Molecular targets for interference with viral replication.

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Molecular targets for interference with viral replication.

Int Conf AIDS. 1993 Jun 6-11;9(1):10 (abstract no. PS-03-1). Unique Identifier : AIDSLINE MED/93333217
Wong-Staal F; Dept. of Medicine, UCSD, La Jolla 92093.

Abstract: Therapeutic intervention of HIV-1 replication can be achieved by interfering with key steps in the virus life cycle, including entry, reverse transcription, transcription, translation, packaging, and virus release. In addition, inhibition of the early, essential regulatory genes, tat and rev, would pre-empt possibility of virus production and spread. Tat and Rev directly bind to their respective RNA targets, TAR and RRE. Cellular proteins also bind to these viral proteins and RNA elements. These components form large functional complexes, the disruption of which should halt virus production. The use of RNA decoys, transdominant proteins and anti-sense/catalytic RNAs all aim at interfering such complex formation. As the technology of gene therapy is refined, the prospects of treatment of AIDS using these approaches would also improve. Finally, the vif, nef, vpu/vpx and vpr genes are also potential targets as they contribute to replication efficiency and pathogenicity in vivo.

Keywords: *Acquired Immunodeficiency Syndrome/THERAPY *HIV-1/PHYSIOLOGY *Virus Replication
931130
M93B5830

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1993. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1993. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .