[Detection of HBV-DNA in peripheral blood mononuclear cells of anti-HIV-positive patients and its relation to other serological markers of HBV]

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

[Detection of HBV-DNA in peripheral blood mononuclear cells of anti-HIV-positive patients and its relation to other serological markers of HBV]

Enferm Infecc Microbiol Clin. 1992 Oct;10(8):445-50. Unique Identifier : AIDSLINE MED/93144371
Sunen E; Malave C; Sarria L; Gorrino C; Campelo C; Martinez J; Cisterna R; Departamento de Microbiologia e Inmunologia, Universidad del; Pais Vasco, Hospital Civil de Bilbao.

Abstract: HBV infection has been investigated in 47 anti-human HIV positive patients in relation to a similar group of 33 anti-HIV negative patients. Serological HBV markers were found in 87% of anti-HIV positive patients. The difference in markers of viral replication (HBeAg, HBV-DNA) was not statistically significant between the two groups. It has been suggested that HBV infection of peripheral blood mononuclear cells could be a cofactor implicated in the development of immunodeficiency due to HIV. For this reason we have investigated the presence of HBV-DNA in peripheral blood mononuclear cells by in situ hybridization. Although its detection was more frequent in anti-HIV positive patients than in anti-HIV negative ones (p < 0.05), it was not related to clinical state of immunodeficiency. With regard to serological HBV markers, HBV-DNA was detected in peripheral blood mononuclear cells from antiHBc w/o antiHBs patients. This fact means the virus may persist in this cells after recovery and suggest they could serve as additional reservoirs of HBV. These cells, that contain the HBV genome, could be implicated in the perpetuation, reactivation of the infection and in its transmission.

Keywords: Adult Comparative Study DNA, Viral/*BLOOD English Abstract Female Hepatitis B/COMPLICATIONS/*DIAGNOSIS/EPIDEMIOLOGY/TRANSMISSION Hepatitis B Antibodies/*BLOOD Hepatitis B Antigens/*BLOOD Hepatitis B Virus/IMMUNOLOGY/*ISOLATION & PURIF/PHYSIOLOGY Human HIV Antibodies/BLOOD HIV Infections/*COMPLICATIONS Leukocytes, Mononuclear/*MICROBIOLOGY Male Prevalence Virus Activation Virus Replication JOURNAL ARTICLE
930530
M9350956

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