1993

HIV testing : who, what, when, where, how. [videorecording]: Marshfield, WI : The Network, [1987] 1 videocassette (31 min.) : sd., col. ; 1/2 in (Medical education for 1987) Unique Identifier : AIDSLINE AV/9300606A; Corey D
Anorectal surgery in HIV-positive patients. [videorecording]: Secaucus, N.J. : Network for Continuing Medical Education, 1992 1 videocassette (15 min.) : sd., col. ; 1/2 in (NCME telecourse ; no. 626) Unique Identifier : AIDSLINE AV/9300529A; Smith LE; Provides diagnostic clues regarding anorectal lesions common in AIDS and AIDS-related disorders, and recommends a conservative approach to surgical intervention. Often minimal or no surgery is the best course of treatment in these infection-prone individuals who heal poorly.
Complications of high-risk pregnancy. [videorecording]: Secaucus, N.J. : Network for Continuing Medical Education, 1992 1 videocassette (49 min.) : sd., col. ; 1/2 in. + 1992 (NCME telecourse ; no. 622) Unique Identifier : AIDSLINE AV/9300535A; Fox HE; Baxi Ashar L; LaSala AP; Risk assessment in pregnancy must be a dynamic and interactive process. The physician must keep abreast of the more than 3000 identified risk factors, keep up to date with innovations in treatment and management, and be sensitive to the medical, psychosocial and emotional needs of the patient.
Contemporary immunization practices. [videorecording]: Secaucus, N.J. : Network for Continuing Medical Education, 1992 1 videocassette (16 min.) : sd., col. ; 1/2 in (NCME telecourse ; no. 630) Unique Identifier : AIDSLINE AV/9300536A; Irons TG; Schedules for routine and delayed childhood immunizations have significantly changed in recent years. In addition, new vaccine products have been licensed and recommended for use. Adult immunizations have also taken on new importance, particularly for individuals with HIV infection and foreign travelers. Dr. Irons out
Fundamentals of dermatologic surgery : skin grafts. [videorecording]: Secaucus, N.J. : Network for Continuing Medical Education, 1992 1 videocassette (10 min.) : sd., col. ; 1/2 in (NCME telecourse ; no. 626) Unique Identifier : AIDSLINE AV/9300544A; Leffell DJ; Discusses the factors which determine the choice of a full thickness graft, split thickness graft, or composite graft, then demonstrates a pinch graft to repair a wound following Mohs excision of a squamous cell carcinoma.
Identifying and managing elder abuse. [videorecording]: Secaucus, N.J. : Network for Continuing Medical Education, 1992 1 videocassette (20 min.) : sd., col. ; 1/2 in (NCME telecourse ; no. 626) Unique Identifier : AIDSLINE AV/9300549A; Fulmer TT; Lacks MS; Surveys confirm the extent of elder abuse and neglect and suggest that 35 per cent of all cases represent serious physical abuse. Program delineates risk factors, abuser and victim profiles, and techniques for recognition and intervention by physicians.
HIV disease update. [videorecording]: Secaucus, N.J. : Network for Continuing Medical Education, 1992 1 videocassette (50 min.) : sd., col. ; 1/2 in + 1 booklet (NCME telecourse ; no. 625) Unique Identifier : AIDSLINE AV/9300547A; Witt DH; Hirschorn E; Highlights latest advances in therapeutics in the care of patients with HIV disease.
Tuberculosis in the age of AIDS. [videorecording]: Secaucus, N.J. : Network for Continuing Medical Education, 1993 1 videocassette (49 min.) : sd., col. ; 1/2 in. + 1 booklet (NCME telecourse ; no. 634) Unique Identifier : AIDSLINE AV/9300570A; Reichman LB; After a century of decline, the incidence of tuberculosis in the United States has steadily increased since 1985. Now the emergence of drug-resistant strains threatens our ability to control this preventable disease. Screening, diagnosing, and treating TB have also changed over the las
[Aids : forholdsregler mot smitte med HIV i laboratoriet.]: [Oslo?] : Helsedirektoratet, 1986 16 p (AIDS-skriv ; nr. 20) Unique Identifier : AIDSLINE CAT/9307508
Policy statement on AIDS : the role of the hospital social work department.: [Chicago, Ill.] : The Society, [1987] 7 p Unique Identifier : AIDSLINE CAT/9306140
Proceedings of WHO/NICD Workshop on Serosurveillance of AIDS, November 16-19, 1987.: Delhi : National Institute of Communicable Diseases, [1987?] 197 p Unique Identifier : AIDSLINE CAT/9307365; Kumari S; Rai A
AIDS : legal and regulatory policy.: Frederick, MD : University Pub. Group, c1988 viii, 381 p Unique Identifier : AIDSLINE CAT/9306662; Curran WJ; Gostin LO; Clark M
Nutrition for the AIDS carrier.: Saratoga, Calif. : R&E Publishers, c1989 56 p. : ill Unique Identifier : AIDSLINE CAT/9306114; Cox E
Health policy readings 1988 : a source book for health service administrators and students of health service administration.: [Sydney?] : Australian Hospital Association, [1989] (Canberra Calico Quick Print) 377 p. : ill., ports Unique Identifier : AIDSLINE CAT/9306362
AIDS and hemophilia : a coordinated education, support, and personal care program.: [Calgary?] : Calgary Region, Canadian Hemophilia Society, [1989] ix, 85 p Unique Identifier : AIDSLINE CAT/9306658; McDonald JR; Dowdle G
AIDS : information and guidelines for nurses.: Pretoria : Dept. of National Health and Population Development, [1989] 16 p Unique Identifier : AIDSLINE CAT/9306663
[AIDS : Orientierungshilfen fur das Bistum Limburg.]: Limburg/Lahn : Caritasverband fur die Diozese Limburg, [1989?] 52 p Unique Identifier : AIDSLINE CAT/9306664
The:Nurse and AIDS : legal issues.: Pretoria : The Association, 1989 15 p Unique Identifier : AIDSLINE CAT/9306892; Strauss SA
Proceedings of the First Southwest Regional Hispanic AIDS Conference, May 17-20, 1989.: San Antonio, Tex. : Hispanic AIDS Committee for Education and Resources, [c1989] iv, 360 p Unique Identifier : AIDSLINE CAT/9306937
Report of the working panel on aboriginals, Torres Strait islanders, and HIV/AIDS.: [Canberra] : Dept. of Community Services and Health, [1989] viii, 30 leaves (Consultation paper ; no. 1) Unique Identifier : AIDSLINE CAT/9306957
Report of the working panel on testing for HIV/AIDS.: [Canberra] : Dept. of Community Services and Health, c1989 vii, 20 p (Consultation paper ; no. 5) Unique Identifier : AIDSLINE CAT/9306958
Report of the working panel on treatment, services and care, HIV/AIDS.: [Canberra] : Dept. of Community Services and Health, c1989 vii, 28 p (Consultation paper ; no. 6) Unique Identifier : AIDSLINE CAT/9306959
Financing care for persons with AIDS : the first studies, 1985-1988.: Frederick, MD : University Pub. Group, c1989 ix, 357 p Unique Identifier : AIDSLINE CAT/9307178; Fox DM; Thomas EH
[Therapeutische Wege : eine Orientierungshilfe fur anti-HIV-positive Menschen.]: Wien : Promedia, c1989 87 p Unique Identifier : AIDSLINE CAT/9307900; Vavrik K
Planning for HIV/AIDS care and treatment services in New South Wales, 1990-1994 : report.: North Sydney, NSW : NSW Health Dept., c1990 193 p. : ill (State health publication ; (AIDS) 90-68) Unique Identifier : AIDSLINE CAT/9306139
[L':ultima epidemia : la guerra batteriologica, dalla peste all'AIDS?.]: S. Domenico di Fiesole : Cultura della pace, c1990 205 p., [16] p. of plates. : ill (Uomo planetario ; 3) Unique Identifier : AIDSLINE CAT/9306240; Santoianni F
[Aids : de jacht op een virus.]: Maastricht : Natuur & techniek, c1990 148 p : ill., ports Unique Identifier : AIDSLINE CAT/9306246; Rozendaal S
Human sexuality : research perspectives in a world facing AIDS : background papers and reports of a workshop held at International Development Research Centre, Ottawa, Ontario, Canada, June 1989.: Ottawa : The Centre, [1990] iii, 210 p Unique Identifier : AIDSLINE CAT/9306377; Chouinard A; Albert J
Common oral lesions associated with HIV infection.: Columbus, Ohio : Ohio State University, c1990 29 p. : ill Unique Identifier : AIDSLINE CAT/9306702; Haring JI
Key issues in HIV infection and AIDS for Victorian GPs.: Melbourne : AIDS/STD Unit, Health Dept., Victoria, 1990 11 p Unique Identifier : AIDSLINE CAT/9307715
[SIDA : una enfermedad de nuestro tiempo.]: [Chile?] : Monte Grande, 1990 132 p. : ill Unique Identifier : AIDSLINE CAT/9307894; Zenteno Pardo M
Homophobia, heterosexism, and AIDS : creating a more effective response to AIDS.: Ottawa : Canadian AIDS Society, 1991 68 p Unique Identifier : AIDSLINE CAT/9306022
Common sense about AIDS.: [Atlanta, Ga.?] : American Health Consultants, v Unique Identifier : AIDSLINE CAT/9306288
[Rad og veiledning til hiv-positive.]: Oslo : Oslo Kommune, Etat for miljorettet helsevern, 1991 52 p. : ill Unique Identifier : AIDSLINE CAT/9306517; Muniz HP
Training drug treatment staff in the age of AIDS : a frontline perspective.: Rockville, Md. (5600 Fishers Ln., Rockville 20857) : U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, Mental Health Administration, National Institute on Drug Abuse, Division of Applied Research, Community Research Branch, [1991] v, 36 p (Clinical report series) Unique Identifier : AIDSLINE CAT/9306558; Ashery RS
AIDS in context : a South African perspective. 1st ed.: Cape Town : Lux Verbi, 1991 111 p Unique Identifier : AIDSLINE CAT/9306660; Van Niekerk AA
Differential diagnosis in AIDS : a color guide.: St. Louis : Mosby Year Book, c1991 159 p. : ill Unique Identifier : AIDSLINE CAT/9306726; Parkin JM; Peters BS
HIV counselor perspectives. Vol. 1, no. 1 (Jan. 1991)-: Sacramento, CA : California Dept. of Health Services, State Office of AIDS, [1991- v. : ill Unique Identifier : AIDSLINE CAT/9306795
HIV/AIDS and prisons : proceedings of a conference held 19-21 November 1990.: Canberra, ACT : Australian Institute of Criminology, c1991 296 p. : ill (Conference proceedings series, ISSN 1034-5086 ; no. 4) Unique Identifier : AIDSLINE CAT/9306796; Norberry J
Men who have sex with men in Australia : AIDS : a report on the Gammaline telephone counselling service.: [Australia : s.n., 1991?] 1 v. (unpaged) : ill Unique Identifier : AIDSLINE CAT/9306863; Palmer WA
Preventing HIV infection among youth.: Rockville, MD (5600 Fishers Ln. (Rockwall II), Rockville 20857) : U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, Office for Substance Abuse Prevention, [1991] vii, 41 p (OSAP technical report ; 5) Unique Identifier : AIDSLINE CAT/9306935; Goplerud EN; Resnik H
AIDS : information for physicians.: Harrisburg, Pa. (777 East Park Dr., Harrisburg 17105-8820) : the Society, [1991] 40 p Unique Identifier : AIDSLINE CAT/9307107
Florence conference update : HIV/AIDS surveillance data base.: Washington, D.C. : Center for International Research, U.S. Bureau of the Census, [1991] 43, 8 leaves Unique Identifier : AIDSLINE CAT/9307180
[Vrouwen en AIDS : advies.]: Amsterdam : Nationale Commissie AIDS-Bestrijding, 1991 63 p. : ill Unique Identifier : AIDSLINE CAT/9307455
State of Alaska AIDS Program.: Anchorage, Alaska (3601 C St. Suite 576, P.O. Box 240249, Anchorage 99524-0249) : Section of Epidemiology, Division of Public Health, Dept. of Health and Social Services, State of Alaska, [1991] 22 p. : ill Unique Identifier : AIDSLINE CAT/9307884
Drug addiction treatment research : German and American perspectives.: Malabar, Fla. : Krieger Pub. Co., 1992 xxii, 528 p. : ill Unique Identifier : AIDSLINE CAT/9306313; Buhringer G; Platt JJ
Ethics and law in the study of AIDS.: Washington, D.C., U.S.A. : Pan American Health Organization, Pan American Sanitary Bureau, Regional Office of the World Health Organization, c1992 x, 273 p (Scientific publication ; no. 530) Unique Identifier : AIDSLINE CAT/9306328; Fuenzalida-Puelma HL; Linares Parada AM; Serrano La Vertu D
The:role of high-risk occupations in the spread of AIDS : truck drivers and itinerant market women in Nigeria.: [Canberra] : Australian National University, [1992] 11 p (Health Transition working paper ; no. 10 (1992)) Unique Identifier : AIDSLINE CAT/9306599; Orubuloye IO
Advances on the AIDS horizon : 1992. 6th ed.: Sacramento, Calif. : R.D. Anderson Pub. Co., c1992 87 p Unique Identifier : AIDSLINE CAT/9306625; Walmer M
AIDS and primary health care : the role of non-governmental organizations.: Amsterdam : VU University Press, 1992 77 p. : ill (Primary health care publications ; 4) Unique Identifier : AIDSLINE CAT/9306659; Wolffers I
AIDS in Australia.: New York : Prentice Hall, c1992 xxiv, 392 p Unique Identifier : AIDSLINE CAT/9306661; Timewell E; Minichiello V; Plummer D
Cytokines in hemopoiesis, oncology, and AIDS II.: Berlin ; New York : Springer-Verlag, c1992 li, 800 p. : ill Unique Identifier : AIDSLINE CAT/9306712; Freund M
[Das:Sexualverhalten Jugendlicher unter der Bedrohung von AIDS.]: Berlin : Berlin Verlag Arno Spitz, c1992 iii, 231 p (Berlin Forschung ; Bd. 26) Unique Identifier : AIDSLINE CAT/9306982; Mischnick H
AIDS/HIV infection and the workplace : NIDA workgroup report. Repr. 1992.: [Rockville, Md.] : Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration ; Washington, DC : For sale by the U.S. G.P.O., Supt. of Docs., 1992 viii, 36 p. : ill (DHHS publication ; no. (ADM) 92-1716) Unique Identifier : AIDSLINE CAT/9307108
AIDS in the industrialized democracies : passions, politics, and policies.: New Brunswick, N.J. : Rutgers University Press, c1992 xi, 393 p Unique Identifier : AIDSLINE CAT/9307539; Kirp DL; Bayer R
[L'Education sexuelle au temps du SIDA.]: Toulouse : Privat, c1992 190 p (Pratiques sociales) Unique Identifier : AIDSLINE CAT/9307727; Ruffiot A
Modeling HIV transmission and AIDS in the United States.: Berlin ; New York : Springer-Verlag, c1992 xi, 234 p. : ill (Lecture notes in biomathematics ; 95) Unique Identifier : AIDSLINE CAT/9307767; Hethcote HW; Van Ark JW
[Vejledning om human immundefekt virus HIV og forebyggelse af blodbaren smitte.]: [Kobenhavn?] : Sundhedsstyrelsen, 1992 86 p. : ill Unique Identifier : AIDSLINE CAT/9307921
Interaction of the human T cell leukemia virus-I transactivator protein Tax with the host cell transcriptional machinery.: Diss Abstr Int [B]; 53(6):2692 1992. Unique Identifier : AIDSLINE ICDB/93690097; Matthews MH; Univ. of Colorado at Boulder; The Tax protein, encoded by human T cell leukemia virus-I (HTLV-I), is a potent transactivator of transcription. Because several of the genes transactivated by Tax are involved in regulation of cell growth, it is thought that transactivation may contribute to viral oncogenesis. Unlike a number of other viral oncogenes
Treatment of lymphomas with 131I-Lym-1 (Meeting abstract).: Fourth Annual Symposium: Current Status and Future Directions of Immunoconjugates. Diagnostic and Therapeutic Applications in Benign and Malignant Disorders. January 23-26, 1992, Key Biscayne, FL, p. 68, 1992.. Unique Identifier : AIDSLINE ICDB/93690321; DeNardo GL; Univ. of California Davis, Molecular Cancer Inst., 1508 Alhambra; Blvd., Sacramento, CA 95816; The development of monoclonal antibodies has stimulated new interest in their use for specific targeting as vehicles for the diagnosis and treatment of cancer. While this approach is analogous to the use of chemotherapy, it has the advantage of specific targeting to the cancer. While targeting of all of the antibody t
Localization and characterization of transforming regions in human cytomegalovirus and human herpesvirus 6.: Diss Abstr Int [B]; 53(7):3300 1993. Unique Identifier : AIDSLINE ICDB/93690162; Thompson JT; Georgetown Univ. Medical Center; Human herpesviruses have been associated with the etiology of several human cancers. The role these viruses play in carcinogenesis has not been delineated. To elucidate the role of human herpesviruses in carcinogenesis, in vitro model systems have been developed which have identified multiple DNA fragments capable of
Pathogenesis of SIVmac251 after atraumatic inoculation of the rectal mucosa in rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 1. Unique Identifier : AIDSLINE PRIM10/93200939; Pauza CD; Emau P; Salvato MS; Trivedi P; Mackenzie D; Malkovsky M; Schultz KT; Wisconsin Regional Primate Research Center, University of; Wisconsin-Madison 53706.; One year old juvenile male rhesus monkeys were infected with SIVmac251 via atraumatic inoculation of the rectal mucosa. Virus doses ranging from 1,000 to 0.1 tissue culture infectious doses (determined on CEMx174 cells) established infection in all animals. Three of four animals receiving 1,000 or 100 doses became ser
Biology of acute infection with macrophage-tropic SIVmac.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 10. Unique Identifier : AIDSLINE PRIM10/93200940; Ringler D; Mori K; Sasseville V; Walsh D; Pauley D; Hesterberg P; Daniel M; Desrosiers R; Division of Pathology, Harvard Medical School, Southborough, MA.; We previously demonstrated that molecularly-cloned SIVmac239 replicates in lymphoid cells and induces AIDS in rhesus macaques, yet replicates poorly in simian alveolar macrophage cultures. In some SIVmac239-infected animals, macrophage-tropic variants of SIVmac239 arise in vivo and can be isolated from the peripheral
Characterization of AZT susceptibility of biological SIVmac and molecular clones, and emergence of AZT resistant mutants in vitro.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 108. Unique Identifier : AIDSLINE PRIM10/93200941; Van Rompay KK; Marthas ML; Lohman BL; Pedersen NC; California Regional Primate Research Center, University of; California, Davis 95616.; BACKGROUND: It is not known whether AZT resistant HIV mutants, which emerge in HIV following long-term AZT therapy, have altered pathogenicity. Therefore, it is still controversial whether or not to discontinue AZT administration in these people. Beca
Correlation of immunological, clinical, neuropathological, and neurochemical and neurochemical parameters with motor and cognitive impairments observed in SIV-infected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 103. Unique Identifier : AIDSLINE PRIM10/93200942; Rausch DM; Murray EA; Lendvay J; Sharer LR; Heyes M; Nohr D; Weihe E; Eiden LE; National Institute of Mental Health Bethesda, MD.; A group of rhesus macaques infected with SIVB670-Delta exhibited variegated cognitive and motor impairments as described in some HIV-infected humans (Murray et al., Science 255:1246, 1992). In each case, CNS impairments preceded signs of SIV-induced illness. Blood and CSF samples taken throughout the course of the stu
Effect of dosing frequency on AZT prophylaxis against SIV infection in cynomolgus monkeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 107. Unique Identifier : AIDSLINE PRIM10/93200943; Tsai CC; Follis KE; Grant R; Nolte RE; Bartz C; Benveniste RE; Sager PR; Regional Primate Research Center, University of Washington,; Seattle 98195.; Early AZT treatment has been shown to prolong life for certain HIV-infected persons if taken before the symptoms of AIDS develop. However, it is still uncertain whether dosing frequency of AZT affects anti-HIV activity. Therefore, we studied the effec
In vivo tracking of lymphocytes in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 105. Unique Identifier : AIDSLINE PRIM10/93200944; Salvato M; Johnson E; Rater M; Pauza CD; Dept. of Pathology and Lab. Medicine, Wisconsin Regional Primate; Research Center, Madison 53706.; Our goal is to develop lymphocyte replacement therapy in SIV-infected rhesus macaques. Pilot studies to determine the efficacy of storing, culturing and re-introducing lymphocytes monitored the distribution and half-life of re-introduced lymphocyte cultures. Lymphocytes were isolated from rhesus monkeys and marked eit
Longitudinal evaluation of immune dysfunction in SIV-infected rhesus macaques, monitored by a novel tri-parametric immunological staging system.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 100. Unique Identifier : AIDSLINE PRIM10/93200945; Lavergne JA; Del Llano AM; Amieiro JP; Kraiselburd EN; Kessler MJ; Malaga C; Department of Microbiology, University of Puerto Rico, San Juan; 00936-5067.; A novel immunological staging system (ISS) based on three in vitro parameters of immune function (blood cell apoptosis, mitochondrial metabolism and proliferative response to PWM) was utilized for the longitudinal follow-up of a group of eight SIV-infected rhesus macaques, during fifteen months after their infection w
Molecular characterization of STLV-1-positive lymphomas in baboons (Papio hamadryas).: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 109. Unique Identifier : AIDSLINE PRIM10/93200946; Voevodin AF; Shields P; Klotz IN; Kutitova OK; Tsargush AS; Institute of Pulmonology, Moscow, Russia.; Epizootiology, pathology, virology and immunology of malignant lymphomas in baboons (Papio hamadryas) were described earlier (for review see B. Lapin in: Viral Diseases in Laboratory and Captive Animals, Ed. G. Darai, 1988, p. 135). A strong, presumably aetiological linkage was found between these lymphomas and the HT
Non-sexual horizontal transmission of SIVSMM.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 101. Unique Identifier : AIDSLINE PRIM10/93200947; McClure HM; Novembre FJ; Hirsch VM; Lockwood E; Saucier M; Hamm T; Johnson PR; Yerkes Primate Research Center, Emory University, Atlanta, GA; 30322.; The mode of transmission of SIV among nonhuman primates has not been fully documented, although studies have suggested sexual transmission, mother-to-infant transmission, and non-sexual horizontal transmission from bites. As information of this type is needed for colony management and to determine the type of housing
Response to superantigens in HIV-1 and HIV-2 infected nonhuman primates.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 102. Unique Identifier : AIDSLINE PRIM10/93200948; Murthy KK; Guevara SM; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, TX 78228.; Superantigens are bacterial endotoxins that act as potent stimulators of T cells from mice and man. According to recent studies, proliferative response to superantigens is depressed in HIV-1 infected humans, presumably due to deletion of T cell clones mediated by viral infection. Therefore, we evaluated the response o
Transmission of SIVMne in adult Macaca nemestrina.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 106. Unique Identifier : AIDSLINE PRIM10/93200949; Thompson J; Kuller L; Watanabe R; Firpo P; Morton WR; Regional Primate Research Center, University of Washington,; Seattle 98195.; We have previously reported results of a pilot study which indicated the heterosexual transmission of the simian immunodeficiency virus (SIVMne) from female to male pigtailed macaques (M. nemestrina). To better quantify this mode of transmission and to exclude other factors of transmission such as biting and scratchin
Characterization of SIV envelope proteins derived from SIVmac infected macaques shortly after infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 117. Unique Identifier : AIDSLINE PRIM10/93200950; Hulskotte EG; Rimmelzwaan GF; Bosch ML; de Vries P; Heeney JL; Osterhaus AD; Laboratory of Immunobiology, RIVM, Bilthoven, The Netherlands.; We have shown that vaccination with an ISCOM preparation based on envelope protein enriched whole SIVmac is effective against subsequent challenge with the homologous strain of SIV. It is of interest to know whether envelope protein alone incorporated into ISCOMs would also be able to confer protection against SIV cha
Dot blot to screen for antibodies to SRV-2 in the field.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 111. Unique Identifier : AIDSLINE PRIM10/93200951; Welch MJ; Thouless ME; University of Washington Regional Research Primate Center,; Seattle.; The establishment of an SRV-free breeding colony of M. nemestrina and M. fascicularis on Tinjil Island, Indonesia requires extensive testing of wild-caught macaques. The animals are currently held in quarantine for many weeks while their SRV status is determined by sensitive ELI1
Human cell-grown HIV-1 vaccine protects macaques against challenge with SIVmac.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 113. Unique Identifier : AIDSLINE PRIM10/93200952; Cranage MP; Polyanskaya N; McBride B; Cook N; Greenaway P; Dennis M; Ashworth T; Farrar G; Division of Pathology, PHLS Centre for Applied Microbiology &; Research, Porton Down, Salisbury, U.K.; The recent observations that protection against SIVmac challenge correlates with anti-cell antibody responses, that cells alone can elicit a degree of anti-viral protection and that protection is limited to challenge stocks grown in human cells, has lead to a re-evaluation of the role of anti-cell antibodies in SIV va1
Immune enhancement and attenuation of vaccinia virus recombinants expressing empty viral particles of SIV and lymphokines.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 115. Unique Identifier : AIDSLINE PRIM10/93200953; Giavedoni LD; Parodi L; Ahmad S; Bassiri M; Yilma T; International Laboratory of Molecular Biology for Tropical; Disease Agents, University of California, Davis 95616.; Simian immunodeficiency virus (SIV) infection in rhesus macaques is a model for human immunodeficiency virus (HIV) in humans. Limited protection against SIV has been demonstrated in rhesus macaques vaccinated with live attenuated or inactivated viral vaccine. However, the use of whole inactivated or live, virus vaccin1
Immunization of rhesus macaques by lipopeptides induces cytolytic T lymphocytes (CTL).: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 112. Unique Identifier : AIDSLINE PRIM10/93200954; Bourgault I; Venet A; Levy JP; ICGM, U 152, Hopital Cochin, Paris, France.; INTRODUCTION: An effective vaccination against HIV/SIV will require the generation of a CTL response in addition to neutralizing antibodies in order to kill early infected cells. After determining that NEF and GAG proteins were highly immunogenic for induction of CTL in SIVmac251-infected macaques (J. Immunol. 1992; 11
Infectious SRV in excreta of viremic M. nemestrina?: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 110. Unique Identifier : AIDSLINE PRIM10/93200955; Welch MJ; Moazed TC; Morton WR; University of Washington Regional Research Primate Center,; Seattle.; SRV is a naturally occurring type D retrovirus which causes disease in macaque species. After exposure to SRV, most macaques become nonviremic seropositive and show no clinical signs of SRV infection. However, a small number become persistently viremic, displaying only mild clinical signs of SRV infection. Previous st1
Pre-challenge neutralization titers reflect post-challenge virus load in HIV-1 vaccinated chimpanzees.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 116. Unique Identifier : AIDSLINE PRIM10/93200956; Heeney J; Thiriart C; Koornstra W; Dubbes R; ten Haaft P; Delers A; Fabry L; Francotte M; von Opstal O; Culp J; et al; Laboratory of Viral Pathogenesis, ITRI-TNO, Rijswijk, The; Netherlands.; A quantitative virus isolation assay was developed for the determination of virus load in HIV-1 infected chimpanzees. In a study designed to study immunological correlates of HIV-1 vaccine protection, two different recombinant HIV-1 envelope preparations were used. Recombinant forms of HIV-1 env gp160 and gp120 (III B1
Production of genetically inactivated SIVsmmPBj14 viruslike particles for use as a potential vaccine.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 114. Unique Identifier : AIDSLINE PRIM10/93200957; Deschamps M; Horth M; Kummert S; Gelderblom H; Thiriart C; Bruck C; Burny A; Laboratory of Biological Chemistry, Free University of Brussels,; Rhode-St-Genese, Belgium.; We have recently established a stable Vero cell line that produces genetically inactivated SIVsmPBj1.9 (molecular clone of SIVsmmPBj14) viral particles that are very similar to the native virus and that are non-infectious in vitro. The SIVsmmPBj1.9 provirus deleted of its 3 LTR, was expressed in Vero cells in stable t1
SIV host range specificity transfer to recombinant HIV-1 virions via SIV envelope glycoproteins.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 11. Unique Identifier : AIDSLINE PRIM10/93200958; Johnston PB; Hunter E; Department of Microbiology, University of Alabama, Birmingham; 35294.; The host range specificity of simian immunodeficiency virus, SIVmac239, appears to be modulated by the cytoplasmic domain of its envelope glycoprotein. Propagation of SIVmac239 in HUT78 cells results in truncation of the transmembrane (TM) protein to 207-211 amino acids. We sought to determine whether further truncati1
Vaccination against SIV infection with subunit proteins vs inactivated virus.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 118. Unique Identifier : AIDSLINE PRIM10/93200959; Israel ZR; Maul DH; Bruck C; Thiriart C; Mullins JI; Fultz PN; Burny A; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523.; The goal of this work was to evaluate the efficacy of immunization with either env or env+gag proteins vs. whole inactivated virus prepared from SIVmac251 clone BK28. Twenty three juvenile M. mulatta were placed into 6 vaccine groups of 3 macaques each as follows: (1) WIV boosts after priming with live intradermal VV 1
Vaccine studies in rhesus macaques using whole inactivated SIVMAC immunogen.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 119. Unique Identifier : AIDSLINE PRIM10/93200960; Kurth R; Hartung S; Konig H; Ennen J; Cichutek K; Jensen F; Norley S; Paul-Ehrlich-Institut, Langen, FRG.; Eight rhesus macaques were immunized intramuscularly four times (0, 1, 2, 4 months) with 0.5 mg or 0.1 mg of formalin inactivated whole SIV immunogen in the presence of muramyl dipeptide (MDP). After intravenous challenge with 50 MID50 of SIVmac251-32H, three of the four animals from the low dose group (plus the nonva1
Cryptic neutralizing epitopes on SIVagm gp120; role in viral entry.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 12. Unique Identifier : AIDSLINE PRIM10/93200961; Allan JS; Whitehead E; Strout K; Dunham R; Kanda P; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78228.; We previously showed that addition of soluble CD4 to SIVagm viruses leads to the enhanced kinetics of infection and cytopathology in human cell lines. We have termed this process receptor-mediated activation. Recent evidence also suggests that HIV-1 and HIV-2 also undergo conformational changes associated with recepto1
Efficiency of a subunit vaccine consisting of GP130 micelles in protection of rhesus monkeys against challenge with SIVmac251/32H.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 122. Unique Identifier : AIDSLINE PRIM10/93200962; Luke W; Voss G; Dittmer U; Coulibaly C; Stahl-Hennig C; Petry H; Hunsmann G; German Primate Center, Gottingen.; Three rhesus monkeys were immunized four times four weeks apart with a total of 400 g of gp130 micelles per animal, mixed with KLH and emulsified in incomplete Freund s adjuvant. All immunized animals have developed antibody titers of about 10(5) against gp130. Neutralizing and CD4-binding inhibiting antibodies could 1
Immunization of cynomolgus macaques with the envelope glycoprotein gp130 of HIV-2ben confers protection against the homologous but not the heterologous virus challenge with HIV-2SBL-6999.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 123. Unique Identifier : AIDSLINE PRIM10/93200963; Luke W; Voss G; Stahl-Hennig C; Coulibaly C; Petry H; Hunsmann G; German Primate Center, Gottingen.; Nine cynomolgus monkeys were immunized over a period of 52 weeks with gp130 of HIV-2ben mixed with KLH containing 1.1 mg of purified gp130 per animal. For the first 3 immunizations we used incomplete Freund s adjuvant. Because of severe inflammatory reactions antigen was adsorbed to aluminium hydroxide for the later 41
Immunization of rhesus monkeys with split and subunit vaccines of SIVagmTYO-7.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 121. Unique Identifier : AIDSLINE PRIM10/93200964; Luke W; Stahl-Hennig C; Wyand MS; Manson K; Petry H; Voss G; Hunsmann G; German Primate Center, Gottingen.; Three rhesus monkeys were immunized with gp130 micelles linked to KLH three times four weeks apart with a total of 60 micrograms of gp130 in incomplete Freund s adjuvant. Three additional rhesus monkeys were vaccinated with a Tween-Ether (TE) extract of purified SIVagmTYO-7 following the same immunization schedule as 1
Immunogenicity of SIV gp120 and gp41 envelope proteins expressed as hybrid Ty-VLPs.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 129. Unique Identifier : AIDSLINE PRIM10/93200965; Stasiak P; Stenner N; Stabler G; Kent K; Almond N; Kitchin P; Mills K; Layton G; Adams S; Kingsman A; British Bio-technology Ltd., Oxford, U.K.; SIV infection of macaques has been developed as a model for AIDS resulting from HIV infection of humans. By analogy with HIV, it is likely that the envelope protein of SIV will play an important role in eliciting neutralising, and possibly protective, responses. It is therefore important to define epitopes within the 1
Modification of viral load after immune stimulation of SIV-infected rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 120. Unique Identifier : AIDSLINE PRIM10/93200966; Le Grand R; Kress JP; Vogt G; Vaslin B; Roques P; Theodoro F; Aubertin AM; Dormont D; CEA/CRSSA, Fontenay aux Roses, France.; OBJECTIVES: To assess the influence of adjuvant injection on the clinical status and on the seric and PBMC viral loads of SIV infected monkeys. METHODS: Two groups of two rhesus monkeys were injected intravenously with cell free SIVmac251 or SIVsm, respectively three and one year before they were injected with 1 ml of1
Molecular cloned SIVmac32H vaccine and challenge virus.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 127. Unique Identifier : AIDSLINE PRIM10/93200967; Rud EW; Yon JR; Quirk J; Corbin AY; Clarke BE; Mackett M; Stott EJ; Kent KA; Corcoran T; Cook N; et al; Wellcome Research Laboratories, Dept. of Mol. Sci., Beckenham,; Kent, U.K.; We molecularly cloned, sequenced and titrated genomic clones of the SIVmac32H vaccine challenge virus used by the British MRC AIDS Directed Programme. The env gene was subcloned out of the full length molecular clone, SIVmac32H(pJ5) and inserted into various expression vectors. The molecular clones of SIVmac32H were s1
Passive immunization and challenge of rhesus macaques with SIVMAC.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 126. Unique Identifier : AIDSLINE PRIM10/93200968; Rosenthal A; Jennings MB; Cotterman R; Schmerl S; Yee JL; Joye S; Gardner MB; Dept. of Pathology, School of Medicine, University of California,; Davis.; 14 monkeys were infused with purified immunoglobulin (Ig) or heat inactivated plasma prior to inoculation with 10-100 I.D. 50 of cell-free SIVMAC. 4 of 8 animals infused with plasma from an SIV-immunized animal were protected against infection. None of the 6 animals that were infused with plasma or Ig from infected an1
Passive protection of neonatal rhesus monkeys born of mothers immunized with whole inactivated SIV.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 125. Unique Identifier : AIDSLINE PRIM10/93200969; Murphey-Corb M; Davison-Fairburn B; Ohkawa S; Martin L; Tulane Primate Center, Covington, LA 70433.; Four pregnant female rhesus monkeys were immunized with three 100 micrograms doses of formalin-inactivated SIV + SAF-M during pregnancy, with the final immunization given 2-4 weeks prior to delivery. One infant was born prematurely due to an incompetent cervix in the mother and died. The remaining 3 infants were deliv1
Simian antibody responses to linear and conformational epitopes of SIV envelope following vaccination or infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 128A. Unique Identifier : AIDSLINE PRIM10/93200970; Silvera P; Flanagan B; Kent K; Powell C; Stott J; National Institute for Biological Standards and Control, Potters; Bar, Herts, UK.; Cynomolgus macaques were infected with SIV or vaccinated with one of three different recombinant envelope proteins. Their antibody responses were quantitated by ELISA using, as antigens, native virus, recombinant proteins or overlapping peptides analogous to the entire envelope protein. Plasma were also examined for a1
Spectrum of neutralizing sera in macaques immunized with either HIV-1B RU/HBsAg or HIV-1 MN/HBsAg hybrid particles.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 128. Unique Identifier : AIDSLINE PRIM10/93200971; Schlienger K; Mancini M; Riviere Y; Tiollais P; Michel ML; Unite de Recombinaison et Expression Genetique, Institut; Pasteur, Paris, France.; Hepatitis B surface antigen (HBsAg) produced by recombinant DNA technology is now largely and safely used for worldwide hepatitis B vaccination. We recently reported that recombinant HIV/HBsAg particles presenting the HIV-1 BRU envelope principal neutralizing determinant (PND) on their surface allowed us to generate p1
Detection of cellular antibodies in SIV immunized monkeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 132. Unique Identifier : AIDSLINE PRIM10/93200972; Yee JL; Jennings MB; Acevedo R; Gardner MB; Department of Medical Pathology, University of California, Davis.; Understanding the specificity and function of antibodies to cells and/or cellular components in immunized monkeys is important in vaccine development. In a retrospective study using frozen pre- and post-immunization sera from monkeys immunized with various inactivated SIVmac (grown in human cell lines)/adjuvant combin1
Immunization of Macaca fascicularis with inactivated SIV preparations: a) challenge with human- or monkey-derived-SIV; b) effects of longer immunization schedule.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 130. Unique Identifier : AIDSLINE PRIM10/93200973; Titti F; Koanga Mogtomo L; Borsetti A; Geraci A; Sernicola L; Panzini G; Turillazzi GP; Pace M; Baroncelli S; Zamarchi R; et al; Istituto Superiore di Sanita, Rome, Italy.; OBJECTIVE: To evaluate i) the efficacy of two different vaccine preparations and schedules of immunization, ii) whether there is a different protection against human (32H) or monkey-derived-SIV, iii) the role of anti-cellular antibodies in protective immunity. RESULTS: 5 males Macaca fascicularis (Mf) (group A) were i1
In vitro cell proliferation study during vaccination of rhesus macaques with purified inactivated SIV.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 131. Unique Identifier : AIDSLINE PRIM10/93200974; Vaslin B; Le Grand R; Vogt G; Carlo D; Jensen F; Salk J; Dormont D; CEA/CRSSA, Fontenay aux Roses, France.; OBJECTIVES: To measure the state of helper T-cell activation in parallel with the humoral response after one, two or three injections of purified inactivated SIV delta emulsified in IFA to which cell wall skeleton (CWS) and monophospholipid (MPL) were added. METHODS: Two groups of 5 macaques were immunized with three 1
Recombinant SIVgp160 does not induce protective immunity against experimental infection of rhesus macaques with SIV.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 133. Unique Identifier : AIDSLINE PRIM10/93200975; Yilma T; Ahmad S; Giavedoni L; el-Amad Z; Scandella C; Haigwood N; Marthas M; Gardner M; Luciw P; University of California, Davis 95616.; Simian immunodeficiency virus (SIV) infection of rhesus macaques is a model for human immunodeficiency virus (HIV) in humans. Inactivated and modified live, whole-virus vaccines have provided limited protective immunity against SIV in rhesus macaques. Because of safety concerns in the use of inactivated or live, whole1
The combined assessment of cellular apoptosis, mitochondrial function and proliferative response to PWM has predictive value in SIV infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 13. Unique Identifier : AIDSLINE PRIM10/93200976; Del Llano AM; Lavergne JA; Department of Microbiology, University of Puerto Rico, San Juan; 00936-5067.; Routine monitoring of SIV-infected macaques includes the assessment of clinical parameters of disease progression, such as persistent lymphadenopathy, diarrhoea or weight loss. However, these clinical signs usually become evident only after significant immunologic impairment has already occurred in the animal. The nee1
Update of HIV and SIV challenge/protection studies in vaccinated nonhuman primates: progress in first and second order studies.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 131A. Unique Identifier : AIDSLINE PRIM10/93200977; Warren JT; Dolatshahi M; EMMES Corporation, Potomac, Maryland 20854.; We maintain an international database (the AIDS Vaccine Surveillance System, AVSS) that tracks the rapidly growing number of preclinical nonhuman primate (NHP) AIDS vaccine/live virus challenge studies (Warren and Dolatshahi, J Med Primatol 21:139-186, 1992). Summary data on more than 100 preclinical HIV/SIV vaccines 1
A cytotoxic T lymphocyte epitope shared between HIV-2 and SIV.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 14. Unique Identifier : AIDSLINE PRIM10/93200978; Gotch F; Gallimore A; Whittle H; McMichael A; Institute of Molecular Medicine, Oxford, U.K.; It has been reported that some strains of HIV-2 are more closely related to SIVsm/SIVmac virus than to any known virus of human derivation. HIV-2 and SIV can cause immunodeficiency, manifested by a reduction in the number of CD4+ lymphocytes, but both viruses are thought to be less pathogenic than HIV-1. Experimental 1
Factors influencing initial infection of resting T-cells with simian immunodeficiency virus.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 15. Unique Identifier : AIDSLINE PRIM10/93200979; Firpo PP; Liang A; Clark E; University of Washington, Primate Center, Seattle.; Both HIV and SIV are highly tropic for cells expressing the CD4 receptor. After viral binding to CD4 and entry of virus into host cells, viral DNA is synthesized in the cytosol and eventually integrated into the host genome. We have previously reported that unstimulated or activated T cells have detectable SIV-DNA 24 1
A neutralization epitope on the surface envelope glycoprotein (gp130) of simian immunodeficiency virus (SIVmac).: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 16. Unique Identifier : AIDSLINE PRIM10/93200980; Torres JV; Malley A; Banapour B; Anderson DE; Benjamini E; Gardner MB; Department of Medical Microbiology and Immunology, School of; Medicine, University of California, Davis 95616.; SIVmac infection of macaques is an important animal model for human AIDS that is being used for development of antiviral therapies and vaccines. For the effective use of this model in vaccine design and testing, we need to acquire a better understanding of the molecular details concerning the immune response to retrov1
Nucleotide changes in the envelope gene of SIVmac239 during neuroadaptation in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 17. Unique Identifier : AIDSLINE PRIM10/93200981; Anderson MG; Hauer DA; Joag SV; Narayan O; Clements JE; Div. Comparative Med., Johns Hopkins University School of; Medicine, Baltimore, MD 21205.; An infectious molecular clone of SIVmac239, which is highly T-cell-tropic and grows poorly in monocytes and macrophages in vitro, maintained its T-cell tropism in infected animals (Kestler et. al., 1990; Naidu et. al., 1988; Sharma et. al., 1991). SIVmac239 infected animals developed AIDS, their macrophages did not be1
Molecular basis of SIVmac neuropathogenesis.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 18. Unique Identifier : AIDSLINE PRIM10/93200982; Kodama T; Kawahara T; Ferber N; Desrosiers RC; Axthelm MK; Oregon Regional Primate Research Center, Beaverton 97007.; Rhesus macaque Mm155-88 died 27 months after infection with molecularly cloned T-cell tropic SIVmac239. This animal was bilaterally blind at the time of death, and histologically showed severe encephalopathy characterized by an accumulation of multinucleated giant cells within the optic chiasm, cerebral white matter, 1
Restricted replication of SIVmac239 in macrophages is determined by env but is not due to restricted entry.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 19. Unique Identifier : AIDSLINE PRIM10/93200983; Mori K; Ringler D; Desrosiers R; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772-9102.; CD4+ T-lymphocytes and macrophages are the major targets of SIV infection in vivo and in vitro, similar to HIV-1. Molecularly cloned SIVmac239 causes AIDS in rhesus monkeys but it replicates very poorly in primary rhesus monkey alveolar macrophage and blood monocyte cultures. We have documented several cases in which 1
Viral distribution and cellular targets of SIV in intestinal mucosa of rhesus macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 2. Unique Identifier : AIDSLINE PRIM10/93200984; Heise C; Vogel P; Lackner A; Dandekar S; Dept. of Internal Medicine, University of California, Davis; 95616.; To examine SIV pathogenesis and the development of intestinal dysfunction, 24 rhesus macaques were inoculated with either a biological isolate of SIV (SIVmac), a pathogenic (SIVmac-239) or non-pathogenic (SIVmac-1A11) clone. Two animals from each group were euthanized at 2, 8, 13 and 23 weeks postinoculation (pi) and 1
Mutational and functional analysis of V3 of SIVmac.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 20. Unique Identifier : AIDSLINE PRIM10/93200985; Kirchhoff F; Desrosiers R; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772-9102.; We have initiated studies to determine whether sequences in SIVmac env that correspond to V3 of HIV-1 are functionally equivalent to V3 of HIV-1. Antibodies raised to V3 of HIV-1 env can neutralize HIV-1 infectivity and the V3 region has been shown to be important for HIV-1 entry into cells. Antibodies raised to the c1
Molecular evolution and epidemiology of SIV during early infection of macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 21. Unique Identifier : AIDSLINE PRIM10/93200986; Hynes NA; Hirsch VM; LID/NIAID/NIH, Rockville, MD.; Many aspects of the early events of SIV-infection of macaques and human AIDS remain poorly defined. In the process of infection, SIV-infected macaques and AIDS patients are apparently exposed to a quasispecies of viral genomes with potentially different pathogenic properties. Whether the host selects a single or multi1
Does sequence diversity of the Nef gene contribute to the disease resistance and susceptibility to SIV infection in naturally infected mangabeys and experimentally infected macaques?: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 22. Unique Identifier : AIDSLINE PRIM10/93200987; Villinger F; Lauro S; Folks TM; Ansari AA; Dept. of Pathology, Emory University School of Medicine, Atlanta,; GA.; Recent studies have demonstrated the in vivo importance of the Nef gene of SIV for the induction of disease in macaques. A large number of sooty mangabeys at the Yerkes Regional Primate Research Center are naturally infected with SIV but, to date, remain asymptomatic. Virus isolated from a mangabey (SIVsmm-9), when in1
In vivo and in vitro effects of SIV mutants deleted in the non-essential genes.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 23. Unique Identifier : AIDSLINE PRIM10/93200988; Gibbs J; Regier D; Daniel M; Desrosiers R; Department of Microbiology, Harvard Medical School, Southborough,; MA.; The so-called non-essential genes of SIV are vif, vpx, vpr and nef. These genes can be deleted with little or no effect on virus growth in vitro under most conditions. However, the roles of these genes remain unclear. Similarly, the importance of the negative regulatory element, or NRE remains to be determined. We hav1
Packaging of SIV RNA into HIV-1 particles; characterization of the SIV encapsidation region.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 24. Unique Identifier : AIDSLINE PRIM10/93200989; Rizvi TA; Panganiban A; McArdle Laboratory for Cancer Research, University of Wisconsin,; Madison 53706.; The putative cis-acting encapsidation sites of SIV and HIV-1 bear no obvious primary sequence similarity. Moreover, while regions of simpler type C retroviruses required for encapsidation have been identified through mutational analysis, the characteristics of the RNA that facilitate incorporation into assembling caps1
The role of NFkB in SIVmac239 replication.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 25. Unique Identifier : AIDSLINE PRIM10/93200990; Bellas R; Hopkins N; Li Y; Center for Cancer Research, Massachusetts Institute of; Technology, Cambridge 02139.; The binding site for nuclear factor kB (NFkB) is highly conserved among isolates of the human and simian immunodeficiency viruses (HIV and SIV, respectively). We have investigated the in vitro growth properties of SIVmac239 possessing 0, 1 (wild-type), or 2 kB sites. These viruses all replicate well in established CD41
Infection of Macaca nemestrina by human immunodeficiency virus type 1: a new primate model for HIV-1 infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 26. Unique Identifier : AIDSLINE PRIM10/93200991; Agy MB; Frumkin L; Corey L; Florey M; Thompson J; Schmidt A; Panther L; Koehler J; Morton WR; Katze MG; Regional Primate Research Center, U. of Washington, Seattle.; We have previously reported HIV-1 in vitro replication in PBMC from M. nemestrina but not in cells from M. fascicularis or M. mulatta. Furthermore, we reported on the infection of 2 M. nemestrina describing virus recovery, detection of HIV-1 specific DNA in PBMC, & antibody response of the infected animals during 1
Lymphomagenesis in SIV immunosuppressed cynomolgus monkeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 27. Unique Identifier : AIDSLINE PRIM10/93200992; Biberfeld P; Feichtinger H; Li SL; Kaaya EE; Ernberg I; Voevodin AF; Putkonen P; Biberfeld G; Immunopathology Lab., Karolinska Institute, Stockholm, Sweden.; OBJECTIVE: To characterize lymphomagenesis observed in malignant lymphomas (ML) of SIV immunosuppressed cynomolgus monkeys. MATERIAL AND METHODS: SIVsm infected cynomolgus monkeys with malignant lymphomas (ML) (15/40) were studied by immunohistopathology, anticomplement immunofluorescence (ACIF), Western blot (WB), po
Analysis of simian T-cell leukemia virus type-1-associated malignancies in a captive baboon colony.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 28. Unique Identifier : AIDSLINE PRIM10/93200993; Mone J; Hubbard G; Leland M; Allan JS; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas.; Simian T-cell leukemia virus type 1 (STLV-I) is a type C retrovirus very similar to human T-cell leukemia virus type 1, the etiologic agent of adult T-cell leukemia/lymphoma in humans. Most species of old-world primates harbor STLV-I, and this virus has been associated with malignancies in several primate species incl
Maternal-fetal transmission of SIV in 2 species of macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 29. Unique Identifier : AIDSLINE PRIM10/93200994; Davison-Fairburn B; Baskin G; Murphey-Corb M; Tulane Primate Center, Covington, LA 70433.; We have previously shown that inoculation of 10 pregnant rhesus monkeys with SIV/DeltaB670 induced 2 abortions coincident with rapid disease progression in the female. The remaining neonates were delivered 10 days prior to term by Caesarean section and found to be uninfected. (Davison-Fairburn et. al. J.Med. Primatol;
