Malignant lymphoma: biology, natural history, and treatment. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Malignant lymphoma: biology, natural history, and treatment.

Malignant Lymphoma: Biology, Natural History, and Treatment. Malvern, PA, Lea and Febiger, 395 p., 1991.. Unique Identifier : AIDSLINE ICDB/93690052
Aisenberg AC; Harvard Medical Sch., Boston, MA

Abstract: This book approaches lymphoma as a subject for scientific inquiry, yet treatment is always in mind. The author cites a 40-yr interest in his subject, but claims to have learned more in the 18 mo before publication than during the preceding decades. These latest data are reviewed: (1) Hodgkin's disease (epidemiology, immunologic status and infections, etiology, histopathology, contiguous vs hematogenous spread, clinical picture, staging, radiation therapy, prognostic features, chemotherapy +/- irradiation, complications of and recommendations for treatment, treatment of relapse, autologous bone marrow transplantation (BMT), special treatment considerations, and future prospects); (2) classifying non-Hodgkin's lymphoma (NHL) morphology (Rappaport, Lukes-Collins, and Kiel classifications; NCI Working Formulation for clinical use; a clinician's classification of the NHLs; miniatlas of NHL morphology); (3) nodal B-cell lymphoma (small lymphocytic, follicular [small cleaved cell (scc), large-cell (lc) or mixed cell (mc)], intermediate lymphocytic [intermediate differentiation], and mantle zone lymphomas; diffuse lymphomas of small + large cells and of lcs; small noncleaved cell [sncc] lymphomas [Burkitt's and non-Burkitt's type]; and immunoblastic lymphoma); (4) T-cell lymphoma (lymphoblastic and peripheral T-cell lymphomas; adult T-cell leukemia/lymphoma; angioblastic lymphadenopathy + dysproteinemia [AILD]; immunoblastic lymphadenopathy [IBL] and AILD-like or IBL-like T-cell lymphoma; polymorphic reticulosis, lethal midline granuloma, and lymphomatoid granulomatosis; and lymphoepithelioid cell (Lennert's) and Ki-1+ lymphomas); (5) treatment of NHL (radiation and chemotherapy; Stage I and II favorable [low-grade] or unfavorable [intermediate- and high-grade], Stage III and IV follicular scc or mc, and advanced-stage diffuse lc and immunoblastic lymphomas; NHLs in the pediatric age group; and undifferentiated sncc [Burkitt's and non-Burkitt's types]; and lymphoblastic lymphoma in adults); (6) salvage drug regimens and BMT in NHL; (7) extranodal lymphoma (mucosa-associated lymphoid tissue; pseudolymphoma; primary NHL of the brain; primary lymphoma of breast, of bone, or of spleen; mediastinal lc, gastric, intestinal, orbital, cutaneous, pulmonary, or testicular lymphoma; and lymphomas of Waldeyer's ring, nasal cavity and paranasal sinuses, salivary gland, thyroid, ovary, cervix or prostate); (8) related disorders (Castleman's disease, progressive transformation of germinal centers, and sinus histiocytosis with massive lymphadenopathy); (9) surface markers of NHLs; (10) cytogenetics (abnormalities in NHLs) and molecular genetics; (11) NHLs in states of altered immunity (lymphomas in transplant recipients, in AIDS, and after anticonvulsant administration; X-linked lymphoproliferative syndrome; primary immunodeficiency states; T-cell lymphomas in patients with chronic EBV infection; Sjogren's disease, Hashimoto's thyroiditis, and collagen vascular disease; and EBV [and HTLV-1] and NHL).
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Bone Marrow Transplantation Giant Lymph Node Hyperplasia Hodgkin's Disease/DIAGNOSIS/IMMUNOLOGY/PATHOLOGY/THERAPY Human *Lymphoma/DIAGNOSIS/IMMUNOLOGY/PATHOLOGY/THERAPY Lymphoma, B-Cell/CLASSIFICATION/DRUG THERAPY/PATHOLOGY/ RADIOTHERAPY/SURGERY Lymphoma, Large-Cell/THERAPY Lymphoma, Non-Hodgkin's/CLASSIFICATION/DIAGNOSIS/GENETICS/ IMMUNOLOGY/PATHOLOGY/THERAPY Lymphoma, T-Cell/CLASSIFICATION/COMPLICATIONS/DRUG THERAPY/ PATHOLOGY/RADIOTHERAPY/SURGERY MONOGRAPHKWDacquiredimmunodeficiencysyndrome/complicationsbonemarrowtransplantationgiantlymphnodehyperplasiahodgkin'sdisease/diagnosis/immunology/pathology/therapyhuman
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Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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