Anti-CD4 antibodies are associated with HIV-1 seroconversion and may be detectable before anti-HIV-1 antibodies. The Multicenter AIDS Cohort Study. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Anti-CD4 antibodies are associated with HIV-1 seroconversion and may be detectable before anti-HIV-1 antibodies. The Multicenter AIDS Cohort Study.

AIDS Res Hum Retroviruses. 1992 Nov;8(11):1919-27. Unique Identifier : AIDSLINE MED/93144001
Keiser P; Keay S; Wasserman S; Wecksler W; Division of Infectious Diseases, University of Maryland School of; Medicine, Baltimore 21201.

Abstract: We examined the sera from 14 HIV-1 seroconverters for the presence of autoantibodies against CD4. Anti-CD4 antibodies were detected in the serum of 11 of 13 HIV-1-infected persons at the time of HIV-1 seroconversion. In 6 of 14 persons from whom a serum was obtained prior to HIV-1 seroconversion, anti-CD4 antibodies were found 90 to 540 days before antibodies to HIV-1 were detectable. In comparison, anti-CD4 antibodies were present in only 7 serum samples from 62 HIV-1 seronegative individuals, including 50 from a seronegative homosexual male cohort. These results suggest that anti-CD4 antibodies are generated in response to early HIV-1 infection and possibly could be used as a marker for HIV-1 infection in some infected persons who are seronegative for HIV-1.
Keywords: Antigens, CD4/*IMMUNOLOGY Autoantibodies/*BLOOD Biological Markers Blotting, Western Cohort Studies Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Human HIV Antibodies/*BLOOD HIV Seropositivity/*IMMUNOLOGY HIV-1/*IMMUNOLOGY Male Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE MULTICENTER STUDYKWDantigens,cd4/KWDimmunologyautoantibodies/KWDbloodbiologicalmarkersblotting,westerncohortstudiesenzyme-linkedimmunosorbentassayfluorescentantibodytechniquehumanhivantibodies/KWDbloodhivseropositivity/KWDimmunologyhiv-1/KWDimmunologymalesupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticlemulticenterstudy
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Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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