In vivo passage of HIV-2 EHO in Macaca nemestrina results in persistent infection, disease progression, and altered cellular tropism.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 3. Unique Identifier : AIDSLINE PRIM10/93200995; McClure J; Misher L; Schmidt A; Steele J; Morton W; Hu SL; Bristol-Myers Squibb, Seattle, WA 98121.; HIV-2EHO is representative of a subgroup of HIV-2 which demonstrates enhanced cytopathogenicity, increased replicative rate, and extended host range in vitro as compared to HIV-2ROD. HIV-2EHO can be further distinguished by the molecular weight of its envelope precursor and external glycoprotein which are 20 kDa small
Animal model for pediatric AIDS: pathology in infant rhesus monkeys infected with SIVSMM through maternal transmission.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 30. Unique Identifier : AIDSLINE PRIM10/93200996; Klumpp SA; Anderson DC; Novembre FJ; McClure HM; Yerkes Regional Primate Research Center, Emory University,; Atlanta, Georgia 30322.; Cases of pediatric acquired immunodeficiency syndrome (AIDS) are increasing due to the rising incidence of HIV infection in women of childbearing age. The literature suggests that disease progression and manifestations of pediatric AIDS are different from adult AIDS. Twenty-five percent of infant rhesus monkeys born t
Vertical transmission of SIVmac239 in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 31. Unique Identifier : AIDSLINE PRIM10/93200997; Mossman SP; O'Neil SP; Hoover EA; Maul DH; Department of Pathology, Colorado State University, Fort Collins; 80523.; We used SIV infection of pregnant macaques to study the targeting of SIV to tissues involved in the transplacental, peri- and post-natal transmission of virus to offspring. Six pregnant rhesus macaques were infected intravenously with 10(4) TCID50 SIVmac239, three at mid-second and three at mid-third trimester. The in
Prenatal inoculation of macaque fetuses with SIV and HIV.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 32. Unique Identifier : AIDSLINE PRIM10/93200998; Ochs HD; Morton WR; Kuller LD; Zhu Q; Tsai CC; Kimpo C; Schmidt A; Agy MB; Benveniste RE; Department of Pediatrics, University of Washington, Seattle; 98195.; To determine the effect of simian (SIV) and human (HIV) immunodeficiency virus on the development of the fetus, we have inoculated pregnant M. nemestrina and their fetuses at various gestational ages with SIVMne or with HIV-1LAI. Intra-amniotic inoculation with SIVMne was attempted in four animals between 91-116 days
Prenatal SIV infection in the rhesus macaque (Macaca mulatta).: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 33. Unique Identifier : AIDSLINE PRIM10/93200999; Tarantal AF; Marthas ML; McChesney MB; Miller CJ; Lerche NW; Pedersen NC; Hendrickx AG; California Regional Primate Research Center, University of; California, Davis 95616-8542.; Current information suggests that HIV infection in human infants can occur during all stages of pregnancy. Based on these data and the varied outcome observed for infants infected with HIV, it has been hypothesized that the timing of infection prenatally may be related to the ultimate disease course postnatally. In an
Simian immunodeficiency virus (SIV) infection of infant rhesus macaques as a model to test antiretroviral drug prophylaxis and therapy: oral AZT prevents SIV infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 34. Unique Identifier : AIDSLINE PRIM10/93201000; Van Rompay KK; Marthas ML; Ramos RA; Mandell CP; McGowan EK; Joye SM; Pedersen NC; California Regional Primate Research Center, University of; California, Davis 95616.; The prophylactic and therapeutic properties of 3 -azido-3 -deoxythymidine ( AZT ) against simian immunodeficiency virus (SIV) infection were tested in 4 three-month-old rhesus macaques. The infant monkeys were inoculated intravenously with a low dose (1
Inactivated SIV in biodegradable microspheres protects rhesus macaques from vaginal challenge.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 35. Unique Identifier : AIDSLINE PRIM10/93201001; Marx PA; Gettie A; Eldridge JH; Staas JK; Gilley RM; Mulligan MJ; Mestecky J; Compans RW; Div. of Virology and Immunology, New Mexico State University,; Holloman AFB 88330.; To test biodegradable copolymer poly (DL-lactide-co-glycolide) (DL-PLG) as a vaccine formulation for mucosal immunity and protection in the simian immunodeficiency virus (SIV) model, 7 macaques received 3 IM injections which consisted of 100 micrograms of formalin-inactivated SIVmac251 (Davis stock) in DL-PLG microsph
Immunization with recombinant SIVmne gp160 vaccines partially protects macaques against uncloned homologous virus challenge.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 36. Unique Identifier : AIDSLINE PRIM10/93201002; Hu SL; Stallard V; Misher L; Langlois AJ; Kuller LR; Morton WR; Benveniste RE; Bristol-Myers Squibb, Pharmaceutical Research Institute, Seattle,; WA.; We previously reported that immunization with recombinant SIVmne gp160 vaccines protected macaques against a low-dose challenge by a cloned homologous virus. We have extended these studies to investigate whether the same immunized animals would also be protected against uncloned homologous virus challenge. Four Macaca
HIV-2 and SIV vaccine efficacy studies using monkey cell grown challenge viruses.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 37. Unique Identifier : AIDSLINE PRIM10/93201003; Putkonen P; Thorstensson R; Biberfeld G; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.; HIV-2 VACCINE STUDY: Four cynomolgus monkeys were first immunized intramuscularly five times with an inactivated HIV-2 preparation (total dose 0.7 mg) in iscoms over a period of 16 months and then boosted at 18 and 20 months with HIV-2 V3 synthetic peptide of HIV-2 gp 125 coupled to iscoms. The four vaccinated animals
Passive immunization with antibodies to conserved envelope peptides protects rhesus macaques from SIV infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 38. Unique Identifier : AIDSLINE PRIM10/93201004; Lewis MG; Shafferman A; McCutchan FE; Benveniste RE; Montifiori DC; Lai CY; Bellah SW; McKinnon KM; Yalley-Ogunro J; Burke DS; et al; Henry M. Jackson Foundation, Rockville MD 20850.; We have previously reported that naive macaques immunized with four conserved peptides (two from the gp120 and two from the gp41) fused to beta-galactosidase (beta gal) and formulated in complete Freund s adjuvant have an altered disease course following infection with SIVmne/E11s. The objective of this study was to e
Horizontal transmission of SIV in juvenile male rhesus immunized with inactivated, whole-virus vaccine.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 39. Unique Identifier : AIDSLINE PRIM10/93201005; Jennings MB; Lowenstine LL; Rosenthal A; Yee JL; Cotterman R; Antipa L; Hendrickx A; Gardner MB; Department of Pathology, School of Medicine, University of; California, Davis.; Four healthy juvenile male rhesus (Macaca mulatta) were inoculated IV with SIVmac and put in a group cage with 4 control animals and 4 animals immunized with inactivated, whole-virus vaccine previously shown to protect against cell-free, IV challenge with SIVmac. All four inoculates were antigenemic and PBMC culture p
Dynamics of the immune system response in cerebrospinal fluid and blood of SIVmac-infected rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 4. Unique Identifier : AIDSLINE PRIM10/93201006; Sopper S; Hemm S; Meixensberger J; Coulibaly C; Stahl-Hennig C; Hunsmann G; ter Meulen V; Dorries R; Institut fur Virologie und Immunbiologie, Universitat; Wurzburg, Germany.; Infection by the human immunodeficiency virus (HIV) regularly afflicts the central nervous system (CNS). To date, little is known about possible relationships between CNS-localized immune responses and HIV-associated encephalopathies. For obvious reasons studies of this question are severely hampered in patients. Thus
A type D SRV-2 virus-specific CD8 T cell that regulates virus-induced T cell proliferation in Celebes macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 40. Unique Identifier : AIDSLINE PRIM10/93201007; Malley A; Pangares N; Mayo SK; Zeleny-Pooley M; Torres JV; Benjamini E; Axthelm MK; Oregon Regional Primate Research Center, Beaverton 97006.; Previous studies in mice and rhesus macaques demonstrated that SRV-1 and SRV-2 viruses induce significant virus-specific T cell proliferation. In addition, these studies defined SRV-2 envelope peptide 96-102 (unique to SRV-2), and envelope peptides 233-249 and 127-152 (shared by SRV-1 and SRV-2) as T cell epitopes tha
Role of SIV-specific cellular and humoral immunity in protection against SIV infection in macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 41. Unique Identifier : AIDSLINE PRIM10/93201008; Mills KH; Jones WC; Kitchin PA; Page M; Chan WL; Taffs F; Bruck C; Thiriart C; DeWilde M; Rud E; et al; NIBSC, Potters Bar, Herts, U.K.; Although protection against SIV infection has been demonstrated by immunization with inactivated SIV, we and others have shown that the protective immune response may be, in part, generated by human T cell components of the crude virus vaccines. The reported success with recombinant SIV vaccines is limited to a study
Beta 2-microglobulin and HLA class II DR co-purify with HIV and SIV, and antisera to these proteins neutralize virus infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 42. Unique Identifier : AIDSLINE PRIM10/93201009; Benveniste R; Henderson L; Sowder R 2d; Bess J Jr; Mann D; Arthur L; National Cancer Institute, Frederick, MD 21702.; Previous studies with subunit vaccines have shown that immunization with viral envelope antigens alone are sufficient to elicit protective immunity against SIV or HIV. The finding that macaques immunized with uninfected human cells were protected against challenge from SIV grown in human cells (Stott, Nature, 1991) ra
SIV and STLV-1 seroprevalence in east African nonhuman primate species.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 43. Unique Identifier : AIDSLINE PRIM10/93201010; Aman RA; Isahakia M; Villinger F; Mayne A; Jehuda-Cohen T; Powell J; Vuchetich M; Suleman MA; Chege A; Chirchir I; et al; Institute for Primate Research, Karen, Nairobi, Kenya.; Blood samples from a total of 176 nonhuman primates of various species were screened for the presence of antibodies that react by ELISA and Western blots (W.B.) against SIVsmm, HIV-2, and STLV-1. In addition, PBMC from each sample was cultured in vitro with pokeweed mitogen, and the supernatant fluid was assayed for a
Identification of the V1 region of the SIV surface glycoprotein as a neutralization determinant.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 44. Unique Identifier : AIDSLINE PRIM10/93201011; Anderson MG; Joag SV; McEntee MF; Narayan O; Clements JE; Johns Hopkins University School of Medicine, Baltimore, Md 21205.; Lentiviruses of horses, sheep and humans have been shown to undergo antigenic variation within the host. To examine whether this occurs in macaques infected with molecularly cloned virus, a monkey (2D) was infected with SIVmac239 and the presence of neutralizing antibody was identified. Viruses were isolated at variou
Analysis of the frequencies of TH0, TH1, and TH2 subsets of cloned lymphoid cells in mangabeys and macaques, based on cytokine profiles.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 45. Unique Identifier : AIDSLINE PRIM10/93201012; Ansari AA; Mayne A; Hunt D; Villinger F; Dept. of Pathology, Emory University School of Medicine, Atlanta,; GA.; Recent evidence suggests that human lymphoid T cells can be distinguished into subsets based on the cytokine profile of each subset, similar to that described in the murine system. TH0 cells are classified as those TH cells that secrete IL-2 , IFN-gamma, IL-4, IL-6, and
Staphylococcal enterotoxins (superantigens) increase viral expression in SIV-infected lymphocytes from Macaca nemestrina.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 46. Unique Identifier : AIDSLINE PRIM10/93201013; Axberg I; Polacino-Firpo P; Clark EA; Regional Primate Research Center, University of Washington,; Seattle 98195.; Staphylococcal enterotoxins, also called superantigens (SAg), are proteins secreted from Staphylococcus aureus (S. aureus) that can cause food poisoning in man and experimental animals. We have found that SAg stimulate macaque peripheral blood lymphocytes (PBL) to proliferate, and the TCR V beta expression changes dep
The induction of heat shock proteins in cells infected with SIV251.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 47. Unique Identifier : AIDSLINE PRIM10/93201014; Bartz SR; Welch WJ; Malkovsky M; Department of Medical Microbiology and Immunology, University of; Wisconsin, Madison 53706.; It has been observed that some viruses (both DNA and RNA) can activate the synthesis of heat shock proteins (HSP s). By Western blotting we show that the infection of MOLT4 clone 8 cells by SIV251 results in an increase in HSP70 and HSP58. In addition, the increase in HSP70 and HSP58 appears to be differentially regul
Pathologic effects of lymphotropic and macrophage-tropic simian immunodeficiency virus (SIVMAC) correlate with decreases in macrophage precursors in progenitor-enriched bone marrow populations obtained by counterflow centrifugal elutriation (CCE).: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 48. Unique Identifier : AIDSLINE PRIM10/93201015; Beltz LA; Zink MC; Adams RJ; Narayan O; Donnenberg AD; University of Pittsburgh School of Medicine, PA 15213.; Pathological findings were compared between groups of rhesus macaques infected with SIV delta (n = 2), SIV251 (n = 3), molecularly cloned lymphotropic SIV239 (n = 3), or SIV239 passaged in vivo (macrophage-tropic, SIV239M phi, n = 7). The frequency of functional macrophage (M phi) progenitors (M phi Pro) in bone marro
Early stages of SIV-induced lymph node pathogenesis in the rhesus macaque.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 49. Unique Identifier : AIDSLINE PRIM10/93201016; Chakrabarti L; Isola P; Cumont MC; Claessens-Maire MA; Hurtrel M; Montagnier L; Hurtrel B; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.; The occurrence of marked symptoms prior to seroconversion are thought to have predictive value for the risk of development of AIDS. Characterization of the early stages of HIV-induced pathogenesis is therefore needed to understand the parameters determining the evolution towards AIDS. Experimental inoculation of SIVma
Early intrathecal events in rhesus macaques infected with pathogenic (SIVmac-239) or nonpathogenic (SIVmac-1A11) clones of SIVmac or with biologic SIVmac.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 5. Unique Identifier : AIDSLINE PRIM10/93201017; Smith MO; Heyes MP; Lackner AA; California Regional Primate Research Center, UC Davis.; We examined changes in cerebrospinal fluid (CSF) in SIV-infected rhesus macaques during the early stages of infection and correlated this data with disease findings at necropsy. Twenty four juvenile male rhesus macaques were divided into groups of 8 and inoculated intravenously with equal doses of biologic SIVmac (der
Detection of simian T-cell leukemia virus type 1 (STLV-1) in lymphomatous tissues from SIV-positive macaques that died of simian AIDS.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 50. Unique Identifier : AIDSLINE PRIM10/93201018; Chikobava M; Shatzel H; Lowenstine L; Yakovleva L; Lapin B; Russian Academy of Medical Sciences, Sochi-Adler Russian; Federation.; Formalin-fixed, paraffin-embedded lymphoid tissues from four stump-tailed macaques (Macaca arctoides), that died of simian AIDS accompanied by lymphoma in 1969-70 at the California Primate Research Center and that were known to be seropositive for SIV, were examined retrospectively for STLV-1 using PCR. Two primer pai
Tumor necrosis factor in SAIDS.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 51. Unique Identifier : AIDSLINE PRIM10/93201019; Didier ES; Soike KF; Tulane University Regional Primate Research Center, Covington, LA; 70433.; Tumor necrosis factors (TNF-alpha and -beta) play important roles during viral, bacterial and parasitic infections. Beneficial effects of TNF include regulating immune responses for controlling pathogen growth, however, TNF also contributes to the cachexia and septic shock sometimes associated with these infections. T
Biological comparison of the LTR sequences from the acutely pathogenic SIVSMMPBj14 and a closely related non acute strain.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 52. Unique Identifier : AIDSLINE PRIM10/93201020; Dollard SC; Fultz PN; Dewhurst S; Dept. of Microbiology and Immunology, University of Rochester; Medical Center, NY 14642.; Molecularly cloned SIVs capable of inducing acute fatal disease in pig-tailed macaques have been derived previously from a biological clone (bcl-3) of the PBj14 isolate of SIV from sooty mangabey monkeys (SIVSMMPBj14). A closely related biological clone (bcl-1), also derived from the PBj14 isolate, fails to induce acu
Differing infectivity of SIVsm and HIV-1 for human and rhesus cell-lines expressing human/rhesus chimeric CD4 molecules.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 53A. Unique Identifier : AIDSLINE PRIM10/93201021; Fomsgaard A; Johnson PR; Hirsch VM; Dept. of Clin. Microbiol., University Hospital of Copenhagen,; Denmark.; Differences in the pathogenicity, cellular tropism and cytopathic effects of various HIV and SIV may depend on host-specific factors in addition to viral determinants. CD4 is the cellular receptor for HIV and SIV and variation in CD4 structures involved in virus binding (V1-domain), entry, and syncytia formation (J1-d
Induced simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 53. Unique Identifier : AIDSLINE PRIM10/93201022; Follis KE; Tsai CC; Grant R; Wu HN; Benveniste RE; Regional Primate Research Center, University of Washington,; Seattle 98195.; Seventeen naive cynomolgus macaques were used for this study. An uncloned SIVmne viral stock that had been propagated in a human T cell line was used for intravenous inoculation (viral challenge). First, in order to determine the MID50 (monkey infectious dose 50%) for SIVmne, ten macaques were challenged with 10 fold
Evidence for increased cytokine production in early stages of SIV infection of macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 54. Unique Identifier : AIDSLINE PRIM10/93201023; Fox LM; Poli G; Hirsch VM; Fauci AS; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892.; Pro-inflammatory and immunoregulatory cytokines are capable of stimulating both HIV and SIV expression in vitro. Elevated cytokine levels in the plasma or secreted in vitro from peripheral blood mononuclear cells (PBMC) have been found in individuals infected with HIV, and from alveolar macrophages of macaques infecte
DNA sequence analysis of the env region of HIV-2 isolates from a macaques transmission study.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 55. Unique Identifier : AIDSLINE PRIM10/93201024; Grant R; Misher L; Schmidt A; Morton WR; McClure J; Hu SL; University of Washington Primate Research Center, Seattle.; We previously reported that two prototype HIV-2 isolates, ROD and EHO, have distinct in vitro and in vivo properties. The ROD isolate is minimally cytopathic in macaque peripheral blood mononuclear cells (PBMC) and has a surface glycoprotein of 130 kD as determined by gel electrophoresis. The EHO isolate is highly cyt
SIV-associated diarrhea and enteropathy in the African green monkey.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 56. Unique Identifier : AIDSLINE PRIM10/93201025; Guhad FA; Farah IO; Chirchir IO; Machai PN; Institute of Primate Research, Karen, Nairobi, Kenya.; Clinical and necropsy records from 22 African Green Monkeys that were naturally infected with SIV virus and had died of diarrheal diseases were reviewed. The relationship between serostatus and diarrhea as well as enteropathy was evaluated. The seropositive monkeys (n = 10) had averages of 6 bouts and 12.6 days of dia
The benign course of HIV-1 in chimpanzees may be reflected by the infection resistant nature of cells with antigen presenting function.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 57. Unique Identifier : AIDSLINE PRIM10/93201026; Heeney J; Miedema F; Kootstra N; Meyaard L; Koornstra W; Dubbes R; Tersmette M; Schuitemaker H; Laboratory of Viral Pathogenesis, ITRI-TNO, Rijswijk, The; Netherlands.; We propose that one mechanism of lymphocyte dysfunction and death in the development of AIDS may be due to altered lymphocyte activation signals caused in part by defects of infected antigen presenting cells (APC). Unlike human peripheral blood lymphocytes (PBLs) we found that in all but one chimpanzee we were unable
The natural history of early simian immunodeficiency virus infection of macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 58. Unique Identifier : AIDSLINE PRIM10/93201027; Hynes NA; Goldstein S; London WT; Elkins WR; Hirsch VM; LID/NIAID/NIH, Rockville, MD.; The natural history of simian immunodeficiency virus (SIV) infection of macaques remains poorly understood. This is particularly true of the early stages of infection when critical virus-host interactions may determine the ultimate disease course of infected animals. Early events may play a similar role in HIV-1 infec
Antigenic variation of molecularly cloned SIVmac239 during persistent infection in a rhesus macaque.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 59. Unique Identifier : AIDSLINE PRIM10/93201028; Joag SV; Anderson MG; Clements JE; McEntee MF; Adams RJ; Narayan O; Division of Comparative Medicine, Johns Hopkins University School; of Medicine, Baltimore, MD 21205.; 8 rhesus macaques inoculated with SIVmac239 developed viremia and virus-binding antibodies, but only one (macaque 2D) developed neutralizing antibodies to the virus. Macaque 2D plasma also neutralized SIVmac251, although at a lower titer. Viremia persisted in macaque 2D even in the presence of neutralizing antibodies.
VCAM-1 is induced and mediates monocyte adhesion to endothelium in SIV encephalitis.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 6. Unique Identifier : AIDSLINE PRIM10/93201029; Sasseville V; Newman W; Lackner A; Smith M; Lausen N; Hesterberg P; Beall D; Ringler D; Division of Pathology, Harvard Medical School, Southborough, MA.; SIV/HIV encephalitis is characterized by the presence of parenchymal and perivascular macrophages and multinucleated giant cells in the brain. Like other inflammatory responses in the brain, these cells, as monocytes, traverse from the vascular lumen to the Virchow-Robin space. Requisite for this process is the succes
Infection of Macaca nemestrina with HIV-2/EHO by vaginal inoculation with and without Lactobacillus acidophilus.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 60. Unique Identifier : AIDSLINE PRIM10/93201030; Klebanoff S; Morton W; Hillier S; McClure J; Thompson J; Schmidt A; University of Washington, Seattle 98195.; Peroxidases, combined with H2O2 and halide, form a powerful antimicrobial system that is effective against a variety of microorganisms, including viruses. Lactic acid bacteria, including lactobacilli, generate H2O2 that can be toxic to bacteria, fungus, and viruses, particularly when combined with peroxidase and halid
Successful intrarectal inoculation of two macaque species with SIVMne CL E11S.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 61. Unique Identifier : AIDSLINE PRIM10/93201031; Kuller L; Benveniste RE; Clark EA; Katze MG; Morton WR; Regional Primate Research Center, University of Washington,; Seattle 98195.; In a previous study of six M. nemestrina inoculated intrarectally with SIVMne CL E11S, a single-cell clone of SIVMne, virus was isolated at various time points from the animals inoculated with 1 x 10(4) and 1 x 10(3) tissue culture infectious dose (TCID) and one animal died of AIDS at 19 weeks post-inoculation. In a m
Specificity, sensitivity, and reproducibility for the detection of SIV-specific antibodies in the serum and supernatant fluid of PWM-stimulated PBMC from mangabeys and macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 62. Unique Identifier : AIDSLINE PRIM10/93201032; Mayne A; Jehuda-Cohen T; Villinger F; Ansari AA; Dept. of Pathology, Emory Univ. School of Medicine, Atlanta, GA.; Most laboratories either utilize the commercially available HIV-2 kit or laboratory-prepared SIV preparations for the detection of SIV-specific antibodies by ELISA and then perform Western blot or RIPA on ELISA-positive samples for confirmatory purposes. The relative specificity, sensitivity, and reproducibility of th
Isolation of a new foamy virus from an orangutan with encephalopathy.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 63. Unique Identifier : AIDSLINE PRIM10/93201033; McClure MO; Schulz TF; Simpson G; Christie I; Cunningham A; Kirkwood J; Ali M; Weiss RA; Department of Genitourinary Medicine, St Mary's Hospital Medical; School, London.; Although Foamy viruses (Spumaretroviruses) have been isolated from a variety of species, including on rare occasions from humans, their association with any disease is still controversial. We report here the isolation of a new foamy virus form, and the prevalence of neutralising antibodies to this virus in, captive Or
Serial in vivo passage of SIV from infected macaques with end stage viremia results in increase in strain virulence.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 64. Unique Identifier : AIDSLINE PRIM10/93201034; Niphuis H; Holterman L; Dubbes RH; Koornstra WH; Laman JD; Baskin GB; Murphy-Corb M; Heeney JL; Dept. of Chronic and Infectious Diseases, ITRI-TNO, Rijswijk, The; Netherlands.; To determine if repeated in vivo passage of SIVB670 resulted in increased virulence, peripheral blood mononuclear cells (PBMC) of endstage SIV infected macaques were passed intravenously into naive animals. Ten age-matched juvenile rhesus macaques were infected with an equivalent dose of SIVB670. The first macaque to
Structure of nef genes of long term healthy survivors of HIV-1 infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 65. Unique Identifier : AIDSLINE PRIM10/93201035; Premkumar D; Salkowitz J; Hirsch M; Kestler HW; Department of Molecular Biology, Cleveland Clinic Foundation.; The nef gene of molecular clone SIVmac239 has been shown to be required for viral pathogenesis and for maintaining high virus loads in infected rhesus monkeys. The deletion of 182 base pairs in the nef gene of SIVmac239 resulted in virus that was unable to sustain high loads and eliminated its pathogenic potential (Ke
Early events in simian immunodeficiency virus-infected macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 66. Unique Identifier : AIDSLINE PRIM10/93201036; Ramos RA; Lohman BL; Van Rompay KK; Miller CL; Marthas ML; Department of Medicine, School of Veterinary Medicine, University; of California, Davis.; High cell-associated virus load and high plasma virus titers have been detected between 2 and 23 weeks post-inoculation (p.i.) in macaques infected with pathogenic SIV (uncloned SIVmac and SIVmac239), but not nonpathogenic SIVmac1A11 (R.A. Ramos, et al., manuscript in preparation). This suggests that critical events w
Association of arthritis in SIV infected rhesus macaques with Shigella flexneri breakdown products in the intestine, mesenteric lymph node and synovium.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 67. Unique Identifier : AIDSLINE PRIM10/93201037; Roberts ED; Smith V; Dept. of Pathol., Tulane Regional Primate Research Center,; Covington, Louisiana 70433.; Arthritis is increasingly being recognized in HIV patients who test negative for rheumatoid factor, negative for HLA-B27 and negative for psoriatic arthritis. A reactive joint disease has been recently documented in SIV/Delta-infected rhesus macaques. A primary-viral arthritis was demonstrated in only 11% of the macaq
Immunological deterioration and proviral levels in LN of SIV-infected macaques predicts progression to AIDS.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 68. Unique Identifier : AIDSLINE PRIM10/93201038; Rosenberg YJ; Zack PM; Greenhouse JJ; Leon EC; Papermaster SF; White BD; Eddy GA; Burke DS; Lewis MG; Henry M. Jackson Foundation Research Laboratory, Rockville, MD.; Lymphocytes in the blood constitute only 1-2% of the total pool. Although the decline in blood CD4+ cells during HIV and SIV infections is well characterized and has predictive value, how these changes reflect those in lymphoid organs which contain the bulk of lymphocytes is not well understood. Studies in 15 monkeys
The molecular basis of simian immunodeficiency virus (SIV) NEF function.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 69. Unique Identifier : AIDSLINE PRIM10/93201039; Salkowitz J; Premkumar D; Kestler HW; Department of Molecular Biology, Cleveland Clinic Foundation.; The nef gene of the pathogenic molecular clone SIVmac239 was shown to be required for viral pathogenicity and for maintenance of high virus loads in rhesus monkeys (Kestler et al., Cell 65: 651-662). Deletion of 182 base pairs in the nef gene produced a virus that was unable to sustain high loads observed in rhesus mo
Early events and cellular targets in bone marrow of SIV-infected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 7. Unique Identifier : AIDSLINE PRIM10/93201040; Mandell CP; Jain NC; Miller CJ; Marthas M; Dandekar S; Department of Clinical Pathology, California Primate Research; Center, Davis.; Our previous studies detected SIV-infected mononuclear cells in bone marrow (BM) as early as 2 weeks post-inoculation. Prominent histologic abnormalities included myeloid hyperplasia and megakaryocytic hyperplasia. The purpose of this study was to identify the in vivo cellular targets in BM in early SIV infection and
Expression of cell adhesion molecules in the jejunum of SIV infected rhesus macaques (Macaca mulatta).: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 70. Unique Identifier : AIDSLINE PRIM10/93201041; Stone J; Elices M; Canfield D; Dandekar S; Dept. of Internal Medicine, University of California, Davis; 95616.; SIV-infected rhesus macaques experiencing malabsorption had lymphocytic and histiocytic inflammatory infiltrates accompanied by high levels of SIV RNA in the jejunum. Leukocyte adhesion molecules participate in many leukocyte functions needed for immune and inflammatory responses, by specific receptor-ligand interacti
The role of interferon in the development of AIDS.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 70A. Unique Identifier : AIDSLINE PRIM10/93201042; Tovey MG; Lebon P; Meyer F; Hurtrel B; Gresser I; Venet A; Girard M; Aubertin AM; IRSC-CNRS, Villejuif, Hopital Saint-Vincent de Paul, Strasbourg,; France.; Considerable evidence suggests that co-factors including cytokines play a determining role in the development of the acquired immunodeficiency syndrome (AIDS) following infection by the human immunodeficiency virus (HIV). The presence of acid-labile interferon (IFN) alpha in the sera of AIDS patients has been shown to
Neuro-ophthalmic manifestations of simian immunodeficiency virus infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 71. Unique Identifier : AIDSLINE PRIM10/93201043; Vogel P; Lackner AA; Lowenstine LJ; Miller CJ; California Regional Primate Research Center, UC Davis.; Ophthalmic lesions are seen in up to 94% of AIDS patients and often are the result of opportunistic infections or neoplasms. The existence of a primary HIV-induced retinopathy has been difficult to demonstrate in humans because of frequently superimposed CMV-induced lesions in terminal AIDS. HIV has been isolated from
Rearing history and survival time in SIV-infected juvenile rhesus monkeys (Macaca mulatta).: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 72. Unique Identifier : AIDSLINE PRIM10/93201044; Clarke MR; Harrison RM; Martin LN; Tulane Regional Primate Research Center, Covington LA 70433.; Data from two samples of SIV-infected animals were analyzed to compare developmental, social, and environmental histories with survival time following inoculation. The first data set included animals that were infected for different research protocols (e.g., progression of disease, controls for drug studies), and incl
Cyclic patterns of cell free SIV production and spread in peripheral blood of rhesus macaque monkeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 73. Unique Identifier : AIDSLINE PRIM10/93201045; Emau P; MacKenzie D; Malkovsky M; Pauza CD; Department of Pathology & Laboratory Medicine, University of; Wisconsin, Madison 53706.; We examined the temporal changes in cell free virus titres to determine the humoral mechanisms that control virus dissemination in rhesus monkeys. Plasma virus titres were compared to accumulated levels of total SIV DNA, circular viral DNA, SIV-specific antibody and CD4+ T cells. Three monkeys were infected by either
Prevalence of antibodies to HTLV-1/STLV-1 in a large colony of captive chimpanzees.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 74. Unique Identifier : AIDSLINE PRIM10/93201046; Harrison RE; Murthy KK; Melendez GI; Tuck PA; Eichberg JW; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, TX 78228.; Serum samples from a colony of 198 chimpanzees (Pan troglodytes) were screened for the presence of antibody to HTLV-1/STLV-1 by enzyme immunoassay. All positive serum was analyzed for confirmation by Western blot; 20 of the 198 samples were confirmed to be positive. No evidence of vertical transmission of infection wa
Establishment of quantitative cytokine assays and detection of mRNA coding for the cytokines in lymphoid cells from rhesus macaques and sooty mangabeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 75. Unique Identifier : AIDSLINE PRIM10/93201047; Hunt D; Vuchetich M; Villinger F; Findley H; Mayne A; Folks T; Ansari AA; Dept. of Pathology, Emory Univ. School of Medicine, Atlanta, GA.; Certain select cytokines such as TNF have been shown to markedly influence the replication of lentivirus in vitro, and marked increases of cytokines such as IL-6 have been shown to occur in the sera of lentivirus-infected humans and nonhuman primates. It is hypothesized that qualitative and/or quantitative changes in
CD8 mediated suppression generated in macaques following vaccination with SIV GP160 does not affect viral load after challenge.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 76. Unique Identifier : AIDSLINE PRIM10/93201048; Lohman B; McChesney M; Ahmed S; Giavedoni L; Yilma T; Marthas M; California Regional Primate Research Center, University of; California, Davis 95616.; Immunization with SIVgp160 does not protect against primary infection with SIVmac (T. Yilma, et al., abstract submitted), but we have found that some immunized groups have decreased viral load after challenge. CD8 mediated suppression has been proposed as a mechanism of controlling HIV and SIV infection. In this study
SIVagm in lymphoid tissues of experimentally infected African green monkeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 77. Unique Identifier : AIDSLINE PRIM10/93201049; Miller CL; Ramos RA; Vogel AP; Isahakia M; Marthas ML; Marx PA; California Regional Primate Research Center, University of; California, Davis.; The simian immunodeficiency virus (SIVagm) isolated from African green monkeys (AGMs) is a lentivirus distantly related to SIVmac. This virus does not cause simian acquired immune deficiency (SAIDS) in its natural host. Other investigators have demonstrated that virus can be recovered from peripheral blood mononuclear
In vivo reactivation of SRV-2/W by experimentally-induced immunosuppression.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 78. Unique Identifier : AIDSLINE PRIM10/93201050; Moazed TC; Maggio-Price L; Shiota F; Kennedy B; Thouless ME; Department of Pathobiology, University of Washington, Seattle; 98195.; SRV-2/W (Simian Retrovirus serotype 2 Washington) is a widespread retrovirus of pig-tailed macaques (M. nemestrina) at the University of Washington Regional Primate Research Center (UWRPRC). After infection and seroconversion the virus is assumed to establish latency with affected animals demonstrating no apparent cli
Primary human brain capillary endothelial cells are permissive for HIV infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 79. Unique Identifier : AIDSLINE PRIM10/93201051; Moses AV; Bloom FE; Pauza CD; Nelson JA; Department of Immunology, Scripps Research Institute, La Jolla,; CA 92037.; The AIDS dementia complex is a sequelae commonly observed in HIV-infected individuals, but the pathogenic mechanisms involved in this neurological disorder are still obscure. The principal cellular targets identified for HIV in the CNS are cells of the macrophage lineage and brain
The absence of T-cell priming for programmed cell death and GP120 induced anergy correlates with natural resistance of chimpanzees to immunosuppressive disease development.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 8. Unique Identifier : AIDSLINE PRIM10/93201052; Heeney J; Gougeon ML; Di Rienzo AM; Montagnier L; Laboratory of Viral Pathogenesis, ITRI-TNO, Rijswijk, The; Netherlands.; A cohort of chimpanzees infected experimentally or naturally with HIV-1 or related lentiviruses has been studied together with uninfected controls for evidence of disease progression. The aim of this study group is to elucidate possible mechanisms of natural disease resistance in this species to the development of AID
Biosafety guidelines for working with non-human primates in retrovirus research.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 80A. Unique Identifier : AIDSLINE PRIM10/93201053; Richmond JY; Brown B; Khabbaz R; Kaplan J; Centers for Disease Control, Atlanta, GA 30333.; Guidelines for work with infectious pathogens in laboratory animals are detailed in the CDC/NIH publication, Biosafety in Microbiological and Biomedical Laboratories. These guidelines describe suitable precautions for working with pathogens at various levels of containment (i.e., Animal Biosafety Levels 1, 2, 3, and 4
Fetal and postnatal immune responses to S.I.V. following in utero infection of rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 80. Unique Identifier : AIDSLINE PRIM10/93201054; Otsyula M; Tarantal A; Lerche N; Marthas M; Miller C; Pedersen N; Hendrickx A; McChesney M; California Regional Primate Research Center, University of; California-Davis 95616-8542.; Infection of infants with the Human Immunodeficiency Virus results in a fatal immunodeficiency disease in infancy or in later childhood. We have used the animal model of AIDS, Simian Immunodeficiency Virus (SIV) infection of rhesus macaques, to understand disease pathogenesis in pediatric HIV infection. Rhesus monkey
SIV variants evolving in vivo from molecularly cloned virus are fast replicating and highly cytopathic to cells in culture.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 81. Unique Identifier : AIDSLINE PRIM10/93201055; Rudensey L; Overbaugh J; Department of Microbiology, University of Washington, Seattle; 98195.; We have previously demonstrated that the progression to simian AIDS is associated with the evolution of envelope genotypes with mutations primarily localized to the V1 and V4 regions of the SIV env gene. A representative mixture of the variants present at later stages of disease in the animal was maintained when the v
Activation of macaque lymphocyte subsets by SIVsmmPBj14.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 82. Unique Identifier : AIDSLINE PRIM10/93201056; Schwiebert R; Fultz PN; Department of Comparative Medicine, University of Alabama,; Birmingham 35294.; In vitro SIVsmmPBj14 replicates efficiently in both resting and mitogen-stimulated PBMCs and appears to induce proliferation of cells as virus accumulates in the culture supernatants. Infection of pig-tailed macaques (Macaca nemestrina) with SIVsmmPBj14 generally results in acute disease and death in 1 to 2 weeks. Acu
Transfection and transformation with simian AIDS-RF DNA in NIH3T3 cells.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 83. Unique Identifier : AIDSLINE PRIM10/93201057; Tsai CC; Wu HN; Malinak CJ; Grant RF; Regional Primate Research Center, University of Washington,; Seattle 98195.; Certain pigtailed macaques with simian D-retrovirus serotype 2 (SRV-2)-induced simian acquired immunodeficiency syndrome (AIDS) have a high incidence of retroperitoneal fibromatosis (RF) and other neoplasia. The mechanisms of SRV-2 induced AIDS-associated neoplasia have not been determined. We investigated the transfo
The failure of a recombinant SIV vaccine is not solely due to the evolution of escape mutants in vivo.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 84. Unique Identifier : AIDSLINE PRIM10/93201058; Almond N; Jenkins A; Heath AB; Kitchin P; AIDS Collaborating Centre, NIBSC, Potters Bar, UK.; To date there has been only one report describing the successful use of a monotypic recombinant vaccine to protect macaques against experimental infection with SIV (Hu et al, Science, 1992, 255, 456). One reason for this may be the variability of the retroviral genome. Thus, new viral sequence variants emerge upon inf
Characterization of a SRV-2 3' open reading frame present in virus infected tumor cells.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 85. Unique Identifier : AIDSLINE PRIM10/93201059; Grant RF; Malinak CJ; Wu H; Tsai CC; University of Washington Primate Research Center, Medical Lake; 99022.; The polymerase chain reaction (PCR) was used to amplify SRV-2 messenger RNA from several cases of retroperitoneal fibromatosis (RF). mRNA was purified from frozen tissue samples of RF origin dating from 1988 through 1992. Complementary DNA (cDNA) was synthesized using reverse transcriptase and the cDNA was used as tem
Isolation, cloning, and sequencing of simian foamy virus from chimpanzee.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 86. Unique Identifier : AIDSLINE PRIM10/93201060; Herchenroder O; Renne R; Mergia A; Cobb KE; Murthy KK; Luciw PA; Dept. of Medical Pathology, University of California, Davis; 95616.; Foamy viruses, also called syncytium-forming or spumaviruses, are one of seven genera of retroviruses and have been found in various species including primates and man. Apparently they induce a latent infection in their host. Although foamy viruses infect several cell types representing various tissues of numerous spe
Partial characterization of SIVsm chronically infected CEM X 174 cells.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 87. Unique Identifier : AIDSLINE PRIM10/93201061; Hernandez S; Beltran M; Lavergne J; Malaga C; Kessler M; Kraiselburd E; SIVsm chronically infected cultures were obtained after infection of CEM X 174 cells with either SIVsm H3 or SIVsm/E660. These phenotypically CD4-cells, formed syncytia when cocultivated with CD4+ cells, and produced infectious, as well as non-infectious viruses. Single cell clones derived from these cultures were gro
Simian AIDS type D retrovirus serotype 2 and variant viruses: molecular cloning and sequence analyses of the envelope glycoprotein genes.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 88. Unique Identifier : AIDSLINE PRIM10/93201062; Horenstein GR; Neilson K; Kelley RD; Crabtree L; Searles RP; Nipper V; Hallick LM; Axthelm MK; Machida CA; Dept. of Microbiology, Oregon Health Sciences University,; Portland 97201.; Type D simian retrovirus (SRV) infection is the cause of most Simian Acquired Immunodeficiency Syndrome (SAIDS)-associated mortality in biomedical research colonies of Asian macaques. Serotype 2 retroviruses have been associated with severe immunodeficiency and retroperitoneal fibromatosis in Celebes, pigtailed, and l
tat relieves the host dependence of HIV in stimulated primary human macrophages.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 89. Unique Identifier : AIDSLINE PRIM10/93201063; Moses AV; Ibanez CE; Gaynor R; Nelson JA; Ghazal P; Department of Immunology, Scripps Research Institute, La Jolla,; CA 92037.; Macrophages constitute a key cell lineage harboring HIV in AIDS patients. Stimulation of macrophages from asymptomatic individuals via a T cell mediated pathway results in reactivation of HIV replication. We have utilized an in vitro model system to identify transcription elements that regulate latent or productive HI
Seroconversion to simian immunodeficiency virus (SIV) in two laboratory workers.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 9. Unique Identifier : AIDSLINE PRIM10/93201064; Khabbaz R; Rowe T; Murphey-Corb M; Heneine W; Schable C; George JR; Pau C; Parekh B; Folks T; Centers for Disease Control, Atlanta, GA 30333.; SIV infection can cause AIDS in macaque monkeys. We report on two laboratory workers who seroconverted to SIV after exposures in SIV-research laboratories. The first is an animal worker who was accidentally stuck with a needle used to collect blood from a macaque monkey experimentally infected with SIV. Serial serolog
Regulatory elements in the long terminal repeat (LTR) of simian foamy virus type 3 (SFV-3).: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 90. Unique Identifier : AIDSLINE PRIM10/93201065; Renne R; Mergia A; Renshaw-Gegg LW; Neumann-Haefelin D; Luciw PA; University of California, Davis 95616.; Spumaviruses, or foamy viruses, are one of seven genera in the retroviridae family, and unique isolates have been recovered from many mammalian species including cats, hamsters, cows, sea lions, several non-human primates and man. Simian foamy virus type 3 (SFV-3), isolated from African green monkeys, has a complex ge
A molecular clone of STLV-I isolated from a diseased African green monkey.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 91. Unique Identifier : AIDSLINE PRIM10/93201066; Traina-Dorge V; Blanchard J; Murphey-Corb M; Tulane Regional Primate Research Center, Covington, LA.; Human T-cell leukemia virus (HTLV-I) is a type C retrovirus associated with adult T-cell leukemia. Seroepidemiological evidence suggests almost all species of Old World monkeys are naturally infected with the closely related simian virus, STLV-I. STLV-I can immortalize monkey cells in vitro. However, no direct viral l
Identification of a generalised packaging sequence for D-type retroviruses and generation of a D-type retroviral vector.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 92. Unique Identifier : AIDSLINE PRIM10/93201067; Vile RG; Ali M; Hunter E; McClure MO; Department of Communicable Diseases, St. Mary's Hospital Medical; School, London.; In order to construct vectors based upon D-type, rather than C-type, retroviruses, a 624 bp fragment of Mason Pfizer monkey virus (MPMV) has been identified, which can serve as a packaging sequence for at least two D-type retroviruses. When this fragment is included in a h
Analysis of the TNF-beta gene in rhesus macaques and sooty mangabeys.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 93. Unique Identifier : AIDSLINE PRIM10/93201068; Villinger F; Folks T; Mayne A; Vuchetich M; Findley H; Ansari AA; Dept. of Pathology, Emory Univ. School of Medicine, Atlanta, GA.; The regulation of HIV-1 and SIV virus replication in vitro by cytokines has been studied by a number of laboratories. Cytokines such as TNF have been shown to markedly upregulate HIV-1 replication. Recent data have shown that there is a functional polymorphism in the TNF-beta gene in humans which results in individual
Correlation of pathological findings at necropsy with a novel immunological evaluation and staging system in SIV-infected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 94. Unique Identifier : AIDSLINE PRIM10/93201069; Amieiro JP; Del Llano AM; Lavergne JA; Kraiselburd E; Kessler MJ; Malaga CA; Animal Resources Center, University of Puerto Rico.; A group of eight juvenile Rhesus macaques, infected with different concentrations of SIVsm/E660 (10(4.8)TCID50/ml) were euthanized fifteen month post-infection. Pathological findings at the time of necropsy were correlated with a novel staging system based on a tri-parametric immunological evaluation recently develope
Titration in pig-tailed macaques of the HIV-1 IIIB vaccine virus challenge stock.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 95. Unique Identifier : AIDSLINE PRIM10/93201070; Benveniste R; Agy M; Katze M; Corey L; Hu SL; Tsai CC; Morton W; Arthur L; NCI, Frederick, MD.; The observation that pig-tailed macaques (M. nemestrina) can be infected with HIV-1 (Science 257: 103, 1992) has raised the possibility that this primate species may become useful for the evaluation of HIV-1 vaccines and antiviral therapies. Recent HIV-1 vaccine trials in chimpanzees have used HIV-1 IIIB (lot 040) as
Quality control in immunophenotyping of nonhuman primate AIDS animal models.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 96. Unique Identifier : AIDSLINE PRIM10/93201071; Brodie AR; Brown AS; McClure HM; Yerkes Primate Research Center, Emory University, Atlanta, GA.; A critical determination in AIDS patients and in nonhuman primate AIDS animal models is the determination of CD4+ lymphocytes. This value is used to monitor disease progression and response to therapy, and should be reported in absolute numbers. The latter depends on determining the percent of lymphocytes in a differe
Quantification of intraocular inflammatory responses to subretinal inoculation of rhesus CMV in eyes of normal and SIV immunosuppressed rhesus macaques.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 97. Unique Identifier : AIDSLINE PRIM10/93201072; Conway MD; Peyman GA; Murphey-Corb M; Soike KF; Bohn R; Martin L; LSU Eye Center, Louisiana State University Medical Center School; of Medicine, New Orleans 70112.; Three rhesus macaque monkeys (Macaca mulatta) were injected subretinally with 100 microliters of rhesus cytomegalovirus resuspended in phosphate buffered saline to a titer of 10(4) pfu/ml. Two animals were immunosuppressed as a result of infection with SIV/Delta B670 as evidenced b
Immunological and virological effects of opiate dependency in rhesus macaques: studies on SIV/SMM infection.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 98. Unique Identifier : AIDSLINE PRIM10/93201073; Donahoe RM; Bryd L; McClure HH; Fultz P; Brantley M; Marsteller F; Ansari AA; Aceto M; Emory University, Atlanta, GA.; A 2-1/2 year study was conducted to determine the effect of morphine on the immunological status of rhesus monkeys in the presence and absence of infection with the sooty mangabey strain of simian immunodeficiency virus (SIV/SMM). Opiate dependency was maintained by injection of 3mg/kg morphine per monkey, every 6 hr.
