Effects of intravenous immunoglobulin on clinical and immunological findings of patients with humoral immunodeficiency diseases.

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Effects of intravenous immunoglobulin on clinical and immunological findings of patients with humoral immunodeficiency diseases.

Turk J Pediatr. 1992 Oct-Dec;34(4):203-9. Unique Identifier : AIDSLINE MED/93310983
Ersoy F; Tezcan I; Sanal O; Immunology Unit, Hacettepe University Institute of Child Health,; Ankara.

Abstract: We evaluated nine patients with humoral immunodeficiency (6 immunodeficiency with hyper-IgM, 2 X-linked agammaglobulinemia, 1 common variable immunodeficiency) who were being treated with intravenous immunoglobulins (IVIG). After the use of the IVIG regimen in a dose of 250-300 mg/kg/4 weeks for one year, the severity and frequency of infections, even in patients with chronic lung disease, decreased significantly. An improvement in pulmonary function tests was observed in four patients who had airway obstruction prior to IVIG therapy. Side effects such as chills and fever were observed in 21 of 91 infusions, particularly in the early months of therapy. Preinfusion administration of aspirin and diphenhydramine prevented these side effects. The inversion of the CD4+/CD8+ ratio was detected in most patients during both intramuscular gammaglobulins (IMIG) and IVIG therapy.

Keywords: Adolescence Adult Agammaglobulinemia/BLOOD/COMPLICATIONS/*THERAPY Child Common Variable Immunodeficiency/BLOOD/COMPLICATIONS/*THERAPY CD4-CD8 Ratio Dysgammaglobulinemia/BLOOD/COMPLICATIONS/*THERAPY Follow-Up Studies Human IgG/BLOOD IgM/*DEFICIENCY Immunoglobulins, Intravenous/*THERAPEUTIC USE Infection/EPIDEMIOLOGY/ETIOLOGY Leukocyte Count T-Lymphocyte Subsets JOURNAL ARTICLE
931030
M93A0765

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