Regression mechanism of mycoplasma pulmonis-infected AH66 tumor (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Regression mechanism of mycoplasma pulmonis-infected AH66 tumor (Meeting abstract).

FASEB J; 6(4):A1151 1992. Unique Identifier : AIDSLINE ICDB/93687070
Ding XD; Ishiguro T; Tamura H; Maejima K; Lab. Animal Center, KIEO Univ. Sch. of Medicine, 35; Shinano-machi, Shinjuku, Tokyo 160, Japan

Abstract: AH66 is a hepatoma tumor cell line that was derived from rat ascites. After being iv injected into syngeneic rats, the tumor cells were expanded in the lung, and the recipient rats died in 12 days. However, if the tumor cells had been infected with Mycoplasma pulmonis before injection, tumor regression was observed after an initial proliferation. The rats in which tumor regression occurred were subsequently resistant to mycoplasma-uninfected tumor. The mechanism by which tumor regression occurred has been investigated. Tumors from rats with low titers of antimycoplasma antibody (less than or equal to 1:160) were more invasive and metastatic than tumors from rats with higher titers of antimycoplasma antibody (greater than 1:160). The tumor size as well as the tendency to metastasize was inversely correlated with the amount of mycoplasma in the lung. FACS analysis of lymphocytes isolated from the blood and the tumor-infiltrated tissues revealed that the CD4/CD8 ratio was increased in rats injected with mycoplasma-infected tumor cells, whereas the CD4/CD8 ratio was decreased in the rats injected with mycoplasma-uninfected HG66 tumor cells. A study of the T-cell repertoire involved in this response is under way.
Keywords: Animal Antibodies, Bacterial/ANALYSIS CD4-CD8 Ratio Liver Neoplasms, Experimental/*MICROBIOLOGY/PATHOLOGY Lymphocytes/PATHOLOGY Mycoplasma/IMMUNOLOGY/*ISOLATION & PURIF Rats Tumor Cells, Cultured ABSTRACTKWDanimalantibodies,bacterial/analysiscd4-cd8ratioliverneoplasms,experimental/KWDmicrobiology/pathologylymphocytes/pathologymycoplasma/immunology/KWDisolation&purifratstumorcells,culturedabstract
930330
M9331103

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