Susceptibility of macaque T lymphocytes and monocyte/macrophages to HIV-1.: Symp Nonhum Primate Models AIDS. 1992 Nov 17-20;10:abstract no. 99. Unique Identifier : AIDSLINE PRIM10/93201074; Gartner S; Liu Y; Rosenberg Y; Lewis M; Zack P; Eddy G; Henry M. Jackson Foundation Research Laboratory, Rockville,; Maryland 20850.; Peripheral blood mononuclear cells from a number of pig-tailed, cynomolgus and rhesus macaques were screened in parallel in vitro for susceptibility and permissivity to several strains of HIV-1. Cultures of monocyte/macrophages (MM) as well as T lymphocytes, were monitored for extracellular HIV-1 p24 production. Polym
Efficacy of ivermectin in the treatment of strongyloidiasis complicating AIDS.: Abstr Gen Meet Am Soc Microbiol. 1992;92:11 (abstract no. A-62). Unique Identifier : AIDSLINE ASM92/93201075; Torres J; Isturiz R; University Hospital, Universidad Central de Venezuela.; Strongyloides stercoralis is endemic in tropical regions worldwide. At least six documented cases of disseminated disease and AIDS have been reported. In the immunocompromised host, persistent or relapsing complications of extra-intestinal infection may ensue despite adequate standard courses of treatment. Recently, i
Enhancement of HTLV-I/II, HIV-I and HLA-DQ alpha PCR amplification efficiency using uracil-N-glycosylase.: Abstr Gen Meet Am Soc Microbiol. 1992;92:116 (abstract no. D-121). Unique Identifier : AIDSLINE ASM92/93201076; Kinard S; Butcher A; Wang Z; Spadoro J; Roche Diagnostic Systems, Fair Lawn, New Jersey.; Uracil-N-Glycosylase (UNG) has been used to prevent the occurrence of false positives due to the carryover of PCR amplified DNA. We determined the effects of UNG on amplification efficiency in PCR-based, colorimetric detection systems for HTLV-I/II, HIV-I and HLA-DQ alpha. Peripheral blood mononuclear cells were isola
Antigenic and DNA analyses of different clinical isolates of Mycoplasma penetrans, a new species of mycoplasma from patients with AIDS.: Abstr Gen Meet Am Soc Microbiol. 1992;92:159 (abstract no. G-2). Unique Identifier : AIDSLINE ASM92/93201077; Wang RY; Hayes M; Kotani H; Newton P 3d; Shih J; Lo SC; ARP, Armed Forces Inst. of Pathol., Wash. D.C.; An unusual organism (GTU-54), isolated from urine of an HIV+ male homosexual, has remarkable pathobiological properties of adhesion, hemadsorption and cytadsorption known to be associated with in vivo virulence. Biochemical, ultrastructural, antigenic and DNA studies revealed it to be a previously unknown mycoplasma t
Comparison of urogenital mycoplasmas found in the urine of AIDS and non-AIDS individuals.: Abstr Gen Meet Am Soc Microbiol. 1992;92:159 (abstract no. G-1). Unique Identifier : AIDSLINE ASM92/93201078; Hayes MM; Dawson MS; Wang R; Pierce P; Shih J; Lo SC; ARP, AFIP, Wash. DC.; Mycoplasma fermentans has been shown to be associated with AIDS-associated nephropathy in HIV+ patients and has been isolated from and detected by the polymerase chain reaction (PCR) in the urine of a number of HIV+ patients. To determine the extent of M. fermentans and other genital mycoplasmas found in HIV+ individu
Recovery of mycoplasma in respiratory cultures from HIV+ and HIV- patients: effect of isolation medium.: Abstr Gen Meet Am Soc Microbiol. 1992;92:160 (abstract no. G-3). Unique Identifier : AIDSLINE ASM92/93201079; Antik N; Wakefield T; Debiase J; Britton B; Tully J; Rose D; Oldach D; Mundy L; Auwaerter P; Burton A; et al; Johns Hopkins Med. Institutions, Baltimore, Md.; Throat swabs from patients with community acquired pneumonia, transported in SP 4 medium were stored at -70 degrees C until processed. Of > 450 samples, 11/1/90-10/30(91, 94 have been processed in 4 media. To date, 40 are positive (43 isolates), 45 negative, 9 in progress. Recoveries compared in Hanna RS flasks (HF),
Characterization of a new drug-resistant Mycobacterium species associated with pulmonary disease in AIDS patients.: Abstr Gen Meet Am Soc Microbiol. 1992;92:169 (abstract no. U-24). Unique Identifier : AIDSLINE ASM92/93201080; Yakrus M; Butler W; Kilburn J; Plikaytis B; Moss C; Silcox V; Floyd M; Vadney F; Gross W; Centers for Disease Control, Atlanta, Ga.; Seventeen isolates of biochemically identical, drug-resistant strains classified as either Mycobacterium avium complex or M. xenopi were further characterized. Specimen sources were mainly pulmonary, with seven isolates from AIDS patients. Testing included high-performance liquid chromatography (HPLC) of mycolic acids
Fastidious mycobacteria resembling M. simiae from AIDS patients.: Abstr Gen Meet Am Soc Microbiol. 1992;92:169 (abstract no. U-25). Unique Identifier : AIDSLINE ASM92/93201081; Coyle MB; Carlson LC; Wallis CK; Leonard RB; Raisys V; Harborview Medical Center, Seattle, WA.; Slow-growing fastidious mycobacteria were recovered from blood cultures of 7 AIDS patients within 2 years. The median time to detection in Bactec 13A broth was 28 days longer than for M. avium complex. Isolates failed to grow on routine subcultures to solid media, but grew in broth media including Middlebrook 7H9 and
Isolation of fastidious mycobacteria from AIDS patients.: Abstr Gen Meet Am Soc Microbiol. 1992;92:169 (abstract no. U-26). Unique Identifier : AIDSLINE ASM92/93201082; Jackson KM; Sievers AS; Ross BC; Dwyer BW; Fairfield Hospital, Victoria, Australia.; We have isolated four fastidious mycobacteria from AIDS patients since 1988. These 4 strains were initially isolated in BACTEC 12B and/or BACTEC 13A broths and failed to grow on routine Lowenstein-Jensen medium and egg yolk agar. The first patient had acid fast bacilli isolated from an abdominal lymph node, blood and
A comparative study of Mycobacterium avium complex (MAC) isolated from immunocompromised and immunocompetent patients and from environmental sources. 1. Recovery of MAC from Los Angeles potable water.: Abstr Gen Meet Am Soc Microbiol. 1992;92:170 (abstract no. U-32). Unique Identifier : AIDSLINE ASM92/93201083; Froman S; Glover N; Holtzman A; Aronson T; Berlin OG; Dominguez P; Anderson S; Overturf G; Olive View Med. Ctr, Sylmar, CA.; Los Angeles water is being examined as a possible source of MAC infection in immunocompromised (mainly AIDS) and immunocompetent patients. These studies will include 14 reservoirs supplying 90% of the city s water, 8 major hospitals and 50 homes. One liter water samples were collected in sterile polypropylene bottles
Dissemination of enteric Mycobacterium avium infections in mice infected with MAIDS retrovirus.: Abstr Gen Meet Am Soc Microbiol. 1992;92:170 (abstract no. U-28). Unique Identifier : AIDSLINE ASM92/93201084; Furney SK; Orme IM; Department of Microbiology, Colorado State University, Fort; Collins 80523.; Disseminated M. avium infections in AIDS patients is associated with CD4 T cell deficiency, and probably arises initially as a gut infection. We report here a new model of M. avium infection that may prove useful both in investigating the pathogenesis of the disease, and in testing new anti-mycobacterial drugs. Mice w
Incidence of mycobacterial infections in HIV positive intravenous drug abusers: analysis of 246 necropsy cases.: Abstr Gen Meet Am Soc Microbiol. 1992;92:170 (abstract no. U-30). Unique Identifier : AIDSLINE ASM92/93201085; Kaminski Z; Pearce M; Lombardo J; Goode R; Bloch A; Shilkret K; Lyons M; New Jersey Medical School-UMDNJ, Newark.; The object of this study is to determine whether HIV-Positive, intravenous drug abusers (IVDA) from the Newark, N.J. area who were autopsied at the Office of the N.J. State Medical Examiner were more likely to be culture positive for mycobacteria than the controls consisting of HIV negative IVDA s and HIV negative non
Prospective screening for Mycobacterium avium complex (MAC) in the respiratory and gastrointestinal tract of persons with HIV infection and < 200 CD4+ cells.: Abstr Gen Meet Am Soc Microbiol. 1992;92:170 (abstract no. U-29). Unique Identifier : AIDSLINE ASM92/93201086; Havlik J; Horsburgh C; Barrett K; Diem L; Rimland D; Thompson S; Grady Memorial Hospital, Emory University School of Medicine,; Atlanta, GA.; To evaluate the natural history of MAC in the respiratory or gastrointestinal (GI) tract of persons with HIV infection, we prospectively evaluated HIV infected patients with CD4+ counts less than 200 cells/mm and initial negative MAC blood cultures. Every three months patients were screened with culture of sputum, rec
Studies on Mycobacterium avium complex (MAC) isolates from AIDS patients.: Abstr Gen Meet Am Soc Microbiol. 1992;92:170 (abstract no. U-31). Unique Identifier : AIDSLINE ASM92/93201087; Deshpande RG; Khan MB; Navalkar RG; Morehouse School of Medicine, Atlanta, Georgia.; Mycobacterium avium complex (MAC) isolates from AIDS patients were characterized in order to study the prominent antigens by SDS-PAGE and Western blotting. A major protein antigen of apparent molecular weight of 12,000 was observed in all the sonicates along with other proteins up to a molecular weight of 100,000. Imm
Epidemiologic impact of tuberculosis vaccination in HIV prevalent populations.: Abstr Gen Meet Am Soc Microbiol. 1992;92:171 (abstract no. U-33). Unique Identifier : AIDSLINE ASM92/93201088; Suen JS; Daniel TM; Case Western Reserve University, Cleveland, Ohio.; We created an age-stratified Markov model of tuberculosis and AIDS in a prototypic African population. Separate states of tuberculous infection, HIV infection, tuberculosis, AIDS, and dual infection and disease were included. Ugandan, Tanzanian, and Zambian in-put data were used. A 2% annual incidence of HIV infection
Detection of Mycobacterium kansasii from a brain lesion and Mycobacterium avium from blood of an AIDS patient using PCR and reverse dot blot hybridization.: Abstr Gen Meet Am Soc Microbiol. 1992;92:175 (abstract no. U-62). Unique Identifier : AIDSLINE ASM92/93201089; Fiss E; York MK; Brooks GF; University of California, San Francisco.; A PCR-based reverse dot blot method was used to rapidly detect and speciate mycobacteria in clinical specimens. Genus-specific primers were for a conserved region of the mycobacterial 16S rRNA gene. The PCR product was labeled with digoxigenin during amplification. Species-specific probes for M. tuberculosis, M. avium
Resistance pattern of Mycobacterium avium complex (MAC) strains isolated from MAC infected AIDS patients and beige mice during treatment with clarithromycin.: Abstr Gen Meet Am Soc Microbiol. 1992;92:179 (abstract no. U-86). Unique Identifier : AIDSLINE ASM92/93201090; Grosset J; Doucet-Populaire F; Truffot C; Jarlier V; Ji B; Pitie-Salpetriere School of Medicine, Paris, France.; Clarithromycin (CLARI), the 6-O-methyl erythromycin, was active against Mycobacterium avium complex (MAC) in both AIDS patients and infected beige mice. As a consequence, among 54 AIDS patients infected by CLARI-susceptible MAC, 7 harboured CLARI-resistant MAC after at least 2 months of treatment with CLARI. In beige
Does HIV-1 persist in wastewater? Detection of HIV-1 specific nucleic acid using polymerase chain reaction.: Abstr Gen Meet Am Soc Microbiol. 1992;92:362 (abstract no. Q-161). Unique Identifier : AIDSLINE ASM92/93201091; Ansari SA; Farrah SR; Chaudhry GR; Oakland University, Rochester, MI.; The human immunodeficiency virus (HIV-1) released by infected individuals or present in human and hospital wastes can potentially cause contamination problems. However, little is known about the fate of HIV-1 in various environmental systems. Despite a rapid advancement in the basic and clinical knowledge of HIV-1, on
Characterization of immunoreactive corticotropin in lymphocytes infected with human immunodeficiency virus.: Abstr Gen Meet Am Soc Microbiol. 1992;92:412 (abstract no. T-26). Unique Identifier : AIDSLINE ASM92/93201092; Hashemi FB; Hughes TK; Smith EM; University of Texas Medical Branch, Galveston 77550.; The immune, nervous and endocrine systems are affected by the human immunodeficiency virus (HIV). Numerous studies suggest that a regulatory link normally exists among these three systems through cytokines and hormones such as adrenocorticotropin (ACTH). Newcastle disease virus (NDV) is known to induce ACTH production
Contribution of hydrophobic residues in the functional expression of HIV env gene product.: Abstr Gen Meet Am Soc Microbiol. 1992;92:412 (abstract no. T-21). Unique Identifier : AIDSLINE ASM92/93201093; Seaman WT; Belshe RB; Fenger TW; Marshall Univ. Sch. of Med., Huntington, W.V. 25755-9330.; The envelope glycoprotein of HIV (gp160 and its mature cleaved form, gp120/41) forms a homooligomer through interactions between subunits of the transmembrane protein, gp41. We are interested in defining regions of gp41 involved in the assembly of gp160. We have constructed a plasmid containing the env coding sequence
Delayed expression of HIV-1 proteins in CD(8+)-infected peripheral lymphocytes as compared to their CD4+ counterparts.: Abstr Gen Meet Am Soc Microbiol. 1992;92:412 (abstract no. T-25). Unique Identifier : AIDSLINE ASM92/93201094; Mercure L; Phaneuf D; Wainberg MA; Lady Davis Institute for Medical Research, Montreal, Canada.; INTRODUCTION. In this study, we have compared the kinetics of infection by HIV-1 of both CD4+ and CD8+ lymphocytes. MATERIALS AND METHODS. PBMCs from healthy, HIV-1 seronegative donor, were isolated on Ficoll gradient and stimulated 3 days with PHA prior to infection with HIV-1LAI strain at 0.03 TCID50/cell. At day 7
Genetic diversity within the envelope V3 region of HIV-1 specimens from Cote D' Ivoire (CI).: Abstr Gen Meet Am Soc Microbiol. 1992;92:412 (abstract no. T-23). Unique Identifier : AIDSLINE ASM92/93201095; Brown V; Potts K; Kalish M; Bandea C; Schochetman G; Brattegaard K; Boateng E; Adjorlolo G; Decock K; Ou CY; Centers for Disease Control, Atlanta, Ga.; The degree of heterogeneity exhibited by HIV-1 viral isolates presents a challenge to the scientific community by complicating both immunological and genetic analysis. A great deal of recent research has focused on one of the more variable regions of the virus, the V3 region of the envelope gene (env). Sequences from
Simian immunodeficiency virus infection of macaque-PBL-SCID mice.: Abstr Gen Meet Am Soc Microbiol. 1992;92:412 (abstract no. T-22). Unique Identifier : AIDSLINE ASM92/93201096; Hall E; Greenhouse J; White B; Papermaster S; Eddy G; Burke D; Rosenberg Y; Henry M. Jackson Foundation, Rockville, MD.; CB.17-scid (SCID) mice lack mature B and T lymphocytes but become susceptible to infection with HIV when engrafted with human lymphoid tissue. Such mice are therefore useful for assessing the efficacy of anti-HIV therapeutics, drugs and immune lymphocytes populations. The present studies describe the development of SC
Measurement of CD4 binding to envelope glycoproteins of HIV-1 and SIV.: Abstr Gen Meet Am Soc Microbiol. 1992;92:413 (abstract no. T-27). Unique Identifier : AIDSLINE ASM92/93201097; Scandella CJ; Obegi I; Lidster W; Wolfe S; Burman D; Coates SR; Higgins K; Yamada JT; Chiron Corp., Emeryville, CA.; CD4 binding is a critical indicator of the correct conformation of HIV envelope glycoproteins. In order to assess the integrity of recombinant HIV and SIV envelope glycoproteins, a rapid, reproducible and precise CD4 binding assay has been developed. The assay uses HPLC gel filtration chromatography to separate gp120
Detection of HIV-1 infection in pediatric patients.: Abstr Gen Meet Am Soc Microbiol. 1992;92:415 (abstract no. T-41). Unique Identifier : AIDSLINE ASM92/93201098; Villanueva L; Cadilla C; Diaz AM; Delgado R; Rios O; Jimenez E; Kraiselburd E; Univ. of Puerto Rico, Sch. of Medicine, Municipal Hospital, San; Juan.; HIV-1 infection in children born to HIV-1 seropositive mothers was detected by in vitro polyclonal activation of lymphocytes with pokeweed mitogen (PWM) and by the polymerase chain reaction (PCR). Peripheral blood mononuclear cells were isolated and incubated in RPMI medium supplemented with the mitogen; seven days la
Detection of HTLV-I and HTLV-II in an intravenous drug abuser population using PCR in combination with a colorimetric microtiter plate assay.: Abstr Gen Meet Am Soc Microbiol. 1992;92:415 (abstract no. T-42). Unique Identifier : AIDSLINE ASM92/93201099; Wolfe L; Schilling W; Metzger D; MacGregor R; PCR Division, Roche Diagnostic Systems Inc, Fair Lawn, NJ.; Numerous studies have shown that intravenous drug abusers (IVDA) are at increased risk for HTLV-II infection. The association of HTLV-I with adult T-cell leukemia and tropical spastic parapheresis make it important to differentiate HTLV-I and HTLV-II. Although the Western Blot has been used as a supplemental test for
Indeterminate western blot results in populations of varying risk for HIV infection.: Abstr Gen Meet Am Soc Microbiol. 1992;92:415 (abstract no. T-43). Unique Identifier : AIDSLINE ASM92/93201100; Spruill C; Onorato I; Centers for Disease Control, Atlanta, GA.; Indeterminate Western blot (WB) band patterns occur in HIV testing, even in persons at low risk for HIV infection. We looked at WB results from CDC-funded unlinked surveys conducted in 1989 and 1990 in STD clinics (STD), drug treatment centers (DTC), and women s health clinics (WHC) from ten metropolitan areas. All ar
Rapid quantitative dilutional HIV-1 PCR to detect viral load in HIV-1 infected blood samples from intravenous (i.v.) drug abusers.: Abstr Gen Meet Am Soc Microbiol. 1992;92:415 (abstract no. T-44). Unique Identifier : AIDSLINE ASM92/93201101; Jones SW; Contoreggi CS; Meyer WA 3d; Maryland Medical Laboratory, Inc., Baltimore.; The polymerase chain reaction (PCR) technology provides for rapid laboratory confirmation of HIV-1 infection, when compared to other methods. We sought to determine how viral load could be quantitated in a set of HIV-1 infected IV drug abusers, using HIV-1 DNA and RNA PCR. These techniques amplify a few copies of vira
Ability of the Innogenetics Inno-LIA to distinguish HIV-1, HIV-2 and dually reactive sera.: Abstr Gen Meet Am Soc Microbiol. 1992;92:416 (abstract no. T-47). Unique Identifier : AIDSLINE ASM92/93201102; Granade TC; Phillips SK; George JR; Centers for Disease Control, Atlanta, Ga.; A recombinant and peptide based line immunoassay--Innogenetics Inno-LIA (IIL)--was used to differentiate HIV-1, HIV-2, and dually reactive sera. A total of 121 West African sera previously characterized by standard EIA, Western blot, PCR, viral culture and other peptide based assays were further tested by the IIL test
Analysis of HIV-1 infected patients and their seronegative partners by PCR and a rapid non-radioactive microtiter plate hybridization assay.: Abstr Gen Meet Am Soc Microbiol. 1992;92:416 (abstract no. T-50). Unique Identifier : AIDSLINE ASM92/93201103; Kung K; MacGregor R; Dragon E; Roche Diagnostic Systems Inc., Fair Lawn, N.J.; Sexually active heterosexual and homosexual couples, in which one partner was positive for HIV-1 were studied by EIA, WB, p24 antigen assay, PCR, and viral culture. PCR was performed in the presence of the primers, SK431/462 and the amplification product was detected using a rapid, non-radioactive microtiter plate hyb
Measurement of p24 Ag before and after acid dissociation of circulating immune complexes (CICS) with HCl or glycine (Gly) in the sera of HIV+ patients (pts).: Abstr Gen Meet Am Soc Microbiol. 1992;92:416 (abstract no. T-46). Unique Identifier : AIDSLINE ASM92/93201104; Pokriefka R; Manzor O; Markowitz N; Saravolatz L; Henry Ford Hospital, Detroit, Michigan.; Assays of p24 Ag assays fail to demonstrate Ag in many HIV+pts. Since tests do not detect p24 Ag-Ab complexes, we compared 2 systems, Abbott EIA for HIV-1 Ag (Abt) and the Coulter p24 Ag EIA (Col), after acid dissociation of CICS. Aliquots of sera from 106 unselected HIV+ pts collected at routine visits and stored at
Re-evaluating HIV-1 antibody indeterminate sera utilizing HIV-1/HIV-2 synthetic peptide EIA's.: Abstr Gen Meet Am Soc Microbiol. 1992;92:416 (abstract no. T-49). Unique Identifier : AIDSLINE ASM92/93201105; Myers RA; Patel JD; Joseph JM; Maryland Department of Health Laboratories, Baltimore.; Several investigators have demonstrated the improved sensitivity and increased specificity of HIV serological assays based on synthetic peptide antigens comprising the immunodominate transmembrane sequences of HIV-1 and HIV-2. We devised a testing algorithm using envelope specific HIV-1/HIV-2 synthetic peptide EIA s i
Use of recombinant or synthetic peptide HIV-1 assays in the resolution of indeterminant western blot results.: Abstr Gen Meet Am Soc Microbiol. 1992;92:416 (abstract no. T-48). Unique Identifier : AIDSLINE ASM92/93201106; Coffee S; Alexander R; San Bernardino County Public Health Laboratory, CA.; Indeterminant Western Blot results have been found to rarely signify the presence of infection with HIV-1 in patients with no symptoms or risk factors. However, follow-up testing in six months is recommended to assess progression of the individual s Western Blot pattern. We studied the use of recombinant (RE) (SYVA, P
Detection of HTLV-I and HTLV-II in an EIA repeat reactive blood donor population using PCR in combination with a colorimetric microtiter plate assay.: Abstr Gen Meet Am Soc Microbiol. 1992;92:417 (abstract no. T-52). Unique Identifier : AIDSLINE ASM92/93201107; Rios M; Schilling W; Duran M; Bianco C; Wolfe L; New York Blood Center, NYC.; Pre-transfusion screening of blood units for antibodies to HTLV-I/II is performed with EIA. Units repeatedly reactive on EIA screen are discarded. Donor notification is based on confirmation by Western Blot (WB) and RIPA, which generate a large proportion of indeterminant test results and are unable to differentiate H
Evaluation of a single primer pair for the detection of HIV-1 in clinical specimens by PCR amplification: comparison of a non-radioactive microtiter plate assay with solution hybridization.: Abstr Gen Meet Am Soc Microbiol. 1992;92:417 (abstract no. T-51). Unique Identifier : AIDSLINE ASM92/93201108; Butcher A; Salter L; Kinard S; Kung K; McCreedy B; Spadoro J; Roche Diagnostic Systems, Inc., Fair Lawn, New Jersey.; The sensitivity of the polymerase chain reaction (PCR) coupled with oligonucleotide solution hybridization (OH) for the detection of HIV-1 DNA sequences is well known. Historically, several primer pairs have been used to confirm positive results. This technique is both time consuming and labor intensive. We have coupl
Evaluation with PCR of HIV-1 infection before seroconversion in individuals at high-risk.: Abstr Gen Meet Am Soc Microbiol. 1992;92:417 (abstract no. T-54). Unique Identifier : AIDSLINE ASM92/93201109; Coutlee F; Olivier C; Voyer H; St-Antoine P; Cassol S; Kessous A; Hopital Notre-Dame and Clinique medicale l'Actuel, University; of Montreal, Canada.; BACKGROUND: The presence of a prolonged period of infection with HIV-1 before seroconversion is supported by some, but remains controversial. GOALS: We have investigated with the polymerase chain reaction (PCR) the occurrence of HIV-1 infection in seronegative individuals at very high-risk. METHODS: Peripheral blood m
HIV DNA titer in infected infants.: Abstr Gen Meet Am Soc Microbiol. 1992;92:417 (abstract no. T-55). Unique Identifier : AIDSLINE ASM92/93201110; Brandt C; Sison A; Rakusan T; Saxena E; Sever J; Children's National Medical Center, Washington, DC.; Our polymerase chain reaction (PCR) technique routinely detects less than 10 copies of HIV DNA and has detected 97.9% of HIV-positive pediatric samples (see J. Clin. Microbiol., Jan. 1992). In efforts to study the HIV load in infants born to HIV-positive mothers, we determined specimen DNA endpoint dilution titers for
Quantitation of HIV plasma viremia by peripheral blood mononuclear cell (PBMC) microculture.: Abstr Gen Meet Am Soc Microbiol. 1992;92:417 (abstract no. T-53). Unique Identifier : AIDSLINE ASM92/93201111; Lathey J; Spector SA; University of California, San Diego, La Jolla.; To facilitate the development of antiretroviral drugs, there is a need to quantitate the amount of infectious virus present in patient materials. Therefore, we have evaluated microculture methods for measuring HIV in plasma. Samples from patients with symptomatic HIV infection were set up in duplicate with 5-fold seri
Use of beta 2 microglobulin (B2) and P24 antibody (P24) in predicting progression to AIDS in a heterogeneous population.: Abstr Gen Meet Am Soc Microbiol. 1992;92:417 (abstract no. T-56). Unique Identifier : AIDSLINE ASM92/93201112; McCarter Y; Mayo D; Sheppard H; Hartford Hospital, CT.; B2 and P24 levels were determined for 294 HIV positive (HIV+) subjects whose sera was submitted for anonymous HIV testing during June to December, 1990. Demographic data (age, sex, race, risk group) were collected on all samples. HIV+ individuals had significantly higher B2 levels than matched HIV- individuals (p
Amplification of HIV-1 gag gene from microdissected cells of kidney biopsy archival material.: Abstr Gen Meet Am Soc Microbiol. 1992;92:418 (abstract no. T-57). Unique Identifier : AIDSLINE ASM92/93201113; Ferreira-Centeno A; Kimmel PL; Rodriguez ER; Abrahan AA; Garrett CT; George Washington University Medical Center, Washington, D.C.; Patients infected with the HIV virus may develop a form of renal disease known as HIV-associated nephropathy. To elucidate whether HIV could cause renal disease directly, we developed a technique that combines the high sensitivity of PCR with the ability of microdissection to localize the target sequence to certain re
HIV antigen detection in acid hydrolyzed plasma and sera of AIDS infants: effect of specimen dilution.: Abstr Gen Meet Am Soc Microbiol. 1992;92:418 (abstract no. T-59). Unique Identifier : AIDSLINE ASM92/93201114; Paul M; Pahwa S; Samples of plasma and sera of infants and newborns are often at a premium because of the small quantity available. In order to optimize the use of such samples, we sought to determine if they can be diluted, without loss of sensitivity or specificity, in the HIV p24 antigen assay of these specimens from AIDS infants.
Intermittent HIV-1 antibody and antigen seropositivity in 2 healthy individuals.: Abstr Gen Meet Am Soc Microbiol. 1992;92:418 (abstract no. T-62). Unique Identifier : AIDSLINE ASM92/93201115; Lianou P; Papadopoulos N; Fortis A; Papavassiliou I; Department of Microbiology, University of Athens.; OBJECTIVE: This report describes 2 healthy individuals, a 28 year old man and a 44 year old woman, found to be intermittently positive for HIV-1 antibodies and antigen. METHODS: Antibody seropositivity was determined with ELISA and confirmed with Western Blot and Immunofluorescence. A sandwich enzymeimmunoassay was us
Performance evaluation of a PCR-microtiter plate hybridization assay for the detection of HIV-1 DNA.: Abstr Gen Meet Am Soc Microbiol. 1992;92:418 (abstract no. T-58). Unique Identifier : AIDSLINE ASM92/93201116; Wang Z; Kinard S; Kung K; Butcher A; Spadoro J; Roche Diagnostic Systems, Inc. Fairlawn, N.J.; The polymerase chain reaction (PCR) has been coupled with a microtiter plate hybridization format to produce a rapid, non-radioactive assay for the detection of HIV-1 DNA in clinical specimens. Leucocytes are obtained from patients blood by a lysis procedure that eliminates the need for gradient purification of targee
Anti-CD4 as an early marker for HIV-1 infection. The Multicenter AIDS Cohort Study.: Abstr Gen Meet Am Soc Microbiol. 1992;92:419 (abstract no. T-68). Unique Identifier : AIDSLINE ASM92/93201117; Keiser P; Keay S; Wecksler W; Wasserman S; University of Maryland, Balto.; Antibodies to HIV-1 may not be detectable for months to years after HIV-1 infection in some persons. Anti-CD4 antibodies are present in 3% to 20% of HIV-1 seropositive persons but are not found in uninfected individuals. We studied the prevalence of anti-CD4 antibodies in the sera of HIV-1 seroconverters before and afe
Improved immunogenicity of HIV-1 gp160 expressed by vaccinia virus.: Abstr Gen Meet Am Soc Microbiol. 1992;92:419 (abstract no. T-64). Unique Identifier : AIDSLINE ASM92/93201118; Carroll MW; Mackett M; Paterson Institute for Cancer Research, Manchester, U.K.; Recombinant vaccinia viruses expressing the env gene of HIV-1 have been used extensively in the study of gp160. We have attempted to use a live vaccinia env recombinant as an antigen source in the production of (neutralising) monoclonal antibodies to gp160. Our initial attempts have been relatively unsuccessful and wee
In vivo transactivation of HIV-1 by herpes simplex virus type 1 (HSV-1).: Abstr Gen Meet Am Soc Microbiol. 1992;92:419 (abstract no. T-65). Unique Identifier : AIDSLINE ASM92/93201119; Prakash O; Wang TY; Coleman R; Hill JM; Alton Ochsner Medical Foundation, New Orleans, LA.; The majority of the opportunistic viral infections which the HIV-infected individuals acquire belong to the herpes group of viruses. To understand the interaction between HIV and herpes viruses in vivo, we studied the effects of HSV-1 infection on the expression of HIV-1 long terminal repeat (LTR)-directed CAT gene exe
Mutation of the fusion peptide of human immunodeficiency virus.: Abstr Gen Meet Am Soc Microbiol. 1992;92:419 (abstract no. T-63). Unique Identifier : AIDSLINE ASM92/93201120; Martin A; Hunter E; Gallagher W; LSU Medical Center, New Orleans.; The fusion peptide region of Human Immunodeficiency Virus (HIV) has been shown to play an important role in the entry process of HIV. In order to map the critical amino acids in the fusion peptide, we have constructed mutations based on the natural variation found in another human retrovirus, HTLV-II. The first constre
Phosphorylation of HIV-1 p17gag by protein kinase C (PKC) in vivo & in vitro.: Abstr Gen Meet Am Soc Microbiol. 1992;92:419 (abstract no. T-67). Unique Identifier : AIDSLINE ASM92/93201121; Burnette B; Yu G; Wade J; Felsted R; Natl. Cancer Institute, Bethesda, MD.; HIV-1 replication is stimulated by phorbol esters & inhibited by PKC specific inhibitors suggesting the involvement of PKC in the HIV life cycle. We have demonstrated a direct role for PKC in the phosphorylation of HIV p17gag by treatment of Cos-7 cells expressing HIV-1 gag proteins with phorbol 12-myristate 13-ace
Transactivation of HIV-1 by JCV in human fetal brain culture: model of PML in AIDS.: Abstr Gen Meet Am Soc Microbiol. 1992;92:419 (abstract no. T-66). Unique Identifier : AIDSLINE ASM92/93201122; Haggerty S; Frisque RJ; Stevenson M; University of Nebraska Medical Center, Omaha.; Progressive multifocal leukoencephalopathy (PML) is a fatal human brain disease caused by the reactivation of a latent JC Virus (JCV) infection during a period of cellular immune suppression. Although JCV is ubiquitous in the human population, PML has been a rare disease. However since the advent of HIV virus infectio
HIV infection of HT-29 intestinal cells: a model of HIV enteropathy.: Abstr Gen Meet Am Soc Microbiol. 1992;92:420 (abstract no. T-70). Unique Identifier : AIDSLINE ASM92/93201123; Asmuth DM; Hammer SM; Wanke CA; New England Deaconess Hospital, Harvard Medical School, Boston,; MA.; The role of direct infection of intestinal cells with HIV 1 in the pathogenesis of HIV related enteropathy is not clear. To try to establish an in vitro model we have infected HT29-c1 intestinal cells with the IIIB strain of HIV and examined the effects on brush border enzymes (BBE) and intracellular free calcium (ICC
Inhibition of HIV replication by peptides containing viral nuclear localization sequences.: Abstr Gen Meet Am Soc Microbiol. 1992;92:420 (abstract no. T-69). Unique Identifier : AIDSLINE ASM92/93201124; Gulizia J; Dempsey M; Sharova N; Bukrinsky M; Stevenson M; University of Nebraska Medical Center, Omaha.; Integration of retroviral DNA with the host cell genome and establishment of the provirus is an obligate step in the life cycle of retroviruses. The integration reaction is catalyzed by a virus-encoded integrase (IN) which after reverse transcription of genomic viral RNA remains associated with the viral cDNA in a hig
Simultaneous detection of HIV-1 targets and an HLA DQ alpha control target in a multiplexed PCR assay.: Abstr Gen Meet Am Soc Microbiol. 1992;92:449 (abstract no. C-170). Unique Identifier : AIDSLINE ASM92/93201125; Klein JS; Inderlied CB; USC Childrens Hospital, Los Angeles.; We developed a multiplexed PCR assay that simultaneously detects the SK38/39 and SK145/150 targets within the gag gene of HIV-1, and the GH26/27 target of the HLA DQ alpha gene. The 2 HIV-1 gag targets are within 30 bp of each other which in a multiplexed reaction produce a third amplimer defined by the SK145/39 prime
Assessment of in vitro susceptibility of CMV to ganciclovir and foscarnet in AIDS patients with retinitis.: Abstr Gen Meet Am Soc Microbiol. 1992;92:458 (abstract no. C-227). Unique Identifier : AIDSLINE ASM92/93201126; Forman M; Dunn JP; Apuzzo L; Jabs D; Johns Hopkins Med. Inst., Baltimore, MD.; Cytomegalovirus retinitis occurs in approximately 20% of AIDS patients and is the most common cause of visual loss in this population. Long term therapy with ganciclovir (G) and foscarnet (F) has been used to control viral replication and disease progression. Although these agents are effective in stabilizing cases of
In vitro susceptibility of Streptococcus pneumoniae isolates from HIV-1 seropositive and seronegative patients to 12 antimicrobial agents.: Abstr Gen Meet Am Soc Microbiol. 1992;92:465 (abstract no. C-267). Unique Identifier : AIDSLINE ASM92/93201127; Nassos PS; Yajko DM; Sanders CA; Gonzalez PC; Hadley WK; San Francisco General Hospital Medical Center, University of; California.; A study was performed to determine if differences exist in the susceptibility profiles of Streptococcus pneumoniae isolates recovered from HIV-1 seropositive patients versus isolates from a group of patients who were either HIV-1 seronegative or whose HIV-1 serostatus was unknown. Among 51 isolates tested, 25 were fro
Comparison of the GENIE 1/2 test with reference methods for detection of antibodies to human immunodeficiency virus type 1 (HIV-1).: Abstr Gen Meet Am Soc Microbiol. 1992;92:485 (abstract no. C-391). Unique Identifier : AIDSLINE ASM92/93201128; Wilcoski LM; Gorniak L; Janda WM; Mandel KL; Stevens JM; Univ. of Illinois Hosp., Chicago.; The GENIE 1/2 test (GT) is a rapid enzyme immunoassay (EIA) for detection of antibodies (Abs) to HIV-1 and HIV-2. The antigens used are synthetic peptides containing immunodominant portions of gp41 and gp36 of HIV-1 and HIV-2 respectively. Abs in serum are absorbed onto an antigen-coated filter, then an enzyme-labeled
Evaluation of a second generation HIV-1/HIV-2 confirmatory test.: Abstr Gen Meet Am Soc Microbiol. 1992;92:485 (abstract no. C-390). Unique Identifier : AIDSLINE ASM92/93201129; Miler C; Shockley R; Newhouse R; Serologicals, Inc., Clarkston, GA.; InnoLIA HIV-1/HIV-2 a confirmatory test which incorporates synthetic and recombinant peptides was evaluated. One hundred plasma/serum samples were selected from a repository of HIV-1/HIV-2 specimens. Biorad Western blot (HIV-1) was used as the comparator test. An HIV-2 recombinant blot was used to resolve the discorda
Detection of Abs to HIV-1 in serum using the recombinant MicroTrak HIV-1 EIA.: Abstr Gen Meet Am Soc Microbiol. 1992;92:486 (abstract no. C-392). Unique Identifier : AIDSLINE ASM92/93201130; Gleaves C; Dworkin R; Gilbert D; Providence Medical Center, Portland, OR.; The MicroTrak HIV-1 recombinant protein assay (RCP) is an in vitro qualitative EIA for the detection of HIV-1 Abs in serum or plasma. We compared the RCP assay to the Genetic Systems LAV Ab assay (GSC) for the detection of HIV-1 Ab in 351 patient sera. Samples that were reactive with both or either assay were re-teste
Diagnostic evaluation of neurosyphilis in HIV-infected persons using a TPHA-index and cerebrospinal fluid (CSF) western blot.: Abstr Gen Meet Am Soc Microbiol. 1992;92:495 (abstract no. C-446). Unique Identifier : AIDSLINE ASM92/93201131; Holtom P; Larsen R; Owen J; Byrne R; LAC + USC Medical Center.; OBJECTIVE: To determine the utility of the TPHA-index and CSF Western Blot as diagnostic tools for asymptomatic neurosyphilis in HIV-infected persons. METHODS: 60 HIV-infected patients with latent syphilis (positive serum RPRs and MHA-TPs) and no recent syphilis therapy had CSF sampling. Quantitative serum and CSF MHA
Sensitivity of induced sputum specimens in diagnosis of Pneumocystis carinii infections in a low human immunodeficiency virus (HIV) prevalence tertiary care center.: Abstr Gen Meet Am Soc Microbiol. 1992;92:497 (abstract no. C-459). Unique Identifier : AIDSLINE ASM92/93201132; Lindsley MD; Cockerill FR 3d; Smith TF; Clinical Microbiology, Mayo Clinic, Rochester, MN 55905.; Data from primary care centers in areas of high HIV prevalence suggest that at least 50-90% of Pneumocystis carinii pneumonia (PCP) cases can be diagnosed using induced sputa. Our experience at a tertiary care center in a low HIV prevalence area has resulted in a much lower sensitivity. Only 3 of 39 (7.7%) induced spu
Actinomadura madurae pneumonia in an AIDS patient.: Abstr Gen Meet Am Soc Microbiol. 1992;92:503 (abstract no. F-27). Unique Identifier : AIDSLINE ASM92/93201133; McNeil M; Brown J; Scalise G; Piersimoni C; Centers for Disease Control, Atlanta, GA.; Actinomadura madurae, an aerobic actinomycete, has been a frequent cause of actinomycotic mycetoma. Recently, A. madurae peritonitis has also been reported in a patient undergoing long-term ambulatory peritoneal dialysis. A 39-yr-old AIDS patient with a history of Pneumocystis carinii pneumonia and
Diagnosis of pneumonia due to Cryptococcus neoformans in AIDS patients.: Abstr Gen Meet Am Soc Microbiol. 1992;92:510 (abstract no. F-73). Unique Identifier : AIDSLINE ASM92/93201134; Hananel J; Hulbert T; Larsen R; Vashon L; Chandrasoma P; Evans S; Los Angeles County + USC Med. Ctr.; Forty-eight AIDS patients with pulmonary infections due to C. neoformans were managed at the Los Angeles County + USC Med. Ctr. between 1986 and 1991. Twenty-two patients had cryptococcal meningitis and an additional five had disseminated cryptococcosis without meningitis. Serum cryptococcal antigen (SCAg) was detecte
Strain variation and in vitro susceptibility patterns in AIDS patients receiving fluconazole (flu) for oral candidiasis (OC).: Abstr Gen Meet Am Soc Microbiol. 1992;92:511 (abstract no. F-79). Unique Identifier : AIDSLINE ASM92/93201135; Pfaller MA; Rhine-Chalberg J; Redding SW; Fothergill AW; Rinaldi MG; OHSU, Portland, OR.; We used DNA subtyping with pulsed field electrophoresis and in vitro susceptibility testing to study strain variation and flu resistance in C. albicans (CA) from 17 AIDS pts enrolled in clinical trials of flu therapy for OC. DNA subtyping of 55 isolates revealed 32 subtypes. Eight pts were infected by a single subtype
Cryptococcal antigen detection from urine in AIDS patients.: Abstr Gen Meet Am Soc Microbiol. 1992;92:512 (abstract no. F-81). Unique Identifier : AIDSLINE ASM92/93201136; Chapin-Robertson K; Bechtel C; Waycott S; Edberg SC; Yale University School of Medicine, New Haven, CT.; Cryptococcal disease occurs in up to 10% of AIDS patients. Detection of the capsular polysaccharide antigen of the organism in spinal fluid and/or serum and positive culture confirms the diagnosis. Despite treatment, follow-up cryptococcal antigen (CA) titers remain positive. These are often used to adjust treatment a
Emergence of multi-drug-resistant (MDR) M. tuberculosis (M. tb) isolated from HIV-infected patients.: Abstr Gen Meet Am Soc Microbiol. 1992;92:517 (abstract no. L-1). Unique Identifier : AIDSLINE ASM92/93201137; Lue YA; McLean TI; Hewlett D Jr; Horn D; Jones B; Garcia N; Lincoln Medical and Mental Health Center, New York Medical; College, Bronx.; As of April 1991 the resistance patterns observed in the M. tb isolates recovered at Lincoln Medical and Mental Health Center were, resistant to isoniazid (INH) or Streptomycin (SM) or Rifampin (Rif) or to both INH and Rif. Since April 1991, 6 M. tb isolates, resistant to INH, SM, Rif and ethambutol (EMB) were recover
Incidence of infection in totally implantable venous access systems (TIVAS) in AIDS.: Abstr Gen Meet Am Soc Microbiol. 1992;92:523 (abstract no. L-35). Unique Identifier : AIDSLINE ASM92/93201138; Karam-Sarkis D; Leresche M; Johanet H; Salmon D; Benhamou G; Bergogne-Berezin E; Bichat-Cl. Bernard hospital, Paris, France.; This study was performed to determine the frequency of infection following the use of TIVAS in a group of AIDS patients (pts) (group A) and in a control group (group B). 78 pts were included in a retrospective study. 22 TIVAS were implanted in 19 consecutive AIDS pts. The total duration of maintenance of TIVAS was 239
Inhibition enzyme immunoassay for human antibody to Haemophilus ducreyi: antigenicity of lipooligosaccharide and effect of HIV on relative antibody affinity.: Abstr Gen Meet Am Soc Microbiol. 1992;92:528 (abstract no. V-24). Unique Identifier : AIDSLINE ASM92/93201139; Desjardins M; Filion LG; Cameron DW; University of Ottawa, Ontario, Canada.; OBJECTIVES: To use inhibition enzyme immunoassay (EIA) to measure antigenicity of lipooligosaccharide (LOS) in H. ducreyi serology, and to compare affinities of antibody response to H. ducreyi in human immunodeficiency virus (HIV) co-infection. METHODS: A standardised anti- H. ducreyi IgG EIA was adapted to measure in
An automated novel enzyme immunoassay for detection of antibodies to human immunodeficiency virus (HIV) 1/2 in donor serum and plasma.: Abstr Gen Meet Am Soc Microbiol. 1992;92:530 (abstract no. V-39). Unique Identifier : AIDSLINE ASM92/93201140; Plier P; Wachholz J; Walker K; Nicol E; Baxter Diagnostic Inc., Pandex Division, Mundelein, Illinois.; A totally automated novel enzyme immunoassay (EIA) has been developed using paramagnetic particles coated with HIV-1 antigen lysate and a synthetic peptide derived from an envelope protein of HIV-2. Beta-galactosidase labeled goat anti-human immunoglobulin is used as the detector. Beta-galactosidase on substrate resul
Development of a rapid HIV-1 and HIV-2 assay using the Cambridge Biotech Agglutination Slide and Slide Instrument reader.: Abstr Gen Meet Am Soc Microbiol. 1992;92:530 (abstract no. V-38). Unique Identifier : AIDSLINE ASM92/93201141; Petrone RM; Lamalva J; Chan T; Cambridge BioTech, Worcester, MA 01605.; We have developed a 5 minute latex based assay for the detection of HIV-1 and HIV-2 antibodies in serum, plasma and whole blood. The assay is performed on the patented Cambridge BioTech Corp. (CBC) Agglutination Slide, which is based on capillary action as the source of kinetic energy, replacing the traditional rotato
HIV-1 antibody screening tests: a comparison of Ortho Diagnostics Recombigen HIV-1 EIA with Genetic Systems viral lysate EIA.: Abstr Gen Meet Am Soc Microbiol. 1992;92:530 (abstract no. V-37). Unique Identifier : AIDSLINE ASM92/93201142; Matzner P; Ballou D; Salyer J; S.E.D. MEDICAL Laboratories, Albuquerque, NM.; Current problems with HIV-1 antibody screening tests include the frequency of false positive results. For this reason we compared the Ortho Diagnostics (Cambridge BioScience) Recombigen (RC) HIV-1 EIA with the Genetic Systems (GS) viral lysate EIA. Sera collected from in-patient and out-patient sources including both
Zidovudine effect on lysozyme activity and release in human granulocytes.: Abstr Gen Meet Am Soc Microbiol. 1992;92:96 (abstract no. D-4). Unique Identifier : AIDSLINE ASM92/93201143; Styrt B; Mummaw N; Michigan State University, East Lansing.; Because there are increasing indications for zidovudine treatment of individuals infected with human immunodeficiency virus, effects of this drug on cells of host defense may have increasing importance. We examined the effect of zidovudine on degranulation responses of human granulocytes to opsonized zymosan (op Z) or
[Evaluation of various tests for the detection of antigen and antibodies in the diagnosis of primary HIV infection]: Enferm Infecc Microbiol Clin. 1990 Aug-Sep;8(7):434-7. Unique Identifier : AIDSLINE MED/93200179; Soriano V; Tor J; Ribera A; Muga R; Rivas-Mundo M; Unidad de Enfermedades Infecciosas, Hospital de Badalona Germans; Trias i Pujol, Universidad Autonoma, Barcelona.; The effectiveness of different methodologies to identify antigenemia and antibodies against HIV at the time of viral primary infection was evaluated. To this end, 6 consecutive serum samples of a patient who had had symptomatic seroconversion were assessed. The detection of antigenemia was earlier than that of antibod
[Pyomyositis in AIDS]: Enferm Infecc Microbiol Clin. 1990 Aug-Sep;8(7):441-2. Unique Identifier : AIDSLINE MED/93200181; Montejo M; Aguirrebengoa K; Urkijo JC; Mendoza F; Prieta R; Mateos I; Gaztelurrutia L; Aguirre C; Servicio de Medicina Interna, Hospital de Cruces, Universidad del; Pais Vasco, Bilbao.; We describe two cases of pyomyositis in two patients with acquired immunodeficiency syndrome. Neither of the two cases had previous history of predisposing factors and both patients began with fever and pain at the site of the lesions. Aspiration by punction was required in addition to the antimicrobial therapy.
[Seasonal changes in various immunological parameters in patients with hay fever]: Pneumonol Alergol Pol. 1991;59(3-4):102-6. Unique Identifier : AIDSLINE MED/93177348; Kruszewski J; II Kliniki Instytutu Medycyny Wewnetrznej Centralnego Szpitala; Klinicznego WAM, Warszawie.; In 25 subjects with pollinosis the following parameters were assessed three times annually (early spring, pollen seasons, autumn): serum IgE levels and allergen specific IgE (asIgE), T lymphocyte subpopulation in peripheral blood. In selected patients allergen specific IgG-4 levels were calculated. All serum parameter
[AIDS vaccine]: Pneumonol Alergol Pol. 1991;59(3-4):146-52. Unique Identifier : AIDSLINE MED/93177356; Sikorska EJ; Zaklad Immunologii Instytutu Gruzlicy i Chorob Pluc.
Dentistry--who is in charge? Ethics in a regulated society.: Ann R Australas Coll Dent Surg. 1991 Oct;11:137-44. Unique Identifier : AIDSLINE MED/93182972; Croxson LJ
Surgical techniques and infectious disease.: Ann R Australas Coll Dent Surg. 1991 Oct;11:218-25. Unique Identifier : AIDSLINE MED/93182980; Story RD; Dentists are at risk of acquiring blood-borne infectious diseases by accidental inoculation whilst performing oral surgical procedures. These risks have been well discussed in the literature and by most assessments are considered to be minimal. They are, however, very real to those at risk. One response to these risks
[Intestinal Microspora infections in a patient with acquired immunodeficiency syndrome]: Rev Med Chil. 1991 May;119(5):559-63. Unique Identifier : AIDSLINE MED/93205919; Oddo D; Chuaqui R; Hofmann E; Garcia M; Departamento de Anatomia Patologica, Escuela de Medicina,; Pontificia Universidad Catolica de Chile, Santiago de Chile.; A 24 year old man with AIDS diagnosed in 1989 and a history of several episodes of pulmonary pneumocystosis developed chronic diarrhea and severe epigastric pain. Endoscopy revealed a granular intestinal mucosa. There was atrophy of villi and Giemsa, Ziehl-Nielsen and Gram staining identified 1.5 to 2 u spores in the
[HTLV-I seroprevalence in blood donors (letter)]: Rev Med Chil. 1991 May;119(5):600. Unique Identifier : AIDSLINE MED/93205926; Sanchez G; Vasquez P
Viral protein cleavages as a drug design target.: Acta Biol Hung. 1991;42(1-3):203-11. Unique Identifier : AIDSLINE MED/93206564; Korant BD; Central Research and Development Department, Du Pont Company; Experimental Station E 328, Wilmington, Delaware 19880-0328.; Many animal and plant viruses encode proteolytic enzymes which are involved in regulation of viral replication and assembly. The proteases are becoming well-characterized, and offer attractive features for the design of selective antiviral agents. Approaches to the assay of viral
Transgenic models of human cancer.: Princess Takamatsu Symp. 1991;22:259-74. Unique Identifier : AIDSLINE MED/93203118; Hinrichs SH; Fontes JD; Bills ND; Schneider PD; Department of Pathology, University of Nebraska Medical Center,; Omaha 68198.; Transgenic animal technology has been useful for the direct demonstration of the tumorigenic potential of oncogenes in vivo. Over the past eight years a wide variety of oncogenes and proto-oncogenes from viral and cellular sources have been inserted into the germline of mice with subsequent development of neoplasia. M
Preventing transfusion-transmitted infections: issues related to migrating populations and increasing world travel.: Haematologia (Budap). 1991;24(4):197-210. Unique Identifier : AIDSLINE MED/93202525; Sandler SG; Fang C; Georgetown University Medical Center, Department of Medicine,; Georgetown University Hospital, Washington, DC 20007.; Blood donations by emigrants or other travelers from distant lands require special attention for the prevention of transfusion-transmitted infections. The human immunodeficiency virus, type 1 (HIV-1) is only one of several bloodborne viruses that may be introduced into non-epidemic areas by transfusion and spread furt
Inability of human immunodeficiency virus to infect human microvascular endothelial cells [letter]: Pathobiology. 1992;60(6):330-1. Unique Identifier : AIDSLINE MED/93176319; Ades EW; Nicholson JK; Browning SW; Comans TW; Centers for Disease Control, Atlanta, GA 30333.
Predictors of condom use in sexually active adolescents.: J Adolesc Health. 1992 Dec;13(8):651-7. Unique Identifier : AIDSLINE MED/93176775; Brown LK; Diclemente RJ; Park T; Department of Child Psychiatry, Rhode Island Hospital, Providence; 02903.; Unprotected sexual intercourse places a substantial number of adolescents at risk for sexually transmitted disease (STD) and human immunodeficiency virus (HIV) infection. While the most effective means of preventing STD/HIV infection among sexually active adolescents is consistent condom use, little is known about the
HIV infected professionals versus patient's rights [news]: Trends Health Care Law Ethics. 1992 Spring-Summer;7(3-4):4-5. Unique Identifier : AIDSLINE MED/93177156
Laboratory reports of human viral and selected non-viral infections in Canada--1991.: Can Commun Dis Rep. 1992 Oct 16;18(19):145-9. Unique Identifier : AIDSLINE MED/93177412
Disseminated coccidioidomycosis in a Canadian patient with chronic HIV infection--Ontario.: Can Commun Dis Rep. 1992 Oct 16;18(19):149-50. Unique Identifier : AIDSLINE MED/93177413; Gold WL; Campbell I; Vellend H; Department of Microbiology, Toronto Hospital, Ontario.
Guidelines for the identification, investigation and treatment of individuals with concomitant tuberculosis and human immunodeficiency virus infection. Canadian Thoracic Society, the Tuberculosis Directors of Canada and the Department of National Health and Welfare.: Can Commun Dis Rep. 1992 Oct 30;18(20):155-60. Unique Identifier : AIDSLINE MED/93177415
Bloodborne pathogens in the health care setting: risk for transmission.: Can Commun Dis Rep. 1992 Dec 25;18(24):177-84. Unique Identifier : AIDSLINE MED/93177422
[Observation on the phenotypic changes of tumor-infiltrating lymphocytes(TIL) during cultivation in vitro]: Chung-hua Ping Li Hsueh Tsa Chih. 1992 Oct;21(5):281-3. Unique Identifier : AIDSLINE MED/93177908; Zhang BX; Department of Pathology, Beijing Medical University.; Tumor-infiltrating lymphocytes (TIL) were isolated from 5 malignant tumors and their phenotypes were analyzed by flow cytometry when co-cultured with recombinant human interleukin-2 (rIL-2). It was shown that 84% (+/- 8%) of TILs were OKT3+in phenotype after three weeks of cultivation. Among these, OKT8+subpopulations
[A case of hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome with spastic paraparesis and severe distal muscle atrophy of lower limbs]: Rinsho Shinkeigaku. 1992 Jul;32(7):729-32. Unique Identifier : AIDSLINE MED/93177997; Shigeto H; Yamada T; Kobayashi T; Goto I; Department of Neurology, Neurological Institute, Faculty of; Medicine, Kyushu University.; A 16-year-old boy with hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome was reported. He was the second child of first-cousin consanguineous parents. Since childhood, he was mentally retarded and had frequent episodes of vomiting but no unconsciousness attack. Because of progressive gait disturbance s
From the dental chair: An HIV patient's views of his dental treatment [interview by Rudy Bianco]: Dentistry. 1992 Feb;12(1):13-5. Unique Identifier : AIDSLINE MED/93178235
Dental school provisions for HIV-positive patients: should students have a choice?: Dentistry. 1992 Feb;12(1):16-9. Unique Identifier : AIDSLINE MED/93178236; DeGrado J
Should it be mandatory for all health professionals to provide documentation concerning their HIV status?: Dentistry. 1992 Feb;12(1):5-6. Unique Identifier : AIDSLINE MED/93178239; Jacoby T
Facts about AIDS.: Dentistry. 1992 Feb;12(1):7-8. Unique Identifier : AIDSLINE MED/93178240; Coyne J
HIV-related gingival and periodontal disorders.: Dentistry. 1992 Feb;12(1):9-12. Unique Identifier : AIDSLINE MED/93178241; Bianco R
Fatal necrotizing esophagitis due to Penicillium chrysogenum in a patient with acquired immunodeficiency syndrome.: Eur J Clin Microbiol Infect Dis. 1992 Dec;11(12):1158-60. Unique Identifier : AIDSLINE MED/93178463; Hoffman M; Bash E; Berger SA; Burke M; Yust I; Department of Internal Medicine A, Sourasky Medical Center,; Tel-Aviv University, Sackler School of Medicine, Tel-Aviv,; Israel.; Although blue-green molds of the genus Penicillium are ubiquitous in the human environment, invasive penicilliosis is uncommon and primarily encountered among immunosuppressed patients. A patient with HIV infection who died of severe necrotizing esophagitis caused by Penicillium chrysogenum is reported and the relevan
Influence on survival of p24 antigen levels in patients with AIDS or advanced AIDS related complex treated with zidovudine.: Eur J Clin Microbiol Infect Dis. 1992 Dec;11(12):1181-5. Unique Identifier : AIDSLINE MED/93178470; Zamora L; Gatell JM; Barrera JM; Ercilla G; Gil C; Buira E; Miro JM; Soriano E; Infectious Disease Unit, University Hospital, Faculty of; Medicine, Barcelona, Spain.; In a prospective study sixty-eight patients consecutively diagnosed as having AIDS or advanced ARC who were started on zidovudine therapy were followed up for a median period of 725 days. In the 20 patients who had a baseline p24 antigen level above 20 pg/ml, there was a statistically significant trend towards reducti
Oral care of the HIV-infected patient.: Dent Update. 1992 Mar;19(2):56-8. Unique Identifier : AIDSLINE MED/93178711; Samaranayake LP; Prince Philip Dental Hospital, Hong Kong.; There are only a small number of specialized centres that cater for the dental care of the steadily increasing number of HIV-infected individuals. The responsibility will, therefore, be increasingly shared with the dental practitioner who should be knowledgeable on the basic oral management protocols involved in treat
Developing an effective occupational exposure policy for the dental office.: Gen Dent. 1992 Sep-Oct;40(5):379-81, 386, 388. Unique Identifier : AIDSLINE MED/93178879; Leonard RH Jr; Eagle JC Jr; Department of Dental Ecology, University of North Carolina School; of Dentistry, Chapel Hill.
