The effect of cigarette smoking on the development of AIDS in HIV-1-seropositive individuals. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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The effect of cigarette smoking on the development of AIDS in HIV-1-seropositive individuals.

AIDS. 1993 May;7(5):705-10. Unique Identifier : AIDSLINE MED/93305219
Nieman RB; Fleming J; Coker RJ; Harris JR; Mitchell DM; Department of Respiratory Medicine, St Mary's Hospital, London,; UK.

Abstract: OBJECTIVE: To determine whether HIV-1-seropositive cigarette smokers progress more rapidly to AIDS than HIV-1-seropositive non-smokers. SETTING: The genitourinary medicine outpatient department of St Mary's Hospital, London, which is a London University teaching hospital (tertiary care centre). SUBJECTS AND DESIGN: Case series of 84 individuals with AIDS who provided accurate details of their smoking habits before their AIDS-defining diagnosis. MAIN OUTCOME MEASURE: Progression time to AIDS in relation to smoking habit. RESULTS: Progression time to AIDS (all diagnoses) was significantly reduced in HIV-1-seropositive smokers: median time to AIDS was 8.17 months for smokers (n = 43) and 14.50 months for non-smokers (n = 41) (P = 0.003). Smokers developed Pneumocystis carinii pneumonia (PCP) more rapidly than non-smokers, with a median time to PCP of 9.0 months, compared with 16.0 months for non-smokers (P = 0.002). Smoking had no significant effect on progression time to AIDS when not due to PCP. CONCLUSION: Cigarette smoking by HIV-1-seropositive individuals is associated with a more rapid development of AIDS and should be discouraged.
Keywords: Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/*ETIOLOGY Adult Epidemiologic Factors Female Human HIV Seropositivity/*COMPLICATIONS *HIV-1 Life Tables London/EPIDEMIOLOGY Male Middle Age Smoking/*ADVERSE EFFECTS Support, Non-U.S. Gov't Time Factors JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/epidemiology/KWDetiologyadultepidemiologicfactorsfemalehumanhivseropositivity/KWDcomplicationsKWDhiv-1lifetableslondon/epidemiologymalemiddleagesmoking/KWDadverseeffectssupport,non-uKWDsKWDgov'ttimefactorsjournalarticle
931030
M93A0742

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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