite being an important AIDS-related pathogen, little is known about the genome of Pneumocystis carinii. The identification of essential housekeeping genes and comparison of the genes to other organisms will aid in the phylogenetic determination of P. carinii as well as identify potential therapeutic targets for im
Cutaneous Protothecosis in a patient with AIDS.: Abstr Gen Meet Am Soc Microbiol. 1993;93:255 (abstract no. I-86). Unique Identifier : AIDSLINE ASM93/93291805; Koestenblatt E; Woolrich A; Don P; Szaniawski W; Metropolitan Hospital Center, New York Medical College, Valhalla.; Cutaneous Protothecosis an uncommon infection caused by achlorophyllic algae is seen primarily in immunosuppressed patients. Diagnosis may be quite challenging due to the rarity of the infection as well as the non-specific and variable clinical picture. Our patient, a 33 year old Hispanic female with AIDS developed a
Factors involved in microsporidian spore polar filament (infection apparatus) extrusion.: Abstr Gen Meet Am Soc Microbiol. 1993;93:27 (abstract no. B-6). Unique Identifier : AIDSLINE ASM93/93291806; He Q; Leitch GJ; Visvesvara GS; Wallace S; Morehouse Sch. Med., Atlanta, GA.; Microsporidia are obligate intracellular protozoan parasites. An in vitro polar filament extrusion assay was developed using spores from a strain of Encephalitozoon hellem isolated from an AIDS patient and cultured in a monkey kidney cell line. Incubation in a medium resembling extracellular fluid resulted in polar fi
Restriction endonuclease patterns of non-serotypable adenoviruses recovered from AIDS patients.: Abstr Gen Meet Am Soc Microbiol. 1993;93:429 (abstract no. S-13). Unique Identifier : AIDSLINE ASM93/93291807; Chegas PM; Pierce CS; Riepenhoff-Talty MR; Amsterdam D; Children's Hospital of Buffalo, N.Y.; Over a two year period, 25 adenovirus (AV) isolates were recovered from fecal samples of 14 HIV-seropositive males. Specimens were inoculated into A-549 cells. Virus replication as evidenced by cytopathic effect was confirmed by specific AV immunofluorescent staining. Using conventional serum neutralization (SN) three
Cytotoxicity to HIV-infected cells of a Shiga toxin-CD4 fusion protein.: Abstr Gen Meet Am Soc Microbiol. 1993;93:43 (abstract no. B-96). Unique Identifier : AIDSLINE ASM93/93291808; al-Jaufy AY; Haddad JE; Jackson MP; Wayne State Univ. Medical School, Detroit, MI.; Shiga toxin (STX), a cytotoxin produced by Shigella dysenteriae 1, is targeted to a specific glycolipid receptor on susceptible cells by its B subunit. STX enters the cell by receptor mediated endocytosis and the enzymatic (A) subunit is translocated to the ribosomes where it inhibits protein synthesis. The STX A poly
Proviral burden quantitation in peripheral blood mononuclear cells from HIV-1 infected patients by the method of PCR-enzyme-linked-capture-hydroxyapatite-assay (ELCHA) as subrogated marker for AIDS prediction.: Abstr Gen Meet Am Soc Microbiol. 1993;93:433 (abstract no. T-9). Unique Identifier : AIDSLINE ASM93/93291809; Garcia-Cabrera L; Ruiz-Palacios G; Instituto Nacional de la Nutricion Salvador Zubiran, Mexico,; D.F.; CD4+ lymphocytes are the only recognized standard marker to measure the level of immunodeficiency and progression to AIDS in HIV-1 infected patients. It is important to find other markers for AIDS prediction. In this study we developed an enzymatic-colorimetric assay to quantify proviral burden in peripheral blood mon
Quantitation of HIV-1 RNA in plasma using a signal amplification branched DNA (bDNA) assay.: Abstr Gen Meet Am Soc Microbiol. 1993;93:433 (abstract no. T-10). Unique Identifier : AIDSLINE ASM93/93291810; Pachl C; Elbeik T; Saxer M; Kern D; Stempien M; Fong SJ; Sheridan P; Yeghiazarian T; Neuwald P; Urdea M; et al; Chiron Corp., Emeryville, CA.; The level of HIV-1 RNA in plasma has been quantitated using a nucleic acid hybridization assay based on signal amplification branched DNA (bDNA) technology. The RNA target is captured onto a microwell surface, detected via bDNA amplifier molecules and alkaline phosphatase labeled probes, and signal is generated using
p24 antigenemia in HIV-infected pediatric patients: comparison with virus culture.: Abstr Gen Meet Am Soc Microbiol. 1993;93:434 (abstract no. T-14). Unique Identifier : AIDSLINE ASM93/93291811; Paul M; Pahwa S; North Shore Univ. Hosp.-Cornell Univ. Med. Col., Manhasset, N.Y.; Sera (52) from 28 HIV-infected children (CDC class, P2), aged, 0.8-106 months, were examined for HIV p24 antigen (Coulter), without (Cont) and with, acid hydrolysis (AH) treatment. Virus isolation was attempted in corresponding plasma and PBMC of the same patients. Results show: 1. No difference in positivity rates fo
An in-vivo protease inhibitor screening assay using a non-infectious HIV-1 proviral clone.: Abstr Gen Meet Am Soc Microbiol. 1993;93:434 (abstract no. T-16). Unique Identifier : AIDSLINE ASM93/93291812; Heldsinger AA; Antonucci TK; Department of Infectious Diseases, Parke-Davis Pharmaceutical; Research, Division of Warner Lambert Company, Ann Arbor, MI; 48105.; We developed an in-vivo assay to screen for protease inhibitors using a non-infectious HIV-1 proviral clone (X19) with a deletion in the envelope gene. COS 7 cells were transfected by the calcium phosphate technique with 10 micrograms of X19 DNA cloned into the plas
Detecting HIV-1 seroconverters by a sensitive peptide EIA.: Abstr Gen Meet Am Soc Microbiol. 1993;93:434 (abstract no. T-13). Unique Identifier : AIDSLINE ASM93/93291813; Lee-Thomas S; Pau CP; Schochetman G; George JR; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta.; Sixteen overlapping synthetic peptides from the immunodominant region of HIV-1 gp41 (amino acids 581-623) were evaluated in an enzyme immunoassay (EIA) to detect early seroconversion of HIV-1. In addition, two 14 amino-acid peptides, one corresponding to the principle neutralizing domain (V3 region) of HIV-1 gp120, (a
Human immunodeficiency virus culture positivity as related to participation in clinical trials.: Abstr Gen Meet Am Soc Microbiol. 1993;93:434 (abstract no. T-11). Unique Identifier : AIDSLINE ASM93/93291814; Kuk R; Gaur S; Frenkel LD; John JF; Robert Wood Johnson Medical School, New Brunswick, N.J.; Viremia with HIV can provide insights into the progression of HIV infection. Our HIV culture laboratory supports an AIDS Clinical Trials Unit (ACTU) but also processes other non-ACTU samples. We questioned if the rates of positive cultures differed between these two groups. Cultures were performed using 6 x 10(6) pati
HIV-1 detection by PCR and alkaline phosphatase directly labeled DNA probes.: Abstr Gen Meet Am Soc Microbiol. 1993;93:434 (abstract no. T-12). Unique Identifier : AIDSLINE ASM93/93291815; Castro M; Bishr M; Tang K; Vela R; University of North Texas, Denton.; A DNA amplification procedure using a heat stable DNA Polymerase and the polymerase chain reaction is described for the detection of HIV-1. A set of primers was designed to obtain a 500 b.p. amplification product from the gag region of a plasmid containing an inactivated version of HIV-1. Using this set of primers in
Quantitation of HIV-1 RNA by PCR with Tth DNA polymerase.: Abstr Gen Meet Am Soc Microbiol. 1993;93:434 (abstract no. T-15). Unique Identifier : AIDSLINE ASM93/93291816; Mulder J; McKinney N; Christopherson C; Sninsky J; Kwok S; Roche Molecular Systems, Alameda, California.; The development of a quantitative assay for particulate viral RNA involves four critical elements: sample preparation, efficient and reproducible amplification of RNA, internal control, and quantitative detection. A single tube, single enzyme system has been developed for quantitation of HIV RNA in plasma or sera by P
Anti-CD4 antibodies are associated with a specific decrease in CD4-positive lymphocytes in HIV-1 seroconverters. The Multicenter AIDS Cohort Study (MACS).: Abstr Gen Meet Am Soc Microbiol. 1993;93:435 (abstract no. T-22). Unique Identifier : AIDSLINE ASM93/93291817; Keay S; Wecksler W; Wasserman SS; Department of Veterans Affairs Medical Center, Baltimore, MD.; We previously showed that anti-CD4 antibodies may be present in up to 85% of persons at the time of HIV-1 seroconversion, the timing of which response suggests that these anti-CD4 antibodies are generated as anti-idiotype antibodies against anti-gp 120/160 antibodies made in response to HIV-1 infection. Such anti-idio
Chemiluminescent detection of PCR amplified HIV-1 DNA from peripheral blood mononuclear cells of migrant farm workers.: Abstr Gen Meet Am Soc Microbiol. 1993;93:435 (abstract no. T-17). Unique Identifier : AIDSLINE ASM93/93291818; Bankowski MJ; Schulte J; Frees N; Horton P; Landay A; Staes B; Shuburg R; Caueffield D; Knapp R; Glinski B; et al; Diagnostic Services, Inc., Naples Community Hospital, FL.; A recent study of migrant farm workers in Florida showed a high seropositivity rate for both HIV-1 (5%) and syphilis (8%) [CDC. MMWR 1992;41:723-725]. We selected a subgroup of 35 from these 310 participants to further investigate with both HIV-1 co-culture and the polymerase chain reaction (PCR). Our patient group co
Evaluation of HIV-1 perinatal infection by a modified HIV-1 IgA immunoblot assay.: Abstr Gen Meet Am Soc Microbiol. 1993;93:435 (abstract no. T-20). Unique Identifier : AIDSLINE ASM93/93291819; Norman GL; Gross M; Yee J; Carlson J; Microbiology Reference Laboratory, Cypress, CA.; Approximately 13-45% of children born to HIV-infected mothers are expected to become infected with HIV-1. Serological diagnosis of infection in infants is confounded by the presence of passively acquired maternal IgG. Recent reports have documented the efficacy of detecting IgA antibodies to HIV-1 for the early diagno
Isotype and specificity of the antibody response to HIV in Puerto Rico.: Abstr Gen Meet Am Soc Microbiol. 1993;93:435 (abstract no. T-19). Unique Identifier : AIDSLINE ASM93/93291820; Hernandez M; Montealegre F; Diaz AM; Dept. of Microbiology and Medical Zoology, Univ. of P.R.; In this study, we have investigated by Western blot analysis the isotypic profile of the antibody response to HIV structural proteins (env, gag, and pol) for IgG subclasses. The study involves 100 HIV-1 positive Puerto Rican patients at various stages of infection that visited the Centro Latinoamericano de Enfermedade