Hormonal and immunological pattern in a patient with acquired immunodeficiency syndrome related complex and Cushing's syndrome.: J Endocrinol Invest. 1992 Dec;15(11):849-52. Unique Identifier : AIDSLINE MED/93179706; Rossi R; Tommaselli AP; Panza N; Ghiggi MR; Rezza G; Giuliani M; Suligoi B; De Mercato R; Lombardi G; Cattedra di Endocrinologia, II Facolta di Medicina e Chirurgia,; Universita di Napoli, Italy.; A case of Cushing s syndrome in a 24-yr-old homosexual with an AIDS-related complex is reported. In this patient certain symptoms common to both diseases, i.e. weakness, myalgia and muscle atrophy were accentuated, whereas other symptoms pathognomic of the human immunodeficiency virus (HIV) infection, i.e. lymphoadeno
LUDI: rule-based automatic design of new substituents for enzyme inhibitor leads.: J Comput Aided Mol Des. 1992 Dec;6(6):593-606. Unique Identifier : AIDSLINE MED/93179904; Bohm HJ; BASF AG, Central Research, Ludwigshafen, Germany.; Recent advances in a new method for the de novo design of enzyme inhibitors are reported. A new set of rules to define the possible nonbonded contacts between protein and ligand is presented. This method was derived from published statistical analyses of nonbonded contacts in crystal packings of organic molecules and
OSHA's bloodborne pathogen rule what is the role of the dentist?: J Okla Dent Assoc. 1992 Fall;83(2):38-44. Unique Identifier : AIDSLINE MED/93180068; Coury T; Willer R; Miller R; Fruits T; Department of Operative Dentistry, University of Oklahoma College; of Dentistry.
A vertically transmitted HIV-1 gag-subtype variant detected in Taiwan.: Jpn J Med Sci Biol. 1992 Jun;45(3):127-36. Unique Identifier : AIDSLINE MED/93180357; Guo HG; Chang KS; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.; We used polymerase chain reaction (PCR) to amplify a segment, about 560 base pairs (bp), of HIV-1 gag DNA prepared from peripheral blood mononuclear cells of a seropositive Taiwanese pair of mother and infant. TM-1 and TC-1 clones of PCR-amplified DNA derived from the mother and infant, respectively, showed a 94.5% ho
Anticipating Annapolis 1993: an interview with Jose Martinez, M.D., Med Chi Legislative Committee chairperson [interview by Betsy Newman]: Md Med J. 1992 Dec;41(12):1089-92. Unique Identifier : AIDSLINE MED/93180609; Martinez J
Cutaneous phaeohyphomycosis due to Cladosporium cladosporioides.: Mycoses. 1992 Sep-Oct;35(9-10):243-6. Unique Identifier : AIDSLINE MED/93180859; Annessi G; Cimitan A; Zambruno G; Di Silverio A; Clinica Dermatologica, Universita di Modena, Italy.; A 54-year-old man, affected by pemphigus vulgaris and severe steroid-induced diabetes, developed seven red-brown, firm, slightly raised 0.1-1 cm papular lesions on the anterior aspect of both knees and thighs. A cutaneous biopsy showed a granulomatous infiltrate with numerous fungal elements scattered in the dermis an
The risk of transmission of human immunodeficiency virus in dental practice.: Oral Health. 1992 May;82(5):33-4, 37-8. Unique Identifier : AIDSLINE MED/93181030; Epstein JB; Scully C; Porter SR; Vancouver General Hospital.; After a decade of study of the acquired immunodeficiency syndrome (AIDS) there is evidence to address the concerns of dental staff about possible transmission of human immunodeficiency virus (HIV). This paper reviews that evidence which demonstrates an extremely low risk of transmission of HIV to staff and patients. O
AIDS in Spain.: Nurs Times. 1992 Dec 16-29;88(51):50-1. Unique Identifier : AIDSLINE MED/93181309; Sanchis C
Learning disabilities. Sexual awareness.: Nurs Times. 1992 Dec 16-29;88(51):62-4. Unique Identifier : AIDSLINE MED/93181314; McCarthy M
Mandatory teaching to boost AIDS awareness demanded [news]: Nurs Times. 1992 Dec 16-29;88(51):9. Unique Identifier : AIDSLINE MED/93181317; Tattam A
Canada's first hospital dental clinic for patients with HIV infection.: Probe. 1992 Summer;26(2):59-64. Unique Identifier : AIDSLINE MED/93181424; Wooley C
A hospital-based dental clinic for patients with HIV infection in the United States.: Probe. 1992 Summer;26(2):65-8. Unique Identifier : AIDSLINE MED/93181425; Cohen PA; Wilkins EM; Department of Periodontology, Tufts University School of Dental; Medicine, Boston, Massachusetts.
It's your right ... or is it?: RDH. 1992 Sep;12(9):36, 38, 40. Unique Identifier : AIDSLINE MED/93181553; DeVore C
Say it isn't so... [editorial]: SCI Nurs. 1992 Dec;9(4):108. Unique Identifier : AIDSLINE MED/93181738; Thomason SS
[The prevention of HIV infection in the army and navy]: Vrach Delo. 1992 Nov-Dec;(11-12):104-6. Unique Identifier : AIDSLINE MED/93182393; Dmitriev VI; Platonova TN; In the course of 5 years 121 foreign and 13 Soviet military servicemen showed HIV infection; seven of them (officers and warrant officers) are still in service. As distinct from WHO requirements symptomless virus carriers are also registered. Infected servicemen constitute 1.5% from the total number of infected in the
OSHA regulations relating to bloodborne diseases.: Va Dent J. 1992 Jul-Sep;69(3):47-8. Unique Identifier : AIDSLINE MED/93182487; Grier RL
[She makes the best of a necessary evil. Barbro praised for care in Gula Villan]: Vardfacket. 1992 Aug 7;16(12):4-6. Unique Identifier : AIDSLINE MED/93182519; Forslind E
Evaluation of the cryptococcal antigen test as a diagnostic tool of AIDS-associated cryptococcosis in Rwanda.: Ann Soc Belg Med Trop. 1992 Dec;72(4):283-8. Unique Identifier : AIDSLINE MED/93183042; Swinne D; Bogaerts J; Van de Perre P; Batungwanayo J; Taelman H; Laboratory of Mycology, Institute of Tropical Medicine,; Antwerpen, Belgium.; To evaluate the latex test, two different retrospective studies were undertaken. A positive culture for Cr. neoformans was used as the golden standard of active cryptococcal infection. 439 sera selected at random sent to the NSP laboratory for screening of HIV antibody were tested as well as--71 CSF from patients with
[High prevalence of konzo associated with a food shortage crisis in the Bandundu region of zaire]: Ann Soc Belg Med Trop. 1992 Dec;72(4):295-309. Unique Identifier : AIDSLINE MED/93183044; Banea M; Bikangi N; Nahimana G; Nunga M; Tylleskar T; Rosling H; Centre National de Planification de Nutrition Humaine, Kinshasa,; Zaire.; Konzo is a form of spastic paraparesis reported from several rural areas in Sub-Saharan Africa. It has been attributed to cyanide exposure from exclusive consumption of insufficiently processed bitter cassava roots. We have tested this attribution in a community based epidemiological survey in an area of Bandundu regi
[Current problems in syphilis (editorial)]: Enferm Infecc Microbiol Clin. 1992 Dec;10(10):573-5. Unique Identifier : AIDSLINE MED/93184021; Borobio Enciso MV
[Tuberculous meningitis in patients without HIV infection. Presentation of 21 cases]: Enferm Infecc Microbiol Clin. 1992 Dec;10(10):576-80. Unique Identifier : AIDSLINE MED/93184022; Arzuaga JA; de la Fuente J; Tebas P; Perez R; Masa C; Martinez J; de Letona ML; Servicio de Medicina Interna II, Universidad Autonoma, Madrid.; BACKGROUND: Tuberculous meningitis accounts for 5% to 12% of all extrapulmonary tuberculosis cases in western-hemisphere population non infected by HIV virus, and carries a high mortality rate. METHODS: We analyze retrospectively 21 patients with tuberculous meningitis in HIV negative patients seen from 1975 to 1989,
[Pulmonary cryptococcosis in AIDS]: Enferm Infecc Microbiol Clin. 1992 Dec;10(10):607-10. Unique Identifier : AIDSLINE MED/93184028; Martos A; Mascaro J; Santin M; Ariza J; Carratala J; Podzamczer D; Servicio de Enfermedades Infecciosas, Hospital de; Bellvitge-Princeps d'Espanya, Barcelona.; We present here three AIDS patients with disseminated cryptococcal infection and lung involvement. Two patients presented with respiratory symptoms and in the third one, pulmonary disease was only a radiologic finding. Chest X-ray films showed an interstitial pattern in two cases and pulmonary cavitation in one case.
[Coinfection by Nocardia asteroides and Mycobacterium avium- intracellulare in a patient with AIDS (letter)]: Enferm Infecc Microbiol Clin. 1992 Dec;10(10):630-1. Unique Identifier : AIDSLINE MED/93184039; Trinidad JM; Teira R; Zubero S; Santamaria JM
Human B cell lines express the interferon gamma gene.: Cytokine. 1992 Nov;4(6):454-60. Unique Identifier : AIDSLINE MED/93184147; Dayton MA; Knobloch TJ; Benjamin D; Department of Internal Medicine, Ohio State University; Comprehensive Cancer Center/Arthur G. James Cancer Hospital and; Research Institute, Columbus 43210.; Interferon gamma (IFN-gamma) production has been attributed exclusively to activated T cells and NK cells. We sought to determine whether human B cells express IFN-gamma. We studied 28 B cell lines including Epstein-Barr virus (EBV)+ normal lymphoblastoid B cell lines (N = 7), EBV+ B cell lines derived from patients w
Critical sites: a semantic approach to protein sequences. Application to the HIV-1 envelope molecule.: Biomed Pharmacother. 1992;46(8):343-51. Unique Identifier : AIDSLINE MED/93184169; Zagury JF; Cantalloube H; Bernard J; Lachgar A; Fall L; Achour A; Mbika JP; Cosme MH; Pellion F; Issing W; et al; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; We have designed two software systems allowing the study of proteins through a comparison to those stored in data banks. The first one, Automat, locates in a systematic manner all identities shared by a given protein and the proteins in a data bank. The second, Critic enables the selection of specific segments in a gi
Removal of gp160 induced bio-hazards for a safe AIDS vaccine candidate.: Biomed Pharmacother. 1992;46(8):353-7. Unique Identifier : AIDSLINE MED/93184170; Picard O; Bernard J; Lachgar A; Fall L; Carlotti M; Achour A; Carelli C; Salaun JJ; Mbika JP; Lurhuma Z; et al; Hopital St Antoine (Service du Prof Inbert), Paris.; In the first AIDS vaccine trial, immunizing preparations were based on HIV-1 Env protein (gp160). Immunogenic properties of gp160 which trigger both a humoral and cellular immune response have since justified its use in various vaccine programs, both past and present. Many reports however have underlined deleterious e
Cell-mediated immunity against HGP-30, a group-specific peptide of HIV p17 in individuals infected with the AIDS virus.: Biomed Pharmacother. 1992;46(8):359-65. Unique Identifier : AIDSLINE MED/93184171; Willer A; Achour A; Mbika JP; Laaroubi K; Lachgar A; Nihrane A; Picard O; Naylor PH; Sarin PS; Goldstein AL; et al; Universite Pierre et Marie Curie, Paris, France.; HGP-30, the synthetic peptide analogue and active component in an HIV-1 (human immunodeficiency virus, type 1) p 17 core-based experimental vaccine, has previously been shown to induce cytotoxic and helper T-lymphocyte responses. In order to further define the T-helper cell responses which are known to play a role in
HIV-associated tuberculosis in developing countries: epidemiology and strategies for prevention [see comments]: Tuber Lung Dis. 1992 Dec;73(6):311-21. Unique Identifier : AIDSLINE MED/93184281; Narain JP; Raviglione MC; Kochi A; Tuberculosis Programme, World Health Organization, Geneva,; Switzerland.; The association between tuberculosis and HIV presents an immediate and grave public health and socioeconomic threat, particularly in the developing world. In early 1992 WHO estimated that approximately 4 million people had been infected with both Mycobacterium tuberculosis and HIV since the beginning of the pandemic;
Comparative antigenic analysis of Mycobacterium avium complex (MAC) isolates from AIDS patients.: Tuber Lung Dis. 1992 Dec;73(6):356-61. Unique Identifier : AIDSLINE MED/93184288; Deshpande RG; Khan MB; Navalkar G; Department of Microbiology and Immunology, Morehouse School of; Medicine, Atlanta, Georgia 30310.; Sonicates of several Mycobacterium avium complex (MAC) strains isolated from acquired immunodeficiency syndrome (AIDS) patients were characterized in order to study the prominent antigens of these strains. Sonicates of 6-week-old cultures were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-
Nosocomial transmission of multidrug-resistant tuberculosis between AIDS patients [letter]: Tuber Lung Dis. 1992 Dec;73(6):397-8. Unique Identifier : AIDSLINE MED/93184298; Cotte L; Fougerat F; Trepo C
Another view to blood and body substance precaution: 1988-91 [see comments]: Can J Infect Control. 1992 Winter;7(4):107-10. Unique Identifier : AIDSLINE MED/93184350; Dixon C; Bertrand C; McLean AP; Tousignant P; Groome P; Occupational transmission of human immunodeficiency virus (HIV) in hospitals can be prevented with the use of blood and body substance precaution . At the Royal Victoria Hospital, an infection control objective is to get employees automatically to use blood and body substance precaution with all patients--without rel
[Analysis of new criteria for increasing the specificity of commercial Western blots]: Bull Soc Pathol Exot. 1992;85(5):338-41. Unique Identifier : AIDSLINE MED/93184533; Gershy-Damet GM; Koffi K; Soro B; Sanon S; Traore M; Assoa A; N'Goran K; N'Gom A; Laboratorie des retrovirus, Institut Pasteur de Cote-d'Ivoire.; We examined the frequency of serum cross-reactivity on Western blot for HIV1 and HIV2. 661 patients with tuberculosis in Abidjan, and 4,899 asymptomatic persons for HIV1 and HIV2 infections were tested. All specimens positive on ELISA for HIV1 or HIV2 were further characterized by synthetic peptide based tests. Confir
Evaluation in vitro of T-cell mediated immunity in patients with atopic disease. Effects of thymic hormone therapy. I. Phenotypic features of peripheral T-lymphocytes.: Pneumonol Alergol Pol. 1992;60 Suppl 1:76-80. Unique Identifier : AIDSLINE MED/93184797; Dabrowska-Bernstein B; Smietanka R; Malec I; Rychlicka J; Dabrowski MP; Immunology Department, Central Clinical Hospital, Warsaw.
High dose aerosol pentamidine for secondary Pneumocystis carinii pneumonia prophylaxis in AIDS patients.: Infection. 1992 Nov-Dec;20(6):309-12. Unique Identifier : AIDSLINE MED/93186238; Flamholc L; Haidl S; Westin E; Borgdalen L; Prellner T; Dept. of Infectious Diseases, Malmo General Hospital, University; of Lund, Sweden.; In a prospective trial of aerosolized pentamidine as secondary prophylaxis for Pneumocystis carinii pneumonia (PCP) 18 patients received 400 mg once weekly for a mean period of 15.5 months. Pentamidine aerosol was administered with an MA2 jet nebulizer. No PCP relapses were observed and no serious side effects occurre
Cerebrospinal fluid neopterin and beta 2-microglobulin levels in neurologically asymptomatic HIV-infected patients before and after initiation of zidovudine treatment.: Infection. 1992 Nov-Dec;20(6):313-5. Unique Identifier : AIDSLINE MED/93186239; Hagberg L; Norkrans G; Andersson M; Wachter H; Fuchs D; Dept. of Infectious Diseases, University of Goteborg, Ostra; Hospital, Sweden.; The effect of zidovudine on beta 2-microglobulin and neopterin in the cerebrospinal fluid (CSF) was studied in ten HIV-seropositive neurologically healthy individuals. CSF concentrations of neopterin decreased by 53% (from 20.3 to 9.5 nmol/l, p
Risk factors of HIV-1 infection among female prostitutes in Khon Kaen, Northeast Thailand.: Infection. 1992 Nov-Dec;20(6):328-31. Unique Identifier : AIDSLINE MED/93186243; Rehle T; Brinkmann UK; Siraprapasiri T; Coplan P; Aiemsukawat C; Ungchusak K; Deutsche Gesellschaft fur Technische Zusammenarbeit, Eschborn,; Germany.; HIV infection has increased to epidemic proportions in Thailand since 1987. There have been separate epidemics among population groups at high risk of infection and significant increases in different localities. The northeast region of Thailand has been affected by the epidemic s
Monoclonal antibodies recognising pol and env proteins of mammalian retroviruses.: Intervirology. 1992;34(2):112-6. Unique Identifier : AIDSLINE MED/93186354; Nishimura N; Kato S; Ishikawa H; Takano T; Department of Microbiology, Keio University School of Medicine,; Tokyo, Japan.; Mouse monoclonal antibodies were generated for three 20- to 23-mer synthetic peptides whose amino acid sequences were highly conserved in the pol or env regions of 14 mammalian and two avian retroviruses. By Western-blot analysis, these antibodies recognised the epitopes in major and minor pol or env proteins of six m
Transmission studies with simian immunodeficiency virus of macaques; persistent infection of baboons.: Intervirology. 1992;34(2):53-61. Unique Identifier : AIDSLINE MED/93186355; Cranage MP; Cook N; Stott EJ; Cook R; Baskerville A; Greenaway PJ; Division of Pathology, PHLS Centre for Applied Microbiology and; Research, Porton Down, Salisbury, UK.; The host range of SIVmac was investigated in three monkey species. Blood-borne and cell-adapted virus inocula obtained from a rhesus macaque infected with SIVmac251 were compared. African green monkeys were not susceptible to infection, whereas baboons and rhesus macaques became persistently infected and showed simila
World AIDS Day 1992--how veterinarians are helping [news]: J Am Vet Med Assoc. 1992 Dec 1;201(11):1663. Unique Identifier : AIDSLINE MED/93186460; Spencer L
Pets prove therapeutic for people with AIDS [news]: J Am Vet Med Assoc. 1992 Dec 1;201(11):1664-8. Unique Identifier : AIDSLINE MED/93186461; Spencer L
Encountering AIDS--a personal perspective [news]: J Am Vet Med Assoc. 1992 Dec 1;201(11):1667. Unique Identifier : AIDSLINE MED/93186462; Spencer L
Study explores health risks and the human/animal bond [news] [see comments]: J Am Vet Med Assoc. 1992 Dec 1;201(11):1669. Unique Identifier : AIDSLINE MED/93186463; Spencer L
Essex reveals new gene therapy for AIDS [news]: J Am Vet Med Assoc. 1992 Dec 1;201(11):1673-4. Unique Identifier : AIDSLINE MED/93186466; Spencer L
Immunodeficiency syndrome makes cats desirable HIV research model [news]: J Am Vet Med Assoc. 1992 Dec 1;201(11):1674-5. Unique Identifier : AIDSLINE MED/93186467; Kahler S
Veterinarian with HIV infection shares views [news]: J Am Vet Med Assoc. 1992 Dec 1;201(11):1676. Unique Identifier : AIDSLINE MED/93186468; Spencer L
Veterinarian writes musical tribute for AIDS victims [news]: J Am Vet Med Assoc. 1992 Dec 1;201(11):1676. Unique Identifier : AIDSLINE MED/93186469
The veterinarian's role in the AIDS crisis.: J Am Vet Med Assoc. 1992 Dec 1;201(11):1683-4. Unique Identifier : AIDSLINE MED/93186471; Gill DM; Stone DM; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman 99164.
An AIDS patient with atopic dermatitis-like eruption responsive to systemic anti-fungal treatment.: J Dermatol. 1992 Dec;19(12):972-5. Unique Identifier : AIDSLINE MED/93187179; Hoashi M; Imayama S; Hori Y; Kashiwagi S; Department of Dermatology, Faculty of Medicine, Kyushu; University, Fukuoka, Japan.; Patients with the acquired immunodeficiency syndrome (AIDS) often develop unusual skin complications. We describe a case of a 58-year-old man with AIDS who had a history of multiple transfusions with anti-hemophilic factor A. He developed papulovesicular and lichenified skin lesions on his head, face, neck and the ext
Diagnosis of mycobacterial infection in acquired immunodeficiency syndrome (AIDS) patients and HIV carriers.: J Hyg Epidemiol Microbiol Immunol. 1992;36(3):293-302. Unique Identifier : AIDSLINE MED/93187355; Martin-Casabona N; Ocana Rivera I; Vidal Pla R; Codina Grau G; Cayla JA; Gonzalez Fuente T; Servicio de Microbiologia y Parasitologia, Ciudad Sanitaria; Universitaria Vall d'Hebron, Barcelona, Spain.; Differences in tuberculosis diagnosis between infected and non-infected HIV patients were described. In Barcelona, tuberculosis is present in 41.6% of 851 patients in whom AIDS was detected between 1981 and the first quarter of 1990. We reviewed the results of the methods used for tuberculosis diagnosis in 270 AIDS pa
AIDS and the Rehabilitation Act.: Nursingconnections. 1992 Winter;5(4):25-7. Unique Identifier : AIDSLINE MED/93189001; Philipsen N
[Prevalence of HIV antigens in cerebrospinal fluid and in serum of patients with both asymptomatic and symptomatic HIV infection]: Pol Tyg Lek. 1992 Sep 7-14;47(36-37):784-6. Unique Identifier : AIDSLINE MED/93189431; Radkowski M; Laskus T; Kopicz-Kaminska E; Mian M; Babiuch L; Slusarczyk J; Zakladu Immunopatologii, Kliniki Nabytych Niedoborow; Immunologicznych Instytutu Chorob Zakaznych i Pasozytniczych,; Warszawie.; Prevalence of HIV-Ag in both serum and CSF has been determined in 19 HIV infected patients, including 7 patients without any symptoms or only generalized lymphadenopathy, 5 patients with ARC and 7 patients with AIDS. The results have been correlated with clinically evident neurological disorders. HIV-Ag have been dete
[Quantitative assay of CD8+ (cytotoxic and suppressor) lymphocytes in patients with both asymptomatic and symptomatic HIV infection]: Pol Tyg Lek. 1992 Sep 7-14;47(36-37):787-9. Unique Identifier : AIDSLINE MED/93189432; Radkowski M; Laskus T; Kopicz-Kaminska E; Babiuch L; Slusarczyk J; Zakladu Immunopatologii, Kliniki Nabytych Niedoborow; Immunologicznych Instytutu Chorob Zakaznych i Pasozytniczych,; Warszawie.; Lymphocytes CD8+ have been assayed prospectively in 245 individuals infected with HIV. Percentage and number of CD8+ have been nearly two-fold higher in asymptomatic patients or patients with lymphadenopathy than those in the control group. The number of CD8+ lymphocytes has been rapidly decreasing parallel to the pro
[Hepatobiliary manifestations in AIDS in adults. Place of cholecystectomy]: Presse Med. 1992 Nov 28;21(40):1901-4. Unique Identifier : AIDSLINE MED/93189540; Wind P; Sales JP; Lowenstein W; Berger A; Frileux P; Cugnenc PH; Service de Chirurgie digestive et generale, Hopital Laennec,; Paris.; In AIDS patients an acalculous cholecystitis may be responsible for abdominal pain subsiding after cholecystectomy. But the indications for cholecystectomy are not clear: cholecystitis is usually associated with diffuse cholangitis and this might cause the symptoms. Since 1985, 8 AIDS patients have undergone cholecyst
[Otorhinolaryngologic localization of malignant lymphomas associated with HIV infection. A new factor in erroneous prognosis? (letter)]: Presse Med. 1992 Nov 28;21(40):1915. Unique Identifier : AIDSLINE MED/93189547; Garnier G; Taillan B; Pesce A; Fuzibet JG; Cassuto JP; Dujardin P
[Social treatment of AIDS]: Rev Infirm. 1992 Oct;42(16):21-3. Unique Identifier : AIDSLINE MED/93189977; Burrus O
[Justice and AIDS (news)]: Rev Infirm. 1992 Nov;42(17):8. Unique Identifier : AIDSLINE MED/93189993
[Information on AIDS in industry (news)]: Rev Infirm. 1992 Nov;42(18):6. Unique Identifier : AIDSLINE MED/93190004
[AIDS--hemophiliacs' risk of dying before The European Human Rights Commission]: Sygeplejersken. 1992 Oct 7;92(41):28. Unique Identifier : AIDSLINE MED/93190222
[Information to relatives--when patients isolate themselves (interview by Grethe Kjaergaard)]: Sygeplejersken. 1992 Oct 14;92(42):23-5. Unique Identifier : AIDSLINE MED/93190228; Erdmann L
[In the wings]: Sygeplejersken. 1992 Oct 14;92(42):24-5. Unique Identifier : AIDSLINE MED/93190229; Hansen FT
[The immunorehabilitative action of thymohexin in treating patients with chronic brucellosis]: Ter Arkh. 1992;64(11):22-6. Unique Identifier : AIDSLINE MED/93190245; Pokrovskii VI; Suleimanov AK; Lebedev VV; Zheludkov MM; Kizenko OA; Shmarov DA; Moskaleva EIu; Karaulov AV
Diffusion and focus in sexual networking: identifying partners and partners' partners.: Stud Fam Plann. 1992 Nov-Dec;23(6 Pt 1):343-51. Unique Identifier : AIDSLINE MED/93190349; Orubuloye IO; Caldwell JC; Caldwell P; Faculty of Social Sciences, Ondo State University, Ado-Ekiti,; Nigeria.; This article describes the second stage of a research project on sexual networking that aims to further understanding of the spread of sexually transmitted diseases and HIV/AIDS in Ondo State, Nigeria . A sample of 488 males aged 15-50 were interviewed in depth to ascertain (1) the
Leprosy in HIV-positive and syphilitic young Paraguayan man.: Acta Leprol. 1992;8(2):103-4. Unique Identifier : AIDSLINE MED/93190745; Graf von Ballestrem W; Alvarenga A; Namiki M; Leprosy Laboratory, German Leprosy Relief Association, Asuncion,; Paraguay.; In a borderline lepromatous patient a positive serology for syphilis and HIV 1 has been detected. The patient also had an urinary tract infection with Acinetobacter calcoaceticus. In Paraguay up till now no leprosy cases infected wi
The role of cytokines in AIDS-dementia complex.: Acta Neurol (Napoli). 1992 Aug-Dec;14(4-6):342-4. Unique Identifier : AIDSLINE MED/93190870; Perrella O; Finelli L; Carrieri PB; Ospedale D. Cotugno, Napoli.
Cerebral toxoplasmosis and AIDS. Clinical, neuroradiological and immunological findings in 15 patients.: Acta Neurol (Napoli). 1992 Aug-Dec;14(4-6):493-502. Unique Identifier : AIDSLINE MED/93190885; Orefice G; Carrieri PB; Chirianni A; Rubino S; Liuzzi G; Napolitano G; Rocco A; Second Neurologic Clinic, Medical School, Federico II University,; Naples.; Cerebral toxoplasmosis is the most common cause of focal CNS disease complicating AIDS and its incidence ranges from 3% to 40% of such patients. This opportunistic infection is generally due to reactivation of chronic toxoplasmosis as a consequence of severe immune deficiency. We present the clinical, neuroradiologica
Knowledge, attitudes and practices of Greek health professionals, in relation to AIDS.: Eur J Epidemiol. 1992 Nov;8(6):812-5. Unique Identifier : AIDSLINE MED/93193774; Roumeliotou A; Kornarou E; Papaevangelou V; Spiropoulou P; Ktenas E; Stergiou G; Papaevangelou G; Athens School of Public Health. Dept. of Epidemiology and Medical; Statistics, Greece.; In order to improve educational programmes directed at health care workers we investigated their knowledge, attitudes and practices in relation to HIV/AIDS. An anonymous self-administered questionnaires was distributed to 609 health care workers. Of these, 59.6% agreed to participate (42.4% of the medical doctors, 74.
HIV-1 infection in Italian blood donors during a 5 year surveillance [letter]: Eur J Epidemiol. 1992 Nov;8(6):885-6. Unique Identifier : AIDSLINE MED/93193788; Ferroni P; Mascolo G; Zaninetti M; Colzani D; Pasquali M; Azzario F
Acquired immunodeficiency syndrome (AIDS) with lymphocytic interstitial pneumonitis (LIP) in a multi transfused child with thalassemia major.: Indian Pediatr. 1992 Nov;29(11):1413-7. Unique Identifier : AIDSLINE MED/93194314; Sen S; Goyal RS; Kumar A; Pande I; Khare SD; Chattopadhya D; Malaviya AN; Department of Pediatrics, Charak Palika Hospital, Moti Bagh, New; Delhi.
HIV/AIDS and sexual health.: Health Visit. 1992 Nov;65(11):397-8. Unique Identifier : AIDSLINE MED/93194569; Massey DE; In including HIV/Aids and sexual health as key areas, The health of the nation stresses that good personal and sexual relationships can actively promote health and well-being . This is a central concept, presenting challenges for professionals working in education and health writes Doreen E Massey, director of the Fa
Significant anti-HIV activity of new modified polyanionic polymers in vitro.: Immunopharmacol Immunotoxicol. 1992;14(4):707-21. Unique Identifier : AIDSLINE MED/93195238; Buckheit RW Jr; White EL; Shannon WM; Guerrero A; Pivel JP; Carrasco L; Leal JA; Chirigos MA; Southern Research Institute, Birmingham, Alabama.; The anti-HIV activities of two new polyanionic polymers (AM 242 and AM 612) were investigated in cell culture-based and biochemical antiviral assays. These compounds inhibited the reverse transcriptases from HIV-1 and HIV-2, using enzyme purified from virions and either a ribosomal RNA or gapped duplex DNA as the temp
Chronic idiopathic esophageal ulceration in the acquired immunodeficiency syndrome. Characterization and treatment with corticosteroids.: J Clin Gastroenterol. 1992 Dec;15(4):284-90. Unique Identifier : AIDSLINE MED/93195264; Kotler DP; Reka S; Orenstein JM; Fox CH; Department of Medicine, St. Luke's-Roosevelt Hospital Center, New; York, New York 10025.; Study objectives were to characterize the clinical syndrome of chronic idiopathic esophageal ulceration in patients with acquired immunodeficiency syndrome (AIDS), to determine the extent of local human immunodeficiency virus (HIV) infection, and to evaluate the effect of corticosteroid therapy upon symptoms and heali
[A case of perinatal transmission of human immunodeficiency virus--diagnosis of HIV infection by culture and PCR]: Kansenshogaku Zasshi. 1992 Nov;66(11):1587-91. Unique Identifier : AIDSLINE MED/93195428; Hachimori K; Negishi M; Ajisawa A; Minamitani M; Honda M; Department of Infectious Disease, Tokyo Metropolitan Komagome; Hospital.; A child born from a mother with HIV infection was reported. We have followed the patient from 3 month old of age. Her HIV antibody disappeared at 7 month by EIA, and at 10 month by WR. But we confirmed her HIV infection by PCR and HIV culture, repeatedly at those times, PCR and HIV culture are thought to be necessary
Monitoring for HIV-1, HIV-2, HTLV-I sero-progression and sero-conversion in a population at risk in east Africa.: J Egypt Public Health Assoc. 1992;67(5-6):535-47. Unique Identifier : AIDSLINE MED/93195471; Constantine NT; Fox E; Rodier G; Abbatte EA; U.S. Naval Medical Research Unit No. 3, Cairo, Egypt.; Thirty-three individuals from East Africa, at risk for acquiring sexually transmitted infections, were selected to be monitored over a five month period for evidence of sero-progression and/or sero-conversion for human immunodeficiency virus type-1 and type-2 (HIV-1, HIV-2), and human T cell leukemia virus type-1 (HTL
[Imaging of HIV+ abdominal involvements]: J Radiol. 1992 Oct;73(10):501-13. Unique Identifier : AIDSLINE MED/93195805; Schmutz GR; Chhem RK; Regent D; Caya J; Angers A; Departement de Radiologie, CHUS, Universite de Sherbrooke,; Quebec, Canada.; Abdominal symptoms are among the most frequent complaints of patients with AIDS. Because precise diagnosis from symptoms alone is difficult, the contribution of radiologist is important to fill in evaluating the cause of various illnesses. The review describes common clinical symptoms and lists the most likely causes
[Anguilluliasis of the small intestine and AIDS. A case and review of the literature]: J Radiol. 1992 Oct;73(10):523-6. Unique Identifier : AIDSLINE MED/93195807; Rabenandrasana A; Soyer P; Levesque M; Service de Radiologie, Hopital Louis-Mourier, Colombes.; The authors report about one patient with an Acquired Immune Deficiency Syndrome (AIDS) presenting with strongyloidiasis involving the small bowel. On the basis of this observation, they describe the appearances of small bowel involvement by strongyloidiasis in patients with AIDS. They emphasize the main features diff
Septic arthritis in patients with acquired immunodeficiency syndrome with human immunodeficiency virus infection.: J Rheumatol. 1992 Dec;19(12):1960-2. Unique Identifier : AIDSLINE MED/93195887; Rivera J; Monteagudo I; Lopez-Longo J; Sanchez-Atrio A; Servicio de Reumatologia, Hospital General Gregorio Maranon,; Madrid, Spain.; We have evaluated the presence and characteristics of septic arthritis in intravenous (iv) drug users with human immunodeficiency virus (HIV) infection. Sixteen patients with both HIV infection and septic arthritis were studied and compared with 5 patients with septic arthritis but no HIV infection. Clinical profile,
[A task force on AIDS (letter)]: Minerva Anestesiol. 1992 Dec;58(12):1347. Unique Identifier : AIDSLINE MED/93196953; Ravagnan R
[Relationship between skin hyperpigmentation in AIDS and serum alpha-Melanocyte Stimulating Hormone level (letter)]: Presse Med. 1992 Dec 5;21(42):2062. Unique Identifier : AIDSLINE MED/93197269; Lacour JP; Ghanem G; Dellamonica P; Cassuto JP; Ortonne JP
[Absence of HIV 1/HTLV I autochtonous coinfection in the region of Nice (letter; comment)]: Presse Med. 1992 Dec 5;21(42):2064. Unique Identifier : AIDSLINE MED/93197271; Quaranta JF; Ferrari P; Tirtaine C; Sanderson F; Follana R; Cassuto JP; Dellamonica P
[Primary non-Hodgkin's malignant lymphoma of the central nervous system]: Rev Neurol (Paris). 1992;148(10):589-600. Unique Identifier : AIDSLINE MED/93197760; Monjour A; Poisson M; Kujas M; Delattre JY; Service de Neurologie, Centre Hospitalier General Louis,; Pasteur, Colmar.; The incidence of primary central nervous system lymphoma (PCNSL) is increasing, not only in immunodeficiency states, but also in apparently normal individuals. The most common presentation of PCNSL is that of an intracranial mass lesion. Ocular involvement is associated in 20% of patients. CT/MR scan typically shows o
[Comparison of tacrine hepatotoxicity in patients with Alzheimer disease or AIDS]: Therapie. 1992 May-Jun;47(3):245-7. Unique Identifier : AIDSLINE MED/93198063; Fredj G; Dietlin F; Barbier G; Jasmin C; Bonhomme L; Esctein S; Misset JL; Meyer P; Kalifa D; Beugre T; Hopital Paul Brousse, Villejuif.; Previously used in Alzheimer disease Tacrine (THA): tetrahydroaminoacridine has shown a rise of hepatic transaminase enzyme activity (TEA) in 18% of patients for Summers and 19% for Ames. Although studies using THA from USA or Canada have noticed a rise of TEA in 30% of the patient
[Eye involvement in AIDS: the first 12 Tunisian cases]: Tunis Med. 1992 Oct;70(10):481-4. Unique Identifier : AIDSLINE MED/93198170; el Matri L; Kammoun M; Cheour M; Cherif F; Touiri H; Ouertani A; Zribi A; Triki F; Institut Hedi Rais d'Ophtalmologie de Tunis.
[Exchangeability of HIV/SIV regulatory genes]: Uirusu. 1992 Dec;42(2):133-43. Unique Identifier : AIDSLINE MED/93198279; Sakuragi J; Sakai H; Adachi A; Institute for Virus Research, Kyoto University.
[Professional risk: hepatitis B. Vaccination strategies in a general hospital]: Acta Gastroenterol Latinoam. 1992;22(1):29-35. Unique Identifier : AIDSLINE MED/93198509; Frider B; Sookoian S; Rebora N; Castano G; Rozenblat E; Hospital General de Agudos C. Argerich, Unidad Clinica Medica A,; Hepatologia, Buenos Aires, Argentina.; The risk of contracting hepatitis B: (HBV) by health workers is widely accepted. In 1989 our Hepatology Service started a voluntary anti-HBV vaccination program, employing recombinant vaccine (SKF) by intramuscular route with a 0-1-6 month schedule after screening with antibody against the anti-core HBV antigen (AntiH
Red blood cells as advanced drug delivery systems for antiviral nucleoside analogues.: Adv Exp Med Biol. 1992;326:239-45. Unique Identifier : AIDSLINE MED/93198735; Magnani M; Rossi L; Casabianca A; Fraternale A; Schiavano G; Brandi G; Mannello F; Piedimonte G; Istituto di Chimica Biologica G. Fornaini, Universita degli; Studi di Urbino, Italy.
[Interactions between human immunodeficiency virus and immune system in lymphoid organs]: Ann Med Interne (Paris). 1992;143(6):375-8. Unique Identifier : AIDSLINE MED/93199148; Emilie D; Peuchmaur M; Devergne O; Galanaud P; Service de Medecine Interne et d'Immunologie Clinique, Hopital; Antoine-Beclere, Clamart, France.
[Central nervous system lesions associated with human immunodeficiency virus infection]: Ann Med Interne (Paris). 1992;143(6):381-6. Unique Identifier : AIDSLINE MED/93199150; Gray F; Laboratoire d'Anatomie Pathologique, Hopital Raymond-Poincare,; Faculte de Medecine Paris Ouest, Garches, France.
A survey of sexual behaviour of Singaporeans.: Ann Acad Med Singapore. 1992 Nov;21(6):723-9. Unique Identifier : AIDSLINE MED/93199172; Heng BH; Lee HP; Kok LP; Ong YW; Ho ML; Disease Control/Epidemiology Department, Ministry of the; Environment, Singapore.; In order to plan education programmes against sexually transmitted diseases (STDs) and HIV infection, a population-based survey on partner relations was conducted on 2,115 Singaporean men and women aged between 15 and 49 years. Of the 605 (60.1%) sexually experienced men and 647 (58.3%) sexually experienced women, 510
Transcriptional activation of the human immunodeficiency virus long terminal repeat sequences by tumor necrosis factor.: Anticancer Res. 1992 Nov-Dec;12(6B):2065-8. Unique Identifier : AIDSLINE MED/93199231; Zoumpourlis V; Eliopoulos AG; Spandidos DA; Institute of Biological Research and Biotechnology, National; Hellenic Research Foundation, Athens, Greece.; The recombinant plasmid pBHIV-1 carrying the long terminal repeat (LTR) of the human immunodeficiency virus 1 (HIV-1), linked to the reported chloramphenicol acetyl transferase (CAT) gene, was introduced into human and rat fibroblasts. Stable transfectants were obtained which were resistant to genetecin and expressed
Progressive spastic paraparesis associated with human T-cell leukemia virus type I (HTLV-I).: Intern Med. 1992 Nov;31(11):1257-61. Unique Identifier : AIDSLINE MED/93200640; Cartier L; Araya F; Castillo JL; Ruiz F; Gormaz A; Tajima K; Department of Neurology, Faculty of Medicine, University of; Chile, Santiago.; Patients with progressive spastic paraparesis (PSP), commonly middle-aged women, are distributed throughout the country of Chile . During the three years from 1987 to 1990, we collected 83 cases of PSP from among 225 patients with various neurological diseases. The clinical picture w
[Anti-HIV activity of complex isoborneol ethers]: Dokl Akad Nauk. 1992;326(2):376-9. Unique Identifier : AIDSLINE MED/93200935; Pokrovskii AG; Pliasunova OA; Sandakhchiev LS; Kiselev OI; Chupakhin ON; Charushin VN; Ponizovskii MG; Dubur GIa; Bisenieks EA
Characterization of zidovudine resistant variants of HIV-1 isolated from patients on prolonged therapy.: Drugs Exp Clin Res. 1992;18(7):283-90. Unique Identifier : AIDSLINE MED/93201960; Wainberg MA; Tremblay M; Rooke R; Fanning M; Tsoukas C; Montaner JS; O'Shaughnessy M; Ruedy J; Lady Davis Institute, Jewish General Hospital, McGill University,; Montreal, Quebec, Canada.; As part of a clinical trial to assess zidovudine related toxic effects, the authors followed 48 initially asymptomatic individuals who received prolonged therapy with this drug at several tertiary care institutions. Blood samples had been obtained for viral isolation every three months and had yielded infectious HIV-1
Association between Staphylococcus aureus nasopharyngeal colonization and septicemia in patients infected with the human immunodeficiency virus.: Eur J Clin Microbiol Infect Dis. 1992 Nov;11(11):985-9. Unique Identifier : AIDSLINE MED/93202120; Weinke T; Schiller R; Fehrenbach FJ; Pohle HD; II. Medizinische Klinik, Universitatsklinikum Rudolf; Virchow/Wedding, Freie Universitat, Berlin, Germany.; In an attempt to identify risk factors for Staphylococcus aureus septicemia, 136 consecutive HIV-infected patients were investigated for the presence of nasopharyngeal colonization with Staphylococcus aureus and subsequent Staphylococcus aureus infection. Sixty of 136 (44.1%) HIV-infected patients had staphylococci wh
ANA issues American Nurses Association position statement on HIV infection and nursing students [news]: Imprint. 1992 Nov-Dec;39(5):24. Unique Identifier : AIDSLINE MED/93202679
The silent scream of HIV [letter]: Imprint. 1992 Nov-Dec;39(5):7. Unique Identifier : AIDSLINE MED/93202688; Michalek M
[Thoracic lymphoma and AIDS]: J Radiol. 1992 Nov;73(11):605-9. Unique Identifier : AIDSLINE MED/93204140; Zompatori M; Canini R; Gavelli G; Costigliola P; Ricchi E; Del Bufalo C; Pisi P; Rimondi MR; Istituto di Radiologia, Universita-Policlino S-Orsola-Malpighi,; Bologna.; During the past 4 years, 122 patients with AIDS and 20 with thoracic lymphoma associated to AIDS were observed. There were 18 cases of non-Hodgkin s lymphoma , mostly at a high grade and a high b-cell stage (Burkitt s or Burkitt-like lymphoma) (16 cases). This prevalence reflects th
Coexistence and competition in HIV infections.: J Theor Biol. 1992 Dec 7;159(3):329-42. Unique Identifier : AIDSLINE MED/93204493; Nowak MA; May RM; Department of Zoology, University of Oxford, U.K.; In this paper we extend our explanation of a model for the dynamics of the interaction between HIV and the cells of the immune system (Nowak et al., 1990). We show that the Simpson index of viral diversity is a Lyapunov function for a simplified version of this model. We also present a more general mathematical charac
Reactivity of bronchoalveolar space cells in lung asbestosis [published erratum appears in Patol Pol 1992;43(2):50]: Patol Pol. 1992;43(1):19-23. Unique Identifier : AIDSLINE MED/93205455; Czarnobilska E; Kopinski P; Pituch-Noworolska A; Chlap Z; Chair of Pathophysiology, University School of Medicine, Krakow.; Preliminary studies to evaluate lymphocyte subsets bronchoalveolar lavage (BAL) and blood were carried out in a group of patients with lung asbestosis. The assessments were made by an indirect immunofluorescent method using monoclonal antibodies as a marker. The results were recorded on a flow cytofluorometer FASC-can
[Results of liver examination in drug addicts infected with HIV virus]: Przegl Epidemiol. 1992;46(3):167-70. Unique Identifier : AIDSLINE MED/93205826; Halota W; Stolarczyk J; Opoka J; Katedra i Klinika Chorob Zakaznych AM Bydgoszczy.; Investigations included 52 drug-addicts with asymptomatic HIV virus infection. 8 of them suffered some years ago, from virus hepatitis of type B. Physical examinations did not reveal in examined persons any deviations from normal condition except for hepatomegaly. Results of liver biochemical investigations remained w
[Complications imminent in patients with salmonellosis]: Przegl Epidemiol. 1992;46(3):207-10. Unique Identifier : AIDSLINE MED/93205832; Prokopowicz D; Klinika Obserwacyjno-Zakazna AM, Bialymstoku.; In 1038 patients with salmonellosis treated in the last 20 years in Department of Infectious Diseases, Medical School, Bialystok and literature data defined, distribution and type of complications and consequences these diseases. In acute period of salmonellosis complications are: hypovolemic or infectious and toxic s
[Treatment of atypical mycobacterium infections: current state and therapeutic perspectives (editorial)]: Rev Pneumol Clin. 1992;48(4):139-41. Unique Identifier : AIDSLINE MED/93205965; Dautzenberg B
[Epidemiology of minor salmonellosis]: Rev Prat. 1992 Nov 15;42(18):2275-8. Unique Identifier : AIDSLINE MED/93206002; Bouvet E; Hubert B; Clinique de reanimation des maladies infectieuses, groupe; hospitalier Bichat/Claude-Bernard, Paris.; Epidemiological data concerning non Typhi salmonella infections in France and other industrialized countries are characterized by the important increase of S. enteritidis salmonellosis due to raw or insufficiently cooked eggs products since 1987, increase of salmonellosis among imm
[Non-typhoid salmonellosis in HIV infection]: Rev Prat. 1992 Nov 15;42(18):2283-4. Unique Identifier : AIDSLINE MED/93206004; Dellamonica P; Pradier C; Service des maladies infectieuses, hopital de l'Archet, Nice.; Non-typhoid Salmonella infections associated with HIV infection are 20 times more frequent than those observed in the general population. Drug addicts and homosexuals are equally infected. Concerning physiopathology, a deficit in gastric acid secretion has been blamed as an etiological factor, together with T-cell def
Alveolar macrophages from AIDS patients spontaneously produce elevated levels of TNF-alpha in vitro.: Allergol Immunopathol (Madr). 1992 Nov-Dec;20(6):249-54. Unique Identifier : AIDSLINE MED/93206846; Antinori A; Tamburrini E; Pagliari G; Maiuro G; Pallavicini F; De Luca A; Ortona L; Istituto di Clinica delle Malattie Infettive, Universita; Cattolica del Sacro Cuore, Roma, Italy.; In vitro production of TNF-alpha by alveolar macrophages was investigated in 15 AIDS patients with acute interstitial pneumonia and in 4 patients with asymptomatic HIV infection (anti-HIV+) and was compared to that observed in 6 patients with chronic pulmonary disease and in 5 normal controls (undergoing a fiberoptic
Nonhuman primates hold clues to search for AIDS vaccine [news] [published erratum appears in J Am Vet Med Assoc 1993 Feb 1;202(3):369]: J Am Vet Med Assoc. 1992 Dec 1;201(11):1670-1. Unique Identifier : AIDSLINE MED/93186464; Zuziak P
Abnormal cervical cytology in adolescents: a literature review.: J Adolesc Health. 1992 Dec;13(8):643-50. Unique Identifier : AIDSLINE MED/93176774; Roye CF; Columbia University School of Nursing, New York, N.Y. 10032.; This article reviews the literature on the subject of cervical cytological abnormalities in teenagers, defined as a Papanicolaou (Pap) smear result more severe than inflammation. There is discussion of the increasing prevalence of this problem in adolescents. Behavioral and biologic risk factors are examined. The role
[The subpopulation structure of human T-lymphocytes studied by using a monoclonal antibody (MCA) to CD27]: Biull Eksp Biol Med. 1992 Nov;114(11):506-8. Unique Identifier : AIDSLINE MED/93177003; Filatov AV; Prokof'ev SA; Shcherbukhin VV; The obtained murine mAb LT27 (IgG2a) assigned to the cluster of differentiation CD27 was used to study the distribution of antigen CD27 among human lymphocytes scbpopulations in normal state and immunopathology. In normal donors the antigen CD27 was found to be expressed most frequently on CD4+ cells (90 +/- 8% of whi
Histopathology and immunohistopathology of lymph nodes of the first autopsy with HIV positivity in China.: Chin Med J (Engl). 1992 Oct;105(10):813-7. Unique Identifier : AIDSLINE MED/93178144; Lai MD; Xu YH; Dai D; Tang DJ; Han YJ; Department of Pathology, Zhejiang Medical University, Hangzhou.; Nineteen lymph nodes of a HIV-positive boy were studied histologically and immunohistologically. According to Stutte s classification of HIV-related lymphadenopathy, 84% of the lymph nodes were at the third or fourth stages in relation to clinical status ARC/AIDS. Lymph follicle atrophy, angiogenesis, histiocytic prol
State dental boards and mandatory HIV testing.: Northwest Dent. 1992 Sep-Oct;71(5):33-5. Unique Identifier : AIDSLINE MED/93181157; DiAngelis AJ; Born DO; Hill AJ; Hennepin County Medical Center, Minneapolis, Minnesota.; Public and professional debate over what, if any, action should be taken by state regulatory agencies regarding AIDS and the HIV status of dentists has increased in recent months. To determine if state boards had workable policies in place or were considering such policies, a telephone survey of all state boards was u
Anti-HIV plant proteins catalyze topological changes of DNA into inactive forms.: Biofactors. 1992 Dec;4(1):37-41. Unique Identifier : AIDSLINE MED/93183329; Huang PL; Chen HC; Kung HF; Huang PL; Huang P; Huang HI; Lee-Huang S; Department of Medicine, Harvard Medical School, Boston, MA 02115.; GAP 31, DAP 32 and DAP 30 comprise a new class of plant proteins with potent anti-HIV activity and insignificant cytotoxicity. We report here the identification and characterization of a new DNA enzyme activity in these three proteins. They irreversibly relax and decatenate supercoiled DNA, as well as catalyze double-
[Ocular toxoplasmosis as the first manifestation of HIV infection. Presentation of a case (letter)]: Enferm Infecc Microbiol Clin. 1992 Dec;10(10):625-6. Unique Identifier : AIDSLINE MED/93184033; Roig P; Porras G; Cuadrado JM; Lopez MM; Tana P
[Treatment with intravitreous ganciclovir in cytomegalovirus retinitis associated with AIDS (letter)]: Enferm Infecc Microbiol Clin. 1992 Dec;10(10):629-30. Unique Identifier : AIDSLINE MED/93184038; Gutierrez A; Martin I; Ferrer E; Torron C; Aguirre JM
Treatment of tuberculosis in HIV infection [see comments]: Tuber Lung Dis. 1992 Dec;73(6):378-83. Unique Identifier : AIDSLINE MED/93184292; Grosset JH; Groupe Hospitalier Pitie Salpetiere, Paris, France.; Whether tuberculosis patients received short-course chemotherapy with treatment of isoniazid (INH) and rifampicin (RIF), combined or not with pyrazinamide (PZA) and ethambutol (EMB) or streptomycin (SM), or long term chemotherapy with INH, SM and thiacetazone (Tb1), the rate of sputum culture conversion was similar in
Failure of antiviral therapy in AIDS-associated cytomegalovirus cholangitis [letter]: Infection. 1992 Nov-Dec;20(6):371-2. Unique Identifier : AIDSLINE MED/93186254; van der Ende ME; van Buuren AC; Kroes AC; ten Kate FJ
Immunologic response to EIAV offers hope for AIDS treatment [news]: J Am Vet Med Assoc. 1992 Dec 1;201(11):1672-3. Unique Identifier : AIDSLINE MED/93186465; Kahler S
[Infections with cytomegalovirus in both adults and neonates. Diagnosis, therapy and prophylactic procedures (editorial)]: Pol Tyg Lek. 1992 Sep 7-14;47(36-37):776-80. Unique Identifier : AIDSLINE MED/93189429; Zawilinska B
[Cytomegalovirus infection. Epidemiology, CMV and pregnancy, CMV and recipients of vaccine, CMV and HIV infection, CMV after transfusion]: Pol Tyg Lek. 1992 Sep 7-14;47(36-37):814-8. Unique Identifier : AIDSLINE MED/93189443; Siwak E; Kondriusik M; Daniluk J; Kliniki Chorob Pasozytniczych i Zawodowych, Bialymstoku.
