Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.
Response to superantigens in HIV-1 and HIV-2 infected nonhuman primates.
Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 102. Unique Identifier : AIDSLINE PRIM10/93200948 Murthy KK; Guevara SM; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, TX 78228.
Abstract:
Superantigens are bacterial endotoxins that act as potent stimulators of T cells from mice and man. According to recent studies, proliferative response to superantigens is depressed in HIV-1 infected humans, presumably due to deletion of T cell clones mediated by viral infection. Therefore, we evaluated the response of chimpanzees, baboons, and macaques to superantigens and, in addition, studied the effect of infection with HIV-1 and HIV-2 in chimpanzees and baboons, respectively. Heparinized blood samples were collected from seven healthy chimpanzees, ten baboons, and six human donors, as well as from seven chimpanzees infected with HIV-1, and five baboons infected with HIV-2. Peripheral blood lymphocytes (PBL's) were cultured for 72 hr with various concentrations of S. aureus enterotoxins (SE) A, B, and C. Cultures were pulsed with H-thymidine and cells were harvested to quantitate the level of T cell proliferation induced by SEA, SEB, and SEC. All three toxins induced significant proliferation of T cells, from all of the species tested, in a dose dependent manner. No marked differences in cell stimulatory function were evident among the three SE in the chimpanzees. Similar observations were made in baboons regardless of their infection status. The response in HIV-1 infected chimpanzees was significantly lower (p < 0.05) than in the uninfected group. There was significant difference in proliferative responses to SEA, SEB, and SEC between chimpanzees and baboons, further, human T cells had significantly higher responses (p < 0.001 to 0.05) to all three SE, compared to chimpanzee or baboon T cells. In conclusion, there appear to be species differences between humans and nonhuman primates in their ability to respond to superantigens, and furthermore, infection with HIV-1 appears to impair the proliferative response of T cells from nonhuman primates.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Animal Cells, Cultured Chimpansee troglodytes Enterotoxins/*PHARMACOLOGY Human *HIV-1 *HIV-2 *Lymphocyte Transformation Papio *Staphylococcus aureus T-Lymphocytes/DRUG EFFECTS/*IMMUNOLOGY ABSTRACT 930630
M9361072
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Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.
