Comparison of transmission rates of HIV-1 and HIV-2 in a cohort of prostitutes in Senegal. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Comparison of transmission rates of HIV-1 and HIV-2 in a cohort of prostitutes in Senegal.

Bull Math Biol. 1993;55(4):731-43. Unique Identifier : AIDSLINE MED/93306241
Donnelly C; Leisenring W; Kanki P; Awerbuch T; Sandberg S; Department of Biostatistics, Harvard School of Public Health,; Boston, MA 02115.

Abstract: To explore the biological similarities and differences between the HIV-1 and HIV-2 viruses, we model the probability of male-to-female transmission of either HIV virus as a function of the number of sexual partners, the prevalence of the viruses and the infectivity per contact. Using maximum likelihood estimation theory and data from a prospective study of registered female prostitutes in Dakar, Senegal, we estimate and compare the infectivities of HIV-1 and HIV-2. Graphical goodness-of-fit methods are used to show that our model fits the data well. We find that in male-to-female transmission HIV-1 is significantly more infectious than HIV-2. This finding is consistent with other data from laboratory and epidemiologic studies comparing the biology of HIV-1 and HIV-2.
Keywords: Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/*TRANSMISSION Cohort Studies Comparative Study Female Human *HIV-1 *HIV-2 Male Mathematics Models, Statistical Prevalence Probability Prospective Studies *Prostitution Senegal/EPIDEMIOLOGY Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/epidemiology/KWDtransmissioncohortstudiescomparativestudyfemalehumanKWDhiv-1KWDhiv-2malemathematicsmodels,statisticalprevalenceprobabilityprospectivestudiesKWDprostitutionsenegal/epidemiologysupport,uKWDsKWDgov't,non-pKWDhKWDsKWDsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
931030
M93A0717

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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