The HIV-1 regulator of virion protein expression (rev).

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

The HIV-1 regulator of virion protein expression (rev).

Harvard AIDS Inst Ser; 1:311-90 1991. Unique Identifier : AIDSLINE ICDB/93686278
Anonymous; No affiliation given

Abstract: A unique feature of the human retroviruses is that they utilize a novel mechanism of post-transcriptional gene regulation that is differential for the expression of regulatory and structural viral proteins. Although a single primary RNA transcript is made, a complex splicing scheme is employed to generate the multiple species of mRNA that encode for the various viral proteins. In a singled cycle of infection or virus replication in transfected cells, the early transcripts that appear are the multiply spliced mRNAs. Early to late switching is brought about by the rev protein of HIV and the rex protein of HTLV, which allow the accumulation and utilization in the cytoplasm of unspliced and singly spliced viral mRNA. Rev, the HIV-1 regulator of virion protein expression, is reviewed in the following chapters: viral and cellular factors that bind to the rev response element; regulation of the HIV genome (functional studies of REV, NEF and cis regulatory sequences); dependency of rev regulation of HIV env RNA on the position of splice sites; a novel post-transcriptional role for HIV-1 and tar; domain structure of the HIV-1 rev protein; and retroviral regulatory proteins and the nucleolus.

Keywords: Gene Expression Regulation, Viral Gene Products, env/GENETICS Gene Products, rev/GENETICS Genes, rev HIV-1/*GENETICS RNA Processing, Post-Transcriptional RNA Splicing RNA-Binding Proteins/GENETICS/METABOLISM RNA, Viral/GENETICS Viral Proteins/GENETICS/METABOLISM Virion MONOGRAPH
930330
M9331109

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1993. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1993. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .