Primary T-cell lymphoma of the gastrointestinal tract associated with human T-cell lymphotropic virus type I. An analysis using in situ hybridization and polymerase chain reaction.

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Primary T-cell lymphoma of the gastrointestinal tract associated with human T-cell lymphotropic virus type I. An analysis using in situ hybridization and polymerase chain reaction.

Cancer. 1993 Feb 1;71(3):708-16. Unique Identifier : AIDSLINE MED/93161237
Tokunaga O; Watanabe T; Shimamoto Y; Tokudome S; Department of Pathology, Saga Medical School, Japan.

Abstract: BACKGROUND. During a population-based local cancer registry, a peculiar type of T-cell lymphoma restricted to the gastrointestinal tract was found in patients living in southwestern Japan. METHODS. Five cases of gastrointestinal (GI) tract T-cell lymphoma were analyzed with immunohistologic examination, ultrastructural analysis, in situ hybridization (ISH), and polymerase chain reaction (PCR). RESULTS. All cases satisfied the criteria of primary GI tract lymphoma at presentation or operation. Four showed a close relationship to human T-cell lymphotropic virus type I (HTLV-I). Those four had positive results for anti-HTLV-I antibody and positive surface markers for CD4, positive hybridization signals by ISH, and HTLV-I gene products by PCR, but they had no lymphoma cells in peripheral blood or bone marrow. The fifth case showed negative signals by ISH and PCR. CONCLUSIONS. These findings suggest that some of the putative adult T-cell leukemia/lymphoma (ATLL) types can be further classified as GI-tract-type lymphoma. The prognosis for the GI tract type is as poor as it is for conventional ATLL.

Keywords: Aged Aged, 80 and over Base Sequence DNA Probes Female Gastrointestinal Neoplasms/*MICROBIOLOGY/PATHOLOGY Human HTLV-I/*GENETICS HTLV-I Antibodies/ANALYSIS HTLV-I Infections/GENETICS/IMMUNOLOGY Immunohistochemistry *In Situ Hybridization Lymphoma, T-Cell/*METABOLISM/PATHOLOGY Male Middle Age Molecular Sequence Data *Polymerase Chain Reaction JOURNAL ARTICLE
930530
M9350378

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