Development of human HIV vaccines.

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Development of human HIV vaccines.

Int Conf AIDS. 1993 Jun 6-11;9(1):10 (abstract no. PS-05-1). Unique Identifier : AIDSLINE MED/93333216
Bolognesi DP; Department of Surgery, Duke University Medical Center, Durham, NC.

Abstract: There are now over a dozen vaccine candidates for prevention of HIV infection undergoing immunogenicity and safety testing in low risk volunteers. Based on promising results obtained in such studies, two products have been selected for further evaluation in a modest number of high risk volunteers again to determine if safety and immunogenicity extend to various target populations for HIV infection. Under usual circumstances, the next step in evaluation of a vaccine would be to conduct efficacy trials in large numbers of individuals at high risk for HIV infection. However, the unprecedented complexities of HIV as vaccine target have made it difficult to devise guidelines for taking such a step. This presentation will review the current status of HIV vaccine development, its bearing on this dilemma as well as highlights of new and promising developments in research that may produce the next generation of vaccines.

Keywords: *AIDS Vaccines/TOXICITY *HIV Infections/PREVENTION & CONTROL
931130
M93B5831

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1993. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1993. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .