B-cell and T-regulatory cell dysfunction in six Chinese children with hypogammaglobulinaemia. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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B-cell and T-regulatory cell dysfunction in six Chinese children with hypogammaglobulinaemia.

Eur J Pediatr. 1993 May;152(5):409-13. Unique Identifier : AIDSLINE MED/93307322
Jones BM; Lau YL; Wong KL; Department of Pathology, Queen Mary Hospital, Hong Kong.

Abstract: We report six Chinese boys with hypogammaglobulinaemia. All but one had very low or undetectable circulating B-lymphocytes, two had reversed CD4/CD8 ratios (in one of whom this latter became normal), one had reduced lymphocyte proliferative responses to concanavalin A and pokeweed mitogen and three had deficient responses to OKT3. Generation of antibody-secreting cells in response to pokeweed mitogen was markedly defective in all patients. Co-cultures of purified lymphocyte subsets from the patients with those of normal donors revealed that in addition to B-cell deficiency seen in all patients, two had T-helper cell deficiency and two had T-suppressor cell hyperactivity. One of the latter patients was treated with cimetidine in an attempt to ablate histamine type 2 receptor-bearing suppressor cells: the absolute number of such cells was temporarily reduced but there was no concurrent correction of the functional hyperactivity. These studies point to the variable nature of T-regulatory cell deficiencies in hypogammaglobulinaemia.
Keywords: Adolescence Agammaglobulinemia/DRUG THERAPY/*IMMUNOLOGY B-Lymphocytes/DRUG EFFECTS/*IMMUNOLOGY Case Report Child Child, Preschool China Concanavalin A/PHARMACOLOGY/THERAPEUTIC USE CD4-CD8 Ratio Human Infant Leukocytes, Mononuclear/DRUG EFFECTS/IMMUNOLOGY Lymphocyte Transformation Male Muromonab-CD3/PHARMACOLOGY/THERAPEUTIC USE Pokeweed Mitogens/PHARMACOLOGY/THERAPEUTIC USE T-Lymphocytes, Helper-Inducer/DRUG EFFECTS/*IMMUNOLOGY T-Lymphocytes, Suppressor-Inducer/DRUG EFFECTS/*IMMUNOLOGY JOURNAL ARTICLEKWDadolescenceagammaglobulinemia/drugtherapy/KWDimmunologyb-lymphocytes/drugeffects/
931030
M93A0712

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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