Kinetics of HIV p24 decrease after initiation of ZDV therapy assessed by immune complex dissociation and non-immune complex dissociation assays.: Abstr Gen Meet Am Soc Microbiol. 1993;93:435 (abstract no. T-21). Unique Identifier : AIDSLINE ASM93/93291821; Donovan RM; Smereck SM; Bush CE; Baxa DM; Griffin N; Markowitz NP; Saravolatz LD; Department of Infectious Diseases, Henry Ford Hospital, Detroit,; Michigan.; HIV p24 antigenemia is a surrogate marker for assessing therapeutic efficacy in clinical trials and monitoring patients on antiretroviral therapy. Recently, measurement of HIV p24 antigenemia after dissociation of immune complexes (IC) has been shown to increase the sensitivity of detection of p24 antigenemia. This st
The use of PCR and a non-radioactive microwell hybridization assay to screen blood from potential corneal donors for the presence of HIV-1.: Abstr Gen Meet Am Soc Microbiol. 1993;93:435 (abstract no. T-18). Unique Identifier : AIDSLINE ASM93/93291822; Kinard SJ; Wang H; Pepose J; Connell S; Batchelor J; Locklear J; McCreedy B; Danagan E; Spadoro JP; Roche Molecular Systems, Branchburg, NJ.; In recent years, it has become increasingly important to assure that transplanted organs and tissues are free of any contaminating agents that may result in disease and/or death to the recipient. Towards that effort, we are testing the efficacy of using PCR coupled with a non-radioactive microwell assay for the detect
Activation of human polyoma virus early gene promoters by HIV-1 transactivator Tat.: Abstr Gen Meet Am Soc Microbiol. 1993;93:436 (abstract no. T-28). Unique Identifier : AIDSLINE ASM93/93291823; Mondal D; Zhang D; Prakash O; Alton Ochsner Medical Foundation, New Orleans, LA.; Progressive multifocal leukoencephalopathy (PML) occurs in AIDS patients at a much higher frequency than in other immunosuppressive disorders. In view of the growing body of evidence that Tat is not only essential for the HIV infectious cycle, but may also be directly involved in many HIV-1 infection-associated compli
Assays to detect AIDS receptor antagonists, compounds that inhibit the binding of the HIV-1 surface glycoprotein, gp120, to the CD4 receptor on human T-lymphocytes.: Abstr Gen Meet Am Soc Microbiol. 1993;93:436 (abstract no. T-23). Unique Identifier : AIDSLINE ASM93/93291824; Tait-Kamradt A; Petitpas J; Clancy J; McGuirk P; Subashi T; Watts P; Wondrack L; Pfizer Central Research, Groton, CT.; The AIDS virus, HIV-1, infects human helper T-lymphocytes via an interaction between gp120, the viral coat protein, and the T-cell receptor, CD4. Disruption of this interaction blocks infection in vitro. Microtiter-based immunoassays developed to measure gp120/CD4 binding were used to screen a variety of compounds for
Clinical characteristics and outcome of HIV patients with Pneumocystis carinii pneumonia at the San Juan VAMC.: Abstr Gen Meet Am Soc Microbiol. 1993;93:436 (abstract no. T-26). Unique Identifier : AIDSLINE ASM93/93291825; Ruiz H; Curet J; Ramirez Ronda C; Rivera Vazquez CR; Laureano A; Ojeda A; San Juan VAMC, Department of Medicine, Puerto Rico.; Although advances in detection and management, Pneumocystis carinii pneumonia (PCP) continue to be a serious problem to HIV infected patients (Pts). The typical pattern of clinical presentation has become increasingly varied with the use of antiviral therapy and anti-Pneumocystis prophylaxis agents. Regardless of pres
Cytomegalovirus polyradiculopathy syndrome in HIV infected patients.: Abstr Gen Meet Am Soc Microbiol. 1993;93:436 (abstract no. T-27). Unique Identifier : AIDSLINE ASM93/93291826; Meier P; Blatt S; Wilford Hall Medical Center, San Antonio, Texas.; Cytomegalovirus polyradiculopathy is a rare neurologic syndrome which is reported to occur in less than 1% of AIDS patients. We describe four patients with CMV polyradiculopathy from a cohort of 216 AIDS patients followed in the USAF HIV Natural History Study (i
In vitro anti HIV-1 activity of alkaline autooxidized catechinic acid (AOCA).: Abstr Gen Meet Am Soc Microbiol. 1993;93:436 (abstract no. T-24). Unique Identifier : AIDSLINE ASM93/93291827; Ferrea G; Ranieri E; Fioredda F; Corradino P; Sampietro F; Astegiano G; Cruciani M; Romussi G; Bassetti D; University of Genoa-Italy.; Certain natural polyphenols possess an antiviral activity. Catechin and catechinic acid belong to these chemical compounds. In this study we evaluated the antiviral activity of AOCA, derived from catechinic acid alkaline autooxidation, on HIV-1 cell cultures. HIV 1 was obtained from culture supernatant of H9/HTLVIIIB
Sequential quantitative analysis of viral activity in HIV-1 infected patients.: Abstr Gen Meet Am Soc Microbiol. 1993;93:436 (abstract no. T-25). Unique Identifier : AIDSLINE ASM93/93291828; Bagnarelli P; Menzo S; Valenza A; Clementi M; Institute of Microbiology, University of Ancona, Italy.; We have developed and used a competitive polymerase chain reaction (cPCR) to examine the level of HIV-1 activity in symptomatic and symptomless infected patients. Using this molecular approach quantitative data on (i) HIV-1 viremia levels (HIV-1 genome molecules in plasma samples), (ii) specific viral transcripts (tra
Discovery of HIV-1 protease inhibitors from natural products and synthetic compounds.: Abstr Gen Meet Am Soc Microbiol. 1993;93:437 (abstract no. T-29). Unique Identifier : AIDSLINE ASM93/93291829; Tomich P; Lynn J; Horng M; Seest E; Dolak L; Bohanon M; Upjohn Company, Kalamazoo, MI.; HIV, the presumed etiological agent that induces AIDS, has elicited a massive effort to control and hopefully cure this disease. To that end, we have instituted a procedure to discover potential therapeutic agents targeted against the viral encoded protease. The virus demands functional utility of this enzyme at sever
Effect of TAT and protease inhibitors on HIV-1 activation in OM-10.1 cells.: Abstr Gen Meet Am Soc Microbiol. 1993;93:437 (abstract no. T-32). Unique Identifier : AIDSLINE ASM93/93291830; Feorino PM; Butera ST; Folks TM; Schinazi RF; Emory University, Atlanta, GA.; OM-10.1 cells consistently remain CD4+ and clonally harbor a single provirus copy while constitutively expressing very low levels of HIV-1. After treatment with TNF-alpha, there is a marked down modulation of CD4+ cells and an extensive increase of HIV expression within 24 hr. Our group has used the OM-10.1 cells to e
Evaluation of Murex rapid microfiltration assay for HIV-1 antibodies in serum.: Abstr Gen Meet Am Soc Microbiol. 1993;93:437 (abstract no. T-34). Unique Identifier : AIDSLINE ASM93/93291831; Arens M; Park C; Dept Pediatrics, Washington Univ Med Sch, St. Louis, MO 63110.; The Murex Single Use Diagnostic System (SUDSR) HIV-1 Test is a 10-min enzyme immunoassay for the detection of HIV-1 antibodies. The test employs affinity-purified p24 antigen and a gp41 transmembrane synthetic peptide. We evaluated the SUDSR HIV-1 test (Murex) and compared it to Organon Teknika ELISA and EpitopeR west
Expression of HIV-1 genes placed under the control of the lac promoter in pUC18 tested in various potential bacterial carrier strains.: Abstr Gen Meet Am Soc Microbiol. 1993;93:437 (abstract no. T-30). Unique Identifier : AIDSLINE ASM93/93291832; Branstrom A; Benson J; Aggarwal A; Franchini G; Sadoff J; Warren R; Walter Reed Army Inst. of Res., Washington, D.C.; The sequence for HIV-1 MN was used to make primers to PCR amplify portions of the genes encoding for ENV, GAG, POL, NEF and VIF. These regions were chosen since they contain epitopes involved in the CTL response, which may prove advantageous for the development of a vaccine. Primers were designed containing BamHI and
High-dose recombinant soluble CD4 (rsCD4) in patients with HIV-1 infection.: Abstr Gen Meet Am Soc Microbiol. 1993;93:437 (abstract no. T-33). Unique Identifier : AIDSLINE ASM93/93291833; Sachs M; Fong KL; Blanchard L; Wikler M; Jefferson Med. Coll., Phila., PA.; A study of rsCD4, administered in a maximal dosage of 30 mg per day, provided suggestive evidence of this drug s antiretroviral activity in humans. Nonetheless, this dosage achieved maximum serum concentrations (Cmax) of only 50 to 300 ng/ml. Thus, we treated patients with a dosage of 5 mg/kg per day of rsCD4 administ
HTLV-II isolates from Italian IVDUs belong to IIb subtype.: Abstr Gen Meet Am Soc Microbiol. 1993;93:437 (abstract no. T-31). Unique Identifier : AIDSLINE ASM93/93291834; Zella D; Salemi M; Achilli G; Cattaneo E; Landini V; Casoli C; Bertazzoni U; IGBE/CNR, Pavia, Italy.; HTLV-II was isolated from two Italian intravenous drug users (IVDUs) coinfected with HIV-1. The new isolates, HTLV-II Gu and Va, were characterized by sequence analysis of LTR and regions of gag, env and X genes. From the sequence of 1988 nucleotides examined, a variability of 1.6% was found between new isolates and o
Detection of BIV provirus in bovine cells by polymerase chain reaction.: Abstr Gen Meet Am Soc Microbiol. 1993;93:438 (abstract no. T-39). Unique Identifier : AIDSLINE ASM93/93291835; Nash JW; Hanson LA; St. Cyr-Coats K; Mississippi State University.; Bovine immunodeficiency-like virus (BIV), a lentivirus related to HIV, causes a syndrome in cattle which is similar to AIDS. Although a seroprevalence greater than 50% was demonstrated in Mississippi dairy herds, the mode of BIV transmission is undefined. The purpose of this study was to develop a PCR probe to amplify
Genetic variability in the HIV-1 principal neutralizing domain from North American and African isolates.: Abstr Gen Meet Am Soc Microbiol. 1993;93:443 (abstract no. T-66). Unique Identifier : AIDSLINE ASM93/93291836; Massey J; Downes F; Johnson D; Martin R; Gath E; Booth C; Shaw M; Maassab H; Mich. Dept. Publ. Hlth., Lansing.; HIV-1 exhibits extensive genetic variability, particularly in the envelope gene (env). The third hypervariable (V3) region of env contains the primary neutralizing domain (PND). Mutants capable of avoiding the hosts immune response may arise from nucleic acid changes in the PND. Whole blood specimens were received fro
