Epstein-Barr virus (EBV)-associated T-cell lymphoma in AIDS (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Epstein-Barr virus (EBV)-associated T-cell lymphoma in AIDS (Meeting abstract).

J Pathol; 167(Suppl):170A 1992. Unique Identifier : AIDSLINE ICDB/93688512
Thomas JA; Cotter F; Hanby A; Morgan P; ICRF/RCS Histopathology Unit, Imperial Cancer Res. Fund, 35-43; Lincoln's Inn Fields, London WC2A 3PN, UK

Abstract: The strictly B-lymphoepitheliotropic nature of EBV has been challenged by recent evidence that normal T cells and thymocytes support short-term EBV infection in vitro. Furthermore, EBV involvement has been clinically documented in small numbers of patients with T-cell disorders ranging from reactive hyperplasia to high-grade malignant lymphoma. Here, we report oral mucosal-associated T-cell lymphoma in 3 HIV-seropositive individuals in which the tumor cells were found to contain EBV DNA and express latent viral gene products. The T-cell nature of the lesions was established by immunophenotyping, and by gene rearrangement studies with the polymerase chain reaction. AIDS-related T-cell lymphoma may be a new clinical entity, and EBV involvement in these lesions has not been described previously. An important implication of these findings is that severe immunosuppression induced by HIV (and possibly other as yet undefined causes) may increase the range of host cells susceptible to EBV infection and sustain neoplastic transformation in these cells.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Cell Transformation, Neoplastic Herpesvirus 4, Human/*ISOLATION & PURIF Human Hyperplasia Lymphoma, T-Cell/*COMPLICATIONS/MICROBIOLOGY Mouth Mucosa/PATHOLOGY Mouth Neoplasms/*COMPLICATIONS/MICROBIOLOGY T-Lymphocytes/IMMUNOLOGY ABSTRACTKWDacquiredimmunodeficiencysyndrome/KWDcomplicationscelltransformation,neoplasticherpesvirus4,human/KWDisolation&purifhumanhyperplasialymphoma,t-cell/KWDcomplications/microbiologymouthmucosa/pathologymouthneoplasms/KWDcomplications/microbiologyt-lymphocytes/immunologyabstract
930330
M9331098

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