Abstract:
KS is a progressive vascular condition presenting itself as an indolent cutaneous lesion in its classical form and with an aggressive visceral and cutaneous pathology in AIDS patients. KS occurs in epidemic proportions in HIV+ homo- and bisexual men in North America and Europe. The classical form is endemic and a major cancer in Africa. Spontaneous occurrence of malignant blood vessel neoplasms in both animals and humans is rare. DMH is one of the few carcinogens capable of inducing blood vessel neoplasms. The objective of our research was to see how the presentation and evolution of angiosarcomas in mice compares with the reported evolution of KS in HIV+ men. We also undertook this research to obtain an experimental animal model of AIDS-related KS. From various and subsequent experiments, we produced angiosarcoma lesions in male mice of several strains: in 39 CD1; 22 DBA/2 and 116 C57BL/6 (totaling 177 animals). All these animals had received sc 20 mg/kg of body wt of DMH once a week for 30-40 wk, depending on the experiment. All animals underwent gross and macroscopic examination to establish the number of lesions and their topography. 120 animals presented only one single lesion, 39 had two lesions and in 18, 3 or more lesions were found. An effort has been made to establish the topography of the primary sites and the pattern of their progression and spread as well as the pathological features of the early changes observed in vessels. The pattern of lesion distribution, when DMH is injected sc, contrasts with that of oral administration. Most primary lesions were found in the pelvic region and lower retroperitoneum. While low-grade lesions remain localized, the high-grade malignancies spread to other parts of the body (kidney, liver or lungs). An angiosarcoma cell line has been developed by tissue culture opening new areas for research. Some of the low-grade lesions observed in animals reproduce the histological features of the HIV-associated KS. The histology of the lesions developed in the immune-suppressed animals does not differ significantly from those of the other groups.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/PATHOLOGY Animal *Dimethylhydrazines Hemangiosarcoma/*COMPLICATIONS/PATHOLOGY Mice Mice, Inbred Strains Sarcoma, Kaposi's/*ETIOLOGY/PATHOLOGY ABSTRACT 931030
M93A0776
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Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.