Structure-function analysis of the HIV-1 envelope V3 loop tropism determinant.: Abstr Gen Meet Am Soc Microbiol. 1993;93:443 (abstract no. T-67). Unique Identifier : AIDSLINE ASM93/93291837; Ratner L; Carrillo A; Ebenbichler C; Gu R; Washington University, St. Louis, Mo.; The V3 loop of the HIV-1 gp120 envelope protein is a critical determinant of macrophage-tropism. Using full-length HIV clones, substitution of a macrophage-tropic V3 loop into a T cell line tropic isolate abolished T cell line replication. Although the V3 loop was insufficient for T cell line tropism in a macrophage-t
A human monoclonal antibody to a cryptic gp41 epitope on HIV-1 infected cells.: Abstr Gen Meet Am Soc Microbiol. 1993;93:444 (abstract no. T-70). Unique Identifier : AIDSLINE ASM93/93291838; Myers R; Meiller T; Falkler W Jr; Patel J; Joseph J; MD Department of Health Laboratories, Baltimore.; The development of HIV-1 human monoclonal antibodies (huMAb) has provided valuable insights into the immune response to HIV-1 infections. We have developed a IgG1 (lambda) HIV-1 gp41 huMAb (MD-1) which exclusively reacts with oligomeric forms of gp41 on immunoblots. The binding of the huMAb has been localized to the N
HIV-1 replication in non-dividing cells.: Abstr Gen Meet Am Soc Microbiol. 1993;93:444 (abstract no. T-73). Unique Identifier : AIDSLINE ASM93/93291839; Dempsey M; Haggerty S; Gulizia J; Bukrinsky M; Stevenson M; University of Nebraska Medical Center, Omaha.; Completion of the retroviral life cycle is dependent upon integration of viral DNA with the host cell genome and establishment of the provirus. Following reverse transcription and prior to integration, the viral RNA remains associated with viral cDNA and integrase in a high molecular weight pre-integration complex. Ta
Inhibition of HIV-1 infection and syncytia formation by synthetic peptides from the V3 loop in gp120: potential for AIDS therapy.: Abstr Gen Meet Am Soc Microbiol. 1993;93:444 (abstract no. T-68). Unique Identifier : AIDSLINE ASM93/93291840; Nehete P; Arlinghaus R; Sastry J; University of Texas M.D. Anderson Cancer Center, Houston.; Several reports described that the V3 loop in the envelope protein gp120 of human immunodeficiency virus type 1 (HIV-1) not only represents an immunodominant region but also is important for virus infection. We observed that synthetic peptides representing V3 loop regions from 11 different HIV-1 strains when used at n
Mutations within the leucine zipper of the transmembrane protein (gp41) of HIV interfere with wild-type mediated membrane fusion.: Abstr Gen Meet Am Soc Microbiol. 1993;93:444 (abstract no. T-71). Unique Identifier : AIDSLINE ASM93/93291841; Seaman WT; Fenger TW; Marshall Univ. Sch. of Med., Huntington, W.V. 25755-9330.; Assembly of the HIV envelope protein into oligomers is mediated by interactions between monomers of the transmembrane protein, gp41. We are interested in determining the significance of oligomerization in the production of functional Env protein. An expression plasmid was constructed containing the env coding sequence
Potential role of a calmodulin-binding segment of HIV-1 TM protein in the uncoupling of signal transduction in HIV-infected cells.: Abstr Gen Meet Am Soc Microbiol. 1993;93:444 (abstract no. T-72). Unique Identifier : AIDSLINE ASM93/93291842; Miller MA; Mietzner TA; Cloyd MW; Montelaro RC; University of Pittsburgh School of Medicine, PA.; It has been well documented that signal transduction within HIV-infected lymphocytes is significantly perturbed resulting in the inability of these cells to become activated and proliferate. We have identified a 28-residue segment localized to the extreme carboxyl terminus of HIV-1 transmembrane (TM) protein which has
Sequential analysis of the V3 loop in HIV-1 from a pediatric population.: Abstr Gen Meet Am Soc Microbiol. 1993;93:444 (abstract no. T-69). Unique Identifier : AIDSLINE ASM93/93291843; Massey J; Downes F; Johnson D; Martin R; Gath E; Booth C; Shaw M; Maassab H; Mich. Dept. Publ. Hlth., Lansing.; Transmission of HIV-1 from mother to infant has become the primary route for pediatric infection. Genetic characteristics of HIV-1 may influence transmission efficiency, while immune modulation may influence the rate of disease progression. HIV-1 gag, LTR and env regions were amplified by the polymerase chain reaction
Characterization of feline immunodeficiency virus mutants selected with ddI alone and in combination with AZT.: Abstr Gen Meet Am Soc Microbiol. 1993;93:445 (abstract no. T-76). Unique Identifier : AIDSLINE ASM93/93291844; Gobert JM; Remington KM; Zhu YQ; North TW; University of Montana, Missoula.; Mutants of feline immunodeficiency virus (FIV) were selected in vitro by passage in the presence of 2 ,3 -dideoxyinosine (ddI) or a combination of ddI and 3 -azido-3 -deoxythymidine ( AZT ). Mutants were selected from both the wild-type, Petaluma strain
Characterization of AZT-resistant mutants of feline immunodeficiency virus selected from a molecular clone.: Abstr Gen Meet Am Soc Microbiol. 1993;93:445 (abstract no. T-77). Unique Identifier : AIDSLINE ASM93/93291845; Remington KM; North TW; Phillips TR; Univ. of Montana, Missoula.; The nucleoside analog, 3 -azido-3 -deoxythymidine ( AZT ), has been widely used for treatment of patients with the acquired immune deficiency syndrome (AIDS). Recently, human immunodeficiency virus (HIV) that is resistant to AZT has been isolated from A
Met184 mutation on HIV-1 RT confers resistance to the oxathiolane nucleoside analogues (-)-BCH-189 and (-)-FTC.: Abstr Gen Meet Am Soc Microbiol. 1993;93:445 (abstract no. T-75). Unique Identifier : AIDSLINE ASM93/93291846; Schinazi RF; Lloyd RM Jr; Nguyen MH; Cannon D; Ilksoy N; Chu CK; Liotta DC; Mellors JW; VA Med. Ctr./Emory Univ, Decatur, GA 30033.; (-)-2 ,3 -Dideoxy-5-fluoro-3 -thiacytidine [(-)-FTC] and (-)-2 ,3 -dideoxy-3 -thiacytidine [(-)-BCH-189] selectively inhibit HIV-1, HIV-2, and HBV in vitro. The potential for HIV resistance to these compounds was evaluated by serial passage of the virus in primary human lymphocytes and MT-2 cells in the presence of in
Modulations in cellular factor availability can synergistically alter the rate of Tat-mediated transactivation of HIV.: Abstr Gen Meet Am Soc Microbiol. 1993;93:445 (abstract no. T-74). Unique Identifier : AIDSLINE ASM93/93291847; Mondal D; Prakash O; Alton Ochsner Medical Foundation, New Orleans, LA.; HIV-1 Tat requires both the promoter elements [Sp1 and TATA] and the Tar region, for transactivation of HIV-1 LTR. In addition to Tat a number of cellular proteins are also essential for transactivation. Since, these cellular factors play a key role in the transactivation it has been our goal to investigate the level
Clinical utility of HIV-1 p-24 antigen assays; an evaluation.: Abstr Gen Meet Am Soc Microbiol. 1993;93:451 (abstract no. C-32). Unique Identifier : AIDSLINE ASM93/93291848; Ndimbie OK; Riddle P; Central Blood Bank, Pittsburgh, PA.; HIV-1 antigen (HIV-1 Ag) testing can facilitate HIV diagnoses in the window period, and in the presence of passive antibody. Neonates with seropositive mothers, tissue donors, persons inadvertently exposed to potentially infectious body fluids, and those with indeterminate (IND) HIV-1 Western Blot (WB) can benefit fro
Evaluation of an automated, contained nonradioisotopic polymerase chain reaction-based assay for detection of human immunodeficiency virus (HIV) type 1 and 2. Nucleic Acid Diagnostic Program members.: Abstr Gen Meet Am Soc Microbiol. 1993;93:451 (abstract no. C-31). Unique Identifier : AIDSLINE ASM93/93291849; Atwood S; Ekeze T; Cummins T; Clinical Diagnostics Division, Eastman Kodak Company, Rochester,; NY 14650-2117.; The polymerase chain reaction (PCR) has revolutionized the direct detection of HIV due to its exquisite sensitivity. However, rigorous protocols such as separate laboratories and designated personnel are currently required to prevent false positives due to amplified sequence contamination. Eastman Kodak Company Clinic
Improved detection and quantitation of HIV-1 antigen after dissociation of immune complexes.: Abstr Gen Meet Am Soc Microbiol. 1993;93:451 (abstract no. C-33). Unique Identifier : AIDSLINE ASM93/93291850; Starkey C; Yen-Lieberman B; Proffitt MR; Cleveland Clinic Foundation, Ohio.; The frequency with which current tests for HIV-1 p24 antigen can detect the antigen in serum of infected individuals is low. This has been attributed, in part, to the presence in the blood of HIV-1 antibodies that complex with antigen and render it undetectable. Based on quantity of specimen available, we selected 40
Microbiology, epidemiology, and prognostic significance of bacteremia (B) and fungemia (F) in HIV-infected (HIV+) and HIV-uninfected (HIV-) patients (pts).: Abstr Gen Meet Am Soc Microbiol. 1993;93:487 (abstract no. C-234). Unique Identifier : AIDSLINE ASM93/93291851; Quartey S; Towns M; Weinstein MP; Mirrett S; Reimer LG; Reller LB; Robert Wood Johnson Medical School, New Brunswick, NJ.; As part of a prospective evaluation of 1000 patients, we are comparing B and F in HIV+ and HIV- pts. Of 555 episodes analyzed to date, 54 (51 unimicrobial, 3 polymicrobial) were in HIV+ pts. The most common isolates in HIV+ pts were S. aureus (15), P. aeruginosa (10), M. avium complex (10), and C. neoformans (6); wher
Epidemiology and natural history of cytomegalovirus (CMV) infection in HIV-1 seropositive women.: Abstr Gen Meet Am Soc Microbiol. 1993;93:494 (abstract no. C-273). Unique Identifier : AIDSLINE ASM93/93291852; Clarke L; Duerr A; Daidone B; Rizvi S; Sierra M; Ehrlich I; Dehovitz J; Minkoff H; SUNY Health Science Ctr, Brooklyn.; CMV seroprevalence and the rate of active urogenital infection were investigated in HIV-infected women without AIDS-defining conditions. Women (71 black, 25 hispanic, 14 other; ages 20-55; 26% hx IVDU) enrolled in the Womens AIDS Cohort Study (WACS) underwent a
