Interaction of human papillomavirus (HPV) and HIV-1 in HPV-immortalized or tumorigenic cervical cells (Meeting abstract).

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Interaction of human papillomavirus (HPV) and HIV-1 in HPV-immortalized or tumorigenic cervical cells (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 34:A3243 1993. Unique Identifier : AIDSLINE MED/93694200
DiPaolo JA; Popescu N; Chen M; Zimonjic D; Berneman Z; Lusso P; NCI, Bethesda, MD 20892

Abstract: HPV infection is associated with cervical cancer, and HIV appears to be a cofactor that accelerates its development. This study demonstrates that HIV-1 can infect cervical epithelial cells and synergize transactivation induced by HIV-1 tat and molecular clones of human herpesvirus-6 (HHV-6), pZVH14 and pZVB70, which are, per se, weak transactivators of HIV-1 LTR CAT. Positive infection occurred with HIV-1BaL (originally isolated from primary cultures of lung) but not with HIV-1(IIIB) (lymphotropic virus). Cervical cells lack the CD4 receptor; OKT4a antibody did not block infection. ELISA analysis of HIV-1 p24 core antigen demonstrated production of HIV-1 virus. These results, including identification of potential HIV transactivators which synergize with Tat in 2 genomic clones of HHV-6, may be important for the dissection of the molecular mechanisms of interaction between viruses in human genital cells.

Keywords: *Cervix Uteri/MICROBIOLOGY *HIV-1/PATHOGENICITY *Papillomavirus/PATHOGENICITY
931130
M93B5836

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1993. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1993. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .