T-cell antigen receptor V beta subsets are not preferentially deleted in AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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T-cell antigen receptor V beta subsets are not preferentially deleted in AIDS.

AIDS. 1993 May;7(5):625-31. Unique Identifier : AIDSLINE MED/93305207
Posnett DN; Kabak S; Hodtsev AS; Goldberg EA; Asch A; Division of Allergy-Immunology, Cornell University Medical; College, New York, New York 10021.

Abstract: OBJECTIVE: Evidence for an HIV-1-associated superantigen (SAg) has been presented. Here we test whether targeted T cells are preferentially depleted in AIDS. DESIGN: The T cell antigen receptor (TCR) V beta repertoire was compared in 44 HIV+ hemophiliac patients and in 27 controls. METHODS: Eleven TCR V gene-specific monoclonal antibodies (MAb), representing approximately one-third of the V beta repertoire were used to measure T-cell numbers expressing V beta and V alpha genes in both the CD4 and the CD8 subsets by two-color immunofluorescence. RESULTS: The percentage of T cells expressing these V genes could be accurately quantitated in both the CD4 and the CD8 T-cell populations and at various clinical stages of disease progression. No preferential deletion of any particular V gene subsets was detected. CONCLUSION: CD4 T-cell depletion in AIDS is not V beta-selective.
Keywords: Acquired Immunodeficiency Syndrome/BLOOD/GENETICS/*IMMUNOLOGY Adult Hemophilia/COMPLICATIONS Human HIV Antigens HIV Seropositivity/COMPLICATIONS/GENETICS/IMMUNOLOGY *HIV-1/IMMUNOLOGY Leukocyte Count Leukopenia/ETIOLOGY Male *Receptors, Antigen, T-Cell, alpha-beta/GENETICS Support, U.S. Gov't, P.H.S. T-Lymphocyte Subsets/*IMMUNOLOGY JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/blood/genetics/KWDimmunologyadulthemophilia/complicationshumanhivantigenshivseropositivity/complications/genetics/immunologyKWDhiv-1/immunologyleukocytecountleukopenia/etiologymaleKWDreceptors,antigen,t-cell,alpha-beta/geneticssupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytesubsets/KWDimmunologyjournalarticle
931030
M93A0749

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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