Patients with AIDS NHL have a higher frequency of circulating CD5+CD21- B cells relative to HIV-infected and -uninfected controls (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Patients with AIDS NHL have a higher frequency of circulating CD5+CD21- B cells relative to HIV-infected and -uninfected controls (Meeting abstract).

FASEB J; 6(5):A1990 1992. Unique Identifier : AIDSLINE ICDB/93687690
McGrath M; Herndier B; Nolan T; Ward A; Mercolino T; Dept. of Lab. Medicine, AIDS Program, San Francisco General; Hosp., Univ. of California, San Francisco, CA 94143

Abstract: AIDS-associated non-Hodgkin's lymphoma (NHL) is one of the most frequent malignancies that occurs in individuals infected with the human immunodeficiency virus (HIV). In our study of AIDS-associated NHL, we observe (by immunohistology) mainly large cell lymphomas of B-cell origin. Half of these tumors have significant numbers of T cells throughout, and unlike B cells in the peripheral blood (PB) of HIV-negative individuals, most NHL cells bear little, if any, CD21. By flow cytometry, we confirm the frequent occurrence of a CD5+CD21- B-cell phenotype NHL with significant T-cell infiltration. We show that the PB of HIV+ individuals, both with and without lymphoma, contains an increased fraction of CD21- B cells. However, lymphoma PBs have double the frequency of B cells; this increase is due primarily to an elevation in the CD5+CD21- subset. These results suggest that immunophenotypic analysis of B cells in the PB of HIV+ patients could be useful in the early detection of AIDS-associated NHL.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Antigens, CD/*IMMUNOLOGY B-Lymphocytes/*IMMUNOLOGY Flow Cytometry Human Immunophenotyping Lymphoma, Non-Hodgkin's/*COMPLICATIONS ABSTRACTKWDacquiredimmunodeficiencysyndrome/KWDcomplicationsantigens,cd/KWDimmunologyb-lymphocytes/KWDimmunologyflowcytometryhumanimmunophenotypinglymphoma,non-hodgkin's/KWDcomplicationsabstract
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M9331101

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