[Simultaneous detection by non-isotopic in situ hybridization of human papilloma viruses and Epstein-Barr virus during the lytic cycle in oral hairy leukoplakia lesions]: Ann Pathol. 1992;12(6):353-7. Unique Identifier : AIDSLINE MED/93191745; Courtade M; Brousset P; Delsol M; Gorguet B; Viraben R; Voigt JJ; Delsol G; Laboratoire d'Anatomie Pathologique, CHU Purpan, Toulouse.; Oral hairy leukoplakia is almost only described in patients infected by the human immunodeficiency virus. Epstein-Barr virus, sometimes associated with human papillomavirus, is always involved in the occurrence of these lesions. We have investigated two cases of oral hairy leukoplakia with the goal of detecting EBV an
Hematological effects of 2',3'-dideoxycytidine in rabbits.: Toxicol Pathol. 1992;20(3 Pt 1):367-75. Unique Identifier : AIDSLINE MED/93197790; Riley JH; Davidovich A; Lipman JM; Arceo R; Anderson TD; Department of Toxicology and Pathology, Hoffmann-La Roche Inc.,; Nutley, New Jersey 07110.; The antiviral nucleoside analogue 2 ,3 -dideoxycytidine ( ddC ) is a DNA chain terminator and/or inhibitor of human immunodeficiency virus (HIV) reverse transcriptase. We evaluated the effects of ddC in 36 New Zealan
[Protective effect against BLV by inoculation with a vaccinia virus-BLV env recombinant]: Uirusu. 1992 Dec;42(2):155-70. Unique Identifier : AIDSLINE MED/93198281; Ohishi K; Laboratory of Molecular Oncology, Tsukuba Life Science Center,; Ibaraki.
An optimal control problem for the administration of a drug by using red blood cells as bioreactors.: Adv Exp Med Biol. 1992;326:247-53. Unique Identifier : AIDSLINE MED/93198736; Beretta E; Bischi GI; Solimano F; Istituto di Biomatematica, Universita degli Studi di Urbino,; Italy.
Cytomegalovirus pneumonitis in AIDS--a case report.: Ann Acad Med Singapore. 1992 Nov;21(6):843-5. Unique Identifier : AIDSLINE MED/93199198; Eng P; Allen DM; Chew SK; Monteiro EH; Sim SC; Department of Medicine II, Tan Tock Seng Hospital, Singapore.; Respiratory infections occur commonly in patients with advanced human immunodeficiency virus (HIV) infection. Prompt accurate diagnosis is essential as many of the various available therapies have significant toxicities. We describe a patient previously diagnosed with the acquired immunodeficiency syndrome (AIDS) who
Effect of lignins on HIV-induced cytopathogenicity and myeloperoxidase activity in human myelogenous leukemic cell lines.: Anticancer Res. 1992 Nov-Dec;12(6B):2225-8. Unique Identifier : AIDSLINE MED/93199259; Kunisada T; Sakagami H; Takeda M; Naoe T; Kawazoe Y; Ushijima H; Muller WE; Kitamura T; Department of Virology and Rickettsiology, National Institute of; Health, Tokyo, Japan.; We have previously reported the potent stimulation effect of lignin on the iodination of myeloperoxidase (MPO)-positive cells. We investigated here the anti-HIV (human immunodeficiency virus) activity of lignins in the MPO-positive (HL-60) and -negative (U-937) human myelogenous leukemic cell lines. Natural lignified
[Intravenous gamma globulins (i.v.IG) in the treatment and prevention of virus infections]: Przegl Epidemiol. 1992;46(3):231-6. Unique Identifier : AIDSLINE MED/93205835; Bucholc B; Zaklad Badania Surowic i Szczepionek, Panstwowego Zakladu; Higieny, Warszawie.; Active research is currently underway to determine the role of intravenous administration of IgG (i.v.Ig) in preventing and treating viral infections ( CMV , HIV, RSV, EB, ECHO, adeno). These studies strongly suggest that immunoglobulin therapy may be beneficial i
World conference update.: Compendium. 1992 Nov;13(11):944, 946. Unique Identifier : AIDSLINE MED/93177768; Glick M; Temple University School of Dentistry.
A world united against AIDS. Report on the Nursing Satellite Conference and the Eighth International Conference on AIDS, Amsterdam, The Netherlands, 19-24 July, 1992.: Midwifery. 1992 Dec;8(4):195-8. Unique Identifier : AIDSLINE MED/93180683; Lachat MF; The dramatic increase of new HIV/AIDS cases in women and their babies continues to require midwives to be vigilant in their efforts to identify clients at risk for HIV. The role of STDs in HIV transmission and disease progression is evident. Research is lacking on the effect of AIDS drugs, pregnancy and birth on the H
Kaposi sarcoma: a cytokine-responsive neoplasia?: Cancer Treat Res. 1992;63:129-40. Unique Identifier : AIDSLINE MED/93183633; Miles SA
[Detection of the HIV p24 antigen on lymphocyte membranes using flow cytometry]: Enferm Infecc Microbiol Clin. 1992 Dec;10(10):592-6. Unique Identifier : AIDSLINE MED/93184025; Madariaga L; Suarez D; Anton I; Campelo C; Lardelli P; Cisterna R; Departamento de Microbiologia e Inmunologia, Facultad de; Medicina, Universidad del Pais Vasco, Bilbao.; The evaluation of the presence of p24 antigen on the membrane of peripheral blood mononuclear cells from 31 HIV infected individuals is presented. The study was performed by indirect immunofluorescence and flow cytometry and the data were analyzed by the Kolmogorov-Smirnov test. Values obtained [D/s(n)] result from th
GEM 91--an antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS [editorial]: Antisense Res Dev. 1992 Winter;2(4):261-6. Unique Identifier : AIDSLINE MED/93184476; Agrawal S; Tang JY
Porphyria cutanea tarda and HIV infection: effect of zidovudine treatment on a patient [letter]: Infection. 1992 Nov-Dec;20(6):373-4. Unique Identifier : AIDSLINE MED/93186255; Gafa S; Zannini A; Gabrielli C
[Recent advances in the etiopathology of chronic B-lymphocytic leukemia]: Postepy Hig Med Dosw. 1992;46(4):381-402. Unique Identifier : AIDSLINE MED/93189464; Rupniewska ZM; Klinika Hematologii II Katedry Chorob Wewnetrznych Akademii; Medycznej, Lublinie.; Considerations to multistep development of B-lymphocytic chronic leukaemia are presented under the following aspects: experimental in vitro cultures of bone marrows B lymphocyte precursors, polyclonal nature of proliferating B lymphocytes in the early stage of CLL, especially in the autoimmune status, the role of viru
[AIDS. 3rd European conference on the clinical aspects and treatment of HIV infection. Paris, 12-13 March 1992. 4th German AIDS congress. Wiesbaden, 25-28 March 1992. 8th International AIDS Conference. Amsterdam, 19-24 July 1992]: Internist (Berl). 1992 Oct;33(10 Suppl [AIDS]):1-24. Unique Identifier : AIDSLINE MED/93194474
Persistent depletion of CD4+ T cells and inversion of the CD4/CD8 T cell ratio induced by anti-CD4 therapy.: J Rheumatol. 1992 Dec;19(12):1845-50. Unique Identifier : AIDSLINE MED/93195869; Horneff G; Emmrich F; Reiter C; Kalden JR; Burmester GR; Max Planck Clinical Research Group, Department of Medicine III,; University of Erlangen-Nuremberg, Germany.; A 49-year-old patient with refractory rheumatoid arthritis was treated repeatedly with anti-CD4 murine monoclonal antibodies. While the first anti-CD4 treatment resulted in a marked, however transient, depletion of CD4+ cells from 1070 to a minimum of 175/microliters, a second treatment cycle resulted in a persistent
Drug therapy for chronic urticaria.: Clin Rev Allergy. 1992 Winter;10(4):349-69. Unique Identifier : AIDSLINE MED/93201413; Juhlin L; Landor M; Department of Dermatology, University Hospital, Uppsala, Sweden.; Given the variability of patient problems, it is difficult to construct a single drug therapy regimen for treatment of chronic urticaria. However, the following regimen should prove to be a useful outline to follow for most cases. The first line of therapy will usually be antihistamines. In general, antihistamines sho
[Control of the diffusion of viral hepatitis in detention and penal institutions: a problem not to be underrated]: Ann Ig. 1992 Mar-Apr;4(2):73-6. Unique Identifier : AIDSLINE MED/93176393; Patti AM; Pompa MG; Santi AL; Ist. di Igiene G. Sanarelli, Universita degli Studi di Roma, La; Sapienza.
Mouse/human chimeric anti-HIV-1 gp120 antibody to the principal neutralizing determinant: tolerability and pharmacokinetics in cynomolgus monkeys, Macaca fascicularis.: Biotherapy. 1992;5(4):291-9. Unique Identifier : AIDSLINE MED/93176612; Liou RS; Fung MS; Zuhlke U; Gudat F; McKinney S; Gordon W; Bee W; Botta L; Gygax D; Chang TW; et al; Tanox Biosystems, Inc., Houston, TX 77025.; In preparing for testing a pharmaceutical grade preparation of chimeric (mouse/human) antibody CGP 47,439 in HIV-1 infected individuals, it was administered to Macaca fascicularis (cynomolgus) monkeys to study tolerability, immunogenicity and pharmacokinetics. Four groups of monkeys, three males and three females per
Sero-surveillance of transmissible hepatitis B & C viruses in asymptomatic HIV infection in haemophilics.: Indian J Med Res. 1992 Nov;95:256-8. Unique Identifier : AIDSLINE MED/93179054; Sengupta B; De M; Lahiri P; Bhattacharya DK; Society for Research on Haematology & Blood Transfusion,; Calcutta.; In a group of 37 haemophilics, 9 (24.3%) were seropositive for human immunodeficiency virus (HIV), while 9 (24.3%) and 10 (27%) were positive for hepatitis B virus (HBV) and hepatitis C virus (HCV) respectively. Haemophilics who were HIV seropositive had higher prevalence of HBV and HCV. Seropositivity for HIV was mor
Immunohistochemical detection of Pneumocystis carinii in transbronchial lung biopsy specimens: antigen difference between human and rat Pneumocystis carinii.: Jpn J Clin Oncol. 1992 Dec;22(6):387-92. Unique Identifier : AIDSLINE MED/93180345; Kobayashi M; Moriki T; Uemura Y; Takehara N; Kubonishi I; Taguchi H; Miyoshi I; Third Department of Internal Medicine, Kochi Medical School,; Nankoku.; Transbronchial lung biopsy specimens, from three patients with non-AIDS-related Pneumocystis carinii pneumonia (PCP) and rat lung tissue in which PCP was induced by the administration of dexamethasone, were studied to determine the diagnostic usefulness of an immunohistochemical method using commercially available ant
Poly(L-lysine)-conjugated oligonucleotides promote sequence-specific inhibition of acute HIV-1 infection.: Antisense Res Dev. 1992 Winter;2(4):293-301. Unique Identifier : AIDSLINE MED/93184479; Degols G; Leonetti JP; Benkirane M; Devaux C; Lebleu B; Laboratoire de Biochimie des Proteines, UA CNRS 1191,; Universite de Montpellier II, Sciences et Techniques du; Languedoc, France.; Previously, we have reported that conjugation of antisense oligonucleotides to poly(L-lysine) (PLL) lowers their inhibitory concentration in several biological models. We have now tested these conjugates for inhibition of human immunodeficiency virus type 1 (HIV-1) replication. PLL-conjugated oligonucleotides compleme
Chemotherapeutic approaches to human immunodeficiency virus infections.: Fukushima J Med Sci. 1992 Jun;38(1):1-18. Unique Identifier : AIDSLINE MED/93186023; Baba M; Department of Microbiology, Fukushima Medical College, Japan.; Since the discovery of human immunodeficiency virus (HIV) as the causative agent of acquired immune deficiency syndrome (AIDS), various attempts have been made to control this fatal disorder. In the replicative cycle of HIV, several steps have been identified as attractive targets for antiviral chemotherapy. Sulfated
Characterization of a neutralizing monoclonal antibody to the external glycoprotein of HIV-1.: Intervirology. 1992;34(2):86-93. Unique Identifier : AIDSLINE MED/93186358; Pal R; di Marzo Veronese F; Nair BC; Rahman R; Hoke G; Mumbauer SW; Sarngadharan MG; Advanced BioScience Laboratories, Kensington, Md 20895.; The major neutralizing epitope on the external glycoprotein of HIV-1 was studied with an envelope-specific monoclonal antibody and with a human serum positive for antibodies to HIV-1 proteins, both of which were able to neutralize virus infectivity. The monoclonal antibody reacted specifically with gp120 from HIV-1III
Anti-hepatitis C virus antibodies amongst Italian homo-bisexual males.: Eur J Epidemiol. 1992 Nov;8(6):804-7. Unique Identifier : AIDSLINE MED/93193772; Ricchi E; Borderi M; Costigliola P; Miniero R; Sprovieri G; Chiodo F; Istituto Malattie Infettive, Universita di Bologna, Italy.; The authors report on an anti-hepatitis C virus antibody (HCV Ab) prevalence (6.9%) in 622 homo-bisexual males from Northern Italy , voluntarily attending an HIV and STDs screening program in the period 1984-89. The anti-HCV antibody prevalence shows a significant correlation with: i
Immunologic effects in patients with psoriatic arthritis treated with cyclosporine A.: J Rheumatol. 1992 Dec;19(12):1933-7. Unique Identifier : AIDSLINE MED/93195882; Boiardi L; Salvarani C; Macchioni P; Casadei Maldini M; Mancini R; Beltrandi E; Rossi F; Lodi L; Portioli I; 2nd Divisione di Medicina Interna (Unita Reumatologica), Reggio; Emilia, Italy.; Twelve patients with psoriatic arthritis (PsA) and very active articular disease resistant to conventional second line therapy entered into a 6-month open study of cyclosporine A (CsA) at a starting dosage of 3 mg/kg/day. Comparisons of phenotypic characteristics of lymphocytes and response to mitogens of peripheral b
Severe cutaneous hypersensitivity reactions during treatment of tuberculosis in patients with HIV infection in Tanzania.: Trop Geogr Med. 1992 Oct;44(4):308-11. Unique Identifier : AIDSLINE MED/93198117; Dukes CS; Sugarman J; Cegielski JP; Lallinger GJ; Mwakyusa DH; Department of Medicine, Duke University, Medical Center, Durham,; North Carolina.; Concurrent infection with HIV-1 and Mycobacterium tuberculosis is increasingly common in East Africa. In the past, a drug regimen consisting of 2 months of intramuscular streptomycin plus 12 months of isoniazid and thiacetazone has been used in tuberculosis control programs with acceptable efficacy and low incidence o
[The characteristics of the HIV isolated from HIV-infected persons and AIDS patients on the territory of the CIS]: Vestn Ross Akad Med Nauk. 1992;(11-12):10-3. Unique Identifier : AIDSLINE MED/93200828; Nosik DN; Kalnina LB; Bochkova IA; Kiseleva IA; Svirska RV; Petrova MS; Zhigulin AO; Stakhanova VM; Gushchina EA; Iurin OG; et al; HIV strains were isolated from HIV-infected patients and AIDS patients in CIS. A total of 81 HIV isolates were obtained. The isolates were identified by using immunofluorescence and enzyme immunoassay, by determining the activity of reverse transcriptase, immunoblot, electron microscopy, polymerase chain reaction. Of
[The possibilities of using immunological indices as criteria for determining the stage of HIV infection and the disease prognosis]: Vestn Ross Akad Med Nauk. 1992;(11-12):13-5. Unique Identifier : AIDSLINE MED/93200829; Chernousov AD; Eremina OF; Simonova AV; Kulakov VV; Borisova AM; Pinegin BV; The authors studied the immune status of 14 HIV-infected patients, 6 of whom had lymphadenopathy, 4 were diagnosed as having AIDS-related complex and 4, a full-blown AIDS. Analysis of laboratory findings showed that of predictive value are serum levels of immunoglobulin B, a CD4 cell count less than 200, reduced popul
[The expert diagnosis of HIV infection by radioimmunoprecipitation]: Vestn Ross Akad Med Nauk. 1992;(11-12):15-20. Unique Identifier : AIDSLINE MED/93200830; Karamov EV; Lukashov VV; Slepushkin VA; Chaplinskas SA; Petkov V; Vojcehovsky K; Kopecka D; Gorbacheva AP; Apuokene E; Bruckova M; Using a panel of sera from HIV-infected persons and donors, the authors showed that radioimmunoprecipitation assays compare favourably with immunoblotting assays. With radioimmunoprecipitation, cross reactions were observed between HIV-2 antigens and HIV-2 antibodies, and that the nature of cross reactivity differs fr
[The factors that affect the results of the serological diagnosis of HIV infection and the screening for anti-HIV]: Vestn Ross Akad Med Nauk. 1992;(11-12):20-3. Unique Identifier : AIDSLINE MED/93200831; Vasil'eva VI; Iakhno KV; Medvedeva GI; Kozhevnikova LK; Pakhomova AN; Ivanova MIu; The laboratory diagnosis of HIV infection and screening for anti-HIV have determined the factors that influence the results of studies performed by ELISA and Western immunoblot. The factors include sensitivity and specificity of the test systems used, storage conditions of and transportation conditions for serum, erro
[The methodological aspects in enhancing the efficacy of the epidemiological surveillance of HIV infection]: Vestn Ross Akad Med Nauk. 1992;(11-12):23-5. Unique Identifier : AIDSLINE MED/93200832; Churnosov EV; Smol'skaia TT; Terent'eva ZhV; Using a systems approach, the authors examined the main principles underlying an expert-based system for epidemiological surveillance over HIV infection. The principle objective is to control the processes which precede the occurrence of new infected cases and further spread of HIV infection. Accordingly, the system s
[The choice of primers for polymerase amplification in the diagnosis of HIV infection]: Vestn Ross Akad Med Nauk. 1992;(11-12):25-7. Unique Identifier : AIDSLINE MED/93200833; Undritsov IM; Khabakhpasheva NA; Trofimov DIu; Alekssev LP; Khaitov RM
[Reverse transcriptase inhibitors and the therapy of HIV infection]: Vestn Ross Akad Med Nauk. 1992;(11-12):3-6. Unique Identifier : AIDSLINE MED/93200835; Kraevskii AA; Galegov GA; Azidothymidine (retrovir) and didesoxyinosine, which represent nucleoside agents, are major remedies in the treatment of HIV infection and acquired immunodeficiency syndrome (AIDS). The paper describes the molecular mechanism of their action. It implicates that triphosphates of these nucleosides selectively suppress t
[The ajoene blockade of integrin-dependent processes in an HIV-infected cell system]: Vestn Ross Akad Med Nauk. 1992;(11-12):6-10. Unique Identifier : AIDSLINE MED/93200843; Tatarintsev AV; Vrzhets PV; Ershov DE; Shchegolev AA; Turgiev AS; Karamov EV; Kornilaeva GV; Makarova TV; Fedorov NA; Varfolomeev SD; Ajoene, (E,Z)-4,5,9-trithiadodeca-1,6,11-triene-9-oxide, isolated from extracts of garlic (Allium sativum) has been previously shown to inhibit platelet aggregation by inactivating allosterically the platelet integrin, GP IIb/IIIa. The structural and functional similarity of integrins led the authors to suggest that a
Tuberculosis on the increase [news]: World Health Forum. 1993;14(1):94. Unique Identifier : AIDSLINE MED/93176296
Knowledge of AIDS and other sexually transmitted diseases among women attending a family planning clinic in Nairobi, Kenya [see comments]: Am J Prev Med. 1993 Jan-Feb;9(1):1-5. Unique Identifier : AIDSLINE MED/93176485; Garland M; Maggwa BN; Mati JK; Kihoro J; Mbugua S; Achola P; Hunter DJ; Department of Epidemiology, Harvard School of Public Health,; Boston, MA 02115.; We interviewed 1,716 women attending a family planning clinic in Nairobi between January 1990 and May 1991 about their knowledge of the acquired immunodeficiency syndrome (AIDS) and other sexually transmitted diseases (STDs). When participants in the study were asked to name spontaneously the STDs they knew, more than
AIDS knowledge in minorities: significance of locus of control [see comments]: Am J Prev Med. 1993 Jan-Feb;9(1):15-20. Unique Identifier : AIDSLINE MED/93176486; Aruffo JF; Coverdale JH; Pavlik VN; Vallbona C; Department of Psychiatry and Behavioral Sciences, Baylor College; of Medicine, Baylor University, Houston, TX.; A convenience sample of 587 subjects from the community health centers of Harris County, Texas, completed a structured interview that included questions on knowledge of AIDS transmission and prevention and on the Wallston Health Locus of Control (HLOC) Scale. HLOC score was a strong independent predictor of AIDS knowl
Evaluation of two AIDS prevention interventions for inner-city adolescent and young adult women.: Am J Prev Med. 1993 Jan-Feb;9(1):21-6. Unique Identifier : AIDSLINE MED/93176487; Quirk ME; Godkin MA; Schwenzfeier E; University of Massachusetts Medical School, Worcester 01655.; Two hundred and fourteen young women received acquired immunodeficiency syndrome (AIDS) prevention interventions at an inner-city family health center serving minority patients predominantly. The community in which the health center is located has a high incidence of intravenous (IV) drug abuse. Either a peer or a hea
How much do health care providers know about AIDS? [see comments]: Am J Prev Med. 1993 Jan-Feb;9(1):6-14. Unique Identifier : AIDSLINE MED/93176495; Passannante MR; French J; Louria DB; Department of Preventive Medicine and Community Health,; University of Medicine and Dentistry of New Jersey-New Jersey; Medical School, Newark 07103.; We sent a survey to more than 8,000 New Jersey health professionals to collect information on their knowledge level, attitudes, and prevention practices relating to the human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS). The surveys were distributed through the mail in three separate
Validity, reliability, and generalizability in studies of AIDS knowledge, attitudes, and behavioral risks based on subject self-report [comment]: Am J Prev Med. 1993 Jan-Feb;9(1):62-4. Unique Identifier : AIDSLINE MED/93176496; Hingson R; Strunin L; Social and Behavioral Sciences Department, Boston University; School of Public Health 02118-2389.
Tumour growth inhibition in mice by glycosylated recombinant human lymphotoxin: analysis of tumour-regional mononuclear cells involved with its action.: Br J Cancer. 1993 Mar;67(3):447-55. Unique Identifier : AIDSLINE MED/93176682; Funahashi I; Watanabe H; Abo T; Indo K; Miyaji H; Department of Pathology, Hyogo College of Medicine, Japan.; We compared the antitumour effects of glycosylated LT (gLT), nonglycosylated LT and TNF against a solid tumour in mice. We found that: (a) The systemic administration of gLT showed significant antitumour activity. These effects were, however, quite small in nude mice. Nonglycosylated LT and TNF attained the same degre
Secondary syphilis and the nephrotic syndrome.: J Am Soc Nephrol. 1993 Jan;3(7):1351-5. Unique Identifier : AIDSLINE MED/93176948; Hunte W; al-Ghraoui F; Cohen RJ; Cleveland Clinic Foundation, Ft. Lauderdale, FL.; A case of nephrotic syndrome in a 21-yr-old black man with secondary syphilis and diabetes mellitus is described. A renal biopsy was performed, which showed membranous glomerulopathy stage I associated with mesangial hyperplasia and mesangial deposits. The clinical course and the histologic findings, compatible with s
Quantitative immunohistochemical analysis of lymphocyte subsets in alcoholic liver disease.: J Gastroenterol Hepatol. 1993 Jan-Feb;8(1):39-43. Unique Identifier : AIDSLINE MED/93176967; Sakai Y; Izumi N; Marumo F; Sato C; Second Department of Internal Medicine, Faculty of Medicine,; Tokyo Medical and Dental University, Tokyo, Japan.; To investigate the role of lymphocytes frequently observed in the parenchyma of alcoholic liver disease (ALD), lymphocytes infiltrating into the liver were stained immunohistochemically with monoclonal antibodies (MoAb) and were quantitatively assessed by a morphometric analysis in 17 patients with ALD and, for compar
Microsporidiosis in AIDS patients.: Can Commun Dis Rep. 1993 Jan 30;19(2):13-5. Unique Identifier : AIDSLINE MED/93177430; Svenson J; MacLean JD; Kokoskin-Nelson E; Szabo J; Lough J; Gill MJ; McGill University Centre for Tropical Diseases, Montreal, Quebec.
Auditory projections to the anterior telencephalon in the budgerigar (Melopsittacus undulatus).: Brain Behav Evol. 1993;41(2):97-116. Unique Identifier : AIDSLINE MED/93177476; Hall WS; Cohen PL; Brauth SE; Department of Psychology, University of Maryland, College Park; 20742.; The connections of a higher order auditory area in the neostriatum intermedium pars ventrolateralis (NIVL) were mapped with pathway tracing techniques in order to elucidate possible pathways by which auditory feedback may influence vocal learning in the budgerigar (Melopsittacus undulatus). Previous research has shown
Pulmonary edema induced by fluid administration in acquired immune deficiency syndrome patients with cardiac autonomic dysfunction.: Can J Cardiol. 1993 Jan-Feb;9(1):115-7. Unique Identifier : AIDSLINE MED/93177532; Palaic M; Lisbona R; Sniderman AD; Cardiology Division, Royal Victoria Hospital, McGill University,; Montreal, Quebec.; Two patients with the acquired immune deficiency syndrome developed acute pulmonary edema following intravenous fluid administration. Both recovered with diuretic therapy. In neither case was there evidence of persistent severe left ventricular dysfunction, nor was there evidence (either clinically or by thallium stud
A 14-month-old HIV-positive female with a 2-day history of fever and vomiting.: Clin Imaging. 1993 Jan-Mar;17(1):86-8. Unique Identifier : AIDSLINE MED/93177563; Caravella BA; Govoni AF; Department of Radiology, New York Hospital-Cornell University; Medical College, NY 10021.
Why are there so many myths about AIDS? [editorial; comment] [see comments]: Can Med Assoc J. 1993 Mar 1;148(5):745-9. Unique Identifier : AIDSLINE MED/93177646; Wainberg MA
HIV antibody testing in children. Infectious Diseases and Immunization Committee, Canadian Paediatric Society.: Can Med Assoc J. 1993 Mar 1;148(5):759-64. Unique Identifier : AIDSLINE MED/93177648
Free AIDS pamphlets aimed at parents and women [news]: Can Med Assoc J. 1993 Mar 1;148(5):790. Unique Identifier : AIDSLINE MED/93177652
AIDS: the fictions, the facts [see comments]: Can Med Assoc J. 1993 Mar 1;148(5):802-5. Unique Identifier : AIDSLINE MED/93177654; Schechter MT; Department of Health Care and Epidemiology, Faculty of Medicine,; University of British Columbia.
Induction of cell differentiation by human immunodeficiency virus 1 vpr.: Cell. 1993 Feb 26;72(4):541-50. Unique Identifier : AIDSLINE MED/93177836; Levy DN; Fernandes LS; Williams WV; Weiner DB; Department of Medicine, University of Pennsylvania, Philadelphia.; Cell lines from rhabdomyosarcomas, which are tumors of muscle origin, have been used as models of CD4-independent HIV infection. These cell lines can be induced to differentiate in vitro. We report here that the vpr gene of HIV1 is sufficient for the differentiation of the human rhabdomyosarcoma cell line TE671. Diffe
Human transcription factor USF stimulates transcription through the initiator elements of the HIV-1 and the Ad-ML promoters.: EMBO J. 1993 Feb;12(2):501-11. Unique Identifier : AIDSLINE MED/93178424; Du H; Roy AL; Roeder RG; Laboratory of Biochemistry and Molecular Biology, Rockefeller; University, New York, NY 10021.; Earlier in vitro studies identified USF as a cellular factor which activates the adenovirus major late (Ad-ML) promoter by binding to an E-box motif located at position -60 with respect to the cap site. Purified USF contains 44 and 43 kDa polypeptides, and the latter was found (by cDNA cloning) to be a helix-loop-heli
Failure to detect genomic material of HTLV-I or HTLV-II in mononuclear cells of Italian patients with multiple sclerosis and chronic progressive myelopathy.: Eur Neurol. 1993;33(1):23-6. Unique Identifier : AIDSLINE MED/93178494; Merelli E; Sola P; Marasca R; Salati R; Torelli G; Neurological Department, University of Modena, Italy.; To contribute to the undecided question if a retrovirus of the human T-cell lymphotropic virus (HTLV) family may be involved in the development of multiple sclerosis (MS), we investigated by the polymerase chain reaction (PCR) the presence of HTLV-I and HTLV-II sequences in the peripheral blood mononuclear cell DNAs f
Bilineage hematopoietic inhibitor and T lymphocyte dysfunction in a patient with pure red cell aplasia, myasthenia gravis and thymoma.: Exp Hematol. 1993 Mar;21(3):451-5. Unique Identifier : AIDSLINE MED/93178577; Murase T; Department of Internal Medicine, Second Tokyo National Hospital,; Japan.; The case history, laboratory findings and clinical course of a patient with pure red cell aplasia (PRCA) combined with myasthenia gravis and thymoma are reported herein. In vitro study revealed bilineage complement-dependent IgG inhibitor(s) in both the granulocyte-macrophage and erythroblastic progenitor cells. His s
Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection.: Eur J Haematol. 1993 Feb;50(2):90-4. Unique Identifier : AIDSLINE MED/93178605; Fuchs D; Zangerle R; Artner-Dworzak E; Weiss G; Fritsch P; Tilz GP; Dierich MP; Wachter H; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.; The pathogenesis of anaemia associated with human immunodeficiency virus infection is still far from being understood. It cannot be explained by direct effects of the virus on the haematopoietic system. Recent data suggest a role for immune activation. In a cross-sectional study we compared blood cell counts, haemoglo
Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1.: J Biol Chem. 1993 Feb 25;268(6):4259-66. Unique Identifier : AIDSLINE GENBANK/L05515; Nomura N; Zu YL; Maekawa T; Tabata S; Akiyama T; Ishii S; Laboratory of Molecular Biology, Nippon Medical School, Kanagawa,; Japan.; Among multiple CRE (cyclic AMP response element)-binding proteins, CRE-BP1 (also designated ATF-2) has two unique characteristics: it mediates the adenovirus E1A-induced trans-activation and forms a heterodimer with c-Jun. Two structures, a putative metal finger and a leucine zipper, in CRE-BP1 are responsible for the
Survival of elderly patients with transfusion-related acquired immunodeficiency syndrome.: J Am Geriatr Soc. 1993 Mar;41(3):214-6. Unique Identifier : AIDSLINE MED/93179654; Sutin DG; Rose DN; Mulvihill M; Taylor B; Department of Geriatrics and Adult Development, Mount Sinai; School of Medicine, New York, NY.; OBJECTIVE: To determine the influences of age and risk group on the survival of AIDS patients. We concentrated on transfusion because it is the commonest risk factor for AIDS in patients over 70 years of age. DESIGN: Survival curve regression analysis. PARTICIPANTS: Patients aged 13 years and over with AIDS acquired t
Mycobacterium tuberculosis transmission in healthcare settings: is it influenced by coinfection with human immunodeficiency virus? [editorial; comment] [published erratum appears in Infect Control Hosp Epidemiol 1993 Jun;14(6):306] [see comments]: Infect Control Hosp Epidemiol. 1993 Feb;14(2):65-6. Unique Identifier : AIDSLINE MED/93179719; Castro KG; Dooley SW
Transmission of HIV-associated tuberculosis to healthcare workers [see comments]: Infect Control Hosp Epidemiol. 1993 Feb;14(2):67-72. Unique Identifier : AIDSLINE MED/93179720; Di Perri G; Cadeo GP; Castelli F; Micciolo R; Bassetti S; Rubini F; Cazzadori A; Marocco S; Carlotto A; Adami T; et al; Institute of Immunology and Infectious Diseases, University of; Verona, Italy.; OBJECTIVE: A retrospective investigation was made to compare the occupational risk of tuberculosis in personnel assisting human immunodeficiency virus (HIV)-infected and uninfected subjects with active tuberculosis. DESIGN: We retrospectively reviewed 6 years of hospital activity in 3 units where HIV-infected patients
Esophageal disease in AIDS is associated with pathologic processes rather than mucosal human immunodeficiency virus type 1 [see comments]: J Infect Dis. 1993 Mar;167(3):547-52. Unique Identifier : AIDSLINE MED/93179775; Smith PD; Eisner MS; Manischewitz JF; Gill VJ; Masur H; Fox CF; Laboratory of Immunology, National Institute of Dental Research,; National Institutes of Health, Bethesda, Maryland.; Twenty-five patients with AIDS and esophageal symptoms were evaluated for the presence of esophageal disease and human immunodeficiency virus type 1 (HIV-1) in the esophageal mucosa. A single infectious process caused by Candida albicans, cytomegalovirus , herpes simplex virus, vari
Intensity of infection in AIDS-associated cryptosporidiosis.: J Infect Dis. 1993 Mar;167(3):704-9. Unique Identifier : AIDSLINE MED/93179795; Goodgame RW; Genta RM; White AC; Chappell CL; Department of Medicine, Baylor College of Medicine, Ben Taub; General Hospital, Houston, TX 77030.; A fluorescent monoclonal anti-Cryptosporidium antibody was used to count the oocysts in stools of 12 AIDS patients with chronic cryptosporidiosis. Oocyst excretion was present throughout the day in all 12 patients. Stool-to-stool variation in oocyst concentration was within one order of magnitude. Small variations wer
Prevalence of human immunodeficiency virus types 1 and 2 infections in Nigeria.: J Infect Dis. 1993 Mar;167(3):710-4. Unique Identifier : AIDSLINE MED/93179796; Olaleye OD; Bernstein L; Ekweozor CC; Sheng Z; Omilabu SA; Li XY; Sullivan-Halley J; Rasheed S; Laboratory of Viral Oncology and AIDS Research, University of; Southern California School of Medicine, Los Angeles 90033.; The prevalence of human immunodeficiency virus (HIV) types 1 and 2 infections in Nigeria was estimated from 3854 serum samples collected at 21 locations from 1985 to 1990. Seventy-eight samples (2.0%) were reactive for HIV-1 and 49 (1.3%) for HIV-2 antibodies; 5 samples were react
Assessment of candidate anticryptosporidial agents in an immunosuppressed rat model.: J Infect Dis. 1993 Mar;167(3):766-8. Unique Identifier : AIDSLINE MED/93179810; Lemeteil D; Roussel F; Favennec L; Ballet JJ; Brasseur P; Department of Parasitology, Hopital Charles-Nicolle, Centre; Hospitalier Universitaire, Rouen, France.; Cryptosporidium parvum causes life-threatening diarrhea in immunocompromised patients, especially those with AIDS. The efficiency of currently proposed anticryptosporidial therapies is limited or doubtful. In this report, molecular candidates for curative or preventive activity were investigated in an immunocompromise
Herpes simplex virus infection as a risk factor for human immunodeficiency virus infection in heterosexuals [letter; comment]: J Infect Dis. 1993 Mar;167(3):772. Unique Identifier : AIDSLINE MED/93179812; Cowan FM; Johnson AM; Mindel A
SP-40,40 immunoreactivity in inflammatory CNS lesions displaying astrocyte/oligodendrocyte interactions.: J Neuropathol Exp Neurol. 1993 Mar;52(2):129-34. Unique Identifier : AIDSLINE MED/93179893; Wu E; Brosnan CF; Raine CS; Department of Pathology Neuropathology, Albert Einstein College; of Medicine, Bronx, NY 10461.; Immunoreactivity for SP-40,40, a putative complement inhibitor, adhesion or protective molecule, has been examined in a variety of inflammatory CNS lesions that displayed associations between hypertrophic astrocytes and oligodendrocytes, a phenomenon previously suggested to be related to oligodendrocyte phagocytosis o
Examiner dependence on physical diagnostic tests for the detection of splenomegaly: a prospective study with multiple observers.: J Gen Intern Med. 1993 Feb;8(2):69-75. Unique Identifier : AIDSLINE MED/93180024; Tamayo SG; Rickman LS; Mathews WC; Fullerton SC; Bartok AE; Warner JT; Feigal DW Jr; Arnstein DG; Callandar NS; Lyche KD; et al; Department of Biology, University of California, San Diego.; OBJECTIVE: To determine the reliability and validity of various physical diagnostic techniques (including three methods of palpation and three methods of percussion) in detecting ultrasonographically identified splenomegaly. DESIGN: Prospective, double-blind study. SETTING: University hospital. PATIENTS: Twenty-seven
Mycobacterium tuberculosis: resurgence of an old disease--current problems [editorial]: J Natl Med Assoc. 1993 Feb;85(2):95-6. Unique Identifier : AIDSLINE MED/93180248; Idemyor V
From the Centers for Disease Control and Prevention. Business responds to AIDS program--1992-1993.: JAMA. 1993 Mar 17;269(11):1370-2. Unique Identifier : AIDSLINE MED/93180260
Mucosal immunity, HIV transmission, and AIDS.: Lab Invest. 1993 Feb;68(2):129-45. Unique Identifier : AIDSLINE MED/93180435; Miller CJ; McGhee JR; Gardner MB; California Regional Primate Research Center, School of Veterinary; Medicine, University of California, Davis.
Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3).: Mol Cell Biol. 1993 Mar;13(3):1315-22. Unique Identifier : AIDSLINE MED/93180775; Duckett CS; Perkins ND; Kowalik TF; Schmid RM; Huang ES; Baldwin AS Jr; Nabel GJ; Department of Internal Medicine, Howard Hughes Medical Institute,; University of Michigan Medical Center, Ann Arbor 48109-0650.; Inducible expression of human immunodeficiency virus (HIV) is regulated by a cellular transcription factor, nuclear factor kappa B (NF-kappa B). NF-kappa B is composed of distinct subunits; five independent genes, NFKB1(p105), NFKB2(p100), RelA(p65), c-rel and relB, that encode related proteins that bind to kappa B DN
More on vaginal inflammation in Africa [letter; comment]: N Engl J Med. 1993 Mar 25;328(12):888-9. Unique Identifier : AIDSLINE MED/93180884; Irwin K; Mibandumba N; Mbuyi K; Ryder R; Sequeira D
Endocrine effects of HIV infection [letter; comment]: N Engl J Med. 1993 Mar 25;328(12):889-90. Unique Identifier : AIDSLINE MED/93180886; Chakrabarti J
Endocrine effects of HIV infection [letter; comment]: N Engl J Med. 1993 Mar 25;328(12):890. Unique Identifier : AIDSLINE MED/93180887; Bornemann M; Johnson AC 3d
Endocrine effects of HIV infection [letter; comment]: N Engl J Med. 1993 Mar 25;328(12):890. Unique Identifier : AIDSLINE MED/93180888; Denenberg R
French AIDS team wins Faisal Prize [news]: Nature. 1993 Feb 25;361(6414):674. Unique Identifier : AIDSLINE MED/93180897; Dickson D
Viral transactivation. Pleiotropy and henchman X [news; comment]: Nature. 1993 Feb 25;361(6414):687-8. Unique Identifier : AIDSLINE MED/93180903; Gilman M
Dental HIV transmission? [letter] [see comments]: Nature. 1993 Feb 25;361(6414):691. Unique Identifier : AIDSLINE MED/93180905; DeBry RW; Abele LG; Weiss SH; Hill MD; Bouzas M; Lorenzo E; Graebnitz F; Resnick L
Rotational symmetry in ribonucleotide strand requirements for binding of HIV-1 Tat protein to TAR RNA.: Nucleic Acids Res. 1993 Jan 11;21(1):151-4. Unique Identifier : AIDSLINE MED/93181168; Barnett RW; Delling U; Kuperman R; Sonenberg N; Sumner-Smith M; Allelix Biopharmaceuticals Inc. Mississauga, Ontario, Canada.; Transactivation of human immunodeficiency virus (HIV) gene expression requires binding of the viral Tat protein to a RNA hairpin-loop structure (TAR) which contains a two or three-nucleotide bulge. Tat binds in the vicinity of the bulge and the two adjacent duplex stems, recognising both specific sequence and structur
Dispensable role of the NF-kappa B sites in the UV-induction of the HIV-1 LTR in transgenic mice.: Nucleic Acids Res. 1993 Jan 11;21(1):79-86. Unique Identifier : AIDSLINE MED/93181184; Zider A; Mashhour B; Fergelot P; Grimber G; Vernet M; Hazan U; Couton D; Briand P; Cavard C; Laboratoire de Genetique et Pathologie Experimentales, CJF; INSERM 90-03, Institut Cochin de Genetique Moleculaire, Paris,; France.; We have previously reported the epidermis-specific expression of the HIV-1 LTR in transgenic mice and its induction by UV-B rays. To dissect the underlying mechanism of the UV induction of the LTR in mice, we developed two approaches. We first demonstrated by gel mobility shift analysis, using mice epidermal extracts,
Folding of DNA substrate-hairpin ribozyme domains: use of deoxy 4-thiouridine as an intrinsic photolabel.: Nucleic Acids Res. 1993 Jan 25;21(2):201-7. Unique Identifier : AIDSLINE MED/93181192; Dos Santos DV; Vianna AL; Fourrey JL; Favre A; Groupe de Photobiologie Moleculaire, Institut Jacques Monod,; CNRS Universite Paris VII, France.; Hairpin ribozymes derived from (-)sTRSV RNA exhibit substantial cleavage activity when wobble GU base pairs are introduced in place of the AU pairs normally involved in helices I and II between substrate and ribozyme. This finding prompted us to synthesize by in vitro transcription a new hairpin ribozyme, active again
Cysteine and glutathione deficiency in AIDS patients: a rationale for the treatment with N-acetyl-cysteine.: Pharmacology. 1993;46(2):61-5. Unique Identifier : AIDSLINE MED/93181447; Droge W; Division of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, BRD.; A series of clinical studies and laboratory investigations suggests that the acquired immunodeficiency syndrome (AIDS) may be the consequence of a virus-induced cysteine deficiency. HIV-infected persons at all stages of the disease were found to have decreased plasma cystine and cysteine concentrations and decreased i
N-acetylcysteine: potential for AIDS therapy.: Pharmacology. 1993;46(3):121-9. Unique Identifier : AIDSLINE MED/93181452; Roederer M; Staal FJ; Ela SW; Herzenberg LA; Herzenberg LA; Department of Genetics, Stanford University, Calif. 94305.; The observations that people infected with HIV suffer not only from an inflammatory stress but also from depleted glutathione levels have led to a general hypothesis that these two are causally related, and that treatment of AIDS should include thiol-replenishment therapy. In particular, inflammatory stimulations are
[HIV, nutrition and immune defence]: Tidsskr Nor Laegeforen. 1993 Jan 30;113(3):315-6. Unique Identifier : AIDSLINE MED/93181866; Froland SS
[Nutritional counseling to patients with HIV infection. Can nutritional intervention prevent, expose or relieve symptoms in HIV-positive persons?]: Tidsskr Nor Laegeforen. 1993 Jan 30;113(3):324-6. Unique Identifier : AIDSLINE MED/93181870; Thommessen M; Rundberget J; Etat for miljorettet helsevern, Oslo kommune.; Patients with HIV-infection often exhibit progressive loss of weight and poor nutritional status. The problems, which may appear during all stages of the HIV-infection, may be explained by low intake of food or selected nutrients as a result of anorexia and eating problems, and by impaired gastro-intestinal function a
Late airway changes in rat lung allografts: chronic rejection is a causative factor.: Transplant Proc. 1993 Feb;25(1 Pt 2):1169-71. Unique Identifier : AIDSLINE MED/93181989; Uyama T; Sakiyama S; Monden Y; Winter JB; Prop J; Second Department of Surgery, School of Medicine, University of; Tokushima, Japan.
Kaposi's sarcoma in renal transplant recipients: a report on 26 cases from a single institution.: Transplant Proc. 1993 Feb;25(1 Pt 2):1402-5. Unique Identifier : AIDSLINE MED/93182087; Qunibi WY; Barri Y; Alfurayh O; Almeshari K; Khan B; Taher S; Sheth K; Department of Medicine, King Faisal Specialist Hospital and; Research Center, Riyadh, Saudi Arabia.
Impact asymptomatic HIV-1 infection on renal allograft recipients.: Transplant Proc. 1993 Feb;25(1 Pt 2):1478-80. Unique Identifier : AIDSLINE MED/93182117; Keay S; Behrens MT; Klassen D; Weir MR; Schweitzer E; Evans D; Constantine NT; Bartlett S; Department of Medicine, University of Maryland School of; Medicine, Baltimore 21201.
Risk of AIDS (HIV) transmission in 581 renal transplants.: Transplant Proc. 1993 Feb;25(1 Pt 2):1483-4. Unique Identifier : AIDSLINE MED/93182119; Zaleski C; Burke G; Nery J; Roth D; Fernandez J; Babischkin S; Esquenazi V; Miller J; University of Miami School of Medicine, Department of Surgery, FL; 33101.
A follow-up study of neuropsychological function in asymptomatic HIV-infected patients.: Acta Neurol Scand. 1993 Feb;87(2):83-7. Unique Identifier : AIDSLINE MED/93182581; Karlsen NR; Reinvang I; Froland SS; Department of Behavioural and Psychosomatic Medicine, National; Hospital, Oslo, Norway.; A group of asymptomatic HIV-infected patients (CDC II and III) was followed-up over a two year period with semi-annual neuropsychological testing. Of the total sample of 36 subjects, all were retested at test two (T2), 19 at test three (T3) and 13 at test four (T4). A subgroup of subjects was further tested on a simpl
Cognitive performance in HIV-1 infection: relationship to severity of disease and brain atrophy.: Acta Neurol Scand. 1993 Feb;87(2):88-94. Unique Identifier : AIDSLINE MED/93182582; Poutiainen E; Elovaara I; Raininko R; Hokkanen L; Valle SL; Lahdevirta J; Iivanainen M; Department of Neurology, Helsinki University Hospital, Finland.; We examined cognitive performance in 72 HIV-1 infected patients and 34 controls. None of the patients had opportunistic infections or unusual neoplasms of the central nervous system (CNS). Factors other than HIV-1 known to cause cognitive decline were excluded from both groups. Cognitive functioning analysed with spec
Neuronal damage in the cerebral cortex of AIDS brains: a morphometric study.: Acta Neuropathol (Berl). 1993;85(2):185-9. Unique Identifier : AIDSLINE MED/93182594; Weis S; Haug H; Budka H; Institute of Neuropathology, University of Munich, Federal; Republic of Germany.; Using stereological methods, two cerebral cortical areas from AIDS brains were investigated. Neuronal density, profile area of neurons, and perikaryon volume fraction were measured and compared to age-matched control brains. In the fronto-orbital cortex (area 11) of AIDS brains, a significant loss of neurons was seen.
