Phagocytosis and microbicidal capacity of human monocytes in the course of HIV infection. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Phagocytosis and microbicidal capacity of human monocytes in the course of HIV infection.

Immunol Lett. 1992 Jul;33(2):145-50. Unique Identifier : AIDSLINE MED/93077186
Szkaradkiewicz A; Institute of Microbiology and Infectious Diseases, Academy of; Medicine, Poznan, Poland.

Abstract: Phagocytosis and bactericidal activity of human monocytes were studied in asymptomatic HIV carriers and in patients with clinically apparent HIV infection, diagnosed as persistent generalised lymphadenopathy (PGL) or AIDS-related complex (ARC). Monocytes of asymptomatic HIV carriers manifested no significant changes while a decreased phagocytosis was shown by monocytes in the majority of patients with PGL or ARC. The latter patients also exhibited a decreased bactericidal activity of the cells. Tuftsin and even serum from healthy donors were found to normalise the disturbed monocyte function, the effect of tuftsin being more pronounced. Nevertheless, the examined sera contained neither factors which could stimulate nor factors which could inhibit phagocytosis. The obtained results indicated that the productive phase of HIV infection is associated with disturbed phagocytosis and disturbed microbicidal activity of monocytes, reflecting deficiency of serum factor(s) needed for the normal function of the cells.
Keywords: Adolescence Adult AIDS-Related Complex/IMMUNOLOGY Blood Bactericidal Activity/*IMMUNOLOGY Colony Count, Microbial Female Human HIV Antibodies/IMMUNOLOGY HIV Infections/*IMMUNOLOGY HIV Seropositivity/IMMUNOLOGY HIV-1/*IMMUNOLOGY HIV-2/*IMMUNOLOGY Male Monocytes/DRUG EFFECTS/*IMMUNOLOGY Phagocytosis/*IMMUNOLOGY Staphylococcus aureus/IMMUNOLOGY Support, Non-U.S. Gov't Tuftsin/PHARMACOLOGY JOURNAL ARTICLEKWDadolescenceadultaids-relatedcomplex/immunologybloodbactericidalactivity/KWDimmunologycolonycount,microbialfemalehumanhivantibodies/immunologyhivinfections/KWDimmunologyhivseropositivity/immunologyhiv-1/KWDimmunologyhiv-2/KWDimmunologymalemonocytes/drugeffects/KWDimmunologyphagocytosis/KWDimmunologystaphylococcusaureus/immunologysupport,non-uKWDsKWDgov'ttuftsin/pharmacologyjournalarticle
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Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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