Detection of Cryptosporidium in induced sputum using ELISA and direct immunofluorescence.: Abstr Gen Meet Am Soc Microbiol. 1993;93:522 (abstract no. C-431). Unique Identifier : AIDSLINE ASM93/93291853; Atkinson DM; Moore DF; Orange County Public Health Laboratory, Santa Ana, CA.; Cryptosporidium, an intestinal protozoan, is a well recognized cause of diarrhea in AIDS patients. It can also colonize the oropharynx, the trachea and the lungs. Respiratory cryptosporidiosis is a rare complication of intestinal infection in AIDS and immunocompromised patients with only 13 human cases reported since
Diagnosis of intestinal microsporidiosis in AIDS patients by examination of stool and duodenal aspirates with a modified trichrome stain.: Abstr Gen Meet Am Soc Microbiol. 1993;93:522 (abstract no. C-433). Unique Identifier : AIDSLINE ASM93/93291854; Degirolami PC; Desai G; Ezratty C; McCullough A; Federman M; New England Deaconess Hospital, Boston, MA.; Intestinal microsporidiosis caused by Enterocytozoon bieneusi and other microsporidia is an emerging opportunistic infection associated with severe chronic diarrhea in patients with AIDS. Recently a chromotrope based modified trichrome stain (MTS) was described for det
Development of Candida albicans resistance to fluconazole during treatment for thrush over a two year period in AIDS.: Abstr Gen Meet Am Soc Microbiol. 1993;93:527 (abstract no. F-3). Unique Identifier : AIDSLINE ASM93/93291855; Redding S; Smith J; Farinacci G; Pfaller M; Rinaldi M; Fothergill A; Univ. Tx. Hlth Sci Ctr. San Antonio.; It has been reported previously that fluconazole is an effective therapy for thrush in AIDS patients, even over multiple infections. The purpose of this study was to follow a patient with AIDS over multiple infections over a two year period to determine if fluconazole remained
Efficacy of oral (PO) amphotericin B (AB) in AIDS patients with thrush clinically resistant to fluconazole (F).: Abstr Gen Meet Am Soc Microbiol. 1993;93:527 (abstract no. F-2). Unique Identifier : AIDSLINE ASM93/93291856; Dewsnup DH; Stevens DA; Santa Clara Valley Med. Ctr., San Jose, CA.; Reports of thrush in AIDS patients clinically refractory to clotrimazole, ketoconazole and F and resistant to azoles in vitro are increasing with increasing use of these agents. Several cases have been successfully treated with systemic AB. Regarding other PO alternatives, nyst
Analysis of rat T-cell responses to a surface antigen of rat derived Pneumocystis carinii.: Abstr Gen Meet Am Soc Microbiol. 1993;93:530 (abstract no. F-17). Unique Identifier : AIDSLINE ASM93/93291857; Theus S; Linke M; Andrews R; Walzer P; Univ. Cincinnati Coll. Med., OH.; Despite improved diagnosis and therapy, Pneumocystis carinii (Pc) remains a serious threat to the immunocompromised host, particularly patients with the acquired immune deficiency (AIDS). Resistance to Pc appears to involve both a humoral and a cellular immune response. We have previously identified a major surface gl
Geographic clustering of Pneumocystis carinii pneumonia.: Abstr Gen Meet Am Soc Microbiol. 1993;93:534 (abstract no. F-42). Unique Identifier : AIDSLINE ASM93/93291858; Vigdorth E; Hertzberg V; Frame P; Walzer P; Univ Cincinnati, OH.; We have analyzed the epidemiologic features of primary Pneumocystis carinii pneumonia (PcP) occurring in HIV patients over a 4 year period using the data base generated by the AIDS Clinical Trials Unit (ACTU) which cares for > 90% of the AIDS patients in the Cincinnati area. The 118 cases of PcP were compared with two
Structure of the glucuronoxylomannan of Cryptococcus neoformans obtained from patients with AIDS.: Abstr Gen Meet Am Soc Microbiol. 1993;93:543 (abstract no. F-89). Unique Identifier : AIDSLINE ASM93/93291859; Cherniak R; Morris L; Meyer SA; Georgia State Univ. Atlanta.; Structural analyses were done on purified glucuronoxylomannan (GXM) obtained from 3 clinical isolates of C. neoformans. The three isolates, 118, 150, and 194, were serotype A. The GXMs were analyzed by GLC-MS, and 13C NMR spectroscopy. Purified GXMs obtained from 3 isolates of C. neoformans were treated by ultrasonic
Base dissociation assay (BDA), a simplified method for immune-complex dissociation and detection of HIV-1 p24 antigen in serum and plasma.: Abstr Gen Meet Am Soc Microbiol. 1993;93:556 (abstract no. V-22). Unique Identifier : AIDSLINE ASM93/93291860; Hyman J; Lockwood D; Holody T; Youngbar P; Organon Teknika Corp., Durham, NC.; The presence and amount of HIV-1 p24 antigen in serum or plasma from HIV-1 infected individuals has been correlated with viral replication and disease progression. A method for measuring p24 antigen levels is desired as a means of determining patient prognosis and the efficacy of anti-viral therapy. However, measuring
Comparison of a viral lysate based EIA (genetic systems) (GSC) and a recombinant antigen based EIA (Cambridge Biotech) (CB) for detection of antibodies to HIV-1 in hemodialysis (HD) patients.: Abstr Gen Meet Am Soc Microbiol. 1993;93:556 (abstract no. V-23). Unique Identifier : AIDSLINE ASM93/93291861; Carlyn C; Yen-Lieberman B; Paganini E; Rehm SJ; Proffit M; Starkey C; Cleveland Clinic, OH.; Numerous reports describe excessive false positive (FP) HIV-1 EIA rates with most viral lysate based ELISAs in HD pts. This has been explained by Abs to cellular antigens such as DR4. Proposed mechanisms include prior sensitization by multiple transfusions, exposure to nonbiologic surfaces during dialysis triggering i
Evaluation and assessment of the SUDS HIV-1/2 antibody test.: Abstr Gen Meet Am Soc Microbiol. 1993;93:556 (abstract no. V-25). Unique Identifier : AIDSLINE ASM93/93291862; Haynes T; Mazzaferro P; Lowery K; Flowers T; Shockley K; Murex Corporation, Norcross, GA.; Infection with HIV with subsequent development of AIDS requires accurate serologic procedures to identify infected individuals. Since the identification of HIV-1 in 1983 and HIV-2 in 1985/1986, numerous HIV serologic tests have been developed and employed on a truly global scale. Current strategies in most countries r
Evaluation of an indirect immunofluorescence assay for confirmation of human immunodeficiency virus type 1 antibody in previously screened sera.: Abstr Gen Meet Am Soc Microbiol. 1993;93:556 (abstract no. V-24). Unique Identifier : AIDSLINE ASM93/93291863; Steece R; Neumann L; Yendung V; Oty G; Zanto S; Public Health Laboratory Division, Minneapolis, Minnesota 55440.; An indirect immunofluorescence assay (IFA), Fluoroqnost HIV-1 was evaluated as a confirmatory test for antibody to human immunodeficiency virus type 1 in specimens previously submitted and tested by enzyme immunoassay (EIA) and confirmed with Western blot (WB). IFA results were 100% concordant with a licensed WB for 2
Physician satisfaction and opportunities for improving the quality of human immunodeficiency virus type 1 (HIV-1) antibody and hepatitis B virus (HBV) testing.: Abstr Gen Meet Am Soc Microbiol. 1993;93:556 (abstract no. V-26). Unique Identifier : AIDSLINE ASM93/93291864; Peddecord K; Hofherr L; Benenson A; Garfein R; Francis D; Rau J; Cross J; Graduate School of Public Health, San Diego State University.; We surveyed all licensed physicians in San Diego County (N = 6570) on their experiences in use, perceptions of quality, preferences for report content, criteria for choosing a laboratory and problem areas encountered in testing for HIV-1 or HBV. Response rates were 64% for HIV-1 and 65% for HBV including all medical s
[Salmonella osteomyelitis in an AIDS patient (letter)]: An Med Interna. 1989 Nov;6(11):603. Unique Identifier : AIDSLINE MED/93271304; Gato Diez A; Perez Gomez V; Ballesteros Moreno P; Gaspar Alonso-Vega G
[Haemophilus influenzae pneumonia in patients with the human immunodeficiency virus (letter)]: An Med Interna. 1989 Sep;6(9):500-1. Unique Identifier : AIDSLINE MED/93271330; Teira Cobo R; Munoz Sanchez J; Merino Mugica JM; Santamaria Jauregui JM
The virology of AIDS: 1990.: AIDS. 1990;4 Suppl 1:S1-8. Unique Identifier : AIDSLINE MED/93270685; Coffin JM; Department of Molecular Biology and Microbiology, Tufts; University School of Medicine, Boston, MA 02111.
HIV infection and injecting drug users: from epidemiology to public health.: AIDS. 1990;4 Suppl 1:S105-9. Unique Identifier : AIDSLINE MED/93270686; Wodak A; Moss A; Alcohol and Drug Service, St Vincent's Hospital, Sydney,; Australia.
HIV-1 infection in pregnancy: implications for women and children.: AIDS. 1990;4 Suppl 1:S111-7. Unique Identifier : AIDSLINE MED/93270687; Newell ML; Peckham CS; Lepage P; Department of Paediatric Epidemiology, Institute of Child Health,; London, UK.
HIV risks in the health care organization.: AIDS. 1990;4 Suppl 1:S119-22. Unique Identifier : AIDSLINE MED/93270688; Gerberding JL; Department of Medicine and Infectious Diseases, University of; California, San Francisco.; Health-care workers who sustain an accidental parenteral exposure to HIV are at risk of infection. Although only incomplete data are available to assess the risk, these data are reassuring. The most important lesson for health-care workers in the AIDS era is that nearly all risky exposures can and should be prevented.
HIV and design of intervention studies for control of sexually transmitted diseases.: AIDS. 1990;4 Suppl 1:S123-6. Unique Identifier : AIDSLINE MED/93270689; Nkowane BM; Lwanga SK; Global Programme on AIDS, World Health Organization, Geneva,; Switzerland.
AIDS 1990. Vaccines and immunology: overview.: AIDS. 1990;4 Suppl 1:S127-8. Unique Identifier : AIDSLINE MED/93270690; Bolognesi DP; Schild GC; Department of Surgery, Duke University Medical Center, Durham, NC; 27710.
Antigenic variation in HIV.: AIDS. 1990;4 Suppl 1:S129-36. Unique Identifier : AIDSLINE MED/93270691; Putney SD; McKeating JA; Repligen Corporation, Cambridge, Massachusetts.
Progress in the development of simian immunodeficiency virus vaccines: a review.: AIDS. 1990;4 Suppl 1:S137-41. Unique Identifier : AIDSLINE MED/93270692; Gardner MB; Stott J; Department of Medical Pathology, University of California, Davis; 95616-8652.
Progress in the development of HIV vaccines.: AIDS. 1990;4 Suppl 1:S143-50. Unique Identifier : AIDSLINE MED/93270693; Girard MP; Eichberg JW; Pasteur Institute, Paris, France.
