HIV-associated T-cell lymphoma: monoclonal integration of a lentivirus adjacent to a proto-oncogene (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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HIV-associated T-cell lymphoma: monoclonal integration of a lentivirus adjacent to a proto-oncogene (Meeting abstract).

FASEB J; 6(5):A1979 1992. Unique Identifier : AIDSLINE ICDB/93687683
Herndier B; Shiramizu B; Reyes G; McGrath M; Dept. of Pathology, AIDS Program, San Francisco General Hosp.,; Univ. of California, San Francisco, CA 94143

Abstract: A man at risk for HIV-infection died after a short hospital course, with a multisite CD4-positive T-cell lymphoma. The tumor consisted of large pleomorphic lymphomas expressing HIV p24 antigen and IL-2 receptor (CD25) and was negative for B-cell, monocyte and myeloid markers. The tumor contained a single clonally integrated HIV-1 and was negative for HTLV-1, EBV and HHV-6. The HIV integration site was mapped within the fur gene, just 5' to the fes/fps proto-oncogene on chromosome 15, using an inverse PCR method. cDNA PCR analysis demonstrated that tumor tissue, but not other lymphoid tissue in the patient, expressed the 3' exon of fur, the fes/fps, IL-2 and the IL-2R genes. These data suggest that HIV may have contributed to T-cell transformation through induction of an autocrine growth process (IL-2/IL-2R) and/or through insertional mutagenesis activation of the fes/fps oncogene. This is the first lymphoma where HIV has been shown to be directly implicated in the transformation process.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Antibodies, Monoclonal Antigens, CD4/ANALYSIS Cell Transformation, Viral DNA Human HIV Core Protein p24/METABOLISM Lymphoma, T-Cell/*COMPLICATIONS Male Polymerase Chain Reaction *Proto-Oncogenes Receptors, Interleukin-2/METABOLISM *Virus Integration ABSTRACTKWDacquiredimmunodeficiencysyndrome/KWDcomplicationsantibodies,monoclonalantigens,cd4/analysiscelltransformation,viraldnahumanhivcoreproteinp24/metabolismlymphoma,t-cell/KWDcomplicationsmalepolymerasechainreactionKWDproto-oncogenesreceptors,interleukin-2/metabolismKWDvirusintegrationabstract
930330
M9331102

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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