Hospital will hire HIV-infected pharmacist [news]: Am J Hosp Pharm. 1993 Mar;50(3):405. Unique Identifier : AIDSLINE MED/93182652
Outpatient compliance with zidovudine therapy in French Polynesia [letter]: Am J Hosp Pharm. 1993 Mar;50(3):444. Unique Identifier : AIDSLINE MED/93182658; Berod T; Simon P
An HIV-infected pharmacist must be employed without restraints to his practice [news]: Am J Nurs. 1993 Mar;93(3):9. Unique Identifier : AIDSLINE MED/93182708
Rapid assessment of human immunodeficiency virus seroprevalence in a community-based hospital.: Am J Infect Control. 1993 Feb;21(1):9-15. Unique Identifier : AIDSLINE MED/93182784; Rhodes LV 3d; Reed JF; Faust LA; Moser K; Lehigh Valley Hospital, Epidemiology and Infection Control; Section, Allentown, PA.; BACKGROUND: To aid in development of patient testing policy, in-service education, and resource planning, it is necessary to have a useful and meaningful tool for determining the population-specific HIV seroprevalence rate for our hospital patients. We were offered by the Centers for Disease Control a newly developed
Decreased surfactant protein A in patients with bacterial pneumonia.: Am Rev Respir Dis. 1993 Mar;147(3):653-7. Unique Identifier : AIDSLINE MED/93182864; Baughman RP; Sternberg RI; Hull W; Buchsbaum JA; Whitsett J; Department of Internal Medicine, University of Cincinnati Medical; Center, Ohio.; Abnormalities have been previously noted in the lipid content of the lavage fluid of patients with bacterial pneumonia. In order to determine if these changes were also seen in surfactant apoproteins, we studied levels of surfactant protein A (SP-A) in patients with bacterial pneumonia. Patients without human immunode
Pulmonary complications of human immunodeficiency virus infection in Bujumbura, Burundi.: Am Rev Respir Dis. 1993 Mar;147(3):658-63. Unique Identifier : AIDSLINE MED/93182865; Kamanfu G; Mlika-Cabanne N; Girard PM; Nimubona S; Mpfizi B; Cishako A; Roux P; Coulaud JP; Larouze B; Aubry P; et al; Department of Medicine, University of Bujumbura School of; Medicine, Burundi.; To determine the types of pulmonary disease associated with human immunodeficiency virus (HIV) infection, we conducted a prospective study of 302 consecutive patients admitted for acute respiratory disease to a university hospital in Bujumbura, Burundi . Diagnoses were made accordi
Neurosyphilis. A comparative study of the effects of infection with human immunodeficiency virus [published erratum appears in Arch Neurol 1993 Jun;50(6):614]: Arch Neurol. 1993 Mar;50(3):243-9. Unique Identifier : AIDSLINE MED/93183093; Katz DA; Berger JR; Duncan RC; Department of Neurology, University of Miami (Fla) School of; Medicine 33151.; BACKGROUND--The course of neurosyphilis has been reported to be altered by human immunodeficiency virus (HIV) infection. Prior reports of neurosyphilis occurring in association with HIV infection have been largely anecdotal and have failed to compare neurosyphilis in patients with HIV infection with an uninfected cont
Magnetic resonance imaging morphometric analysis of cerebral volume loss in human immunodeficiency virus infection. The HNRC Group.: Arch Neurol. 1993 Mar;50(3):250-5. Unique Identifier : AIDSLINE MED/93183094; Jernigan TL; Archibald S; Hesselink JR; Atkinson JH; Velin RA; McCutchan JA; Chandler J; Grant I; San Diego Department of Veterans Affairs Medical Center, CA.; Magnetic resonance imaging was used to compare male subjects seropositive for antibody to human immunodeficiency virus type 1 (HIV positive), with and without medical symptoms, with two groups of men who were seronegative (HIV negative). The control subjects included men at high risk for exposure to HIV-1 and those at
HIV infection and severe malnutrition: a clinical and epidemiological study in Burkina Faso.: AIDS. 1993 Jan;7(1):103-8. Unique Identifier : AIDSLINE MED/93183408; Prazuck T; Tall F; Nacro B; Rochereau A; Traore A; Sanou T; Malkin JE; Apaire-Marchais V; Masson D; Dublanchet A; et al; Groupe d'Etudes Epidemiologiques et Prophylactiques (GEEP),; Villeneuve St Georges, France.; OBJECTIVE: To define a clinical profile indicative of HIV infection in a population of severely malnourished children in Burkina Faso . A total of 433 children (average age, 19 months) were recruited at the Sanou Souro National Hospital, Bobo Dioulasso, Burkina Faso. RESULTS: Sixty
A novel use of the link-file system for longitudinal studies of HIV infection: a practical solution to an ethical dilemma.: AIDS. 1993 Jan;7(1):109-13. Unique Identifier : AIDSLINE MED/93183409; Avins AL; Woods WJ; Lo B; Hulley SB; Division of General Internal Medicine, San Francisco General; Hospital, California.; BACKGROUND: Longitudinal studies that collect sensitive data, such as test results for HIV antibodies, present difficult ethical problems for investigators. Personal identifiers are needed for longitudinal follow-up, but current regulations in the United States require that all subject
No connection between alcohol use and unsafe sex among gay and bisexual men.: AIDS. 1993 Jan;7(1):115-9. Unique Identifier : AIDSLINE MED/93183410; Weatherburn P; Davies PM; Hickson FC; Hunt AJ; McManus TJ; Coxon AP; Project SIGMA, London, UK.; OBJECTIVE: To investigate the relationship between alcohol use and unsafe sexual behaviour. METHODS: The paper discusses data collected from 461 gay and bisexual men interviewed in England and Wales by Project SIGMA during 1991-1992. These data were collected during face-to-face interviews using retrospective weekly d
'What does the phrase safer sex mean to you?' Understanding among Glaswegian 18-year-olds in 1990.: AIDS. 1993 Jan;7(1):121-5. Unique Identifier : AIDSLINE MED/93183411; Macintyre S; West P; Medical Research Council, Medical Sociology Unit, Glasgow,; Scotland, UK.; OBJECTIVE: To ascertain what young people in western Scotland understand by the phrase safer sex , and the social correlates of this knowledge. DESIGN: Face-to-face interviews with 18-year-olds participating in the third stage of a longitudinal study of the social patterning of health and illness. SETTING: The Centra
Administration of zidovudine during primary HIV-1 infection may be associated with a less vigorous immune response [letter]: AIDS. 1993 Jan;7(1):127-8. Unique Identifier : AIDSLINE MED/93183412; Tindall B; Carr A; Goldstein D; Penny R; Cooper DA
Does zidovudine reduce tumour necrosis factor-alpha in HIV-positive patients? [letter]: AIDS. 1993 Jan;7(1):128-9. Unique Identifier : AIDSLINE MED/93183413; Cremoni L; Vaira LL; D'Amico P; Grassi MG; Milazzo F
Effect of the oral anticoagulant, warfarin, on HIV-1 replication and spread [letter]: AIDS. 1993 Jan;7(1):129-30. Unique Identifier : AIDSLINE MED/93183414; Bourinbaiar AS; Tan X; Nagorny R
Dideoxyinosine-associated nephrotoxicity [letter]: AIDS. 1993 Jan;7(1):131-2. Unique Identifier : AIDSLINE MED/93183416; Crowther MA; Callaghan W; Hodsman AB; Mackie ID
Estimating HIV prevalence in Switzerland [letter]: AIDS. 1993 Jan;7(1):132-3. Unique Identifier : AIDSLINE MED/93183417; Zwahlen M; Ledergerber B
Quantifying the risk of HIV-1 transmission via breast-milk [letter]: AIDS. 1993 Jan;7(1):134-5. Unique Identifier : AIDSLINE MED/93183418; Dunn D; Newell ML
Anti-CD4 antibodies generated in response to HIV-1 rgp160 immunization of HIV-1-infected chimpanzees [letter]: AIDS. 1993 Jan;7(1):136-8. Unique Identifier : AIDSLINE MED/93183419; Keiser P; Fernie B; Tacket C; Wecksler W; Keay S
Human T-lymphotropic virus type I infections in western India [letter]: AIDS. 1993 Jan;7(1):138-9. Unique Identifier : AIDSLINE MED/93183420; Singhal BS; Lalkaka JA; Sonoda S; Hashimoto K; Nomoto M; Kubota R; Osame M
Trichosporon beigelii fungaemia in an AIDS patient [letter]: AIDS. 1993 Jan;7(1):139-40. Unique Identifier : AIDSLINE MED/93183421; Barchiesi F; Morbiducci V; Ancarani F; Arzeni D; Scalise G
Zidovudine half-life in haemodialysis patients [letter; comment]: AIDS. 1993 Jan;7(1):141-2. Unique Identifier : AIDSLINE MED/93183423; Stellbrink HJ; Averdunk R; Stoehr A; Albrecht H
Toxoplasmic encephalitis during pregnancy [letter]: AIDS. 1993 Jan;7(1):142-3. Unique Identifier : AIDSLINE MED/93183424; Vanhems P; Irion O; Hirschel B
5-Fluoro-uracil-clindamycin for treatment of cerebral toxoplasmosis [letter]: AIDS. 1993 Jan;7(1):143-4. Unique Identifier : AIDSLINE MED/93183425; Dhiver C; Milandre C; Poizot-Martin I; Drogoul MP; Gastaut JL; Gastaut JA
Patterns of immunoglobulin G subclass reactivity to HIV-1 envelope peptides in children born to HIV-1 infected mothers.: AIDS. 1993 Jan;7(1):2nd page following p. 147. Unique Identifier : AIDSLINE MED/93183428; Jansson M; Wahren B; Scarlatti G; Principi N; Lombardi V; Livadiotti S; Elia L; Plebani A; Wigzell H; Rossi P
HIV-1 strains from India are highly divergent from prototypic African and US/European strains, but are linked to a South African isolate.: AIDS. 1993 Jan;7(1):23-7. Unique Identifier : AIDSLINE GENBANK/X68407; Dietrich U; Grez M; von Briesen H; Panhans B; Geissendorfer M; Kuhnel H; Maniar J; Mahambre G; Becker WB; Becker ML; et al; Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus,; Frankfurt, Germany.; OBJECTIVE: To gain molecular insights into different HIV-1 strains present in two different states of India , nucleotide sequences derived from the env region of four HIV-1 strains were analysed. DESIGN: HIV-1 was isolated from high-risk patients from the states of Maharashtra (city
In vivo decrease in the expression of complement receptor 2 on B-cells in HIV infection.: AIDS. 1993 Jan;7(1):37-41. Unique Identifier : AIDSLINE MED/93183432; Scott ME; Landay AL; Lint TF; Spear GT; Department of Pediatrics, Rush-Presbyterian-St Luke's Medical; Center, Chicago, Illinois 60612.; OBJECTIVE: To investigate changes in the expression of complement receptor 2 (CR2) on B-cells from HIV-infected individuals. CR2 is the C3d/Epstein-Barr virus receptor and has been implicated in B-cell activation. Changes in its level of expression may therefore be associated with B-cell dysfunction. DESIGN: Cross-sec
Primary prophylaxis for Pneumocystis carinii pneumonia: a randomized trial comparing cotrimoxazole, aerosolized pentamidine and dapsone plus pyrimethamine.: AIDS. 1993 Jan;7(1):59-64. Unique Identifier : AIDSLINE MED/93183435; Mallolas J; Zamora L; Gatell JM; Miro JM; Vernet E; Valls ME; Soriano E; SanMiguel JG; Infectious Disease Service, Hospital Clinic, Faculty of Medicine,; University of Barcelona, Spain.; OBJECTIVE: To compare the efficacy and tolerance of monthly aerosolized pentamidine versus cotrimoxazole versus dapsone plus pyrimethamine to prevent the initial episodes of Pneumocystis carinii pneumonia (PCP) in HIV-infected patients. DESIGN: An open randomized clinical trial. PATIENTS AND METHODS: HIV-infected pati
Efficacy and safety of rechallenge with low-dose trimethoprim-sulphamethoxazole in previously hypersensitive HIV-infected patients.: AIDS. 1993 Jan;7(1):65-71. Unique Identifier : AIDSLINE MED/93183436; Carr A; Penny R; Cooper DA; Centre for Immunology, St Vincent's Hospital, Sydney, Australia.; OBJECTIVE: This study was undertaken to determine whether patients infected with HIV and with prior hypersensitivity to trimethoprim-sulphamethoxazole (TMP-SMX) can be rechallenged successfully with TMP-SMX, what factors predict successful rechallenge, and whether hypersensitivity is due to TMP or to SMX. DESIGN: A pr
Pleural effusion, tuberculosis and HIV-1 infection in Kigali, Rwanda.: AIDS. 1993 Jan;7(1):73-9. Unique Identifier : AIDSLINE MED/93183437; Batungwanayo J; Taelman H; Allen S; Bogaerts J; Kagame A; Van de Perre P; Department of Internal Medicine, Centre Hospitalier de Kigali,; Rwanda.; OBJECTIVE AND METHODS: An increasing number of diagnoses of pleural effusions (PE) have been made over the last 8 years in the Department of Internal Medicine of the Centre Hospitalier de Kigali, Rwanda . In order to determine the aetiology of PE and to examine its possible associat
Q fever and HIV infection [see comments]: AIDS. 1993 Jan;7(1):81-6. Unique Identifier : AIDSLINE MED/93183438; Raoult D; Levy PY; Dupont HT; Chicheportiche C; Tamalet C; Gastaut JA; Salducci J; Unite des Rickettsies, Faculte de Medecine, Marseille, France.; OBJECTIVE: To study the frequency of Q fever in HIV-infected individuals. DESIGN: A seroprevalence study. SETTING: French National Reference Centre for Rickettsial Agents, Marseille, France . PATIENTS AND METHODS: Five out of the 68 hospitalized cases of Q fever diagnosed in 1987-19
Disseminated meningococcal infection in HIV-seropositive patients.: AIDS. 1993 Jan;7(1):87-90. Unique Identifier : AIDSLINE MED/93183439; Nitta AT; Douglas JM; Arakere G; Ebens JB; Division of Infectious Diseases, University of Colorado Health; Sciences Center, Denver.; OBJECTIVE: Although increasing numbers of infections due to various bacterial pathogens have been described in HIV-infected individuals, there have been few reports to date of disseminated Neisseria meningitidis infections in such individuals. We describe here the presentation and clinical course of systemic meningoco
Chemotherapy of African AIDS diarrhoea: a preliminary study.: AIDS. 1993 Jan;7(1):91-3. Unique Identifier : AIDSLINE MED/93183440; Kelly P; Buve A; Monze District Hospital, Zambia.; OBJECTIVE: To determine whether combined chemotherapy with tinidazole, thiabendazole and cotrimoxazole is more effective than placebo in treatment of AIDS diarrhoea in Zambia . DESIGN: Single-blind prospective comparison in consecutive patients, randomized alternately to placebo or
Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study [see comments]: AIDS. 1993 Jan;7(1):95-102. Unique Identifier : AIDSLINE MED/93183441; Laga M; Manoka A; Kivuvu M; Malele B; Tuliza M; Nzila N; Goeman J; Behets F; Batter V; Alary M; et al; Projet SIDA, Kinshasa, Zaire.; OBJECTIVES: The heterosexual spread of HIV-1 is occurring at different rates in different parts of the world. The transmission probability of HIV-1 per sexual contact is low, but may be greatly enhanced by several cofactors. Sexually transmitted diseases (STD), especially genital ulcers, may be such factors. So far, e
Alert! Don't abbreviate zidovudine as AZT.: Aspens Advis Nurse Exec. 1993 Mar;8(6):2. Unique Identifier : AIDSLINE MED/93183596
Pamphlet AIDS/HIV advice is not sufficient [news]: Nurs Stand. 1993 Jan 6-12;7(15-16):16. Unique Identifier : AIDSLINE MED/93183716
Pre-ejaculatory fluid risk for HIV spread [news]: Nurs Stand. 1993 Jan 6-12;7(15-16):17. Unique Identifier : AIDSLINE MED/93183717
HIV/AIDS education: philately will get you everywhere.: Nurs Stand. 1993 Jan 6-12;7(15-16):47-9. Unique Identifier : AIDSLINE MED/93183728; Howe J
HIV and AIDS: a positive response (continuing education credit).: Nurs Stand. 1993 Jan 6-12;7(15-16 Suppl NU):9-16. Unique Identifier : AIDSLINE MED/93183733; Boylan P; Corbett K; Smith C
N-acetylcysteine enhances T cell functions and T cell growth in culture.: Int Immunol. 1993 Jan;5(1):97-101. Unique Identifier : AIDSLINE MED/93183831; Eylar E; Rivera-Quinones C; Molina C; Baez I; Molina F; Mercado CM; Department of Biochemistry, Ponce School of Medicine, Puerto Rico; 00732.; N-Acetylcysteine (NAC) is highly nontoxic for peripheral blood T cells and immunostimulatory enhancing T cell functions such as mitogenesis, interleukin-2 ( IL-2 ) production, and growth in culture. NAC has been proposed for the treatment of AIDS based on its inhibition
Specific recognition of CG base pairs by 2-deoxynebularine within the purine.purine.pyrimidine triple-helix motif.: Biochemistry. 1993 Mar 9;32(9):2177-85. Unique Identifier : AIDSLINE MED/93183881; Stilz HU; Dervan PB; Beckman Institute, California Institute of Technology, Pasadena; 91125.; The sequence-specific recognition of double-helical DNA by oligodeoxyribonucleotide-directed triple-helix formation is limited mostly to purine tracts. Within the geometric constraints of the phosphate-deoxyribose position of a purine-purine-pyrimidine triple-helical structure, model building studies suggested that th
Transfusion in transplant patients: the good, the bad, and the ugly.: J Heart Lung Transplant. 1993 Jan-Feb;12(1 Pt 1):S7-12. Unique Identifier : AIDSLINE MED/93183923; Klein HG; Department of Transfusion Medicine, National Institutes of; Health, Bethesda, Md. 20892.; Several transfusion-related complications have particular relevance to the transplant setting. Transfusions reportedly improve solid organ graft survival, especially when the donor and recipient share at least one HLA-DR antigen. Whereas the mechanism for this effect is unclear, less favorable immunomodulating effects
Serum adenosine deaminase 2 and neopterin levels are increased in a majority of hemophiliacs irrespective of infection with human immunodeficiency virus type 1 [see comments]: Clin Infect Dis. 1993 Feb;16(2):260-4. Unique Identifier : AIDSLINE MED/93184102; Matsuda J; Tsukamoto M; Gohchi K; Saitoh N; Kawasugi K; Kinoshita T; Department of Medicine, Teikyo University School of Medicine,; Tokyo, Japan.; We investigated serum levels of adenosine deaminase 2 (ADA2) and neopterin (NP) in hemophiliacs with or without infection with human immunodeficiency virus type 1 (HIV-1). The mean (+/- SD) serum ADA2 level in hemophiliacs positive for HIV-1 (45.2 +/- 17.6 U/L) and negative for HIV-1 (34.9 +/- 15.8 U/L) was significan
Use of paromomycin for treatment of cryptosporidiosis in patients with AIDS [see comments]: Clin Infect Dis. 1993 Feb;16(2):298-300. Unique Identifier : AIDSLINE MED/93184111; Fichtenbaum CJ; Ritchie DJ; Powderly WG; Division of Infectious Diseases, Washington University School of; Medicine, St. Louis, Missouri 63110.; Cryptosporidiosis in patients with AIDS often leads to a severe wasting illness that is difficult to treat. Recent reports suggest that paromomycin may be useful in the treatment of intestinal cryptosporidiosis. We reviewed our experience using paromomycin for the treatment of cryptosporidiosis in seven patients with
Oral candidiasis is associated with low levels of parotid calprotectin in individuals with infection due to human immunodeficiency virus.: Clin Infect Dis. 1993 Feb;16(2):301-2. Unique Identifier : AIDSLINE MED/93184112; Muller F; Froland SS; Brandtzaeg P; Fagerhol MK; Kaptein W. Wilhelmsen og frues Institute of Bacteriology,; University of Oslo, National Hospital, Norway.; The level of the antifungal leukocyte protein calprotectin was determined in parotid saliva from 44 individuals with infection due to human immunodeficiency virus (HIV) and 19 healthy HIV-seronegative controls. Nine of the HIV-infected subjects suffered from oral candidiasis. Similar calprotectin levels were found in
Pancreatic tuberculosis as a manifestation of infection with the human immunodeficiency virus [letter]: Clin Infect Dis. 1993 Feb;16(2):332. Unique Identifier : AIDSLINE MED/93184117; Eyer-Silva WA; de Sa CA; Pinto JF; Gameiro CA
Diagnosis of perirectal Pneumocystis carinii infection by direct immunofluorescence [letter]: Clin Infect Dis. 1993 Feb;16(2):336-7. Unique Identifier : AIDSLINE MED/93184121; Buggy BP
New curriculum for AIDS education [news]: Concern. 1993 Feb;22(1):5. Unique Identifier : AIDSLINE MED/93184504
Vaccines in AIDS. Present state of knowledge.: Int Arch Allergy Immunol. 1993;100(2):93-8. Unique Identifier : AIDSLINE MED/93184521; Barrett PN; Dorner F; Immuno AG, Biomedical Research Center, Orth/Donau, Austria.; The identification of a virus, HIV-1, as the etiological agent of AIDS has opened the door to the development of a vaccine against this disease, for both prophylactic and therapeutic purposes. A number of different vaccine strategies have been developed in pursuit of this aim. The first major advances in this directio
Gallo guilty of AIDS misconduct [news]: BMJ. 1993 Jan 16;306(6871):161-2. Unique Identifier : AIDSLINE MED/93184571; Connor S
Tuberculosis in Britain today [editorial] [see comments]: BMJ. 1993 Jan 23;306(6872):221-2. Unique Identifier : AIDSLINE MED/93184615; Watson JM
Zinc- and sequence-dependent binding to nucleic acids by the N-terminal zinc finger of the HIV-1 nucleocapsid protein: NMR structure of the complex with the Psi-site analog, dACGCC.: Protein Sci. 1993 Jan;2(1):3-19. Unique Identifier : AIDSLINE MED/93184722; South TL; Summers MF; Department of Chemistry and Biochemistry, University of Maryland; Baltimore County 21228.; The nucleic acid interactive properties of a synthetic peptide with sequence of the N-terminal CCHC zinc finger (CCHC = Cys-X2-Cys-X4-His-X4-Cys; X = variable amino acid) of the human immunodeficiency virus (HIV) nucleocapsid protein, Zn(HIV1-F1), have been studied by 1H NMR spectroscopy. Titration of Zn(HIV1-F1) with
Retroviral nucleocapsid proteins possess potent nucleic acid strand renaturation activity.: Protein Sci. 1993 Feb;2(2):231-43. Unique Identifier : AIDSLINE MED/93184741; Dib-Hajj F; Khan R; Giedroc DP; Department of Biochemistry and Biophysics, Texas A&M University,; College Station 77843-2128.; The nucleocapsid protein (NC) is the major genomic RNA binding protein that plays integral roles in the structure and replication of all animal retroviruses. In this report, select biochemical properties of recombinant Mason- Pfizer monkey virus (MPMV) and HIV-1 NCs are com
A case of a hepatitis B infected practitioner.: J Can Dent Assoc. 1993 Jan;59(1):52-7. Unique Identifier : AIDSLINE MED/93184903; Christianson C; Epstein J; Mathias R; College of Dental Surgeons of British Columbia.; The first case of a dental practitioner infected by a blood-borne pathogen to be identified to the College of Dental Surgeons of B.C. and reviewed by the Dental Profession Advisory Program s infected practitioner program committee is reported. After the committee was contacted, the infected practitioner s status was e
The use of blood in resuscitation of the trauma patient [published erratum appears in Can J Surg 1993 Apr;36(2):114] [see comments]: Can J Surg. 1993 Feb;36(1):21-7. Unique Identifier : AIDSLINE MED/93184946; Hamilton SM; Department of Surgery, University of Alberta, Edmonton.; The ability to transfuse blood (a form of tissue transplantation) with relatively few immediate and long-term complications has led to increased survival in victims of injury who require massive amounts of blood. The primary deficit in hypovolemic shock secondary to trauma is in oxygen transport to the hypoperfused ti
CD23/Fc epsilon R11 expression in contact sensitivity reactions: a comparison between aeroallergen patch test reactions in atopic dermatitis and the nickel patch test reaction in non-atopic individuals.: Clin Exp Immunol. 1993 Mar;91(3):357-61. Unique Identifier : AIDSLINE MED/93185287; Buckley C; Ivison C; Poulter LW; Rustin MH; Department of Dermatology, Royal Free Hospital, London, UK.; The immunopathology of patch test reactions to aeroallergens in patients with atopic dermatitis (AD) has been compared to that of contact sensitivity reactions to nickel in non-atopic individuals. Both reactions were found to exhibit equivalent erythema and induration on gross examination at 48 h. Four millimetre punc
Rheumatoid factor expression and complement activation in children congenitally infected with human immunodeficiency virus.: Clin Immunol Immunopathol. 1993 Apr;67(1):50-4. Unique Identifier : AIDSLINE MED/93185330; Jarvis JN; Taylor H; Iobidze M; Dejonge J; Chang S; Cohen F; Department of Pediatrics, Wayne State University School of; Medicine/Children's Hospital of Michigan, Detroit 48201.; Rheumatic disease manifestations and autoimmune phenomena are common in adults infected with human immunodeficiency virus (HIV). On the other hand, rheumatic disease manifestations are rare in children congenitally infected with HIV. We studied the relationship between autoimmune phenomena and rheumatic diseases by ex
Proline-dependent structural and biological properties of peptides and proteins.: Crit Rev Biochem Mol Biol. 1993;28(1):31-81. Unique Identifier : AIDSLINE MED/93185400; Yaron A; Naider F; Department of Membrane Research and Biophysics, Weizmann; Institute of Science, Rehovot, Israel.; Proline residues confer unique structural constraints on peptide chains and markedly influence the susceptibility of proximal peptide bonds to protease activity. This review presents a critical analysis of peptidases involved in the cleavage of proline-containing peptide bonds, with particular attention to the role of
[Mycobacterium genavense infection in AIDS]: Dtsch Med Wochenschr. 1993 Mar 5;118(9):296-300. Unique Identifier : AIDSLINE MED/93185548; Heiken H; Kirschner P; Stoll M; Bottger EC; Schmidt RE; Abteilung Immunologie und Transfusionsmedizin, Medizinische; Hochschule Hannover.; Fever, loss of weight, anaemia, hepatosplenomegaly and lymphadenopathy developed in two HIV-infected patients. At first malignant lymphoma with septicaemia was thought to be the cause. In both patients Salmonella enteritidis was isolated by blood culture and found to be sensitive against the antibiotics that were give
Rational approach to the diagnosis of Pneumocystis carinii pneumonia (PCP) [editorial; comment]: Eur Respir J. 1993 Feb;6(2):166-8. Unique Identifier : AIDSLINE MED/93185806; Lode H; Schaberg T
Cost effectiveness of the induced sputum technique for the diagnosis of Pneumocystis carinii pneumonia (PCP) in HIV-infected patients [see comments]: Eur Respir J. 1993 Feb;6(2):248-52. Unique Identifier : AIDSLINE MED/93185818; Chouaid C; Housset B; Poirot JL; Roux P; Lebeau B; Respiratory Departement, Saint Antoine Hospital, Paris, France.; The purpose of this study was to assess: 1) the percentage of human immunodeficiency virus (HIV)-infected patients with suspected Pneumocystis carinii pneumonia (PCP) but unable to undergo the induced sputum procedure, together with the reasons involved; 2) the sensitivity and specificity of induced sputum procedure,
Governor Chiles assigns 'Red Ribbon Panel on AIDS': Barbara Russell selected.: Fla Nurse. 1993 Feb;41(2):1, 19. Unique Identifier : AIDSLINE MED/93185856; Frankel LJ
ANA meets with transition team to discuss AIDS [news]: Fla Nurse. 1993 Feb;41(2):2. Unique Identifier : AIDSLINE MED/93185859
Guidelines for preventing transmission of HIV and hepatitis B from health care workers to patients. Division of Public Health, Delaware Health and Social Services.: Del Med J. 1993 Mar;65(3):197-200. Unique Identifier : AIDSLINE MED/93185864; Silverman PR; Konigsberg C Jr; Delaware Health and Social Services, Division of Public Health.
Use of DNA end joining activity of a Xenopus laevis egg extract for construction of deletions and expression vectors for HIV-1 Tat and Rev proteins.: Gene. 1993 Feb 28;124(2):275-80. Unique Identifier : AIDSLINE MED/93185935; Schaal H; Pfeiffer P; Klein M; Gehrmann P; Scheid A; Institut fur Medizinische Mikrobiologie und Virologie,; Heinrich-Heine-Universitat, Dusseldorf, Germany.; We have developed a cloning strategy which combines conventional T4 DNA ligation with the highly efficient nonhomologous DNA end joining (EJ) activity of an extract from Xenopus laevis eggs. The nonhomologous EJ activity allowed the rapid construction of deletion mutants by the intramolecular rejoining of nonhomologou
HIV seroprevalence among long-stay patients in a state psychiatric hospital.: Hosp Community Psychiatry. 1993 Mar;44(3):282-4. Unique Identifier : AIDSLINE MED/93186106; Meyer I; McKinnon K; Cournos F; Empfield M; Bavli S; Engel D; Weinstock A; New York State Office of Mental Health, NY.
APA updates guidelines for care of HIV-infected inpatients, confidentiality and disclosure of HIV [news]: Hosp Community Psychiatry. 1993 Mar;44(3):296-7. Unique Identifier : AIDSLINE MED/93186113
HIV prevalence among clients attending a sexually transmitted diseases clinic in Amsterdam: the potential risk for heterosexual transmission.: Genitourin Med. 1993 Feb;69(1):23-8. Unique Identifier : AIDSLINE MED/93186146; Fennema JS; van Ameijden EJ; Coutinho RA; van Doornum GJ; Henquet CJ; van den Hoek JA; Department of Public Health and Environment, Municipal Health; Service, Amsterdam, The Netherlands.; INTRODUCTION--Patients attending a clinic for sexually transmitted diseases (STD) in general have engaged in at risk sexual behaviour. Therefore they are at increased risk of acquiring HIV through sexual contact. OBJECTIVE--To determine the HIV prevalence among patients attending a STD clinic in Amsterdam. METHODS--An
The testing of saliva samples for HIV-1 antibodies: reliability in a non-clinic setting.: Genitourin Med. 1993 Feb;69(1):29-30. Unique Identifier : AIDSLINE MED/93186147; Hunt AJ; Connell J; Christofinis G; Parry JV; Weatherburn P; Hickson FC; Coxon AP; Davies PM; McManus TJ; Sutherland S; Dulwich Hospital PHLS, London, UK.; AIMS--To assess the reliability of saliva samples as a means of testing for HIV-antibodies outside clinic settings. METHODS--Men taking part in a non-clinic longitudinal study of homosexually active men provided samples of saliva and blood. Sera were screened using a competitive ELISA (Wellcozyme) and positive sera we
The prevalence of human retroviral infections in female patients attending a central London sexually transmitted disease clinic: 1985-1990.: Genitourin Med. 1993 Feb;69(1):31-4. Unique Identifier : AIDSLINE MED/93186149; Loveday C; Mercey D; Division of Virology, University College, Middlesex School of; Medicine, London, UK.; OBJECTIVES--To determine the prevalence of infection with HIV-1, HIV2, HTLV-1 and HTLV-2 in female attenders at a central London sexually transmitted disease clinic in an 8 week period in 1989-1990, and compare it with similar samples studied between 1985 and 1987. DESIGN--Anonymous testing of serum samples from conse
Wassermann reaction in peripheral blood of patients with secondary syphilis and human-immunodeficiency virus infection [letter]: Genitourin Med. 1993 Feb;69(1):77. Unique Identifier : AIDSLINE MED/93186160; Weismann K; Petersen LJ; Petersen CS
Oro-anal sex and the occurrence of Kaposi's sarcoma [letter]: Genitourin Med. 1993 Feb;69(1):77-8. Unique Identifier : AIDSLINE MED/93186161; van Griensven GJ; Boucher EC; Coutinho RA
Primary HIV-1 infection associated with prominent genital ulcers [letter]: Genitourin Med. 1993 Feb;69(1):78-9. Unique Identifier : AIDSLINE MED/93186162; Felten A; Lecompte T; Ferchal F; Agbalika F
HIV infection in Tirupathi, India [letter; comment]: Genitourin Med. 1993 Feb;69(1):81. Unique Identifier : AIDSLINE MED/93186165; Tharakaram S
Skin manifestations observed in HIV-infected persons [letter]: Int J Dermatol. 1993 Mar;32(3):228. Unique Identifier : AIDSLINE MED/93186306; Mutalik S
OSHA's bloodborne pathogens standard: analysis and recommendations.: Health Devices. 1993 Feb;22(2):35-92. Unique Identifier : AIDSLINE MED/93186413; Just over a year ago, the Occupational Safety and Health Administration (OSHA) issued the final bloodborne pathogens standard, Occupational Exposure to Bloodborne Pathogens; Final Rule, which requires healthcare institutions to protect their employees from all occupational exposure to bloodborne pathogens. According t
Arkansas HIV/AIDS report 1983-1993.: J Ark Med Soc. 1993 Mar;89(10):508-9. Unique Identifier : AIDSLINE MED/93186647
Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappa B.: J Biol Chem. 1993 Mar 5;268(7):5032-9. Unique Identifier : AIDSLINE MED/93186814; Laherty CD; Perkins ND; Dixit VM; Department of Pathology, University of Michigan Medical School,; Ann Arbor 48109-0602.; A20 was originally identified as a primary tumor necrosis factor alpha (TNF)-responsive gene, which encodes a 790-amino acid zinc finger protein. A20 is expressed in a wide variety of cell lines, including fibroblasts, in which A20 expression protects cells from TNF cytotoxicity. An analysis of A20 expression in lymph
Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein.: J Biol Chem. 1993 Mar 5;268(7):5279-84. Unique Identifier : AIDSLINE MED/93186846; Weeks BS; Desai K; Loewenstein PM; Klotman ME; Klotman PE; Green M; Kleinman HK; Laboratory of Developmental Biology, National Institute of Dental; Research, National Institutes of Health, Bethesda, Maryland; 20892.; The HIV-1 transactivator protein Tat is essential for viral gene expression and replication. Tat is taken up by cells and transactivates the HIV-LTR promoter in the cell nucleus. The present studies show that cells adhere to both synthetic and recombinant Tat, and, using synthetic peptides, we localize the binding sit
Increased de novo hepatic lipogenesis in human immunodeficiency virus infection.: J Clin Endocrinol Metab. 1993 Mar;76(3):559-65. Unique Identifier : AIDSLINE MED/93186981; Hellerstein MK; Grunfeld C; Wu K; Christiansen M; Kaempfer S; Kletke C; Shackleton CH; Department of Nutritional Sciences, University of California,; Berkeley 94720.; We measured de novo lipogenesis in human immunodeficiency virus (HIV) infected men using a newly developed stable isotope method. HIV-infected subjects with a history of weight loss (n = 17, mean weight loss 14.9 +/- 3.2 kg), asymptomatic HIV-seropositive subjects with normal CD4 T-cell counts (n = 7) and healthy HIV
Kaposi's sarcoma. Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy.: J Am Acad Dermatol. 1993 Mar;28(3):371-95. Unique Identifier : AIDSLINE MED/93187046; Tappero JW; Conant MA; Wolfe SF; Berger TG; San Francisco General Hospital, California.; The acquired immunodeficiency syndrome (AIDS) epidemic has had a profound impact on our understanding of Kaposi s sarcoma (KS). Epidemiologic features suggest a sexually transmitted cofactor in the pathogenesis of AIDS-associated KS (AIDS-KS), and several putative agents have received intense scrutiny. Cell culture st
AIDS-associated Kaposi's sarcoma in Romanian children.: J Am Acad Dermatol. 1993 Mar;28(3):449-53. Unique Identifier : AIDSLINE MED/93187055; Orlow SJ; Cooper D; Petrea S; Kamino H; Popescu V; Lawrence R; Leibovitz E; Ronald O. Perelman Department of Dermatology, New York University; Medical Center, NY 10016.; BACKGROUND: Kaposi s sarcoma (KS) is commonly associated with the acquired immunodeficiency syndrome (AIDS) in adults. Little is known regarding its occurrence in children. OBJECTIVE: Our purpose was to report the clinical and epidemiologic characteristics of KS in three Romanian children with AIDS and to compare them
Histologic features of foreign body reactions in patients infected with human immunodeficiency virus type 1. The Military Medical Consortium for Applied Retroviral Research.: J Am Acad Dermatol. 1993 Mar;28(3):470-6. Unique Identifier : AIDSLINE MED/93187059; Smith KJ; Skelton HG 3d; Yeager J; Angritt P; Wagner KF; Department of Dermatopathology, Armed Forces Institute of; Pathology, Bethesda, Maryland.; BACKGROUND: Within a large population of patients seropositive for human immunodeficiency virus type 1 (HIV-1), seven had biopsy specimens that showed foreign body reactions with histologic features different from those seen in non-HIV-1-positive patients. OBJECTIVE: These cases were reviewed to determine whether ther
Acquired hairy pinnae in a patient infected with the human immunodeficiency virus [letter; comment]: J Am Acad Dermatol. 1993 Mar;28(3):513. Unique Identifier : AIDSLINE MED/93187077; Tosti A; Gaddoni G; Peluso AM; Misciali C; Piraccini BM; Menni B
Structured controversy versus lecture on nursing students' beliefs about and attitude toward providing care for persons with AIDS.: J Contin Educ Nurs. 1993 Mar-Apr;24(2):74-81. Unique Identifier : AIDSLINE MED/93187084; Pederson C; Like many nurses in clinical practice, a small sample of RN-to-BSN nursing students reported their negative attitude toward providing care for persons with AIDS (PWA). Structured controversy is an interactive educational approach that may promote positive attitudes. This experimental study compared the effectiveness o
Lack of evidence for patient-to-patient transmission of HIV in a dental practice [see comments]: J Am Dent Assoc. 1993 Jan;124(1):38-44. Unique Identifier : AIDSLINE MED/93187217; Gooch B; Marianos D; Ciesielski C; Dumbaugh R; Lasch A; Jaffe H; Bond W; Lockwood S; Cleveland J; Centers for Disease Control and Prevention, Atlanta, Ga 30333.; This report reviews data pertaining to the hypothesis that transmission of HIV to five patients of a Florida dentist with AIDS resulted from the patient-to-patient transfer of infectious materials through the reuse of contaminated instruments. Findings strongly suggest that patient-to-patient transmission of HIV throu
Salivary diagnosis: more than a lick and a promise [published erratum appears in J Am Dent Assoc 1993 Apr;124(4):20-1]: J Am Dent Assoc. 1993 Jan;124(1):85-7. Unique Identifier : AIDSLINE MED/93187224; Mandel ID; Columbia University School of Dental and Oral Surgery, New York,; N.Y. 10032.; There is a growing appreciation for the use of oral fluid as an easily collected, non-invasive diagnostic medium in a variety of disease states and clinical situations. Dental applications include differential diagnosis of salivary gland disease, caries and periodontal disease activity and susceptibility tests, Candid
Occupational infectious disease exposures in EMS personnel.: J Emerg Med. 1993 Jan-Feb;11(1):9-16. Unique Identifier : AIDSLINE MED/93187268; Reed E; Daya MR; Jui J; Grellman K; Gerber L; Loveless MO; Portland Bureau of Fire, Rescue and Emergency Services, OR; 97204-3590.; Reports of occupationally transmitted hepatitis B virus (HBV) and human immunodeficiency virus (HIV) prompted the Portland Bureau of Fire Rescue and Emergency Services (PFB) to institute a comprehensive program for handling and tracking on-the-job infectious disease exposures. Data were collected for a 2-year period b
AIDS-related cholangitis: diagnostic features and course in 15 patients.: J Hepatol. 1993 Jan;17(1):34-9. Unique Identifier : AIDSLINE MED/93187309; Bouche H; Housset C; Dumont JL; Carnot F; Menu Y; Aveline B; Belghiti J; Boboc B; Erlinger S; Berthelot P; et al; Unite d'Hepatologie, Hopital Laennec, Paris, France.; About 60 cases of cholangitis in patients with the acquired immune deficiency syndrome (AIDS) have been described. We report our experience concerning 15 patients infected with the human immunodeficiency virus (HIV) and who had cholangitis as defined by radiological findings. Cholangitis was the revealing event of AID
Use of particulate forms of protein antigens to increase the sensitivity of antigen-specific proliferation assays.: J Immunol Methods. 1993 Feb 26;159(1-2):39-45. Unique Identifier : AIDSLINE MED/93187403; Wu JY; Munroe KJ; Gardner BH; Wyand MS; Newman MJ; Cambridge Biotech Corporation, Worcester, MA 01605.; Different forms of recombinant HIV-1 gp160 and tetanus toxoid were adsorbed onto latex microspheres and this particulate form of the proteins was used to measure antigen-specific proliferation in vaccinated rhesus macaques. Proliferative responses to proteins bound to microspheres were significantly greater and allowe
Human coagulation factor IX: assessment of thrombogenicity in animal models and viral safety.: J Lab Clin Med. 1993 Mar;121(3):394-405. Unique Identifier : AIDSLINE MED/93187489; Herring SW; Abildgaard C; Shitanishi KT; Harrison J; Gendler S; Heldebrant CM; Alpha Therapeutic Corp., Los Angeles, CA 90032.; Thromboembolic complications associated with prothrombin complex concentrate treatment may be related to the high levels of factors II and X in these products. We report here results from preclinical safety studies with a human coagulation factor IX product (AlphaNine; Alpha Therapeutic Corp., Los Angeles, Calif.) tha
Molecular characterization of two isolates of human T cell leukaemia virus type II from Italian drug abusers and comparison of genome structure with other isolates.: J Gen Virol. 1993 Mar;74 ( Pt 3):437-44. Unique Identifier : AIDSLINE MED/93187605; Zella D; Cavicchini A; Salemi M; Casoli C; Lori F; Achilli G; Cattaneo E; Landini V; Bertazzoni U; Istituto di Genetica Biochimica ed Evoluzionistica del C.N.R.,; Pavia, Italy.; The human T cell leukaemia virus type II (HTLV-II), whose pathogenicity is as yet unclear, was recently found to be associated with intravenous drug abuse in North America and Europe. HTLV-II was isolated from two Italian drug abusers belonging to the same cohort and coinfected with human immunodeficiency virus type 1
Sensory and sympathetic ganglia in HIV-1 infection: immunocytochemical demonstration of HIV-1 viral antigens, increased MHC class II antigen expression and mild reactive inflammation.: J Neurol Sci. 1993 Feb;114(2):178-87. Unique Identifier : AIDSLINE MED/93187651; Esiri MM; Morris CS; Millard PR; Department of Neuropathology, Radcliffe Infirmary, Oxford, UK.; Sensory and sympathetic ganglia from 12 cases of human immunodeficiency virus type 1 (HIV-1) infection, all but one without clinical evidence of peripheral nerve disease, were studied immunocytochemically for their content of lymphocytes, macrophages, MHC Class II antigens and HIV-1 and
Double-gloving and the incidence of perforations during specific oral and maxillofacial surgical procedures.: J Oral Maxillofac Surg. 1993 Mar;51(3):261-3. Unique Identifier : AIDSLINE MED/93187735; Upton LG; Barber HD; Department of Oral Medicine, Pathology, and Surgery, School of; Dentistry, University of Michigan, Ann Arbor 48109-1078.; The concerns of surgeons about effective means of barrier protection during surgery is increasing owing to concern about the human immunodeficiency virus (HIV). There are various oral and maxillofacial surgical procedures that require the use of sharp instruments, and the oral and maxillofacial surgeon may be at risk
In situ PCR [editorial]: J Pathol. 1993 Feb;169(2):187-8. Unique Identifier : AIDSLINE MED/93187754; Murray GI
Oral findings in Mexican AIDS patients with cancer.: J Oral Pathol Med. 1993 Feb;22(2):87-91. Unique Identifier : AIDSLINE MED/93187880; Ramirez-Amador V; Gonzalez M; de la Rosa E; Esquivel L; Volkow P; Ochoa FJ; Meneses A; Mohar A; Department of Health Care, Universidad Autonoma; Metropolitana-Xochimilco, Mexico City, Mexico.; Oral findings of 42 Mexican AIDS patients with cancer were reviewed. Kaposi s sarcoma (KS) was the most frequent malignancy (81%) followed by non-Hodgkin s lymphoma (NHL) (12%). All cases of NHL were of high or intermediate grade and most of them were extranodal. Out of the 34 indi
The human immunodeficiency virus type 1 long terminal repeat specifies two different transcription complexes, only one of which is regulated by Tat.: J Virol. 1993 Apr;67(4):1752-60. Unique Identifier : AIDSLINE MED/93188120; Lu X; Welsh TM; Peterlin BM; Howard Hughes Medical Institute, University of California, San; Francisco 94143-0724.; The human immunodeficiency virus type 1 long terminal repeat sets up two different transcription complexes, which have been called processive and nonprocessive complexes. By mutating and substituting cis-acting sequences, we mapped elements of the human immunodeficiency virus long terminal repeat that are responsible
Transdominant inhibition of wild-type human immunodeficiency virus type 2 replication by an envelope deletion mutant.: J Virol. 1993 Apr;67(4):1854-9. Unique Identifier : AIDSLINE MED/93188133; Steffy KR; Wong-Staal F; Department of Medicine, University of California San Diego, La; Jolla 92093-0665.; The envelope glycoprotein of human immunodeficiency virus type 2 (HIV-2) is primarily responsible for virus attachment and entry into the target cell population. We constructed an HIV-2 mutant virus containing an in-frame deletion within the putative CD4-binding sequences of the envelope glycoprotein and confirmed tha
trans-dominant interference with virus infection at two different stages by a mutant envelope protein of Friend murine leukemia virus.: J Virol. 1993 Apr;67(4):2026-33. Unique Identifier : AIDSLINE MED/93188152; Matano T; Odawara T; Ohshima M; Yoshikura H; Iwamoto A; Department of Bacteriology, Faculty of Medicine, University of; Tokyo, Japan.; A dominant negative mutant Friend murine leukemia virus (FMLV) env gene was cloned from an immunoselected Friend erythroleukemia cell. The mutant env had a point mutation which resulted in a Cys-to-Arg substitution at the 361st amino acid in the FMLV envelope protein (Env). The mutant Env was retained in the endoplasm
Envelope-binding domain in the cationic amino acid transporter determines the host range of ecotropic murine retroviruses.: J Virol. 1993 Apr;67(4):2091-6. Unique Identifier : AIDSLINE MED/93188159; Albritton LM; Kim JW; Tseng L; Cunningham JM; Department of Medicine, Brigham and Women's Hospital, Boston,; Massachusetts.; Infection of rodent cells by ecotropic type C retroviruses requires the expression of a cationic amino acid transporter composed of multiple membrane-spanning domains. By exchanging portions of cDNAs encoding the permissive mouse and nonpermissive human transporters and examining their abilities to specify virus infec
Quantitation of human immunodeficiency virus type 1 infection kinetics.: J Virol. 1993 Apr;67(4):2182-90. Unique Identifier : AIDSLINE MED/93188170; Dimitrov DS; Willey RL; Sato H; Chang LJ; Blumenthal R; Martin MA; Section on Membrane Structure and Function, National Cancer; Institute, Bethesda, Maryland 20892.; Tissue culture infections of CD4-positive human T cells by human immunodeficiency virus type 1 (HIV-1) proceed in three stages: (i) a period following the initiation of an infection during which no detectable virus is produced; (ii) a phase in which a sharp increase followed by a peak of released progeny virions can b
Requirements for incorporation of Pr160gag-pol from human immunodeficiency virus type 1 into virus-like particles.: J Virol. 1993 Apr;67(4):2266-75. Unique Identifier : AIDSLINE MED/93188179; Smith AJ; Srinivasakumar N; Hammarskjold ML; Rekosh D; Department of Microbiology, State University of New York, Buffalo; 14214.; The roles of the human immunodeficiency virus precursor polyproteins Pr55gag and Pr160gag-pol in viral core assembly were studied in CMT3-COS cells. To do this, the precursors were expressed separately by using a simian virus 40 late replacement vector system described previously. Consistent with previously published
The blocks to human immunodeficiency virus type 1 Tat and Rev functions in mouse cell lines are independent.: J Virol. 1993 Apr;67(4):2349-54. Unique Identifier : AIDSLINE MED/93188188; Winslow BJ; Trono D; Infectious Disease Laboratory, Salk Institute, La Jolla,; California 92037-1099.; Rodent cells present two blocks precluding the expression of the human immunodeficiency virus type 1 (HIV-1) genome. First, the viral protein Tat is only poorly active in these cells. Second, when the HIV-1 provirus is integrated in the genome of mouse cells, it electively fails to express the viral structural protein
The p12I, p13II, and p30II proteins encoded by human T-cell leukemia/lymphotropic virus type I open reading frames I and II are localized in three different cellular compartments.: J Virol. 1993 Apr;67(4):2360-6. Unique Identifier : AIDSLINE GENBANK/L08433; Koralnik IJ; Fullen J; Franchini G; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892.; Three protein isoforms are encoded by the human T-cell leukemia/lymphotropic virus type I pX region open reading frames (ORF) I and II through alternative splicing. Both the singly and doubly spliced mRNAs from ORF I encode a single 12-kDa protein (p12I), whereas two distinct proteins of 13 kDa (p13II) and 30 kDa (p30
Tuberculosis and AIDS in South Carolina: a case-control study [see comments]: J S C Med Assoc. 1993 Feb;89(2):71-6. Unique Identifier : AIDSLINE MED/93188425; Sy FS; Timbo BB; Addy CL; Richter DL; Macera CA; Pozsik CJ; Department of Epidemiology and Biostatistics, School of Public; Health, University of South Carolina, Columbia 29208.; The epidemiologic features of tuberculosis patients with AIDS or HIV infection in this study do not appear to be different from those reported from previous studies. Tuberculosis patients with AIDS or HIV positive antibody in South Carolina are predominantly black males who live in the urban areas and are 25 to 44 yea
The white plague returneth [editorial; comment]: J S C Med Assoc. 1993 Feb;89(2):93-5. Unique Identifier : AIDSLINE MED/93188428; Bryan CS
Pepstatins: aspartic proteinase inhibitors having potential therapeutic applications.: Med Res Rev. 1993 Mar;13(2):199-208. Unique Identifier : AIDSLINE MED/93188575; Tumminello FM; Bernacki RJ; Gebbia N; Leto G; Institute of Pharmacology, Faculty of Medicine, University of; Palermo, Italy.
HIV disease in pregnancy.: Md Med J. 1993 Jan;42(1):33-6. Unique Identifier : AIDSLINE MED/93188659; Levin N; Department of Obstetrics and Gynecology, Maryland General; Hospital, Baltimore.; The years from 1981 to the present have seen a steady increase in the incidence of AIDS in the female population. The corollary increase in the incidence of AIDS in pregnancy increases the responsibility of the obstetrician to become aware of the effect of AIDS on pregnancy and the effect of pregnancy on AIDS.
[The isolation and purification of a nonspecific DNAse from Mycoplasma fermentans PG-18]: Mikrobiol Zh. 1993 Jan-Feb;55(1):12-8. Unique Identifier : AIDSLINE MED/93188751; Sitailo SZ; Babichev VV; Skripal' IG; Nonspecific endogenic DNAase has been isolated from biomass of Mycoplasma fermentans PG-18 cells and purified to the homogeneous state. The scheme of isolation consists of purification stages on columns with phosphocellulose, DNA-cepharose CL-8B and phenylcepharose. DNAase was not bound to phosphocellulose, its volume
False-positive serologic tests for human T-cell lymphotropic virus type I among blood donors following influenza vaccination, 1992.: MMWR Morb Mortal Wkly Rep. 1993 Mar 12;42(9):173-5. Unique Identifier : AIDSLINE MED/93188824; From October 31 through December 15, 1991, 10 blood donors to the American Red Cross Blood Services, Badger Region (ARCBS), were found to have false-positive screening enzyme-linked immunosorbent assays (ELISAs) for antibodies to two or more of the following viruses: human immunodeficiency virus type 1 (HIV-1), human
A disappointing decade of AIDS [news]: Nature. 1993 Mar 4;362(6415):13. Unique Identifier : AIDSLINE MED/93188946; Maddox J
Kessler stays, Healy goes [news]: Nature. 1993 Mar 4;362(6415):3. Unique Identifier : AIDSLINE MED/93188954; Gershon D; Mervis J
Tuberculosis and the HIV virus--a growing problem in health care.: Nephrol News Issues. 1993 Mar;7(3):36-8. Unique Identifier : AIDSLINE MED/93188994; Peacock E; Wolf K
[Granuloma inguinale (donovanosis): vigilance should be exercised]: Ned Tijdschr Geneeskd. 1993 Feb 20;137(8):396-9. Unique Identifier : AIDSLINE MED/93189013; Engelkens HJ; Niemel PL; Menke HE; Stolz E; Afd. Dermatologie en Venereologie, Academisch Ziekenhuis; Rotterdam-Dijkzigt.
AIDS update.: Nursing. 1993 Mar;23(3):21, 23. Unique Identifier : AIDSLINE MED/93189139
To tell or not to tell [see comments]: Nursing. 1993 Mar;23(3):50-3. Unique Identifier : AIDSLINE MED/93189146
End of life care for infants with AIDS: ethical and legal issues.: Pediatr Nurs. 1993 Jan-Feb;19(1):79-83, 94. Unique Identifier : AIDSLINE MED/93189358; Rushton CH; Hogue EE; Billett CA; Chapman K; Greenberg-Friedman D; Joyner M; Park CD; Complex cases involving end-of-life care for infants with AIDS raise a variety of ethical and legal concerns. Health care providers should understand the issues involving proper treatment, including adequate relief of pain at the end of life, and a context for examining the suffering of caregivers.