Clinical research 1990: a summary.: AIDS. 1990;4 Suppl 1:S15-8. Unique Identifier : AIDSLINE MED/93270694; Collier AC; Department of Medicine, University of Washington School of; Medicine, Seattle.
Neutralization and enhancement of in vitro and in vivo HIV and simian immunodeficiency virus infections.: AIDS. 1990;4 Suppl 1:S151-62. Unique Identifier : AIDSLINE MED/93270695; Robinson WE Jr; Mitchell WM; Department of Pathology, Vanderbilt University, School of; Medicine, Nashville, TN 37232.; Over the past year significant progress has been made in mapping those regions of the HIV-1 envelope glycoproteins involved in virus neutralization and virus enhancement. These functional, antigenic domains of the gp160 are illustrated in Fig. 1. The role of neutralization in vaccine development is still unresolved, a
Research strategies for AIDS vaccine development and evaluation: the MRC programme.: AIDS. 1990;4 Suppl 1:S167-78. Unique Identifier : AIDSLINE MED/93270697; Karn J; Almond JW; Tyrrell DA; MRC Laboratory of Molecular Biology, Cambridge, UK.
AIDS vaccines 1990: a brief update.: AIDS. 1990;4 Suppl 1:S179-84. Unique Identifier : AIDSLINE MED/93270698; Koff WC; Schultz AM; Division of AIDS, National Institute of Allergy and Infectious; Diseases, Bethesda, Maryland.
AIDS 1990. Clinical treatment: overview.: AIDS. 1990;4 Suppl 1:S185-6. Unique Identifier : AIDSLINE MED/93270699; Pinching AJ; Mills J; Department of Immunology, St Mary's Hospital Medical School,; London, UK.
A critical analysis of recent data on zidovudine therapy: use in asymptomatic HIV infection and early HIV disease, dosing and resistance issues.: AIDS. 1990;4 Suppl 1:S187-91. Unique Identifier : AIDSLINE MED/93270700; Peto TE; Nuffield Department of Clinical Medicine, John Radcliffe; Hospital, Oxford, UK.
New messages to caregivers.: AIDS. 1990;4 Suppl 1:S19-22. Unique Identifier : AIDSLINE MED/93270701; Willoughby AD; Pediatric, Adolescent, and Maternal AIDS Branch, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, MD 20892.
New anti-HIV-1 therapies and combinations: current data and prospects.: AIDS. 1990;4 Suppl 1:S193-200. Unique Identifier : AIDSLINE MED/93270702; Eron JJ Jr; Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital, Boston; 02114.
Immunological and virological surrogate markers in the evaluation of therapies for HIV infection.: AIDS. 1990;4 Suppl 1:S201-6. Unique Identifier : AIDSLINE MED/93270703; Valentine FT; Jacobson MA; Department of Medicine, New York University School of Medicine,; New York.
Clinical trials: patient perspectives.: AIDS. 1990;4 Suppl 1:S207-8. Unique Identifier : AIDSLINE MED/93270704; Grimshaw JM; The Landmark, Tulse Hill, London, UK.
Treatment of opportunistic infections.: AIDS. 1990;4 Suppl 1:S209-15. Unique Identifier : AIDSLINE MED/93270705; Feinberg J; Mills J; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland.
Current approaches to the treatment of HIV-related Kaposi's sarcoma and lymphoma by chemotherapy.: AIDS. 1990;4 Suppl 1:S217-21. Unique Identifier : AIDSLINE MED/93270706; Stewart JS; Department of Oncology, St Mary's Hospital, London, UK.
Dermatological aspects of HIV disease: 1990 update.: AIDS. 1990;4 Suppl 1:S223-5. Unique Identifier : AIDSLINE MED/93270707; Berger TG; Department of Dermatology, San Francisco General Hospital, CA; 94110.
Recent advances in the management of the HIV-infected infant [published erratum appears in AIDS 1991 May;5(5):following 615]: AIDS. 1990;4 Suppl 1:S227-34. Unique Identifier : AIDSLINE MED/93270708; Indacochea FJ; Scott GB; Department of Pediatrics, University of Miami, Florida.
The epidemiology of AIDS and HIV infection.: AIDS. 1990;4 Suppl 1:S23-8. Unique Identifier : AIDSLINE MED/93270709; Lifson AR; AIDS Office, Department of Public Health, San Francisco, CA; 94102.
AIDS 1990. Social, cultural and political aspects.: AIDS. 1990;4 Suppl 1:S243-5. Unique Identifier : AIDSLINE MED/93270711; Carballo M; Bayer R; Programme on Substance Abuse, World Health Organization, Geneva,; Switzerland.
Global AIDS: revolution, paradigm and solidarity.: AIDS. 1990;4 Suppl 1:S247-50. Unique Identifier : AIDSLINE MED/93270712; Mann J; Department of Epidemiology, Harvard School of Public Health,; Boston, MA 02115.
HIV-related discrimination.: AIDS. 1990;4 Suppl 1:S251-6. Unique Identifier : AIDSLINE MED/93270713; Tindall B; Tillett G; National Centre in HIV Epidemiology and Clinical Research,; University of New South Wales, Australia.
The psychosocial impact of AIDS on health workers.: AIDS. 1990;4 Suppl 1:S257-62. Unique Identifier : AIDSLINE MED/93270714; Eakin JM; Taylor KM; Department of Behavioural Science, University of Toronto,; Ontario, Canada.
Drug prevention and HIV policy.: AIDS. 1990;4 Suppl 1:S263-7. Unique Identifier : AIDSLINE MED/93270715; Power R; Stimson GV; Strang J; Centre for Research on Drugs and Health Behaviour, Charing Cross; & Westminster Medical School, University of London, UK.
Opportunities for overcoming the continuing restraints to behavior change and HIV risk reduction.: AIDS. 1990;4 Suppl 1:S269-76. Unique Identifier : AIDSLINE MED/93270716; Sittitrai W; Brown T; Sterns J; Institute of Population Studies, Chulalongkorn University,; Thailand.
Global estimates of AIDS cases and HIV infections: 1990.: AIDS. 1990;4 Suppl 1:S277-83. Unique Identifier : AIDSLINE MED/93270717; Chin J; Surveillance, Forecasting and Impact Assessment Unit, World; Health Organization, Geneva, Switzerland.
Psychosocial aspects of AIDS: policy implications.: AIDS. 1990;4 Suppl 1:S29-33. Unique Identifier : AIDSLINE MED/93270718; Carballo M; World Health Organization, Geneva, Switzerland.
Public policy issues.: AIDS. 1990;4 Suppl 1:S35-7. Unique Identifier : AIDSLINE MED/93270719; Helquist MJ; AIDSCOM/Academy for Educational Development, Washington DC 20037.
AIDS 1990. Virology: overview.: AIDS. 1990;4 Suppl 1:S39-40. Unique Identifier : AIDSLINE MED/93270720; Goudsmit J; Martin M; Academisch Medisch Centrum, Department of Virology, Amsterdam,; The Netherlands.
Molecular pathogenesis of HIV-1.: AIDS. 1990;4 Suppl 1:S41-8. Unique Identifier : AIDSLINE MED/93270721; O'Brien WA; Zack JA; Chen IS; Department of Microbiology & Immunology, UCLA School of Medicine,; Jonsson Comprehensive Cancer Center 90024.
Biological and molecular features of HIV-1 related to tissue tropism.: AIDS. 1990;4 Suppl 1:S49-56. Unique Identifier : AIDSLINE MED/93270722; Cheng-Mayer C; Cancer Research Institute, University of California, San; Francisco 94143-0128.
Interactions between HIV and the host immune system in the pathogenesis of AIDS.: AIDS. 1990;4 Suppl 1:S57-66. Unique Identifier : AIDSLINE MED/93270723; Tersmette M; Miedema F; Central Laboratory, Netherlands Red Cross Blood Transfusion; Service, Amsterdam.
Understanding HIV-1 infection of the brain: a challenge for neurobiologists.: AIDS. 1990;4 Suppl 1:S67-76. Unique Identifier : AIDSLINE MED/93270724; Dubois-Dalcq ME; Jordan CA; Kelly WB; Watkins BA; Laboratory of Viral and Molecular Pathogenesis, National; Institute of Neurological Disorders and Stroke, National; Institutes of Health, Bethesda, MD 20892.
Variation in HIV virus load of individuals at different stages in infection: possible relationship with risk of transmission.: AIDS. 1990;4 Suppl 1:S77-83. Unique Identifier : AIDSLINE MED/93270725; Simmonds P; Department of Medical Microbiology, Medical School, University of; Edinburgh, UK.
How old is the immunodeficiency virus?: AIDS. 1990;4 Suppl 1:S85-93. Unique Identifier : AIDSLINE MED/93270726; Eigen M; Nieselt-Struwe K; Max-Planck-Institut fur biophysikalische Chemie, Gottingen,; Germany.
AIDS 1990. Epidemiology: overview.: AIDS. 1990;4 Suppl 1:S95-7. Unique Identifier : AIDSLINE MED/93270728; Winkelstein W Jr; Johnson AM; School of Public Health, University of California, Berkeley; 94720.
Sexual transmission of HIV and the epidemiology of other sexually transmitted diseases.: AIDS. 1990;4 Suppl 1:S99-103. Unique Identifier : AIDSLINE MED/93270729; Cameron DW; Padian NS; Department of Medicine, University of Ottawa, Canada.
[Patients with an indeterminate serological diagnosis of HIV-1 infection]: Rev Med Chil. 1990 Nov;118(11):1235-40. Unique Identifier : AIDSLINE MED/93289103; Ramirez E; Soto G; Mora J; Vera L; Munoz G; Sanchez G; Seccion Virologia, Instituto de Salud Publica, Santiago de; Chile.; Western blot is the technique most frequently used to determine the presence of HIV-1 antibodies. However, some patients remain with an indeterminate diagnosis for HIV-1 according to the technique. We followed 8 such patients for 2 to 18 months. Immunologic studies included standard ELISA, immunofluorescence and Abbot
[HTLV-1 in a Mapuche population]: Rev Med Chil. 1990 Dec;118(12):1326-9. Unique Identifier : AIDSLINE MED/93289119; Inostroza J; Diaz P; Saunier C; Laboratorio Inmunologia, Hospital Regional de Temuco, Chile.; The seroprevalence of HTLV-1 in 405 serum samples from South American Indians, Mapuches, from the IXth region of Chile was investigated using enzyme linked immunosorbent assay (ELISA). Six samples were positive and only 3 of them were also positive by western blot and radio immuno p
[The value of cerebral biopsy in patients with AIDS and extensive cerebral lesions]: Rev Med Chil. 1990 Dec;118(12):1367-71. Unique Identifier : AIDSLINE MED/93289126; Torrealba G; Acuna G; Tagle P; Tapia J; Huete I; Departamento de Neurologia y Neurocirugia, Medicina Interna y; Radiologia, Escuela de Medicina, P. Universidad Catolica de; Chile, Santiago.; We performed cerebral biopsy in 4 patients with AIDS and evidence of expanding intracerebral lesions. Three patients had cerebral toxoplasmosis and the fourth had Chagas encephalitis. No patient developed complications. We feel that cerebral biopsy is warranted and safe in patients with AIDS and intracerebral lesions
Feline immunodeficiency virus as a model for AIDS vaccination.: AIDS. 1990;4 Suppl 1:S163-5. Unique Identifier : AIDSLINE MED/93270696; Jarrett O; Yamamoto JK; Neil JC; Department of Veterinary Pathology, University of Glasgow, UK.
