Alcohol as a risk factor in B cell lymphoproliferative disorders (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Alcohol as a risk factor in B cell lymphoproliferative disorders (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 34:A1082 1993. Unique Identifier : AIDSLINE ICDB/93692055
Mufti SI; Odeleye OE; Nachiappan V; Dept. of Pharmacology, Univ. of Arizona, Tucson, AZ 85721

Abstract: Patients with immunodeficiency diseases including HIV infected persons exhibit a predominance of B lymphocyte proliferation. Excessive alcohol consumption by such individuals may serve to enhance the disorder. In our studies, we used C57BL/6 mice and infected them with 0.1 ml of LP-BM5 murine leukemia retrovirus inoculum. The mice were then fed an isocaloric Lieber-DeCarti liquid diet containing 4.5% (V/V) ethanol. Hepatic indices of lipid peroxidation were measured at 20 wk after infection. The results showed that compared to controls ethanol administration increased lipid fluorescence from 51.4 +/- 1.3 to 83.1 +/- 6.5 units/g x 10(3), diene conjugates from 163 +/- 22 to 288 +/- 30 units/g and malondialdehyde from 41 +/- 12 to 352 +/- 31 pmol/mg protein. With supplementary feeding of vitamin E, there was a significant reduction in these values. Initial data from spleen also support these observations and histopathology indicates that the incidence of LP-BM5 induced B cell lymphoma is significantly increased with ethanol administration. We propose that alcohol consumption may play a role in such lymphoproliferative disorders.
Keywords: Alcohol, Ethyl/*PHARMACOLOGY Animal B-Lymphocytes/*DRUG EFFECTS Lipid Peroxidation/*DRUG EFFECTS Lymphoma, B-Cell/*ETIOLOGY Mice Mice, Inbred C57BL Risk Factors ABSTRACTKWDalcohol,ethyl/KWDpharmacologyanimalb-lymphocytes/KWDdrugeffectslipidperoxidation/KWDdrugeffectslymphoma,b-cell/KWDetiologymicemice,inbredc57blriskfactorsabstract
931030
M93A0774

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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