Tuberculosis. The primary care physician's role in eradication.: Postgrad Med. 1993 Feb 15;93(3):46-50, 53-60. Unique Identifier : AIDSLINE MED/93189483; Levin AC; Gums JG; Grauer K; North Adams Regional Hospital, Massachusetts.; The resurgence of tuberculosis in the United States presents a challenge for primary care physicians. The disease remains concentrated in the growing population of socioeconomically disadvantaged persons, immigrants from areas where drug resistance is common, certain racial groups, per
A checklist for evaluation of HIV-infected patients.: Postgrad Med. 1993 Mar;93(4):101-4, 107-8. Unique Identifier : AIDSLINE MED/93189487; Coodley GO; Division of Internal Medicine, Oregon Health Sciences University,; Portland 97201-3098.; To aid in making care of HIV-infected patients part of your office routine, Dr Coodley presents here a checklist that combines the various clinical aspects of initial management. Covering the steps from the history to plans for follow-up, this article should allay anxiety and promote confidence in your entire staff by
Comparison of variable region 3 sequences of human immunodeficiency virus type 1 from infected children with the RNA and DNA sequences of the virus populations of their mothers.: Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1721-5. Unique Identifier : AIDSLINE +; Scarlatti G; Leitner T; Halapi E; Wahlberg J; Marchisio P; Clerici-Schoeller MA; Wigzell H; Fenyo EM; Albert J; Uhlen M; et al; Department of Virology, Karolinska Institute, Stockholm, Sweden.; We have compared the variable region 3 sequences from 10 human immunodeficiency virus type 1 (HIV-1)-infected infants to virus sequences from the corresponding mothers. The sequences were derived from DNA of uncultured peripheral blood mononuclear cells (PBMC), DNA of cultured PBMC, and RNA from serum collected at or
Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication.: Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1839-42. Unique Identifier : AIDSLINE MED/93189592; Li CJ; Zhang LJ; Dezube BJ; Crumpacker CS; Pardee AB; Dana-Farber Cancer Institute, Department of Biological Chemistry; and Molecular Pharmacology, Harvard Medical School, Boston, MA; 02115.; Transcription of type 1 human immunodeficiency virus (HIV-1) provirus is governed by the viral long terminal repeat (LTR). Drugs can block HIV-1 replication by inhibiting activity of its LTR. We report that topotecan, beta-lapachone, and curcumin are potent and selective inhibitors of HIV-1 LTR-directed gene expressio
Enhanced immunity to human immunodeficiency virus (HIV) envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gp160 protein.: Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1882-6. Unique Identifier : AIDSLINE MED/93189601; Cooney EL; McElrath MJ; Corey L; Hu SL; Collier AC; Arditti D; Hoffman M; Coombs RW; Smith GE; Greenberg PD; Department of Medicine, University of Washington, Seattle 98195.; Transmission studies have suggested that an optimal human immunodeficiency virus type 1 (HIV-1) vaccine should induce both neutralizing antibodies and cytolytic T cells to eliminate free virus and infected cells. A phase I trial in healthy HIV-1-seronegative persons was conducted with a combination HIV-1 vaccine regim
Fostering a change in policy. HIV, AIDS and the neuroscience nurse.: Prof Nurse. 1993 Mar;8(6):359-61. Unique Identifier : AIDSLINE MED/93189648; Woodward S; Roberts J; As new treatments and drug therapies enable the control of opportunistic diseases associated with Aids, its neurological manifestations are becoming more prevalent. This poses new challenges to neuroscience nurses, who must reassess their attitude to and understanding of the disease.
Human immunodeficiency virus status in facial fracture patients.: Plast Reconstr Surg. 1993 Apr;91(4):577-80. Unique Identifier : AIDSLINE MED/93189752; Hughes LA; Bailey MH; A prospective study was performed to obtain an indication of the incidence of human immunodeficiency virus (HIV) among the population of facial fracture patients treated at a city hospital in Toronto, Ontario, Canada . This study was stimulated by the observation that a significant
Bryodin, a single-chain ribosome-inactivating protein, selectively inhibits the growth of HIV-1-infected cells and reduces HIV-1 production.: Res Exp Med (Berl). 1993;193(1):1-12. Unique Identifier : AIDSLINE MED/93189872; Wachinger M; Samtleben R; Gerhauser C; Wagner H; Erfle V; Institut fur Molekulare Virologie, GSF Forschungszentrum fur; Umwelt und Gesundheit, Neuherberg, Federal Republic of Germany.; Bryodin, a single-chain ribosome-inactivating protein (RIP) isolated from Bryonia cretica ssp dioica (cucurbitaceae), was found to selectively inhibit the growth of persistently HIV-1-infected T lymphoma cells (KE37/1) and human lung fibroblast when used in concentrations from 2-20 micrograms/ml. Uninfected KE37/1 cel
PCR analysis of HIV1 infection of macrophages: virus entry is CD4-dependent.: Res Virol. 1993 Jan-Feb;144(1):13-9. Unique Identifier : AIDSLINE MED/93189880; Collin M; Herbein G; Montaner L; Gordon S; University of Oxford, Sir William Dunn School of Pathology, UK.; Amplification of early reverse transcripts by the polymerase chain reaction has been used to measure HIV1 entry into H9 cells and primary macrophages. With a single-step method of DNA preparation, we performed time course experiments to follow the appearance of long terminal repeat DNA. In both cell types, the formati
Characterization of HIV1-PAR, a macrophage-tropic strain: cell tropism, virus/cell entry and nucleotide sequence of the envelope glycoprotein.: Res Virol. 1993 Jan-Feb;144(1):21-6. Unique Identifier : AIDSLINE MED/93189881; Schmidtmayerova H; Gayet O; Guettari N; Bolmont C; Hirsch I; Chermann JC; Unite de Recherches INSERM U322 sur les Retrovirus et Maladies; Associees, Campus Universitaire de Luminy, Marseille, France.; The HIV1-PAR strain, isolated from the cerebrospinal fluid of an HIV1-seropositive man suffering from encephalopathy, replicated well in cord blood lymphocytes, poorly in peripheral blood mononuclear cells, and to different levels in blood-derived macrophage (BDM) cultures prepared from different blood donors. In mark
Expression of the Tat protein of HIV1 in human promonocytic U937 cells.: Res Virol. 1993 Jan-Feb;144(1):27-34. Unique Identifier : AIDSLINE MED/93189882; Mace K; Gazzolo L; Laboratoire d'Immuno-Virologie moleculaire et cellulaire, UMR 30; CNRS/UCBL, Faculte de Medecine Alexis Carrel, Lyon, France.; Numerous studies have shown that, upon HIV1 infection, human promonocytic U937 cells were induced to differentiate, as indicated, for example, by increased expression of adhesion molecules. One of the viral proteins involved in this process might be the Tat protein. Indeed, this viral protein, which is essential for p
Expression of macrophage products after in vitro infection of human monocytes/macrophages with HIV.: Res Virol. 1993 Jan-Feb;144(1):35-40. Unique Identifier : AIDSLINE MED/93189883; Glienke W; von Briesen H; Esser R; Muller S; Andreesen R; Rubsamen-Waigmann H; Georg-Speyer-Haus, Chemotherapeutisches Forschungsinstitut,; Frankfurt am Main, Germany.; We studied the response of monocytes/macrophages (MO/MAC) to lipopolysaccharide (LPS) and interferon-gamma (IFN gamma) stimulation with respect to the expression of macrophage-specific products, i.e. macrophage-colony-stimulating factor (M-CSF), c-fms, c-sis, tissue factors, transforming growth factor-beta (TGF beta)
Target cells during early SIV encephalopathy.: Res Virol. 1993 Jan-Feb;144(1):41-6. Unique Identifier : AIDSLINE MED/93189884; Hurtrel B; Chakrabarti L; Hurtrel M; Montagnier L; Unite d'Oncologie virale, Institut Pasteur, Paris, France.; Early encephalopathy was studied in rhesus macaques in the first month following intravenous (i.v.) infection with SIV-mac-251. Histopathological analysis of brain tissues showed slight gliosis, associated with perivascular infiltrates and occasional glial nodules. Immunophenotyping of brain tissue showed microgliosis
Adhesion proteins on human microglial cells and modulation of their expression by IL1 alpha and TNF alpha.: Res Virol. 1993 Jan-Feb;144(1):47-52. Unique Identifier : AIDSLINE MED/93189885; Sebire G; Hery C; Peudenier S; Tardieu M; Laboratoire de Neurovirologie et Neuroimmunologie, Universite; Paris XI, UFR Kremlin-Bicetre.; Expression of adhesion proteins on human microglial cells was studied by immunocytochemistry. Both microglial cells and peripheral blood monocytes expressed beta 2 integrins and molecules of the immunoglobulin superfamily at similar levels whereas the expression of the beta 1 integrins (alpha 2-VLA (very late antigen)
In vitro infection of epidermal Langerhans cells with human immunodeficiency virus type 1 (HTLV-IIIB isolate).: Res Virol. 1993 Jan-Feb;144(1):53-8. Unique Identifier : AIDSLINE MED/93189886; Delorme P; Dezutter-Dambuyant C; Ebersold A; Desgranges C; Thivolet J; Schmitt D; INSERM U346, Peau humaine et Immunite, Hopital Edouard-Herriot,; Lyon, France.; Human epidermal Langerhans cells (LC) isolated from normal skin were infected in vitro with human immunodeficiency virus type 1 (HIV1). To control the permissivity of LC for HIV1, cells isolated from the epidermal sheet of normal skin by trypsinization were cocultured with HIV1-carrying promonocytic cells (U937) and o
Distribution and infection of Langerhans cells in the skin of HIV-infected healthy subjects and AIDS patients.: Res Virol. 1993 Jan-Feb;144(1):59-67. Unique Identifier : AIDSLINE MED/93189887; Muller H; Weier S; Kojouharoff G; Grez M; Berger S; Kappus R; Shah PM; Stutte HJ; Schmidts HL; Senckenbergisches Zentrum, J.W. Goethe-Universitat, Frankfurt am; Main, Germany.; The in situ content of cells of the reticuloendothelial system and lymphatic cells was examined in the skin of eight symptom-free HIV-positive individuals, three AIDS patients and eleven healthy immunocompetent volunteers. The epidermis was obtained in vivo by the suction blister technique. The numbers of CD68+, CD3+,
Decreased haematopoietic colony growth in long-term bone marrow cultures of HIV-positive patients.: Res Virol. 1993 Jan-Feb;144(1):69-73. Unique Identifier : AIDSLINE MED/93189888; Geissler RG; Ottmann OG; Kleiner K; Mentzel U; Bickelhaupt A; Hoelzer D; Ganser A; University of Frankfurt/Main, Department of Haematology, Germany.; Deficiencies in bone marrow stromal cells, i.e. fibroblasts, macrophages, endothelial cells and adipocytes, are considered to play a pathophysiological role in HIV-associated haematopoietic failure. Long-term bone marrow cultures (LTBMC) enable the longitudinal investigation of haematopoietic progenitor cell and bone
Modulation of HIV transcription in and release from human monocytic cells following phagocytosis of Mycobacterium tuberculosis.: Res Virol. 1993 Jan-Feb;144(1):7-12. Unique Identifier : AIDSLINE MED/93189889; Shattock RJ; Friedland JS; Griffin GE; Division of Communicable Diseases, St George's Hospital Medical; School, Tooting, London.; The consequence of phagocytosis of Mycobacterium tuberculosis by human monocytic cells on transcription and release of human immunodeficiency virus (HIV) is unknown. In order to investigate the effects of phagocytosis of M. tuberculosis on HIV transcription, human monocytic THP-1 cells were transfected with constructs
Infection of dendritic cells with HIV1: virus load regulates stimulation and suppression of T-cell activity.: Res Virol. 1993 Jan-Feb;144(1):75-80. Unique Identifier : AIDSLINE MED/93189890; Knight SC; Macatonia SE; Patterson S; Antigen Presentation Research Group, Clinical Research Centre,; Harrow, UK.; Patients with HIV infection show two major types of immunological effects. The first is hyperactivity of both T and B lymphocytes which may be in response to HIV antigens themselves, and the second is a loss in T-cell activity in response to other antigens. Dendritic cells (DC) show a higher rate of infection with HIV
Accessory cells and macrophages in the histopathology of SIVsm-infected cynomolgus monkeys.: Res Virol. 1993 Jan-Feb;144(1):81-92. Unique Identifier : AIDSLINE MED/93189891; Kaaya E; Li SL; Feichtinger H; Stahmer I; Putkonen P; Mandache E; Mgaya E; Biberfeld G; Biberfeld P; Department of Pathology, Karolinska Institute, Stockholm.; Thirty-three out of 39 cynomolgus monkeys (Macaca fascicularis) infected with SIVsm (strain SMM-3) developed various pathologies similar to those seen in human AIDS. Lymphadenopathy was frequently seen (72%) and was characterized by hyperplasia followed by involution of follicle/germinal centres due to follicular dend
The thymic epithelial reticulum and interdigitating cells in SIV-induced thymus atrophy and its comparison with other forms of thymus involution.: Res Virol. 1993 Jan-Feb;144(1):93-8. Unique Identifier : AIDSLINE MED/93189892; Muller JG; Krenn V; Czub S; Stahl-Hennig C; Coulibaly C; Hunsmann G; Muller-Hermelink HK; Institut of Pathology, University of Wurzburg, Germany.; Alterations in the thymus were investigated in the early course of SIV infection of rhesus monkeys and compared with age-related and acute accidental thymus atrophy. The SIV-induced pathology was characterized by shrinkage of the thymic parenchyma and capsule, whereas in age-related thymus atrophy, the size of the cap
Human endothelial cells isolated from the hepatic sinusoids and the umbilical vein display a different permissiveness for HIV1.: Res Virol. 1993 Jan-Feb;144(1):99-104. Unique Identifier : AIDSLINE MED/93189893; Lafon ME; Gendrault JL; Royer C; Jaeck D; Kirn A; Steffan AM; Unite INSERM 74 et Laboratoire Commun U.L.P.-Synthelabo,; Strasbourg, France.; Endothelial cells are now considered as potential targets for HIV infection, together with other non-lymphoid cells. We previously demonstrated that endothelial cells isolated from the human liver sinusoids (SEC) are permissive for HIV1 in vitro (Steffan et al., 1992), whereas human umbilical vein endothelial cells (H
A method to test for a recent increase in HIV-1 seroconversion incidence: results from the Multicenter AIDS Cohort Study (MACS).: Stat Med. 1993 Jan 30;12(2):153-64. Unique Identifier : AIDSLINE MED/93189930; Zhou SY; Kingsley LA; Taylor JM; Chmiel JS; He DY; Hoover DR; Department of Infectious Disease and Microbiology, School of; Public Health, University of Pittsburgh, PA 15213.; We have formulated the problem of determining whether there has been an upturn in HIV-1 seroconversion incidence over the first five years of follow-up in the Multicenter AIDS Cohort Study (MACS) as that of locating the minimum of a quadratic regression or examination of two-knot piecewise spline models. Under a quadr
[Antiretroviral therapy]: Rev Med Liege. 1993 Feb;48(2):100-5. Unique Identifier : AIDSLINE MED/93189934; Demonty J; Service de Medecine interne generale, Universite de Liege.
[Interdisciplinary meeting on AIDS. Introduction]: Rev Med Liege. 1993 Feb;48(2):65-6. Unique Identifier : AIDSLINE MED/93189937; Lefebvre P; Universite de Liege, Service de Medecine interne generale.
[AIDS: epidemiology and diagnosis]: Rev Med Liege. 1993 Feb;48(2):66-72. Unique Identifier : AIDSLINE MED/93189938; Sondag-Thull D; Francois-Gerard C; Centre de reference, Universite de Liege.
[Early manifestations of acquired immunodeficiency]: Rev Med Liege. 1993 Feb;48(2):81-3. Unique Identifier : AIDSLINE MED/93189940; Andre C; Service d'Hematologie, CHR Citadelle de Liege.
[Opportunistic infections in advanced immunodeficiency]: Rev Med Liege. 1993 Feb;48(2):83-91. Unique Identifier : AIDSLINE MED/93189941; Demonty J; Service de Medecine interne generale, Universite de Liege.
[Skin manifestations in human immunodeficiency virus infection]: Rev Med Liege. 1993 Feb;48(2):94-100. Unique Identifier : AIDSLINE MED/93189943; Paquet P; Service de dermatologie, Universite de Liege.
Spectral power and coherence analysis of sleep EEG in AIDS patients: decrease in interhemispheric coherence.: Sleep. 1993 Feb;16(2):137-45. Unique Identifier : AIDSLINE MED/93189955; Terstegge K; Henkes H; Scheuler W; Hansen ML; Ruf B; Kubicki S; Department of Clinical Neurophysiology, Rudolf Virchow University; Hospital, Freie Universitat Berlin, Germany.; Fifteen patients aged between 26 and 55 years with the acquired immunodeficiency syndrome (AIDS) and various cerebral manifestations of the disease underwent an all-night sleep electroencephalogram (EEG) registration. The recordings of 15 age-matched volunteers were examined as controls. Sleep stages were determined v
The evolution of virulence.: Sci Am. 1993 Apr;268(4):86-93. Unique Identifier : AIDSLINE MED/93190082; Ewald PW; Biology Department, Amherst College.
Problems encountered assessing AIDS awareness among rural Mid-West high school students in a family practice setting.: S D J Med. 1993 Mar;46(3):73-5. Unique Identifier : AIDSLINE MED/93190084; Hazard LL; There has been growing interest in assessing AIDS awareness and knowledge of risk behavior among teenagers and how to measure the effectiveness of HIV education programs. A survey modeled after the CDC assisted study was distributed to three populations of high school students within a mid-western community to compare
Effects of enhancer mutations on the expression of human immunodeficiency virus 1-regulated luciferase and diphtheria toxin A chain genes in transfected cells.: Toxicon. 1993 Jan;31(1):85-90. Unique Identifier : AIDSLINE MED/93190321; Harrison GS; Long CJ; Castillo I; Division of Medical Oncology, University of Colorado Health; Sciences Center, Denver 80262.; This study explores human immunodeficiency virus 1 (HIV-1)-regulated diphtheria toxin A (DT-A) gene expression as a means of eradicating HIV-infected cells. Previously, we constructed luciferase and DT-A plasmids, containing cis-acting Tat and Rev responsive elements, which showed low basal expression and required bot
[AIDS--knowledge, behavior and attitude at the University of Aarhus in 1990. A questionnaire study (see comments)]: Ugeskr Laeger. 1993 Feb 8;155(6):402-6. Unique Identifier : AIDSLINE MED/93190414; Andersen MR; Nielsen I; Norrelund H; Petersen SB; Ronberg AM; Wiencke AK; Baelum J; Pedersen OF; Institut for Miljo- og Arbejdsmedicin, Aarhus Universitet.; To describe knowledge, attitude and behaviour regarding AIDS among students and employees at the University of Aarhus an anonymous self-administered questionnaire survey was conducted in April 1990. Of the 2169 and 850 questionnaires to students and employees, respectively, 1548 (71.4%) and 568 (67%) were returned. Th
HTLV-I/II infection is absent among risk groups from Mexico City [letter]: Vox Sang. 1993;64(1):57-8. Unique Identifier : AIDSLINE MED/93190545; Islas S; Yamaguchi K; Silva R; Nishimura Y; Kawano F; Ponce M; Barra R; Takatsuki K
Significance of p24 on immunoblot with a negative anti-HIV ELISA result [letter; comment]: Vox Sang. 1993;64(1):63-4. Unique Identifier : AIDSLINE MED/93190548; Hewitt PE; Barbara JA
Potentially negative effects of AIDS vaccines based on recombinant viruses carrying HIV-1 derived envelope gene. A warning on AIDS vaccine development.: Vaccine. 1993;11(3):291-2. Unique Identifier : AIDSLINE MED/93190589; Veljkovic V; Metlas R; Laboratory for Multidisciplinary Research, VINCA, Beograd,; Yugoslavia.; Various candidate AIDS vaccines based on HIV-1 envelope glycoprotein (gp120/160) are currently under clinical trials (phase 1 and 2) in healthy, HIV-negative volunteers, as well as in HIV-infected persons. Most of these vaccines use recombinant viral vectors carrying the HIV-derived gp120/160 gene. Possible negative e
Evaluation of the DCL Syphilis-G enzyme immunoassay test kit for the serologic diagnosis of syphilis.: Am J Clin Pathol. 1993 Mar;99(3):282-5. Unique Identifier : AIDSLINE MED/93190945; Nayar R; Campos JM; Department of Pathology, George Washington University Medical; Center, Washington, District of Columbia.; Sera have been submitted to the authors laboratory for syphilis testing at a dramatically increased rate since the start of the human immunodeficiency virus type 1 epidemic. Thus they were interested in evaluating a new enzyme immunoassay, the DCL Syphilis-G test kit (DCL-G, Diagnostic Chemicals Ltd., Oxford, CT) for
Peritonitis associated with disseminated Mycobacterium avium complex in an acquired immunodeficiency syndrome patient on chronic ambulatory peritoneal dialysis.: Am J Kidney Dis. 1993 Mar;21(3):319-21. Unique Identifier : AIDSLINE MED/93190969; Perazella M; Eisen T; Brown E; Department of Medicine, Yale University School of Medicine, New; Haven, CT 06510.; Chronic ambulatory peritoneal dialysis (CAPD) is a commonly used form of renal replacement therapy in patients with end-stage renal disease (ESRD) infected with the human immunodeficiency virus (HIV). An increased incidence of peritonitis, as well as an increased rate of infections with unusual and serious organisms,
Fear of contracting AIDS is reason enough [news]: Am J Nurs. 1993 Jan;93(1):9. Unique Identifier : AIDSLINE MED/93191023
Predominance of CD8+ T lymphocytes in the inflammatory lesions of mice with acute Trypanosoma cruzi infection.: Am J Trop Med Hyg. 1993 Feb;48(2):161-9. Unique Identifier : AIDSLINE MED/93191261; Sun J; Tarleton RL; Department of Zoology, University of Georgia, Athens.; Using glycol methacrylate in conjunction with avidin-biotin-peroxidase complex techniques, we studied the contribution of T cell subsets to tissue inflammation during acute Trypanosoma cruzi infection. Two mouse/parasite model systems whose parasitology and pathology behaved differently were used. In C57Bl/6J mice inf
Increased human T lymphotropic virus type-1 (HTLV-1) proviral DNA in peripheral blood mononuclear cells and bronchoalveolar lavage cells from Japanese patients with HTLV-1-associated myelopathy.: Am J Trop Med Hyg. 1993 Feb;48(2):170-7. Unique Identifier : AIDSLINE MED/93191262; Mita S; Sugimoto M; Nakamura M; Murakami T; Tokunaga M; Uyama E; Araki S; First Department of Internal Medicine, Kumamoto University School; of Medicine, Japan.; Human T lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is endemic in tropical areas and in southwestern Japan , and has now been identified among risk groups in the United States and some European count
Prevalence of serum antibodies to human T lymphotropic virus-1 in an isolated tribe in the highlands of Irian Jaya, Indonesia.: Am J Trop Med Hyg. 1993 Feb;48(2):230-6. Unique Identifier : AIDSLINE MED/93191271; Anthony RL; Jennings GB; Sie A; Ratiwayanto S; Bangs MJ; U.S. Navy Medical Research Unit No. 2, Jakarta, Indonesia.; There have been several recent reports on the high prevalence of serum antibodies to human T lymphotropic virus-1 (HTLV-1) in isolated populations residing in the coastal areas and highlands of Papua New Guinea . In the absence of si
Transfusion transmitted infection: viral and exotic diseases.: Anaesth Intensive Care. 1993 Feb;21(1):24-30. Unique Identifier : AIDSLINE MED/93191368; Wylie BR; NSW Red Cross Blood Transfusion Service, Sydney, Australia.; Viral and other exotic diseases may be transmitted by blood transfusion. These infections include human immunodeficiency virus (HIV), hepatitis viruses (A, B, C, D and E), syphilis, malaria, retrovirus HTLV-1, and cytomegalovirus . Other more exotic diseases which may be transmitted
AIDS patient care challenges nursing.: Am Nurse. 1993 Mar;25(3):1, 24. Unique Identifier : AIDSLINE MED/93191405; Cassetta RA
Position statements explore HIV issues.: Am Nurse. 1993 Mar;25(3):12. Unique Identifier : AIDSLINE MED/93191408
Task force builds foundation for ANA's response to HIV.: Am Nurse. 1993 Mar;25(3):13. Unique Identifier : AIDSLINE MED/93191409; Coleman D
A day in the life of a nurse. Patients challenge RN to learn more.: Am Nurse. 1993 Mar;25(3):14. Unique Identifier : AIDSLINE MED/93191410; White S
Long-term AIDS care given from the heart.: Am Nurse. 1993 Mar;25(3):14. Unique Identifier : AIDSLINE MED/93191411; Frank SK
The new faces of the epidemic.: Am Nurse. 1993 Mar;25(3):16. Unique Identifier : AIDSLINE MED/93191412; Cassetta RA
Living with the epidemic--the tragedy in Africa.: Am Nurse. 1993 Mar;25(3):20. Unique Identifier : AIDSLINE MED/93191416; Kirkpatrick SM
States work to combat HIV/AIDS crisis.: Am Nurse. 1993 Mar;25(3):21-2. Unique Identifier : AIDSLINE MED/93191417
RN to develop intervention program for African-American women [interview]: Am Nurse. 1993 Mar;25(3):22. Unique Identifier : AIDSLINE MED/93191418; Jemmott LS
Mental health care designed for AIDS patients.: Am Nurse. 1993 Mar;25(3):25, 27. Unique Identifier : AIDSLINE MED/93191420
It's 1993--do you know where your attitude is?: Am Nurse. 1993 Mar;25(3):26. Unique Identifier : AIDSLINE MED/93191421; Russell B
Pulmonary TB: an AIDS-defining diagnosis.: Am Nurse. 1993 Mar;25(3):27. Unique Identifier : AIDSLINE MED/93191422; Boutotte J
Other nurses honored [letter]: Am Nurse. 1993 Mar;25(3):4. Unique Identifier : AIDSLINE MED/93191427; Lamendola FP
HIV positive nurses: caring for our own.: Am Nurse. 1993 Mar;25(3):5. Unique Identifier : AIDSLINE MED/93191430; Lamendola FP
Nurses' role essential in HIV education.: Am Nurse. 1993 Mar;25(3):6. Unique Identifier : AIDSLINE MED/93191431; Riddel JP; Marquez MJ; Howerton EA; Smith MM; Miner BR
Toxoplasmic papillitis as the initial manifestation of acquired immunodeficiency syndrome.: Ann Ophthalmol. 1993 Feb;25(2):56-7. Unique Identifier : AIDSLINE MED/93191438; Falcone PM; Notis C; Merhige K; Department of Ophthalmology, St. Luke's/Roosevelt Medical Center,; New York, New York.; Toxoplasmic retinochoroiditis has been reported as the initial manifestation of acquired immunodeficiency syndrome (AIDS). Two authors have described two patients with AIDS and toxoplasmic papillitis. We report the case of a patient with a papillitis of unknown origin in whom the workup found systemic toxoplasmosis an
Synovial fluid T cells in HTLV-I positive RA [letter]: Ann Rheum Dis. 1993 Feb;52(2):166-7. Unique Identifier : AIDSLINE MED/93191533; Ijichi S; Maruyama I; Maruyama Y; Osame M; Matsuda T; Niinura T; Sonoda S
CD8 T cells in human immunodeficiency virus infection [letter; comment]: Arch Intern Med. 1993 Mar 22;153(6):779. Unique Identifier : AIDSLINE MED/93191551; Stricker RB
A 'rash' of toxoplasmosis [letter; comment]: Arch Intern Med. 1993 Mar 22;153(6):780; 782. Unique Identifier : AIDSLINE MED/93191553; Chan E
Miliary toxoplasmic retinitis in acquired immunodeficiency syndrome.: Arch Ophthalmol. 1993 Mar;111(3):373-6. Unique Identifier : AIDSLINE MED/93191604; Berger BB; Egwuagu CE; Freeman WR; Wiley CA; University of Texas Health Sciences Center, San Antonio.; A unique pattern of bilateral miliary retinitis due to ocular toxoplasmosis developed in a patient in the late stages of acquired immunodeficiency syndrome. Results of serologic tests for toxoplasmosis remained negative throughout the clinical course of his ocular disease. The retinitis was unresponsive to a brief cou
Managing the HIV positive patient in general practice.: Aust Fam Physician. 1993 Feb;22(2):106-11, 114. Unique Identifier : AIDSLINE MED/93191632; Wray L; Liverpool Sexual Health Centre, Liverpool Hospital, New South; Wales.; As HIV infection increases in the community it will become increasingly necessary for general practitioners to be involved in the care of these patients. The author resolves some of the doubts GPs may have about their ability to provide primary care to patients with HIV infection.
STDs and the overseas traveller.: Aust Fam Physician. 1993 Feb;22(2):125-31. Unique Identifier : AIDSLINE MED/93191634; Rowbottom J; National Centre in HIV Epidemiology and Clinical Research,; Sydney.; Although most HIV and STD patients acquire their infections in Australia there is an increase in the numbers diagnosed with these infections after international travel. Risks to the sexual health of the travellers and their subsequent partners are discussed and suggestions made
Management of sexually transmissible disease. Part 2--Viral infections.: Aust Fam Physician. 1993 Feb;22(2):174-81. Unique Identifier : AIDSLINE MED/93191640; Neilsen G; Plummer D; Sydney Sexual Health Centre, New South Wales.; The management of viral infections, including human immunodeficiency virus (HIV), human papilloma virus (HPV) and herpes simplex virus (HSV), is constantly evolving and should be the domain of all general practitioners. This article reviews current ideas in the treatment of these diseases.
Medical school policies regarding medical students and HIV infection.: Acad Med. 1993 Jan;68(1):87-9. Unique Identifier : AIDSLINE MED/93191833; Tesch B; McKinney WP; Alexanian D; Division of General Internal Medicine, Medical College of; Wisconsin, Milwaukee.; PURPOSE. To ascertain how medical schools address several difficult policy issues regarding medical students and HIV (human immunodeficiency virus), and to examine whether schools policies differ according to the incidences of HIV in the schools locations. METHOD. Between January 5, 1990, and March 20, 1991, 15-minu
Gastrointestinal manifestations of HIV/AIDS.: Crit Care Nurs Clin North Am. 1993 Mar;5(1):121-6. Unique Identifier : AIDSLINE MED/93191987; Gallagher DM; HIV-infected patients are faced with a number of infections that affect every organ system. The gastrointestinal system is highly vulnerable to the many pathogens that are capable of invading the immunocompromised patient, thus creating some of the most frustrating problems for both the patient and the clinician. This
Global programme on AIDS. Profile of the HIV/AIDS epidemic.: Wkly Epidemiol Rec. 1993 Mar 12;68(11):74-7. Unique Identifier : AIDSLINE MED/93192144
Disseminated atypical blastomycosis in two patients with AIDS.: Clin Infect Dis. 1993 Jan;16(1):107-11. Unique Identifier : AIDSLINE MED/93192437; Tan G; Kaufman L; Peterson EM; de la Maza LM; Department of Pathology, University of California, Irvine, Orange; 92668.; Two men with AIDS developed fungal infections and subsequently died as a result of dissemination of the fungal infection. Findings obtained by histologic examination, serological studies, and cultures suggested that the infections were caused by Blastomyces dermatitidis. Tissue sections showed polymorphic yeast-like c
Clinical characteristics of seven cases of diarrhea associated with a novel acid-fast organism in the stool.: Clin Infect Dis. 1993 Jan;16(1):136-8. Unique Identifier : AIDSLINE MED/93192443; Wurtz RM; Kocka FE; Peters CS; Weldon-Linne CM; Kuritza A; Yungbluth P; Division of Infectious Disease, Cook County Hospital, Chicago,; Illinois 60612.; In the last 4 years, we have identified an acid-fast, autofluorescent organism in the stool of seven patients with diarrhea. The organism was identified as a cyanobacterium-like organism by the Centers for Disease Control (Atlanta) and as a coccidian by researchers in
Myositis due to Pleistophora (Microsporidia) in a patient with AIDS.: Clin Infect Dis. 1993 Jan;16(1):15-21. Unique Identifier : AIDSLINE MED/93192448; Chupp GL; Alroy J; Adelman LS; Breen JC; Skolnik PR; Department of Medicine, New England Medical Center Hospitals,; Boston, Massachusetts.; Microsporidia are obligate intracellular protozoa that parasitize both vertebrates and invertebrates and are now recognized as important pathogens in individuals infected with human immunodeficiency virus type 1 (HIV-1). We describe the clinical and morphological features of a case of pleistophora (microsporidian) myo
Hepatic and pulmonary pneumocystosis during primary prophylaxis for Pneumocystis carinii pneumonia with dapsone/pyrimethamine [letter]: Clin Infect Dis. 1993 Jan;16(1):171. Unique Identifier : AIDSLINE MED/93192453; Podzamczer D; Martos A; Ferrer I; Santin M; Gudiol F
A severe systemic reaction to trimethoprim-sulfamethoxazole in a patient infected with the human immunodeficiency virus [letter; comment]: Clin Infect Dis. 1993 Jan;16(1):175-6. Unique Identifier : AIDSLINE MED/93192458; Martin GJ; Paparello SF; Decker CF
A severe hypersensitive reaction to trimethoprim-sulfamethoxazole in a patient infected with human immunodeficiency virus [letter; comment]: Clin Infect Dis. 1993 Jan;16(1):178-9. Unique Identifier : AIDSLINE MED/93192460; Marinac JS; Stanford JF
Pulmonary T-cell lymphoma in a patient with the acquired immunodeficiency syndrome [letter]: Clin Infect Dis. 1993 Jan;16(1):188. Unique Identifier : AIDSLINE MED/93192468; Colebunders R; Mertens V; Blot K; Neetens I; Van Marck E; Batungwanayo J; Taelman H
Intramuscular pentamidine for the prevention of Pneumocystis carinii pneumonia in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1993 Jan;16(1):22-5. Unique Identifier : AIDSLINE MED/93192471; Cheung TW; Matta R; Neibart E; Hammer G; Chusid E; Sacks HS; Szabo S; Rose D; Division of Infectious Diseases, Mount Sinai Medical Center, New; York, New York 10029.; We retrospectively reviewed the charts of 96 patients infected with human immunodeficiency virus (HIV) who received intramuscular pentamidine for the prevention of Pneumocystis carinii pneumonia (PCP). These patients, all of whom had either a history of PCP or a CD4 lymphocyte count of
Infected urachal remnants in the adult: case report and review.: Clin Infect Dis. 1993 Jan;16(1):26-9. Unique Identifier : AIDSLINE MED/93192472; Ward TT; Saltzman E; Chiang S; Infectious Disease Section, Veterans Affairs Medical Center,; Portland, Oregon.; Abnormalities of the urachus in adults are uncommon. Urachal tract remnants that abnormally remain patent are subject to infection. Urachal infection is frequently confused with a wide spectrum of midline intraabdominal or pelvic inflammatory disorders. Because the literature on urachal infection is primarily limited
No new AIDS virus, say scientific reviews [news]: BMJ. 1993 Feb 20;306(6876):477. Unique Identifier : AIDSLINE MED/93192690; Kingman S
Re-emergence of tuberculosis [letter; comment]: BMJ. 1993 Feb 20;306(6876):514-5. Unique Identifier : AIDSLINE MED/93192706; Theodore CM; Forster GE; Goh BT
Re-emergence of tuberculosis [letter; comment] [see comments]: BMJ. 1993 Feb 20;306(6876):515. Unique Identifier : AIDSLINE MED/93192709; Hayward C
AIDS prevention [news]: Addiction. 1993 Jan;88(1):146. Unique Identifier : AIDSLINE MED/93192747
HIV and AIDS education [news]: Addiction. 1993 Jan;88(1):146-7. Unique Identifier : AIDSLINE MED/93192748
Treatment of oral Kaposi sarcoma with intralesional vinblastine.: Cancer. 1993 Mar 1;71(5):1722-5. Unique Identifier : AIDSLINE MED/93193060; Epstein JB; Division of Dentistry, British Columbia Cancer Agency, Vancouver.; BACKGROUND. Kaposi sarcoma (KS) is an acquired immune deficiency syndrome-defining condition in human immunodeficiency virus infection. Oral KS may produce local symptoms and require treatment. Palliation of oral lesions may be achieved with radiation therapy and chemotherapy. This review was conducted to assess the e
Rapid enzymatic analysis for human immunodeficiency virus type 1 DNA in clinical specimens.: Clin Chem. 1993 Mar;39(3):433-9. Unique Identifier : AIDSLINE MED/93193253; Sevall JS; Prince H; Garratty G; O'Brien WA; Zack JA; Specialty Laboratories, Inc., Santa Monica, CA 90404.; A clinical procedure for rapid detection of human immunodeficiency virus type 1 (HIV-1) by DNA amplification is demonstrated. The rapid procedure reduces handling requirements and amplification time and eliminates use of radioactivity for the detection of the amplification product. Total leukocyte lysates are the ampl
Time-resolved fluoroimmunoassay of beta 2-microglobulin in serum and cerebrospinal fluid [letter]: Clin Chem. 1993 Mar;39(3):552-3. Unique Identifier : AIDSLINE MED/93193281; Meillet D; Belec L; Schuller E; Delattre J
HIV and serious mental illness: reducing the risk.: Community Ment Health J. 1993 Feb;29(1):35-47. Unique Identifier : AIDSLINE MED/93193406; Cates JA; Graham LL; AIDS Task Force, Inc., Fort Wayne, IN 46869-3527.; Persons with SMI residing in community mental health center group homes received an educational intervention program on HIV/AIDS. As with virtually all such approaches provided for this population, the intervention was generalized from programs used with other populations, for example, users of intravenous drugs, gay
Bronchial reactivity to methacholine in HIV-infected individuals without AIDS.: Chest. 1993 Mar;103(3):796-9. Unique Identifier : AIDSLINE MED/93193513; Moscato G; Maserati R; Marraccini P; Caccamo F; Dellabianca A; Postgraduate School of Allergology and Clinical Immunology,; University of Pavia, IRC Clinica del Lavoro Foundation, Medical; Center of Pavia, Italy.; To evaluate bronchial reactivity to methacholine in human immunodeficiency virus (HIV) infection, we submitted 25 HIV-seropositive subjects without full-blown AIDS and 25 HIV-seronegative subjects, all inmates in a drug rehabilitation center for previous intravenous drug abuse, to interview and to bronchial challenge
Bronchogenic carcinoma in young patients at risk for acquired immunodeficiency syndrome.: Chest. 1993 Mar;103(3):862-4. Unique Identifier : AIDSLINE MED/93193525; Chan TK; Aranda CP; Rom WN; Bellevue Hospital, Department of Medicine, New York University; School of Medicine, New York.; Several case reports have suggested that bronchogenic carcinoma occurs more frequently in young patients who are human immunodeficiency virus (HIV) seropositive. We investigated the incidence of bronchogenic carcinoma and its clinical presentations in young patients at risk for HIV infection. The tumor registry of Bel
Altered mental status, hypoxemia, and a rash in a 32-year-old man.: Chest. 1993 Mar;103(3):925-7. Unique Identifier : AIDSLINE MED/93193537; Kinnard WV; Cook RM; Neff TA; Division of Pulmonary Sciences and Critical Care Medicine,; University of Colorado Health Sciences Center, Denver.
Persistent bronchopleural fistulae in an AIDS patient with Pneumocystis carinii pneumonia. Successful treatment with chemical pleurodesis [letter]: Chest. 1993 Mar;103(3):981. Unique Identifier : AIDSLINE MED/93193566; Travaline JM; Criner GJ
Is aggressive management of perianal ulcers in homosexual HIV-seropositive men justified?: Dis Colon Rectum. 1993 Mar;36(3):240-6. Unique Identifier : AIDSLINE MED/93193588; Schmitt SL; Wexner SD; Nogueras JJ; Jagelman DG; Department of Colorectal Surgery, Cleveland Clinic Florida, Ft.; Lauderdale 33309.; A study was undertaken to assess the etiology, optimal diagnostic method, and incidence of healing of perianal ulcers in HIV-seropositive men. Between March 1990 and December 1991, 26 HIV-seropositive homosexual or bisexual males were referred with perianal ulcerations. According to CDC criteria, three (12 percent) we
In vitro biochemical activities associated with recombinant HIV-1 integrase.: Biochem Soc Trans. 1993 Feb;21(1):51S. Unique Identifier : AIDSLINE MED/93193923; Pemberton IK; Singh OM; London Hospital Medical College, Whitechapel, UK.
Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid.: Biochem Soc Trans. 1993 Feb;21(1):83-9. Unique Identifier : AIDSLINE MED/93193956; Heyes MP; Section on Analytical Biochemistry, National Institute of Mental; Health, Bethesda, MD 20892.
AIDS: older patients aren't immune [editorial]: Geriatrics. 1993 Mar;48(3):9-10. Unique Identifier : AIDSLINE MED/93194092; Butler RN
HIV transmission by needle stick and eczematous lesion--three cases from Germany.: Infection. 1993 Jan-Feb;21(1):40-1. Unique Identifier : AIDSLINE MED/93194366; Gurtler LG; Eberle J; Bader L; Max-von-Pettenkofer Institut, Universitat Munchen, Germany.; Two cases of documented HIV-1 transmission by needle stick and one case of probable transmission by eczematous lesion in three nurses in Germany are reported in the period 1988 to 1991. In two of the cases the nurse knew of the AIDS status of the index patient. A review of the thr
The frontline of HIV1 diffusion in the Central African region: a geographical and epidemiological perspective.: Int J Epidemiol. 1993 Feb;22(1):127-34. Unique Identifier : AIDSLINE MED/93194428; Tessier SF; Remy G; Louis JP; Trebucq A; Centre International de l'Enfance, Paris, France.; The geographical analysis of the main data on the HIV1 epidemic in Central Africa shows a frontline which has not moved significantly since 1985. The absence of a progressive increase between the countries, demonstrating a discontinuity in space, combined with the observed human and physical continuity within the area
From Barbara Aronson and Irene Bertrand [letter; comment]: Int J Epidemiol. 1993 Feb;22(1):172. Unique Identifier : AIDSLINE MED/93194438
NF-kappa B and Rel: participants in a multiform transcriptional regulatory system.: Int Rev Cytol. 1993;143:1-62. Unique Identifier : AIDSLINE MED/93194469; Grilli M; Chiu JJ; Lenardo MJ; Laboratory of Immunology, National Institute for Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892.
Southernmost carriers of HTLV-I/II in the world.: Jpn J Cancer Res. 1993 Jan;84(1):1-3. Unique Identifier : AIDSLINE MED/93194681; Cartier L; Araya F; Castillo JL; Zaninovic V; Hayami M; Miura T; Imai J; Sonoda S; Shiraki H; Miyamoto K; et al; Department of Neurology, Faculty of Medicine, University of; Chile, Santiago.; To clarify the real distribution of HTLV-I and -II carriers among indigenous people in central and South America, blood samples collected from indigenous people in isolated regions of Southern Chile were examined. Among 199 inhabitants from Chiloe Island and Pitrufquen town, three c
Aberrant expression of the p53 tumor suppressor gene in adult T-cell leukemia and HTLV-I-infected cells.: Jpn J Cancer Res. 1993 Jan;84(1):4-8. Unique Identifier : AIDSLINE MED/93194687; Yamato K; Oka T; Hiroi M; Iwahara Y; Sugito S; Tsuchida N; Miyoshi I; Department of Medicine, Kochi Medical School.; By immunoprecipitation analysis, enhanced p53 expression was detected in 3 of 4 adult T-cell leukemia (ATL) cell lines, 1 of 3 HTLV-I-infected cell lines and 1 of 5 fresh ATL samples, compared with phytohemagglutinin-stimulated peripheral blood lymphocytes. Among these 5 high expressers, p53 missense mutations were in
Prophylaxis for HIV-associated infections in the developing world.: J Antimicrob Chemother. 1993 Feb;31 Suppl B:119-28. Unique Identifier : AIDSLINE MED/93194735; Gilks CF; Nuffield Department of Clinical Medicine, John Radcliffe; Hospital, Oxford, UK.; Prophylaxis for specific HIV-associated infections has made a major difference in the industrialized world to patient survival and the quality of life. However, the HIV epidemic is spreading most rapidly in the poor developing world, where prophylaxis is neither currently used nor recommended. Streptococcus pneumoniae
Cell surface site for mitogenic interaction of erythropoietin receptors with the membrane glycoprotein encoded by Friend erythroleukemia virus.: J Biol Chem. 1993 Mar 15;268(8):5741-7. Unique Identifier : AIDSLINE MED/93194874; Ferro FE Jr; Kozak SL; Hoatlin ME; Kabat D; Department of Biochemistry and Molecular Biology, School of; Medicine, Oregon Health Sciences University, Portland 97201-3098.; The membrane glycoprotein (gp55) encoded by the env gene of Friend spleen focus-forming virus (SFFV) causes mitogenesis of infected erythroblasts and is inefficiently (3-5%) processed from the rough endoplasmic reticulum (RER) to plasma membranes. Recent evidence suggested that gp55 binds to erythropoietin receptors (
Multiple genes encode the major surface glycoprotein of Pneumocystis carinii.: J Biol Chem. 1993 Mar 15;268(8):6034-40. Unique Identifier : AIDSLINE GENBANK/L05907; Kovacs JA; Powell F; Edman JC; Lundgren B; Martinez A; Drew B; Angus CW; Critical Care Medicine Department, National Institutes of Health,; Bethesda, Maryland 20892.; The major surface antigen of Pneumocystis carinii, a life-threatening opportunistic pathogen in human immunodeficiency virus-infected patients, is an abundant glycoprotein that functions in host-organism interactions. A monoclonal antibody to this antigen is protective in animals, and thus this antigen is a good candi
Zidovudine in early HIV disease [editorial]: Hosp Pract (Off Ed). 1993 Mar 30;28(3A):9-10. Unique Identifier : AIDSLINE MED/93194995; McLeod GX
Expression of int-2 oncogene in Kaposi's sarcoma lesions.: J Clin Invest. 1993 Mar;91(3):1191-7. Unique Identifier : AIDSLINE MED/93195046; Huang YQ; Li JJ; Moscatelli D; Basilico C; Nicolaides A; Zhang WG; Poiesz BJ; Friedman-Kien AE; Department of Microbiology, New York University Medical Center,; New York 10016.; Fibroblast growth factors (FGFs), such as basic FGF, have been implicated in the growth of Kaposi s sarcoma (KS) cells in vitro. In the evaluation of the expression of the various genes of the different members of the FGF family and their receptors in fresh KS tissue specimens, int-2 was found to be expressed in more
Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.: J Clin Invest. 1993 Mar;91(3):759-65. Unique Identifier : AIDSLINE MED/93195061; Clerici M; Hakim FT; Venzon DJ; Blatt S; Hendrix CW; Wynn TA; Shearer GM; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.; Infection with HIV results in an incremental loss of T helper cell (TH) function, which can occur years before CD4 cell numbers are critically reduced and AIDS is diagnosed. All TH function is not affected, however, because B cell activation and hypergammaglobulinema are also characteristic of this period. Recently, i
Perceived needs and unmet needs for formal services among people with HIV disease.: J Community Health. 1993 Feb;18(1):11-23. Unique Identifier : AIDSLINE MED/93195109; Piette JD; Fleishman JA; Stein MD; Mor V; Mayer K; Institute for Health Policy Studies, University of California-San; Francisco 94109.; This study presents estimates of the prevalence of perceived needs and unmet needs among people with HIV disease in the United States for six areas of community services: mental health, drug treatment, home care, housing, transportation, and entitlements. The prevalence of service need
African-American adolescents' knowledge, health-related attitudes, sexual behavior, and contraceptive decisions: implications for the prevention of adolescent HIV infection.: J Consult Clin Psychol. 1993 Feb;61(1):104-12. Unique Identifier : AIDSLINE MED/93195114; St. Lawrence JS; Community Health Program, Jackson State University, Mississippi; 39217-0105.; African-American adolescents (N = 195) completed measures of knowledge related to acquired immunodeficiency syndrome (AIDS), attitudes toward condoms, health locus of control, vulnerability to human immunodeficiency virus (HIV) infection, peer sexual norms, personal sexual behavior for the past 6 months, and contracep
Effects of AIDS-related bereavement and HIV-related illness on psychological distress among gay men: a 7-year longitudinal study, 1985-1991.: J Consult Clin Psychol. 1993 Feb;61(1):94-103. Unique Identifier : AIDSLINE MED/93195132; Martin JL; Dean L; Columbia University School of Public Health, AIDS Research Unit,; New York, New York 10032.; In this study we examined the influence of acquired immunodeficiency syndrome (AIDS)-related bereavement on psychological distress from 1985 through 1991. We predicted that this relation would be influenced by personal knowledge of human immunodeficiency virus (HIV) infection and symptoms consistent with HIV-related i
Conference report: Disorders of the Oral Mucosa. 43rd Annual Meeting of the Arbeitsgemeinschaft fur Kieferchirurgie within the German Dental Association (Deutsche Gesellschaft fur Zahn-, Mund- und Keiferheilkunde.: J Dent Res. 1993 Mar;72(3):643-4. Unique Identifier : AIDSLINE MED/93195154; Spitzer WJ; Klinik und Poliklinik fur Mund-, Kiefer-Gesichtschirurgie.; Gluckstrasse 11 D-8520 Erlangen, Germany.