Aids 1990, A Year in Review. Proceedings from the 6th International Conference on AIDS.: AIDS. 1990;4 Suppl 1:S1-285. Unique Identifier : AIDSLINE MED/93270684
Immunology in AIDS in 1990.: AIDS. 1990;4 Suppl 1:S9-14. Unique Identifier : AIDSLINE MED/93270727; Sela M; Department of Chemical Immunology, Weizmann Institute of Science,; Rehovot, Israel.
[New treatments for cryptosporidiosis (letter)]: Rev Med Chil. 1990 Sep;118(9):1037. Unique Identifier : AIDSLINE MED/93303436; Neira P
Special issue on AIDS vaccine developments.: Biotechnol Ther. 1991;2(1-2):1-211. Unique Identifier : AIDSLINE MED/93271826
Idiotypes and anti-idiotypes: an update in potential applications for developing an AIDS vaccine.: Biotechnol Ther. 1991;2(1-2):107-22. Unique Identifier : AIDSLINE MED/93271828; Scinicariello F; Attanasio R; Laghi V; Kennedy RC; Istituto di Clinica delle Malattie Tropicali e Infettive,; Universita degli Studi, La Sapienza, Rome, Italy.
Anti-HIV-1 ADCC: clinical and therapeutic implications.: Biotechnol Ther. 1991;2(1-2):147-57. Unique Identifier : AIDSLINE MED/93271831; Weinhold KJ; Department of Surgery, Duke University Medical Center, Durham,; North Carolina 27710.; The predominant antienvelope cell-mediated cytotoxicity in HIV-1-infected patients is a direct form of antibody-dependent cellular cytotoxicity (ADCC) in which circulating NK/K cells armed with cytophilic antibodies comprise a cytolytic effector cell complex capable of destroying HIV-1-expressing targets. This non-MHC
Development of BCG as a live recombinant vector system: potential use as an HIV vaccine.: Biotechnol Ther. 1991;2(1-2):159-78. Unique Identifier : AIDSLINE MED/93271832; Fuerst TR; Stover CK; de la Cruz VF; Department of Molecular Genetics, MedImmune, Inc., Gaithersburg,; Maryland 20878.; Bacille Calmette-Guerin (BCG), a live attenuated tubercle bacillus, is currently the most widely used vaccine in the world. Because of its unique characteristics, including low toxicity, adjuvant potential, and long-lasting immunity, BCG represents a novel vaccine vehicle with which to deliver protective antigens of m
Induction of anti-HIV-1 immune responses by retroviral vectors.: Biotechnol Ther. 1991;2(1-2):179-93. Unique Identifier : AIDSLINE MED/93271833; Jolly DJ; Warner JF; Viagene, Inc., San Diego, California 92121.; Retroviral vectors encoding HIV-1 proteins, in particular, the envelope from HIV-1 IIIB, have been constructed and used to generate infectious vector particles. Murine cells transduced with these vectors express HIV proteins. Vector-transduced cells, when injected into syngeneic BALB/c mice, induce potent CD8+, class
HIV vaccine development: current status and future challenges.: Biotechnol Ther. 1991;2(1-2):195-203. Unique Identifier : AIDSLINE MED/93271834; Koff WC; Vaccine R&D Branch, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892.
HIV vaccine development: perspective.: Biotechnol Ther. 1991;2(1-2):205-11. Unique Identifier : AIDSLINE MED/93271835; Bolognesi DP; Duke University Medical Center, Durham, North Carolina 27710.
Passive immunization for the treatment and prevention of HIV infection.: Biotechnol Ther. 1991;2(1-2):31-48. Unique Identifier : AIDSLINE MED/93271837; Karwowska S; Zolla-Pazner S; Department of Pathology, New York University Medical Center, New; York.; Passive immunization using serum or immunoglobulin preparations has been used in the prophylaxis and treatment of many bacterial and viral diseases. Preliminary attempts to use these methods to prevent HIV infection in chimpanzees have been promising. With the identification of polyclonal and monoclonal antibodies wit
Methods for analysis of biologically functional antibodies to the HIV-1 gp120 principal neutralizing domain.: Biotechnol Ther. 1991;2(1-2):49-62. Unique Identifier : AIDSLINE MED/93271838; Devash Y; Rusche JR; Nara PL; Ortho Diagnostic Systems Inc., Raritan, New Jersey 08869.; The humoral response to HIV-1 infection has been demonstrated by a variety of immunoassays utilizing viral proteins. While several assays detect HIV-1 infection with high sensitivity and great specificity, little progress has been made to develop immunoassays correlative with disease progression and viral transmission
SIV vaccine protection of rhesus monkeys.: Biotechnol Ther. 1991;2(1-2):9-19. Unique Identifier : AIDSLINE MED/93271840; Gardner MB; Carlson JR; Jennings M; Rosenthal A; Langlois A; Haynes B; Bolognesi D; Palker TJ; Department of Medical Pathology, University of California, Davis.; Rhesus macaques (M. mulatta), immunized with an inactivated whole SIVmac vaccine and muramyl dipeptide or Freund s incomplete adjuvant, were protected against IV challenge infection with 10 animal infectious doses of the homologous virus. The protection in these animals appeared to be complete, with no breakthrough of
Characterization of a vaccinia-derived recombinant HIV-1 gp160 candidate vaccine and its immunogenicity in chimpanzees.: Biotechnol Ther. 1991;2(1-2):91-106. Unique Identifier : AIDSLINE MED/93271841; Barrett N; Eder G; Dorner F; Biomedical Research Center, Immuno AG, Orth/Donau, Austria.; The human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 was produced in large-scale microcarrier cultures of Vero cells, using a system involving coinfection with two recombinant vaccinia viruses. The immunogenicity of this material was studied in conjunction with a number of different adjuvant formulatio
Human recombinant IL-6: clinical promise.: Biotechnol Ther. 1991;2(3-4):285-98. Unique Identifier : AIDSLINE MED/93271846; Bauer J; Psychiatrische Universitatsklinik, Universitat Freiburg,; Germany.; The biology of interleukin-6 (IL-6) has been extensively reviewed. This article therefore does not repeat in detail how this molecule was discovered and its cDNA cloned, or the molecular mechanisms of its synthesis, its structural features, and its basic biological functions. Instead, three questions are addressed mor
Peptides containing multideterminant clusters of human immunodeficiency virus envelope induce murine and human T-cell responses in diverse histocompatibility types.: Trans Assoc Am Physicians. 1991;104:69-77. Unique Identifier : AIDSLINE MED/93276513; Berzofsky JA; Pendleton CD; Clerici M; Ahlers J; Lucey DR; Putney SD; Shearer GM; Metabolism Branch, National Cancer Institute, National Institutes; of Health, Bethesda, MD 20892.
Functional analyses of the type I human T-cell leukemia virus tax gene product.: Trans Assoc Am Physicians. 1991;104:78-91. Unique Identifier : AIDSLINE MED/93276514; Smith MR; Greene WC; Howard Hughes Medical Institute, Department of Medicine, Duke; University Medical Center, Durham, NC 27710.
Ethical dilemma in continuing a zidovudine-placebo trial in symptomatic human immunodeficiency virus infection.: Trans Assoc Am Physicians. 1991;104:92-6. Unique Identifier : AIDSLINE MED/93276515; Simberkoff MS; Hartigan PM; Hamilton JD; Infectious Diseases Section, NY VAMC.
AIDS and the duty to treat.: Univ Tor Dent J. 1991 Summer;4(3 Suppl):3p.. Unique Identifier : AIDSLINE MED/93285065; Bassford HA; Department of Philosophy, Atkinson College, York University.
[Sexually transmitted diseases: epidemiological characteristics of cases notified in the health service of Vina del Mar-Quillota]: Rev Med Chil. 1991 Oct;119(10):1213-8. Unique Identifier : AIDSLINE MED/93289154; Fernandez MS; Lopez IM; Servicio de Salud Vina del Mar-Quillota.; During 1987 and 1988 sexually transmitted diseases affected 87.2 per 100,000 inhabitants of the Vina del Mar-Quillota area. At all ages rates were 3.8 times higher in males compared to females. Gonorrhoea, syphilis and non gonorrheal urethritis accounted for most cases. In males, 82% of cases corresponded to gonorrhoe
Acquired immunodeficiency syndrome precautions for otolaryngology-head and neck surgery.: Arch Otolaryngol Head Neck Surg. 1991 Dec;117(12):1343-4. Unique Identifier : AIDSLINE MED/93298285; Davidson TM; Stabile B
Erythema elevatum diutinum in a patient with acquired immunodeficiency syndrome. Another clinical simulator of Kaposi's sarcoma.: Arch Dermatol. 1991 Dec;127(12):1819-22. Unique Identifier : AIDSLINE MED/93304975; Requena L; Sanchez Yus E; Martin L; Barat A; Arias D; Department of Dermatology, Jimenez Diaz Foundation, Nuestra; Senora de la Concepcion Clinic, Universidad Autonoma, Madrid,; Spain.; Several types of vasculitis have been described in patients with human immunodeficiency virus infection. Erythema elevatum diutinum is a rare variant of cutaneous leukocytoclastic vasculitis which, with the exception of the case reported herein, has been described only once in human immunodeficiency virus-infected pat
Papules and nodules in a patient with the acquired immunodeficiency syndrome and recurrent cryptococcal meningitis. Bacillary angiomatosis or epithelioid angiomatosis.: Arch Dermatol. 1991 Dec;127(12):1832-3, 1835-6. Unique Identifier : AIDSLINE MED/93304980; Szych CM; Rotter SM; Gallant JE; Johns Hopkins University Medical Institutions, Baltimore, Md.
Primary cutaneous cryptococcosis in a patient with the acquired immunodeficiency syndrome [letter]: Arch Dermatol. 1991 Dec;127(12):1848-9. Unique Identifier : AIDSLINE MED/93304985; Cusini M; Cagliani P; Grimalt R; Tadini G; Alessi E; Fasan M
Immunodominant antigenic sites in primate immunodeficiency viruses and in vivo protection.: Biotechnol Ther. 1991;2(1-2):21-9. Unique Identifier : AIDSLINE MED/93271836; Norrby E; Putkonen P; Albert J; Fenyo EM; Department of Virology, Karolinska Institute, School of Medicine,; Stockholm, Sweden.
