Adult T-cell leukemia/lymphoma (ATL) (Meeting abstract).

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Adult T-cell leukemia/lymphoma (ATL) (Meeting abstract).

Asian-Pacific Division International Society of Haematology VII Congress. November 17-21, 1991, Hong Kong, p.70, 1991.. Unique Identifier : AIDSLINE ICDB/93686769
Takatsuki K; Kumamoto Univ. Medical Sch., Kumamoto 860, Japan

Abstract: ATL was first reported in Japan, where it has a high incidence in the southwest region. Typical ATL has the following features: (1) it occurs in adults; (2) ATL cells have the nature of CD4-positive peripheral T cells; (3) skin lesions, hepatomegaly, splenomegaly and lymphadenopathy are seen in a large percentage of patients (pts), sometimes accompanied by pulmonary lesions or gastrointestinal lesions; (4) anemia is usually absent and, if present, is only mild; and (5) hypercalcemia is not rare. ATL can be divided into five types (acute, chronic, smoldering, crisis and lymphoma). The hallmark of ATL is the monoclonal integration of HTLV-1 provirus into the genome of the malignant cells. We present some of our recent experiences with unusual pts: (1) a 58-yr-old male with HTLV-I-associated malignancy mimicking small-cell lung cancer (Matsuzaki, H et al, Cancer 66:1763-8, 1990); (2) a 72-yr-old male with HTLV-I-associated CD4-, CD8- lymphoid malignancy involving the gastrointestinal tract (Hattori T et al, Lancet 337:76-7, 1991); and (3) a 52-yr-old female HTLV-I carrier with progressive wt loss caused by Isospora belli infection. The number of HTLV-I carriers in Japan is estimated to be about one million. Some 500 new pts with ATL are found every year. To prevent infection with HTLV-I, all samples of donated blood in Japan started to be subjected to HTLV-I antibody testing in 1986. HTLV-I antibody-positive mothers are now instructed to refrain from breast feeding. The recently highlighted disease HTLV-I-associated myelopathy is synonymous with tropical spastic paraparesis. More recently, HTLV-I-associated bronchopneumonopathy, arthropathy and other diseases have been reported.

Keywords: Aged Carcinoma, Small Cell/COMPLICATIONS Case Report CD4-Positive T-Lymphocytes Female Gastrointestinal Neoplasms/COMPLICATIONS Hepatomegaly/COMPLICATIONS Human HTLV-I/PHYSIOLOGY HTLV-I Infections/*COMPLICATIONS Japan/EPIDEMIOLOGY Leukemia, T-Cell, Acute/COMPLICATIONS/*EPIDEMIOLOGY Leukocyte Count Lung Neoplasms/COMPLICATIONS Lymphatic Diseases/COMPLICATIONS Male Middle Age Skin Diseases/COMPLICATIONS Splenomegaly ABSTRACT
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