Palliative care in advanced HIV disease: presentation, problems and palliation.: AIDS. 1990;4 Suppl 1:S235-42. Unique Identifier : AIDSLINE MED/93270710; Moss V; Mildmay Mission Hospital, London, UK.
HIV vaccine development: lessons learned to date.: Biotechnol Ther. 1991;2(1-2):1-7. Unique Identifier : AIDSLINE MED/93271827; Putney SD; Repligen Corporation, Cambridge, Massachusetts 02139.
Progress toward an artificial vaccine for HIV: identification of helper and cytotoxic T-cell epitopes and methods of immunization.: Biotechnol Ther. 1991;2(1-2):123-35. Unique Identifier : AIDSLINE MED/93271829; Berzofsky JA; Molecular Immunogenetics and Vaccine Research Section, National; Cancer Institute, National Institutes of Health, Bethesda,; Maryland 20814.; Design of a synthetic vaccine for HIV requires basic knowledge of the structure of helper and cytotoxic T-cell epitopes and neutralizing antibody epitopes, of ways to couple these to produce an effective immunogen, and of the role of viral sequence variation on MHC presentation of antigen. T-cell recognition, and cros
Identification of HIV-1 cytotoxic T-lymphocyte epitopes and implications for vaccine development.: Biotechnol Ther. 1991;2(1-2):137-46. Unique Identifier : AIDSLINE MED/93271830; Johnson RP; Walker BD; Infectious Disease Unit, Massachusetts General Hospital, Boston; 02114.
Importance of conformation on the neutralizing antibody response to HIV-1 gp120.: Biotechnol Ther. 1991;2(1-2):63-89. Unique Identifier : AIDSLINE MED/93271839; Steimer KS; Haigwood NL; Chiron Corporation, Emeryville, California 94608-2916.; We have investigated the role of conformation of HIV-1 gp120 on its potential efficacy as a subunit vaccine. The questions that we set out to answer were: 1) Are there neutralizing antibodies directed to conformational epitopes in gp120? 2) If so, what is the spectrum of virus isolates neutralized by these antibodies?
Characterization of an early thymocyte cell line which is chronically infected with the human immunodeficiency virus.: Trans Assoc Am Physicians. 1991;104:248-57. Unique Identifier : AIDSLINE MED/93276499; Stanley SK; Schnittman SM; Greenhouse JJ; Hatch WC; Lyman WD; Orenstein JM; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
The Mycoplasma genitalium adhesin protein and several human class II MHC proteins exhibit sequence homology: possible ramifications for the development of autoimmunity [letter]: Autoimmunity. 1992;14(2):167-8. Unique Identifier : AIDSLINE MED/93271379; Bisset LR
A molecular model for membrane fusion based on solution studies of an amphiphilic peptide from HIV gp41.: Protein Sci. 1992 Nov;1(11):1454-64. Unique Identifier : AIDSLINE MED/93271895; Fujii G; Horvath S; Woodward S; Eiserling F; Eisenberg D; Molecular Biology Institute, University of California, Los; Angeles 90024-1570.; The mechanism of protein-mediated membrane fusion and lysis has been investigated by solution-state studies of the effects of peptides on liposomes. A peptide (SI) corresponding to a highly amphiphilic C-terminal segment from the envelope protein (gp41) of the human immunodeficiency virus (HIV) was synthesized and tes
[Pulmonary tuberculosis in a man infected with HIV (published erratum appears in Pneumonol Alergol Pol 1993;61(7-8):434)]: Pneumonol Alergol Pol. 1992;60(11-12):77-81. Unique Identifier : AIDSLINE MED/93271917; Zajaczkowska J; Krakowka P; Jodkowski W; Kaminska E; Babiuch L; I Kliniki Gruzlicy i Chorob Pluc Instytutu Gruzlicy i Chorob; Pluc.
[The numbers and distribution studies of natural killer cell, T cell subsets in peripheral blood and local infiltration in patients with squamous cell carcinoma of the oral cavity]: Chung Hua Kou Chiang Hsueh Tsa Chih. 1992 Jul;27(4):225-7. Unique Identifier : AIDSLINE MED/93272592; Pan L
Distribution and trends of HIV infection in blood donors of four metropolitan cities.: Indian J Public Health. 1992 Jul-Sep;36(3):101-4. Unique Identifier : AIDSLINE MED/93273455; Makro RN; Salil P; Bhushan B; Lal S; Screening for HIV infection has been made mandatory for every unit of blood collected for transfusion in major cities of the country, having facilities for such screening. Results of HIV screening among blood donors received from the 4 Metropolitan cities of Delhi, Bombay, Calcutta and Madras have been analysed year w
Presidential address. Public health.: Indian J Public Health. 1992 Oct-Dec;36(4):105-8. Unique Identifier : AIDSLINE MED/93273464; Anjaneyulu G
Human contraception: development of new scientific opportunities.: J Reprod Fertil Suppl. 1992;45:175-92. Unique Identifier : AIDSLINE MED/93274658; Lincoln DW; MRC Reproductive Biology Unit, Centre for Reproductive Biology,; Edinburgh, UK.; Our current methods of contraception were largely developed in the 1950s and 1960s. Collectively these methods can limit population growth, although their acceptability at a personal level remains marginal. The number of abortions in the UK has risen progressively, from 170,000 in 1990, and more
Changing convictions with changing journals? [letter] [see comments]: Natl Med J India. 1992 Jan-Feb;5(1):39-40. Unique Identifier : AIDSLINE MED/93278161; Kulkarni V
HIV surveillance [letter; comment]: Natl Med J India. 1992 Mar-Apr;5(2):97. Unique Identifier : AIDSLINE MED/93278191; Rodrigues JJ
AIDS epidemic [letter]: Natl Med J India. 1992 May-Jun;5(3):144. Unique Identifier : AIDSLINE MED/93278206; Weeks JL
T cell subpopulations in amoebic liver abscess.: Natl Med J India. 1992 Jul-Aug;5(4):166-8. Unique Identifier : AIDSLINE MED/93278214; Tandon A; Agarwal SK; Saha K; Maulana Azad Medical College, New Delhi, India.; BACKGROUND. Cellular immunity may play a major role in the pathogenesis of amoebic liver abscess but there is little data on the effect of treatment on T cell subpopulations in such patients. METHODS. We performed a prospective, controlled study of the T lymphocyte subpopulations in 17 patients with amoebic liver absc
Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1.: Protein Sci. 1992 May;1(5):563-74. Unique Identifier : AIDSLINE MED/93278285; Summers MF; Henderson LE; Chance MR; Bess JW Jr; South TL; Blake PR; Sagi I; Perez-Alvarado G; Sowder RC 3d; Hare DR; et al; Department of Chemistry and Biochemistry, University of Maryland; Baltimore County 21228.; All retroviral nucleocapsid (NC) proteins contain one or two copies of an invariant 3Cys-1His array (CCHC = C-X2-C-X4-H-X4-C; C = Cys, H = His, X = variable amino acid) that are essential for RNA genome packaging and infectivity and have been proposed to function as zinc-binding domains. Although the arrays are capabl
Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling.: Protein Sci. 1992 Aug;1(8):1061-72. Unique Identifier : AIDSLINE MED/93278318; Thanki N; Rao JK; Foundling SI; Howe WJ; Moon JB; Hui JO; Tomasselli AG; Heinrikson RL; Thaisrivongs S; Wlodawer A; Macromolecular Structure Laboratory, NCI-Frederick Cancer; Research and Development Center, ABL-Basic Research Program,; Maryland 21702.; The structure of a crystal complex of recombinant human immunodeficiency virus type 1 (HIV-1) protease with a peptide-mimetic inhibitor containing a dihydroxyethylene isostere insert replacing the scissile bond has been determined. The inhibitor is Noa-His-Hch psi [CH(OH)CH(OH)]Vam-Ile-Amp (U-75875), and its Ki for in
In situ hybridisation: principles and applications.: Malays J Pathol. 1992 Dec;14(2):69-76. Unique Identifier : AIDSLINE MED/93280882; Looi LM; Cheah PL; Department of Pathology, Faculty of Medicine, University of; Malaya, Kuala Lumpur.; In situ hybridisation (ISH) is based on the complementary pairing of labelled DNA or RNA probes with normal or abnormal nucleic acid sequences in intact chromosomes, cells or tissue sections. Compared with other molecular biology techniques applicable to anatomical pathology, ISH enjoys better rapport with histopathol
[Tuberculosis of bronchi and lymph nodes mimicking cancer in a patient with HIV-infection (letter)]: Rev Pneumol Clin. 1992;48(6):282-4. Unique Identifier : AIDSLINE MED/93281872; Coulibaly G; N'Dhatz M; Domoua K; Traore F; Quattara B; Vincent A; Kouassi Y; Zougba A; Konan JB; Yapi A
Polysaccharide-coated liposomal amphotericin B for the treatment of murine pulmonary candidiasis.: Tohoku J Exp Med. 1992 Nov;168(3):483-90. Unique Identifier : AIDSLINE MED/93281973; Miyazaki T; Kohno S; Sasayama K; Inoue Y; Hara K; Ogasawara M; Sato T; Sunamoto J; Second Department of Internal Medicine, Nagasaki University; School of Medicine.; Amylopectin-coated liposomal amphotericin B was investigated in a murine model of pulmonary candidiasis. The LD50 of amylopectin-coated liposomal amphotericin B in normal mice was more than 10.0 mg/kg, and that of conventional amphotericin B was 1.2 mg/kg. Amylopectin-coated liposomes showed twice the concentration in
AIDS awareness amongst school teachers in a rural area of India.: Asia Pac J Public Health. 1992-93;6(1):16-7. Unique Identifier : AIDSLINE MED/93283193; Srivastava VK; Nirupam S; Chandra R; Jain VC; Department of Social & Preventive Medicine, King George's Medical; College, Lucknow, India.; One hundred and eighty-two teachers from a random selection of 15 schools in a rural area of Lucknow district of northern India were interviewed to assess their awareness and knowledge about AIDS using a pretested CARC proposed questionnaire. Observations revealed that only 79.7% of
Peptide models of the Tat-TAR protein-RNA interaction.: Protein Sci. 1992 Dec;1(12):1539-42. Unique Identifier : AIDSLINE MED/93284092; Frankel AD; Department of Biochemistry and Biophysics, University of; California, San Francisco 94143.
Overview: infectious disease policies.: Dentistry. 1992 Dec;12(4):17-8. Unique Identifier : AIDSLINE MED/93284954; Oldham D
[Spontaneous proliferative activity of lymphocytes in normal and EPH gestosis complicated pregnancy]: Ginekol Pol. 1992;63(7):329-36. Unique Identifier : AIDSLINE MED/93285493; Malinowski A; Szpakowski M; Tchorzewski H; Zeman K; Kowalczyk T; Oszukowski P; Katedry Poloznictwa i Ginekologii WAM, Lodzi.; The spontaneous proliferative activity of lymphocytes and CD4+/CD8+ ratio has been estimated in normal and EPH gestosis-affected pregnancy; also the effects of autologous and allogenic sera on this lymphocyte activity was evaluated. Although in normal pregnancy there was a very low CD4+/CD8+ ratio, the spontaneous pro
[Association of Medical Doctors for Asia held AIDS conference--prevention of AIDS is becoming an urgent problem in Japan]: Kango. 1992 Jan;44(1):62-8. Unique Identifier : AIDSLINE MED/93287463; Kobayashi Y
Disabilities Act and AIDS [news]: N J Med. 1992 Jul;89(7):503. Unique Identifier : AIDSLINE MED/93288284
Tuberculosis--the next plague?: West Engl Med J. 1992 Aug;107(2):37. Unique Identifier : AIDSLINE MED/93290934; Burton BJ; U.C.M.S.M., London.
Application of information systems to AIDS risk reduction.: Med Inf (Lond). 1992 Oct-Dec;17(4):199-214. Unique Identifier : AIDSLINE MED/93295142; Li LX; Xu LD; Department of Management Sciences, Ohio State University,; Columbus 43210.; Acquired immune deficiency syndrome (AIDS) is a specific group of diseases which are indicative of severe immunosuppression related to infection with the human immunodeficiency virus (HIV). In response to the epidemic, a variety of intervention and prevention has been instituted. In such intervention and prevention ac
Comparative evaluation of HIV infected foreign students and Indian with AIDS in Chandigarh, India.: Asian Pac J Allergy Immunol. 1992 Dec;10(2):141-3. Unique Identifier : AIDSLINE MED/93298193; Sehgal S; Department of Immunopathology Postgraduate Institute of Medical; Education and Research, Chandigarh, India.; Out of a total of 1,600 foreign students who came to India between June 1989 and October 1990, 22 were seropositive for HIV-1. Ten showed antibodies to all the gene products. Antibodies to gp160 and p24 were present in all the seropositives while antibodies to p53, p15/17 were signi
[Transgenesis and gene therapy]: C R Seances Soc Biol Fil. 1992;186(5):567-74. Unique Identifier : AIDSLINE MED/93299716; Jeanteur P; Institut de Genetique et Biologie cellulaire CNRS, Montpellier.; There are now rather straightforward methods to create transgenic animals whose genome is altered at the germline level. One method consists in the micro-injection of a gene into the pronucleus of a fertilized egg, the second one involves an homologous recombination event obtained in embryonic stem cells in culture. O
HIV and breast-feeding [news]: Midwives Chron. 1992 Nov;105(1258):371. Unique Identifier : AIDSLINE MED/93302562
[Survey on HIV and the control of infection]: Rev Belge Med Dent. 1992;47(3):40-51. Unique Identifier : AIDSLINE MED/93303339; Prieels F; De Cock P; Hop. Univ. St. Pierre, U.L.B., Service de Stomatologie et de; Chirurgie Maxillo-Faciale, Bruxelles.; During FDI World Dental Congress 1990, field specialists set up a scientific question form to obtain specific information about hygiene procedures in dental offices, knowledge about oral lesions in HIV infection and attitude against HIV infected patients. 540 Belgian dentists replied the question forms correctly. In g
Synthetic interface peptides alter dimeric assembly of the HIV 1 and 2 proteases.: Protein Sci. 1992 Oct;1(10):1244-53. Unique Identifier : AIDSLINE MED/93271870; Babe LM; Rose J; Craik CS; Department of Pharmaceutical Chemistry, University of California,; San Francisco 94143-0446.; Retroviral proteases are obligate homodimers and play an essential role in the viral life cycle. Dissociation of dimers or prevention of their assembly may inactivate these enzymes and prevent viral maturation. A salient structural feature of these enzymes is an extended interface composed of interdigitating N- and C-
[Cytomegalovirus retinitis in AIDS. Effectiveness and complications of long-term therapy]: Ophthalmologe. 1992 Oct;89(5):416-26. Unique Identifier : AIDSLINE MED/93278075; Schmitz K; Fabricius EM; Popescu M; Augenabteilung, Stadtisches Krankenhaus, Munchen-Harlaching.; In a retrospective study of the records of 64 patients with AIDS and cytomegalovirus ( CMV ) retinitis, 47 patients were evaluated regarding the effectiveness of initial virustatic therapy, and 41 patients regarding the anatomi
Historical progress and the future of human cell culture research.: Hum Cell. 1992 Dec;5(4):313-33. Unique Identifier : AIDSLINE MED/93283323; Moore GE; Minowada J; University of Colorado Medical Center, Division of Surgical; Oncology, Denver General Hospital.; Progress in human cell culture research is discussed based primarily on our hematopoietic cell culture studies. The article includes a historical background of Burkitt lymphoma cell lines, discovery of EBV, normal B-lymphoblastoid cell lines with EBV, a variety of leukemia, lymphoma, and myeloma cell lines, clinical a
Ethical concerns in AIDS, a national workshop organized by the FIAMC Bio-medical Ethics Centre, Bombay, 27-28 April 1991.: Natl Med J India. 1992 Jan-Feb;5(1):46. Unique Identifier : AIDSLINE MED/93278169; Vas CJ; De Souza EJ
Quality assurance of immunophenotyping [editorial]: Asian Pac J Allergy Immunol. 1992 Dec;10(2):85-7. Unique Identifier : AIDSLINE MED/93298197; Bradley J
[Hepatitis C virus antibodies in patients and the normal population]: Beitr Infusionsther. 1992;30:13-6. Unique Identifier : AIDSLINE MED/93278466; Knodler B; Kuhnl P; Lubitz B; Roos D; Becks M; Gutensohn K; Abt. fur Transfusionsmedizin und Transplantationsimmunologie,; Universitats-Krankenhaus Eppendorf, Hamburg, BRD.; With regard to the controversial issue of a reduction of transfusion-associated infections by non-remunerated donations, epidemiological data on the prevalence of HIV-1, HIV-2 and hepatitis C virus (HCV) are of particular interest in our country. We investigated four sample categories: (1) healthy employees and worker
Detection of antibodies to HCV: comparison of a c100-3 EIA and the 2nd generation EIA.: Beitr Infusionsther. 1992;30:42-5. Unique Identifier : AIDSLINE MED/93278528; Polywka S; Kaars-Wiele P; Schroeter E; Mandler J; Laufs R; Institute of Medical Microbiology and Immunology, University; Hospital Eppendorf, Hamburg, FRG.; The reactivity of 558 serum specimens in Abbott 1st and 2nd generation EIAs was compared. A significant increase in HCV seropositivity was especially found in high risk groups such as hemophiliacs (57.7 vs. 73.1%), IVDA (54.5 vs. 61.8%), HIV positives (21.8 vs. 25.5%) or patients on dialysis (15.7 vs. 16.9%). Reactivi
Recombinant antigens in viral diagnosis.: Beitr Infusionsther. 1992;30:78-81. Unique Identifier : AIDSLINE MED/93278552; Vornhagen R; Baur A; Jahn G; Hinderer W; Nebel-Schickel H; Horn J; Wolf H; Sonneborn HH; Biotest AG, Research Department, Dreieichenhain, FRG.; DNA fragments coding for a variety of different viral antigens have been cloned and expressed in Escherichia coli. Selected purified recombinant antigens were used for detection of specific antibodies by means of the ELISA technique. This approach has been used for the development of four different ELISAs for the dete
[Follow-up of blood donors with indeterminate reaction to anti-HIV 1/2 EIA or isolated detection of antibodies to HIV-1 core antigens (anti-p24)]: Beitr Infusionsther. 1992;30:82-4. Unique Identifier : AIDSLINE MED/93278553; Zimmermann R; Zeiler T; Zingsem J; Weisbach V; Muller C; Huhn D; Eckstein R; Abteilung Innere Medizin, Universitatsklinikum Rudolf-Virchow,; Freie Universitat Berlin, BRD.; Over a period of 20 months we identified 10 voluntary blood donors with indeterminate reactions in anti-HIV 1/2 EIA tests. Western blot (WB) patterns of 6 of these 10 donors showed isolated core antibodies (anti-p24), in 4 cases WB patterns were negative. After a median follow-up period of 58 weeks (range 12-93) we ha
Carbohydrate binding properties of the envelope glycoproteins of human immunodeficiency virus type 1.: Glycoconj J. 1992 Dec;9(6):315-23. Unique Identifier : AIDSLINE MED/93291559; Haidar M; Seddiki N; Gluckman JC; Gattegno L; Laboratoire de Biologie Cellulaire, Faculte de Medecine Paris; Nord, Bobigny, France.; Here, we confirm and extend our previous findings on human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein N-acetylglucosaminyl binding properties. We show the occurrence of saturable, temperature, pH, and calcium dependent carbohydrate-specific interactions between recombinant precursor gp160 (rgp160) and
Microbial antigens and cytokines cause type I allergic reactions in AIDS patients. In vitro studies of basophil histamine release.: Pneumonol Alergol Pol. 1992;60 Suppl 2:74-9. Unique Identifier : AIDSLINE MED/93291744; Pedersen M; Permin H; Kristensen KS; Norn S; Laboratory of Immunology, University Clinic for Infectious; Diseases, Rigshospitalet, Copenhagen.
Prevention of transmission of HIV by organ and tissue transplantation. HIV testing protocol and a proposal for recommendations concerning donor selection.: Transpl Int. 1993 May;6(3):165-72. Unique Identifier : AIDSLINE MED/93270665; Patijn GA; Strengers PF; Harvey M; Persijn G; Eurotransplant Foundation, Leiden, The Netherlands.; Human immunodeficiency virus (HIV) can be transmitted by solid organ and some forms of tissue transplantation. Although routine screening of organ and tissue donors for anti-HIV antibodies was implemented in most Western European countries and North America in 1985, several recent case reports indicate that a definite
[Professional strength creates enthusiasm and growth (interview by Siv Barstad)]: J Sykepleien. 1993 Feb 16;81(3):10-1. Unique Identifier : AIDSLINE MED/93270835; Aune E
[Give patients identity (interview by Siv Barstad)]: J Sykepleien. 1993 Feb 16;81(3):17-9. Unique Identifier : AIDSLINE MED/93270840; Lauvsnes M
[St. Lucia: safe sex instead of abstinence]: J Sykepleien. 1993 Feb 16;81(3):20. Unique Identifier : AIDSLINE MED/93270842; Ninvalle P
[AIDS in Tanzania]: J Sykepleien. 1993 Apr 20;81(7):5-11. Unique Identifier : AIDSLINE MED/93270867; Barstad S
It is time to be HIV interrogative [letter]: Nurs Stand. 1993 Mar 31-Apr 6;7(28):41. Unique Identifier : AIDSLINE MED/93270952; Hollings L
Education needed after AZT failure [news]: Nurs Stand. 1993 Apr 7-13;7(29):6. Unique Identifier : AIDSLINE MED/93270971
'Blind spot' theory for HIV's damaging power [news]: Nurs Stand. 1993 Apr 14-20;7(30):17. Unique Identifier : AIDSLINE ME