High dose L-carnitine improves immunologic and metabolic parameters in AIDS patients.: Immunopharmacol Immunotoxicol. 1993 Jan;15(1):1-12. Unique Identifier : AIDSLINE MED/93195254; De Simone C; Tzantzoglou S; Famularo G; Moretti S; Paoletti F; Vullo V; Delia S; Universita di L'Aquila, Italy.; Several reports indicate that systemic carnitine deficiency could occur in acquired immunodeficiency disease syndrome (AIDS), and that primary and secondary carnitine deficiency leads to critical metabolic dysfunctions. L-carnitine supplementation to peripheral blood mononuclear cells (PBMCs) of AIDS patients resulted
Viewing the client's world through drawings.: J Holist Nurs. 1993 Mar;11(1):21-41. Unique Identifier : AIDSLINE MED/93195284; Salmon PL; This article discusses the therapeutic use of drawings, outlines a specific drawing technique, and describes two case illustrations. Emphasis is placed on the healing quality of the drawing experience, a creative process in and of itself. These case illustrations were derived from an interpretive study in which life h
HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6.: J Immunol. 1993 Mar 15;150(6):2478-86. Unique Identifier : AIDSLINE MED/93195351; Chirmule N; Kalyanaraman VS; Lederman S; Oyaizu N; Yagura H; Yellin MJ; Chess L; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, NY 11030.; The HIV envelope glycoprotein gp160 has been previously demonstrated to induce differentiation of normal B lymphocytes into Ig-secreting cells; the response is T cell-dependent, and T cells pretreated with gp160 can support B cell differentiation. This study investigates the cell surface molecules and cytokines that p
Alcohol intake increases human immunodeficiency virus type 1 replication in human peripheral blood mononuclear cells.: J Infect Dis. 1993 Apr;167(4):789-97. Unique Identifier : AIDSLINE MED/93195378; Bagasra O; Kajdacsy-Balla A; Lischner HW; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, PA 19107.; The effects of alcohol consumption on various T lymphocyte subset functions and on the degree of susceptibility of peripheral blood mononuclear cells (PBMC) to human immunodeficiency virus (HIV) type 1 infection and replication in vitro were investigated. PBMC from 60 HIV-1-seronegative healthy volunteers were studied
Detection of human immunodeficiency virus type 1 in semen: effects of disease stage and nucleoside therapy.: J Infect Dis. 1993 Apr;167(4):798-802. Unique Identifier : AIDSLINE MED/93195379; Hamed KA; Winters MA; Holodniy M; Katzenstein DA; Merigan TC; Department of Medicine, Stanford University Medical Center CA; 94305.; The effects of clinical stage of infection and antiviral therapy on the detection of human immunodeficiency virus type 1 (HIV-1) nucleic acids in semen were investigated by the polymerase chain reaction. HIV-1 was detected in 45 (87%) of 52 semen specimens from 29 (81%) of 36 men. Seventeen (77%) of 22 stage II or III
Patients infected with human immunodeficiency virus type 1 have low levels of virus in saliva even in the presence of periodontal disease.: J Infect Dis. 1993 Apr;167(4):803-9. Unique Identifier : AIDSLINE MED/93195380; Yeung SC; Kazazi F; Randle CG; Howard RC; Rizvi N; Downie JC; Donovan BJ; Cooper DA; Sekine H; Dwyer DE; et al; Department of Virology, Westmead Hospital, Australia.; In two consecutive studies, 80 subjects human immunodeficiency virus (HIV)-1-seropositive (21 asymptomatic, 6 persistent generalized lymphadenopathy, 13 AIDS-related complex, and 40 AIDS) were examined for oral lesions. Paired serum and saliva specimens were tested for HIV isolation, DNA, and antigen. HIV antigen was
Down-regulation of human immunodeficiency virus type (HIV-1) production after stimulation of monocyte-derived macrophages infected with HIV-1.: J Infect Dis. 1993 Apr;167(4):810-7. Unique Identifier : AIDSLINE MED/93195381; Nottet HS; de Graaf L; Machiel de Vos N; Bakker LJ; van Strijp JA; Visser MR; Verhoef J; Eijkman-Winkler Laboratory for Medical Microbiology, University; of Utrecht, Netherlands.; Macrophages infected with human immunodeficiency virus (HIV) can be stimulated as a result of secondary infections. The effect of stimulation of HIV-1-infected monocyte-derived macrophages on HIV-1 production by these cells was studied. Exposure of macrophages to phorbol 12-myristate 13-acetate or to opsonized Escheri
Study of human immunodeficiency virus resistance to 2'-3'-dideoxyinosine and zidovudine in sequential isolates from pediatric patients on long-term therapy.: J Infect Dis. 1993 Apr;167(4):818-23. Unique Identifier : AIDSLINE MED/93195382; Dimitrov DH; Hollinger FB; Baker CJ; Kline MW; Doyle M; Bremer JW; Shearer WT; Division of Molecular Virology, Baylor College of Medicine,; Houston, Texas 77030.; Resistance to zidovudine (3 -azido-3 -deoxythymidine) and 2 ,3 -dideoxyinosine (ddI) has been reported for human immunodeficiency virus (HIV) isolates from adults, but little is known about these drugs in children. A new micrococulture assay was developed for evaluation of drug susceptibility using single-passage HIV
Transferrin, iron, and serum lipids enhance or inhibit Mycobacterium avium replication in human macrophages.: J Infect Dis. 1993 Apr;167(4):857-64. Unique Identifier : AIDSLINE MED/93195387; Douvas GS; May MH; Crowle AJ; Webb-Waring Lung Institute, Division of Immunology, University of; Colorado School of Dentistry, Denver 80262.; Mycobacterium avium grows exponentially over 7 days in human macrophages when they are cultured in serumless medium. Normal serum inhibits this replication. When serum lipids were extracted using chloroform, the inhibitor was present in the lipid-free component. The lipid extract significantly enhanced M. avium replic
Impairment of neutrophil antifungal activity against hyphae of Aspergillus fumigatus in children infected with human immunodeficiency virus.: J Infect Dis. 1993 Apr;167(4):905-11. Unique Identifier : AIDSLINE MED/93195393; Roilides E; Holmes A; Blake C; Pizzo PA; Walsh TJ; Infectious Diseases Section, National Cancer Institute, Bethesda,; MD 20892.; Human immunodeficiency virus (HIV)-infected patients may acquire invasive aspergillosis without previously recognized risk factors, such as neutropenia or corticosteroid therapy. Because neutrophils (PMNL) are an important component of host defense in aspergillosis, the antifungal activity of PMNL against hyphae of As
Determination of human T lymphotropic virus type by polymerase chain reaction and correlation with risk factors in northern California blood donors [published erratum appears in J Infect Dis 1993 Jul;168(1):262]: J Infect Dis. 1993 Apr;167(4):954-7. Unique Identifier : AIDSLINE MED/93195402; Eble BE; Busch MP; Guiltinan AM; Khayam-Bashi H; Murphy EL; Dept. of Laboratory Medicine, UC San Francisco 94143.; To determine the relative prevalence of human T lymphotropic virus (HTLV) types I and II, type-specific polymerase chain reaction (PCR) was done on seropositive northern California blood donors. From October 1988 through March 1990, 67 (0.055%) of 122,517 blood donors had confirmed HTLV antibody. Seropositive donors w
Kaposi's sarcoma in a human immunodeficiency virus-negative patient with asymptomatic human T lymphotropic virus type I infection [letter]: J Infect Dis. 1993 Apr;167(4):987-9. Unique Identifier : AIDSLINE MED/93195411; Zucker-Franklin D; Huang YQ; Grusky GE; Friedman-Kien AE
False-positive ELISA for human immunodeficiency virus after influenza vaccination [letter]: J Infect Dis. 1993 Apr;167(4):989-90. Unique Identifier : AIDSLINE MED/93195412; Hsia J
Modulation of the haematopoietic toxicity associated with zidovudine in vivo with lithium carbonate.: J Intern Med. 1993 Mar;233(3):259-68. Unique Identifier : AIDSLINE MED/93195494; Gallicchio VS; Hughes NK; Tse KF; Haematology/Oncology Division, Lucille P. Markey Cancer Center,; University of Kentucky Medical Center, Lexington.; The drug zidovudine ( AZT ), a synthetic thymidine analogue, has been used in the treatment of acquired immunodeficiency syndrome (AIDS). Clinical use of zidovudine has induced haematopoietic toxicity manifested by anaemia, neutropenia, and overall bone
Cholestatic giant cell hepatitis associated with ultrastructural evidence of intrahepatic retroviral infection in a human immunodeficiency virus-seropositive infant.: J Pediatr Gastroenterol Nutr. 1993 Feb;16(2):199-202. Unique Identifier : AIDSLINE MED/93195637; Gaur S; Rosenthal S; Dadhania J; Lupski D; Mascarhenas M; Amenta PS; Bharucha N; Cappell MS; Department of Pediatrics, UMDNJ-Robert Wood Johnson (formerly; Rutgers) Medical School, New Brunswick 08903-0019.
High levels of anti-gliadin antibodies in HIV-infected children [letter]: J Pediatr Gastroenterol Nutr. 1993 Feb;16(2):220-1. Unique Identifier : AIDSLINE MED/93195642; Resti M; Azzari C; Rossi ME; Galli L; Vierucci A
The NF-kappa B p65 promoter.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):227-30. Unique Identifier : AIDSLINE GENBANK/L01459; Ueberla K; Lu Y; Chung E; Haseltine WA; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, MA 02115.; The promoter of the human gene encoding the p65 subunit of the transcription factor NF-kappa B was cloned and the nucleotide sequence determined. The p65 promoter lacks both TATA and CCAAT consensus sequences. The p65 promoter contains three consensus binding sites of the transcription factor SP1. In contrast to the p
Jurkat-tat but not other tat-expressing cell lines support replication of slow/low type HIV.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):231-6. Unique Identifier : AIDSLINE MED/93195667; Korneyeva M; Stalhandske P; Asjo B; Department of Virology, Karolinska Institute, Stockholm, Sweden.; The Jurkat-tat cell line, carrying the transactivator (tat) gene of HIV-1 IIIB and thus constitutively expressing the tat protein, has the capacity to support replication of HIV isolates obtained from asymptomatic individuals, so called slow/low (s/l) type virus. A major characteristic of the s/l isolates in vitro is
Quantification and comparison of HIV-1 proviral load in peripheral blood mononuclear cells and isolated CD4+ T cells.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):237-40. Unique Identifier : AIDSLINE MED/93195668; Wood R; Dong H; Katzenstein DA; Merigan TC; Division of Infectious Diseases, Stanford University Medical; Center, CA 94305.; HIV proviral load was determined by quantitative DNA polymerase chain reaction (PCR) in peripheral blood mononuclear cells (PBMC) and lymphocyte subsets isolated by cell sorter. Provirus measured in PBMC, when expressed as HIV copy number per million CD4+ cells, resulted in values which approximated those obtained fro
Determination of the etiology of seroreversals in HIV testing by antibody fingerprinting.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):241-4. Unique Identifier : AIDSLINE MED/93195669; Ascher DP; Roberts C; Dpt Pediatrics/SGHP, Wilford Hall Medical Center, Lackland AFB,; TX 78236.; Fifteen sets of seroreversal serum samples (i.e., an initial specimen confirmed as anti-human immunodeficiency virus, HIV, positive and a 2-4-week follow-up specimen that is anti-HIV negative) were identified from 711,684 military members tested by the U.S. Army HIV screening program from January 1990 to May 1991. We
Anthropometric, metabolic, and immunological effects of recombinant human growth hormone in AIDS and AIDS-related complex.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):245-51. Unique Identifier : AIDSLINE MED/93195670; Krentz AJ; Koster FT; Crist DM; Finn K; Johnson LZ; Boyle PJ; Schade DS; Division of Endocrinology and Metabolism, University of New; Mexico School of Medicine, Albuquerque 87131.; Metabolic and anthropometric changes induced by pharmacological versus physiological doses (5.0 vs. 2.5 mg, every other day) of recombinant human growth hormone (rhGH) were compared in 10 human immunodeficiency virus-positive patients with AIDS or AIDS-related complex. Five patients were randomly assigned to each trea
HIV-related ocular microangiopathic syndrome and cognitive functioning.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):252-8. Unique Identifier : AIDSLINE MED/93195671; Geier SA; Perro C; Klauss V; Naber D; Kronawitter U; Bogner JR; Goebel FD; Lund OE; Hippius H; University Eye Hospital, Munich, Germany.; Ocular microangiopathic syndrome is found frequently in patients with AIDS or severe HIV infection. Symptoms of this microvascular syndrome can include cotton-wool spots, hemorrhages, and Roth s spots. The clinical and functional significance of HIV-related ocular microangiopathic syndrome has not been clarified as ye
Weekly doxorubicin in the treatment of patients with AIDS-related Kaposi's sarcoma. AIDS Clinical Trials Group.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):259-64. Unique Identifier : AIDSLINE MED/93195672; Fischl MA; Krown SE; O'Boyle KP; Mitsuyasu R; Miles S; Wernz JC; Volberding PA; Kahn J; Groopman JE; Feinberg J; et al; University of Miami School of Medicine, Department of Medicine,; FL 33101.; Fifty-three patients with AIDS-related Kaposi s sarcoma and no previous treatment with cytotoxic chemotherapy enrolled in a phase II multicenter study to evaluate the safety and efficacy of weekly doxorubicin treatment. Doxorubicin was given intravenously at a dose of 15 mg/m2. Patients were stratified for purposes of
Beta-carotene in HIV infection.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):272-6. Unique Identifier : AIDSLINE MED/93195674; Coodley GO; Nelson HD; Loveless MO; Folk C; Division of Internal Medicine, Oregon Health Sciences University,; Portland 97201-3098.; beta-Carotene has been reported to have an immunostimulatory effect. Recent studies suggest that beta-carotene supplementation can increase CD4 counts in HIV-infected patients. Our double-blind, placebo-controlled clinical trial was designed to test the efficacy of beta-carotene in raising CD4 counts in HIV-infected p
HIV infection in autologous and allogeneic bone marrow transplant patients: a retrospective analysis of the Marseille bone marrow transplant population.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):277-84. Unique Identifier : AIDSLINE MED/93195675; Cooper MH; Maraninchi D; Gastaut JA; Mannoni P; Carcassonne Y; Bone Marrow Transplant Unit, Institut J. Paoli I. Calmettes,; Marseille, France.; Twelve HIV-positive patients who either underwent or seroconverted after bone marrow transplantation (BMT) at the University of Marseille between 1981 and 1985 were reviewed in order to observe their rates of development of AIDS. Two patients were HIV positive prior to transplantation, while ten seroconverted after tr
Reporting of HIV-1 infection through the provision of essential services [editorial; comment] [see comments]: J Acquir Immune Defic Syndr. 1993 Mar;6(3):285-6. Unique Identifier : AIDSLINE MED/93195676; Francis DP; Singleton JA
Maternal and neonatal characteristics associated with HIV infection in infants of seropositive women.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):298-302. Unique Identifier : AIDSLINE MED/93195679; Nair P; Alger L; Hines S; Seiden S; Hebel R; Johnson JP; Department of Pediatrics, University of Maryland School of; Medicine, Baltimore 21201.; In this prospective study of infants born to human immunodeficiency virus (HIV) seropositive mothers, neonatal and maternal characteristics of infected and noninfected infants were compared to determine the factors that may be associated with or contribute to vertical transmission of HIV. Of 134 infants entered as new
Factors associated with human immunodeficiency virus seroconversion in homosexual men in three San Francisco cohort studies, 1984-1989.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):303-12. Unique Identifier : AIDSLINE MED/93195680; Samuel MC; Hessol N; Shiboski S; Engel RR; Speed TP; Winkelstein W Jr; University of California, Berkeley 94720.; A total of 83 HIV seroconversions occurred between 1984 and 1989 in three San Francisco cohorts of homosexual and bisexual men. A nested case-control analysis was performed to assess the risk of seroconversion associated with sexual practices. Strong associations were found with total number of intercourse partners an
HIV-1 and HTLV-I in sexually transmitted disease clinics in the Dominican Republic.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):313-8. Unique Identifier : AIDSLINE MED/93195681; Rodriguez EM; de Moya EA; Guerrero E; Monterroso ER; Quinn TC; Puello E; de Quinones MR; Thorington B; Glasner PD; Zacarias F; et al; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland 20892.; A cross-sectional seroprevalence study of human immunodeficiency virus type 1 (HIV-1) and human T-cell lymphotropic virus type I (HTLV-I) was undertaken among 494 attendees in two Santo Domingo sexually transmitted disease clinics in 1989. All participants were evaluated for Neisseria gonorrhoeae, Chlamydia trachomati
Serologic validation of HIV infection in a tropical area.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):319-22. Unique Identifier : AIDSLINE MED/93195682; Ribeiro TT; Brites C; Moreira ED Jr; Siller K; Silva N; Johnson WD Jr; Badaro R; Retrovirus Laboratory, Federal University of Bahia, Salvador,; Brazil.; We have defined human immunodeficiency virus type 1 (HIV-1) serologic reactivity in Brazilians living in an area endemic for tropical diseases. Enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) analyses were performed on 342 patients with diseases including Chagas disease, schistosomiasis, typhoid fever
HIV infection among long-distance truck drivers in Delhi, India.: J Acquir Immune Defic Syndr. 1993 Mar;6(3):323. Unique Identifier : AIDSLINE MED/93195683; Singh YN; Singh K; Joshi R; Rustagi GK; Malaviya AN
HIV-2 infection in HIV-1 indeterminate sera in Spain [letter; comment]: J Acquir Immune Defic Syndr. 1993 Mar;6(3):323-4. Unique Identifier : AIDSLINE MED/93195684; Soriano V; Gutierrez M; Lago M; Olivan M; Bravo R; Puente S; Baquero M; Gonzalez-Lahoz J
Evidence of HTLV-II infection in Guinea, West Africa [letter] [see comments]: J Acquir Immune Defic Syndr. 1993 Mar;6(3):324-5. Unique Identifier : AIDSLINE MED/93195685; Gessain A; Fretz C; Koulibaly M; Boudret ML; Bah A; Raphael M; de The G; Fournel JJ
HTLV-I/II and multiple sclerosis in Buenos Aires [letter]: J Acquir Immune Defic Syndr. 1993 Mar;6(3):326-7. Unique Identifier : AIDSLINE MED/93195686; Muchinik G; Chamoles N; Zapiola I; Schenone A; Bouzas MB; Gallo D; Hanson C
HTLV-I in Alaska Natives [letter]: J Acquir Immune Defic Syndr. 1993 Mar;6(3):327-8. Unique Identifier : AIDSLINE MED/93195687; Kaplan JE; Lal RB; Davidson M; Lanier AP; Lairmore MD
Hydrogen-bonding contacts in the major groove are required for human immunodeficiency virus type-1 tat protein recognition of TAR RNA.: J Mol Biol. 1993 Mar 5;230(1):111-23. Unique Identifier : AIDSLINE MED/93195920; Hamy F; Asseline U; Grasby J; Iwai S; Pritchard C; Slim G; Butler PJ; Karn J; Gait MJ; Medical Research Council Laboratory of Molecular Biology,; Cambridge, UK.; The binding site for tat on TAR RNA was analysed by preparing a series of model RNA substrates carrying site-specific functional group modifications. The test RNAs were prepared by annealing two short synthetic oligoribonucleotides to form a duplex structure with a U-rich bulge and flanking sequences identical to TAR
High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region.: J Mol Biol. 1993 Mar 5;230(1):90-110. Unique Identifier : AIDSLINE MED/93195948; Churcher MJ; Lamont C; Hamy F; Dingwall C; Green SM; Lowe AD; Butler JG; Gait MJ; Karn J; Medical Research Council, Laboratory of Molecular Biology,; Cambridge, England.; The binding site for tat protein on TAR RNA has been defined in quantitative terms using an extensive series of mutations. The relative dissociation constants for the mutant TAR RNAs were measured using a dual-label competition filter binding assay in which 35S-labelled wild-type TAR RNA (K1) was competed against 3H-l
Decline in intravenous drug use among treatment-seeking opiate users.: J Subst Abuse Treat. 1993 Jan-Feb;10(1):5-10. Unique Identifier : AIDSLINE MED/93195974; Schottenfeld RS; O'Malley S; Abdul-Salaam K; O'Connor PG; Department of Psychiatry, Yale University School of Medicine,; Connecticut Mental Health Center, New Haven 06519.; Opiate users seeking treatment during similar time periods in 1986 (n = 60) and 1988 (n = 82) did not differ significantly with regard to demographic factors, length of addiction, use of cocaine, history of alcohol problems, or indices of depression. In 1988, however, users reported significantly lower rates of curren
Conducting HIV outreach and research among incarcerated drug abusers: a case study of ethical concerns and dilemmas.: J Subst Abuse Treat. 1993 Jan-Feb;10(1):71-5. Unique Identifier : AIDSLINE MED/93195979; Siegal HA; Carlson RG; Falck R; Reece RD; Perlin T; Department of Community Health, Wright State University, School; of Medicine, Dayton Ohio 45401.; This case involves the examination of an ethically problematic event that arose while we were conducting an outreach/early intervention research demonstration project targeted at women who exchange sex for drugs. Subjects were drug abusers--primarily crack-cocaine smokers--recruited by outreach workers on the street a
[Model project: nursing of AIDS-patients]: Krankenpflege (Frankf). 1993 Feb;47(2):98-102. Unique Identifier : AIDSLINE MED/93196134; Gorny C
Health status among persons infected with human immunodeficiency virus. A community-based study.: Med Care. 1993 Mar;31(3):269-76. Unique Identifier : AIDSLINE MED/93196248; Lubeck DP; Fries JF; Department of Medicine, Stanford University, CA.
[Dyslipemia and HIV-1 infection in intravenous drug addicts]: Med Clin (Barc). 1993 Feb 6;100(5):161-3. Unique Identifier : AIDSLINE MED/93196258; Muga R; Tor J; Rey-Joly C; Pardo A; Llobet P; Foz M; Servicio de Medicina Interna, Hospital Universitario Germans; Trias i Pujol, Badalona.; BACKGROUND: It has been demonstrated that hypertriglyceridemia and hypocholesterolemia are frequent signs in homosexual patients with AIDS. Lipid abnormalities of the intravenous drug addict (IVDA) however, and its relation with infection by the human immunodeficiency virus (HIV) have not been sufficiently studied. ME
[Prevalence of human immunodeficiency virus infection among parenteral drug users in the community of Valencia 1987-1991)]: Med Clin (Barc). 1993 Feb 6;100(5):164-7. Unique Identifier : AIDSLINE MED/93196259; Hernandez Aguado I; Santos Rubio C; Torrella Ramos A; Avino MJ; Fernandez Garcia E; Garcia de la Hera M; Salazar Fraile J; Moya Garcia C; Instituto Valenciano de Estudios en Salud Publica.; BACKGROUND: To contribute to the knowledge of the frequency and distribution of infection by the HIV-1 in intravenous drug consumers (IVDC) the prevalence of infection in those in whom the voluntary serologic testing was practised and tendency over 5 years were studied. METHODS: The study included 2794 IVDC from cente
[Mycobacterium avium-intracellulare disseminated infection in patients with AIDS]: Med Clin (Barc). 1993 Feb 6;100(5):171-3. Unique Identifier : AIDSLINE MED/93196261; Herrero Martinez JA; Sanchez Manzano MD; Palenque Mataix E; Medina Iglesias P; Sanchez Rivas JL; Rubio Garcia R; Costa Perez-Herrero JR; Unidad de Enfermedades Infecciosas, Hospital 12 de Octubre,; Madrid.; BACKGROUND: Disseminated infection by Mycobacterium avium-intracellulare is almost exclusively produced in individuals with HIV infection. The incidence of this infection in Spain is unknown. METHODS: The clinical and microbiologic registries of 30 patients with AIDS and disseminate
[Epidemic Kaposi's sarcoma in women: presentation of 4 cases]: Med Clin (Barc). 1993 Feb 6;100(5):179-80. Unique Identifier : AIDSLINE MED/93196264; Monton C; Mallolas J; Miro JM; Alsina M; Gatell JM; Soriano E; Servicio de Enfermedades Infecciosas, Hospital Clinic i; Provincial, Barcelona.; Epidemic Kaposi s sarcoma is the neoplasm most frequently manifested in infection by the human immunodeficiency virus. Its prevalence is considerably higher among homosexual males than among intravenous drug users with practically exclusive infection in this sex. Four cases of Kaposi s sarcoma in women with the human
[Retroviruses and autoimmune diseases]: Med Clin (Barc). 1993 Feb 6;100(5):181-6. Unique Identifier : AIDSLINE MED/93196265; Soriano V; Gonzalez-Lahoz J; Leon-Monzon M; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.
[Clinical course of HIV infection/AIDS in developed countries. Impact on tuberculosis (see comments)]: Med Clin (Barc). 1993 Feb 6;100(5):187-93. Unique Identifier : AIDSLINE MED/93196266; de March Ayuela P; Garcia Gonzalez A; Instituto Municipal de la Salut y miembro del Comite de Expertos; en Tuberculosis de Cataluna.
Human immunodeficiency virus notifications for aborigines and Torres Strait Islanders in Queensland.: Med J Aust. 1993 Feb 1;158(3):155-7. Unique Identifier : AIDSLINE MED/93196521; Neilsen G; Hill PS; AIDS Medical Unit, Specialised Health Services, Brisbane, Qld.; OBJECTIVE: To describe the epidemiology of HIV infection based on notifications of HIV infection in Aboriginal and Torres Strait Islander people in Queensland and to review their implications for Aboriginal and Torres Strait Islander communities. DESIGN: Descriptive study of data obtained through HIV notifications to
HIV-related haematological disease.: Med J Aust. 1993 Feb 1;158(3):172-4. Unique Identifier : AIDSLINE MED/93196527; Street AM; Miliken ST; Haematology Department, Alfred Hospital, Prahran, Vic.; Patients may be referred to a haematologist for clinical and laboratory evaluation of anaemia, neutropenia, thrombocytopenia or lymphoid disorders. Any of these may present the first opportunity to diagnose HIV infection.
HIV-related gastrointestinal disease.: Med J Aust. 1993 Feb 1;158(3):175-8. Unique Identifier : AIDSLINE MED/93196528; Sievert W; La Brooy JT; Monash Medical Centre, Clayton, Vic.; Gastrointestinal disease is common in patients infected with HIV and can represent the first significant clinical illness. Diarrhoea, dysphagia, abdominal pain, jaundice or gastrointestinal bleeding may be the result of opportunistic infection, AIDS-related neoplasia, or infection with HIV alone. The spectrum of gastr
HIV-related skin disease.: Med J Aust. 1993 Feb 1;158(3):179-85. Unique Identifier : AIDSLINE MED/93196529; McCrossin I; Wong D; Standish Medical Centre, Nowra, NSW.; Most patients with HIV infection will develop an HIV-related lesion of the skin or mucous membranes before their progression to AIDS. As the skin is readily observed by patients and easily examined by doctors, skin disease presents a good opportunity for the early diagnosis of HIV infection.
Unusual features of herpes simplex or zoster infection that suggest HIV infection.: Med J Aust. 1993 Feb 1;158(3):186-7. Unique Identifier : AIDSLINE MED/93196530; Crowe SM; Macfarlane Burnet Centre for Medical Research, Fairfield; Hospital, Vic.; Patients with herpes simplex or zoster infections are common in most medical practices. These infections are also very important in HIV medicine, often presenting in an otherwise well person. Knowledge of the effects of immune deficiency on herpes simplex and zoster infection assists in determining when to consider HI
Unexplained fever and drug reactions as clues to HIV infection.: Med J Aust. 1993 Feb 1;158(3):188-9. Unique Identifier : AIDSLINE MED/93196531; Mijch AM; Hoy JF; Fairfield Hospital, Vic.; Unexplained fever, usually self-limiting and often due to a viral infection, is commonly seen in many medical practices. When should a doctor consider HIV in relation to a patient s fever?
Treatment of non-Hodgkin's lymphoma.: N Engl J Med. 1993 Apr 8;328(14):1023-30. Unique Identifier : AIDSLINE MED/93196659; Armitage JO; Department of Internal Medicine, University of Nebraska Medical; Center, Omaha 68198-3332.
[HIV encephalopathy--clinical aspects, neuropathology and pathogenesis]: Nervenarzt. 1993 Feb;64(2):83-90. Unique Identifier : AIDSLINE MED/93196718; Schielke E; Neurologische Klinik, Ludwig-Maximilians-Universitat Munchen,; Klinikum Grosshadern.; HIV encephalopathy, which is probably primarily caused by human immunodeficiency virus, is the most common neurological disorder in HIV-infected patients and is more frequent than opportunistic diseases of the central nervous system. It is characterized most often by slowly progressing cognitive impairment, psychomoto
Differentiation of a medulloblastoma cell line towards an astrocytic lineage using the human T lymphotropic retrovirus-1.: Neuroscience. 1993 Feb;52(4):1069-79. Unique Identifier : AIDSLINE MED/93196853; Giraudon P; Dufay N; Hardin H; Reboul A; Tardy M; Belin MF; CJF 90-10 INSERM, Faculte de Medecine Alexis Carrel, Lyon,; France.; Constituent cells of medulloblastoma, the most common brain tumor occurring in childhood, resemble the primitive neuroepithelial cells normally found in the developing nervous system. However, mutational events prevent their further differentiation. We used the human T cell lymphotrophic virus type 1 to activate these
Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus-seropositive individuals: in vivo 1H magnetic resonance spectroscopic imaging.: Neurology. 1993 Mar;43(3 Pt 1):509-15. Unique Identifier : AIDSLINE MED/93196881; Meyerhoff DJ; MacKay S; Bachman L; Poole N; Dillon WP; Weiner MW; Fein G; We used magnetic resonance imaging (MRI) and water-suppressed proton magnetic resonance spectroscopic imaging to study the effects of human immunodeficiency virus (HIV) infection on the brains of 10 individuals with cognitive impairment due to HIV and seven normal controls. 1H spectra from nine 2.5-ml volumes in the c
EEG findings in asymptomatic HIV [letter; comment]: Neurology. 1993 Mar;43(3 Pt 1):635-6. Unique Identifier : AIDSLINE MED/93196917; Koralnik IJ; Hirschel B
NAON's GRC is developing a bloodborne pathogen position statement.: Orthop Nurs. 1993 Jan-Feb;12(1):56-7. Unique Identifier : AIDSLINE MED/93197009; Arlington R
32 health care workers got HIV while on the job.: Orthop Rev. 1993 Feb;22(2):158. Unique Identifier : AIDSLINE MED/93197013
Lack of detectable human immunodeficiency virus infection in antibody-negative children born to human immunodeficiency virus-infected mothers.: Pediatr Infect Dis J. 1993 Mar;12(3):222-7. Unique Identifier : AIDSLINE MED/93197052; Jones DS; Abrams E; Ou CY; Nesheim S; Connor E; Davenny K; Thomas P; Sawyer M; Krasinski K; Bamji M; et al; Division of HIV/AIDS, Centers for Disease Control, Atlanta, GA.; More than one-half of the children born to women with human immunodeficiency virus (HIV) infection are not infected with HIV. Most of these children, although born antibody-positive, lose maternal antibody and remain asymptomatic. However, it has been unclear how many antibody-negative children of HIV-infected women m
Transferase values in infants at risk from human immunodeficiency virus type 1 perinatal infection.: Pediatr Infect Dis J. 1993 Mar;12(3):248-50. Unique Identifier : AIDSLINE MED/93197058; de Martino M; Tovo PA; Zuccotti GV; Galli L; Gabiano C; Fiocchi A; Rapello G; Giovannini M; Vierucci A; Department of Pediatrics, University of Florence, Italy.
A women's issue: HIV/AIDS.: Perspect Psychiatr Care. 1993 Jan-Mar;29(1):23-5. Unique Identifier : AIDSLINE MED/93197115; Haynes YL; Women have recently been designated as the at risk group for HIV/AIDS infection. The author describes the advantages of doing health education with codependent women in group therapy to change risk behaviors. The assumption is made that as women take their learning home, share it with family and friends, and integrate
Two short basic sequences surrounding the zinc finger of nucleocapsid protein NCp10 of Moloney murine leukemia virus are critical for RNA annealing activity.: Nucleic Acids Res. 1993 Feb 25;21(4):823-9. Unique Identifier : AIDSLINE MED/93197146; De Rocquigny H; Ficheux D; Gabus C; Allain B; Fournie-Zaluski MC; Darlix JL; Roques BP; Unite de Pharmacochimie moleculaire et structurale, U266 INSERM,; URA D1500 CNRS, Universite Rene Descartes, Paris, France.; The 56 amino acid nucleocapsid protein (NCp10) of Moloney Murine Leukemia Virus, contains a CysX2CysX4HisX4Cys zinc finger flanked by basic residues. In vitro NCp10 promotes genomic RNA dimerization, a process most probably linked to genomic RNA packaging, and replication primer tRNA(Pro) annealing to the initiation s
HIV infection in traditional rural communities.: Nurs Clin North Am. 1993 Mar;28(1):231-9. Unique Identifier : AIDSLINE MED/93197180; Carwein VL; Sabo CE; Berry DE; College of Health Sciences, University of Nevada, Las Vegas; 89154.; The challenge to rural nurses to deliver knowledgeable and skilled nursing and health care to individuals with HIV infection and AIDS is indeed tremendous. Isolation of rural communities and health care facilities coupled with limited resources, financial concerns, conservative values of many traditional rural communi
Negative affect, absorption, and immunity.: Physiol Behav. 1993 Mar;53(3):449-57. Unique Identifier : AIDSLINE MED/93197377; Shea JD; Burton R; Girgis A; Psychology Department, University of Newcastle, NSW Australia.; Relationships between the psychological characteristics absorption and neuroticism, and in vitro and in vivo measures of cell-mediated immunity were examined. Thirty-nine female subjects responded to questionnaires, donated blood for analysis of T-cell numbers, and were tested for delayed hypersensitivity skin respons
Response to removal from and return to a social group in adult male rhesus monkeys.: Physiol Behav. 1993 Mar;53(3):599-602. Unique Identifier : AIDSLINE MED/93197398; Gust DA; Gordon TP; Hambright MK; Yerkes Regional Primate Research Center, Emory University,; Atlanta, GA 30322.; The removal of four adult rhesus monkeys from a large social group (n = 85) to peer housing resulted in no significant changes in basal cortisol levels or absolute numbers of T lymphocyte subsets 24 h later. However, the return of these males 1 year later to the same social group resulted in significant increases in c
Progressive multifocal leukoencephalopathy in 47 HIV-seropositive patients: neuroimaging with clinical and pathologic correlation.: Radiology. 1993 Apr;187(1):233-40. Unique Identifier : AIDSLINE MED/93197513; Whiteman ML; Post MJ; Berger JR; Tate LG; Bell MD; Limonte LP; Department of Radiology, University of Miami School of Medicine,; FL.; The authors investigated the spectrum of radiologic findings in a large series (n = 47) of patients seropositive to human immunodeficiency virus (HIV) 1 and with pathologically proved progressive multifocal leukoencephalopathy, to determine the characteristic imaging pattern of the disease. Thirty-six computed tomogra
Toxoplasmic encephalitis in AIDS patients and experimental models for study of the disease and its treatment.: Res Immunol. 1993 Jan;144(1):66-7. Unique Identifier : AIDSLINE MED/93197677; Suzuki Y; Remington JS; Department of Parasitology, Jikei University School of Medicine,; Tokyo.
HIV vs. a nurse's right to work.: RN. 1993 Jan;56(1):63-4, 66. Unique Identifier : AIDSLINE MED/93197805; Kolasa EU
Prevalence of maternal HIV infection in Scotland based on unlinked anonymous testing of newborn babies. Update.: Scott Med J. 1993 Feb;38(1):16-7. Unique Identifier : AIDSLINE MED/93197867; Tappin DM; Girdwood RW; Follett EA; Kennedy R; Brown AJ; Cockburn F; Department of Child Health, Royal Hospital for Sick Children,; Glasgow.; In January 1990, unlinked anonymous testing of Guthrie cards for HIV antibody commenced in Scotland. Ethics Committee approval allowed testing of 99.6% of Scottish births. Twenty-one mothers spontaneously refused to allow testing of their baby s blood. Samples were coded by district postcodes. For 1990 through 1991, e
Basic research (III): Priorities [editorial]: Science. 1993 Mar 5;259(5100):1379. Unique Identifier : AIDSLINE MED/93197876; Koshland DE Jr
House weighs in on NIH AIDS research [news]: Science. 1993 Mar 5;259(5100):1387. Unique Identifier : AIDSLINE MED/93197877
HTLV-1 provirus and mycosis fungoides [letter; comment]: Science. 1993 Mar 5;259(5100):1470; discussion 1471. Unique Identifier : AIDSLINE MED/93197897; Whittaker SJ; Luzzatto L
HTLV-1 provirus and mycosis fungoides [letter; comment]: Science. 1993 Mar 5;259(5100):1470-1. Unique Identifier : AIDSLINE MED/93197898; Bazarbachi A; Saal F; Laroche L; Flageul B; Peries J; de The H
Risk of HIV infection in the homeless and chronically mentally ill.: South Med J. 1993 Mar;86(3):276-81. Unique Identifier : AIDSLINE MED/93197924; Tynes LL; Sautter FJ; McDermott BE; Winstead DK; Department of Psychiatry and Neurology, Tulane University School; of Medicine, New Orleans, La. 70112.; Recent data suggest that the homeless and those with chronic mental illness may be at increased risk for HIV infection. A review of the recent literature reveals insufficient rigorously collected data to identify with confidence any particular subgroup of chronically mentally ill patients at increased risk. Nonetheles
Syringe and needle exchange programs: Part I.: South Med J. 1993 Mar;86(3):318-22. Unique Identifier : AIDSLINE MED/93197934; Schwartz RH; Department of Pediatrics, Georgetown University School of; Medicine, Washington, DC.; Syringe and needle exchange (SANE) programs appear to be a pragmatic approach to reducing the rising incidence of human immunodeficiency virus (HIV) infection among intravenous drug users (IVDUs). One purported indication of the effectiveness of SANE programs is lower prevalence rates of cases of AIDS or of HIV seropo
Evaluation of rapid enzyme immunobinding assays for the detection of antibodies to HIV-1.: S Afr Med J. 1993 Feb;83(2):115-7. Unique Identifier : AIDSLINE MED/93197968; Lyons SF; MRC AIDS Virus Research Unit, University of the Witwatersrand,; Johannesburg.; Three rapid enzyme immunobinding assays, Abbott s TestPack HIV-1/HIV-2, Clonatec s Rapid HIV1/HIV2 AB and the DuPont HIVCHEK 1 + 2, were evaluated using a panel of 20 selected sera with Western blot-proven reactivity to at least one envelope glycoprotein of HIV-1. The Abbott assay had the highest sensitivity and detec
Corneal transplantation from an HIV seroconverting donor [letter]: S Afr Med J. 1993 Feb;83(2):132-3. Unique Identifier : AIDSLINE MED/93197973; Keen GA; Murray A; Smuts H; Becker M; Berger RR; Roome D
Follow-up on AIDS at Hottentots Holland Hospital [letter; comment]: S Afr Med J. 1993 Feb;83(2):135. Unique Identifier : AIDSLINE MED/93197977; Van Wyk C
Important case addresses blood transfusions, expert witnesses, and informed consent.: Tex Med. 1993 Mar;89(3):55-6. Unique Identifier : AIDSLINE MED/93198041; Wilcox DP
Pathogenesis and early lesions in extranodal lymphoma.: Toxicol Lett. 1993 Apr;67(1-3):237-47. Unique Identifier : AIDSLINE MED/93198085; Isaacson PG; Department of Histopathology, University College & Middlesex; School of Medicine, London, UK.; Extranodal lymphomas that arise in tissues normally devoid of lymphoid tissue provide a unique opportunity for the study of the pathogenesis of lymphoma without the distraction of surrounding lymphoid tissue. This applies particularly to mucosa-associated lymphoid tissue (MALT) B-cell lymphomas, so named because they
HIV seroprevalence among patients attending a Milwaukee clinic for sexually transmitted diseases: findings from four annual surveys, 1988-1991.: Wis Med J. 1993 Feb;92(2):61-5. Unique Identifier : AIDSLINE MED/93198367; Hoxie NJ; Vergeront JM; Schlenker T; Pfister J; Davis JP; Milwaukee Health Department.; Blinded HIV seroprevalence surveys were conducted annually from 1988 through 1991 among patients at a Milwaukee sexually transmitted disease (STD) clinic. Among 5,295 patients tested, 70 (1.3%) were HIV-1 Western blot positive. HIV seroprevalence rates were higher among male patients (1.7%) than among female patients
A study of inpatients with AIDS in Racine County.: Wis Med J. 1993 Feb;92(2):73-4. Unique Identifier : AIDSLINE MED/93198369; Venu L; Gullberg R; Bigley S; St Mary's Medical Center, Racine, WI.; Since the first patient with AIDS was reported in 1981, the incidence of this illness has continued to rise. It is estimated that the cost of AIDS-related illnesses will be $15.2 billion by 1995. In this paper, we analyzed the number of admissions for AIDS to St Mary s Medical Center and St Luke s Hospital, both in Ra
[Public health: an interdisciplinary challenge]: Soz Praventivmed. 1993;38(1):1-7. Unique Identifier : AIDSLINE MED/93198399; Gutzwiller F; Institut fur Sozial- und Praventivmedizin, Universitat; Zurich.; Presented as an opening lecture of the new postgraduate education programme of both the Technical and the Free University of Berlin, sponsored by the German Federal Minister of Research and Technology, this lecture recalls the foundation of the first School of Public Health (The Johns Hopkins School of Hygiene and Pub
Streptococcal toxic shock [letter; comment]: J Am Board Fam Pract. 1993 Mar-Apr;6(2):204. Unique Identifier : AIDSLINE MED/93198696; Wittig G
[Acute focal bacterial nephritis in a case of AIDS]: Actas Urol Esp. 1993 Jan;17(1):84-5. Unique Identifier : AIDSLINE MED/93198712; Angulo JC; Loizaga A; de Garay MG; Flores N; Servicio de Urologia, Santo Hospital Civil de Bilbao.; Presentation of one case of bacterial acute focal nephritis (acute lobe nephrosis) in a parenterally drug-abuser, HIV-infected male. From the clinical point of view, the picture was interpreted as acute hepatitis, and the lesion was detected by ultrasound techniques. A right side location, relative lack of urological
Trends in the first ten years of AIDS in New York City. The New York City Department of Health AIDS Surveillance Team.: Am J Epidemiol. 1993 Jan 15;137(2):121-33. Unique Identifier : AIDSLINE MED/93198852; Thomas PA; Weisfuse IB; Greenberg AE; Bernard GA; Tytun A; Stellman SD; Office of AIDS Surveillance, New York City Department of Health,; NY 10013.; With over 37,000 cases of acquired immunodeficiency syndrome (AIDS) reported by the end of 1991, New York City had reported nearly 20% of all US cases in the first decade of the AIDS epidemic. This report examines cases diagnosed through 1990 and reported through 1991 to describe rates and trends in the affected subpo
Antifungal prophylaxis: to prevent or not [editorial; comment]: Am J Med. 1993 Mar;94(3):233-4. Unique Identifier : AIDSLINE MED/93198882; Perfect JR
The febrile parenteral drug user: a prospective study in 121 patients.: Am J Med. 1993 Mar;94(3):274-80. Unique Identifier : AIDSLINE MED/93198888; Weisse AB; Heller DR; Schimenti RJ; Montgomery RL; Kapila R; Department of Medicine, New Jersey Medical School, Newark 07103.; OBJECTIVE: To determine the most efficient approach to the diagnosis of infective endocarditis (IE) in febrile parenteral drug users (PDUs) and evaluate possible effects of human immunodeficiency virus (HIV) infections or acquired immunodeficiency syndrome (AIDS) on susceptibility to IE and final outcome. DESIGN: A pr
Kaposi's sarcoma presenting as lymphadenopathy in two HIV-negative elderly patients.: Am J Med. 1993 Mar;94(3):342-4. Unique Identifier : AIDSLINE MED/93198897; Wang JC; Rosen Y; Goel PC; Teplitz H; Goldberg M; Friedman-Kien AE; Huang YQ; Brookdale Hospital Medical Center, Brooklyn, New York.
Fleroxacin in the treatment of chancroid: an open study in men seropositive or seronegative for the human immunodeficiency virus type 1.: Am J Med. 1993 Mar 22;94(3A):85S-88S. Unique Identifier : AIDSLINE MED/93198930; Tyndall MW; Plourde PJ; Agoki E; Malisa W; Ndinya-Achola JO; Plummer FA; Ronald AR; WHO Collaborating Centre for Research and Training in Sexually; Transmitted Diseases, University of Nairobi, Kenya.; Fleroxacin was prescribed to treat both HIV-negative and HIV-positive men with proven chancroid in an open study. HIV-negative men were treated with a single 400-mg dose of fleroxacin, and HIV-positive men were treated with 400 mg daily for 5 days. Three of the 58 evaluable HIV-negative men were clinical and microbiol
Pharmacokinetics of nevirapine: initial single-rising-dose study in humans.: Antimicrob Agents Chemother. 1993 Feb;37(2):178-82. Unique Identifier : AIDSLINE MED/93199283; Cheeseman SH; Hattox SE; McLaughlin MM; Koup RA; Andrews C; Bova CA; Pav JW; Roy T; Sullivan JL; Keirns JJ; Department of Medicine, University of Massachusetts Medical; School, Worcester 01655.; Nevirapine, a nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, was administered for the first time to humans in a pilot study designed to investigate the pharmacokinetics and tolerance of the drug following single-dose administration to 21 HIV-1-infected individuals. The st
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.: Antimicrob Agents Chemother. 1993 Feb;37(2):332-8. Unique Identifier : AIDSLINE MED/93199312; Balzarini J; Holy A; Jindrich J; Naesens L; Snoeck R; Schols D; De Clercq E; Rega Institute of Medical Research, Katholieke Universiteit; Leuven, Belgium.; The (S)- and (R)-enantiomers of acyclic purine nucleoside phosphonate analogs (i.e., 3-hydroxy-2-phosphonomethoxypropyl [HPMP] derivatives, 3-fluoro-2-phosphonomethoxypropyl [FPMP] derivatives, and 2-phosphonomethoxypropyl [PMP] derivatives of adenine [A], 2-aminopurine, 2,6-diaminopurine [DAP], and guanine [G]) have
Comparison of the effects of 3'-azidothymidine with those of neutralizing antibodies on simian immunodeficiency virus infection in macrophages.: Antimicrob Agents Chemother. 1993 Feb;37(2):360-2. Unique Identifier : AIDSLINE MED/93199319; McEntee MF; Flexner C; Farzadegan H; Pitha P; Narayan O; Division of Comparative Medicine, Johns Hopkins University School; of Medicine, Baltimore, Maryland 21205.; We previously showed that simian immunodeficiency virus-infected macaque macrophages contacting uninfected CD4+ lymphocytes caused extensive cell fusion and synthesis of phlogistic cytokines. In this study, macaque macrophage cultures inoculated with SIVmac251 and treated simultaneously with 10 microM 3 -azidothymidin
Surgical management of spontaneous pneumothorax in patients with AIDS [letter; comment]: Ann Thorac Surg. 1993 Mar;55(3):808-9. Unique Identifier : AIDSLINE MED/93199430; Albort JV; Callejas MA; Canalis EA; Catalan M; Sanchez-Lloret J
Skeletal muscle lymphoma in patients with the acquired immunodeficiency syndrome: a diagnostic challenge.: Arthritis Rheum. 1993 Mar;36(3):426-7. Unique Identifier : AIDSLINE MED/93199590; Chevalier X; Amoura Z; Viard JP; Souissi B; Sobel A; Gherardi R; Hopital Henri-Mondor Creteil, France.
Human antibodies to HIV-1 by recombinant DNA methods.: Chem Immunol. 1993;56:112-26. Unique Identifier : AIDSLINE MED/93199686; Burton DR; Barbas CF 3d; Department of Immunology, Scripps Research Institute, La Jolla,; Calif.
B cell antigenic site mapping of HIV-1 glycoproteins.: Chem Immunol. 1993;56:34-60. Unique Identifier : AIDSLINE MED/93199689; Neurath AR; Laboratory of Biochemical Virology, Lindsley F. Kimball Research; Institute, New York Blood Center, N.Y.
Antigenic and immunogenic sites of HIV-2 glycoproteins.: Chem Immunol. 1993;56:61-77. Unique Identifier : AIDSLINE MED/93199690; Chiodi F; Bjorling E; Samuelsson A; Norrby E; Department of Virology, Karolinska Institute, Stockholm, Sweden.
Photopheresis for ARC: a nursing perspective.: Dermatol Nurs. 1993 Feb;5(1):39-41. Unique Identifier : AIDSLINE MED/93199925; Cahill C; Keyes B; Crater D; Meyer K; Degnan E; Nunez L; Photopheresis, an approved treatment for cutaneous T-cell lymphoma (CTCL), is the basis of a trial involving patients with AIDS-related complex (ARC). This study has provided the opportunity to identify unique nursing challenges along with satisfaction from innovative nursing interventions.
HIV and associated cutaneous diseases.: Dermatol Nurs. 1993 Feb;5(1):51-7, 64. Unique Identifier : AIDSLINE MED/93199928; Simpson S; Sadick NS; HIV infections manifest a wide spectrum of dermatologic diseases. These can be classified and described as primary bacterial infections, fungal infections, associated cutaneous disorders, and hypersensitivity reactions. The presentation of each disease can be clearly identified, and current preferred medical therapies
Clinical features, diagnosis, and prognosis in rheumatoid arthritis.: Curr Opin Rheumatol. 1993 Mar;5(2):184-90. Unique Identifier : AIDSLINE MED/93199969; Morgan GJ Jr; Chow WS; Department of Rheumatology, Dartmouth Hitchcock Medical Center,; Lebanon, NH 03756.; The past year has witnessed a modest expansion in our understanding of the clinical, diagnostic, and prognostic features of rheumatoid arthritis. Almost every continent has reported prevalence, phenotype, and clinical features of rheumatoid arthritis subpopulations. Reviews of the natural history and therapy of cervic
Concern over nurses' lack of AIDS knowledge [news]: Nurs Stand. 1993 Jan 27-Feb 2;7(19):16. Unique Identifier : AIDSLINE MED/93200002
A tribute to a marvellous man [letter]: Nurs Stand. 1993 Jan 27-Feb 2;7(19):41-2. Unique Identifier : AIDSLINE MED/93200010; Raper J
Studies of adhesion of lymphocytic cells: implications for sexual transmission of human immunodeficiency virus.: Biol Reprod. 1993 Mar;48(3):431-45. Unique Identifier : AIDSLINE MED/93200250; Pearce-Pratt R; Phillips DM; Population Council, New York, New York 10021.; Considerable evidence suggests that sexual transmission of human immunodeficiency virus (HIV) is mediated via mononuclear cells that can infect epithelia of the genital tract. We describe here an in vitro model that can be used to examine the mechanism of cell-to-cell transmission of this virus. We have employed the s
Arguments against the chemoprophylactic use of zidovudine following occupational exposure to the human immunodeficiency virus [comment]: Clin Infect Dis. 1993 Mar;16(3):357-60. Unique Identifier : AIDSLINE MED/93200295; Robinson EN Jr; Department of Medicine, University of North Carolina School of; Medicine, Greensboro.; Following the paradigm of the hospitals of the National Institutes of Health and the University of California at San Francisco, many medical facilities have instituted a policy of administering zidovudine to health care workers after exposure to blood potentially contaminated with the human immunodeficiency virus. The
Sinusitis due to Pseudomonas aeruginosa in patients with human immunodeficiency virus infection.: Clin Infect Dis. 1993 Mar;16(3):404-6. Unique Identifier : AIDSLINE MED/93200305; O'Donnell JG; Sorbello AF; Condoluci DV; Barnish MJ; Division of Infectious Diseases, School of Osteopathic Medicine,; University of Medicine and Dentistry of New Jersey, Stratford; 08084.; Community-acquired sinusitis due to Pseudomonas aeruginosa developed in four patients with advanced human immunodeficiency virus (HIV) infection who had no local predisposing factors or neutropenia. Two persons were bacteremic. Combination antibiotic therapy and surgical drainage were necessary for adequate treatment.
Necrotizing pancreatitis and multisystem organ failure associated with toxoplasmosis in a patient with AIDS.: Clin Infect Dis. 1993 Mar;16(3):432-4. Unique Identifier : AIDSLINE MED/93200310; Ahuja SK; Ahuja SS; Thelmo W; Seymour A; Phelps KR; Department of Medicine, Kings County Medical Center, Brooklyn.; Extraneural manifestations of toxoplasmosis often are not recognized antemortem in patients with AIDS. We describe a patient who was seropositive for human immunodeficiency virus and presented with lethargy, abdominal tenderness, rapidly progressive ventilatory failure, rhabdomyolysis, myoglobinuria, and disseminated
Prosthetic hip infection and bacteremia due to Campylobacter jejuni in a patient with AIDS.: Clin Infect Dis. 1993 Mar;16(3):439-40. Unique Identifier : AIDSLINE MED/93200312; Peterson MC; Farr RW; Castiglia M; Department of Medicine, School of Medicine, West Virginia; University Health Sciences Center, Morgantown.; Campylobacter jejuni is a common enteric pathogen in healthy individuals and in patients with AIDS. It usually causes a self-limited diarrheal illness with fever and abdominal pain. We report what we believe is a unique case of C. jejuni osteomyelitis in a 60-year-old man who had hemophilia A, AIDS, and a hip prosthes
Infection due to Klebsiella rhinoscleromatis in two patients infected with human immunodeficiency virus.: Clin Infect Dis. 1993 Mar;16(3):441-2. Unique Identifier : AIDSLINE MED/93200313; Paul C; Pialoux G; Dupont B; Fleury J; Gonzalez-Canali G; Eliaszewicz M; Sansonetti P; Genereau T; Hospital of the Pasteur Institute, Department of Infectious and; Tropical Diseases, Paris, France.; Two cases of rhinoscleroma in patients infected with the human immunodeficiency virus (HIV) who had stayed in an area of endemic Klebsiella rhinoscleromatis are reported. One of the patients presented with oropharyngeal lesions, an unusual clinical picture. Both patients suffered from a major cellular immune deficienc
[Kaposi's sarcoma and portal hypertension in human immunodeficiency virus infection (letter)]: An Med Interna. 1993 Feb;10(2):101-2. Unique Identifier : AIDSLINE MED/93200328; Geijo MP; Rosa C; Hervas MJ; Dimas J
[Acute human immunodeficiency virus infection associated with facial diplegia]: An Med Interna. 1993 Feb;10(2):80-2. Unique Identifier : AIDSLINE MED/93200338; Soto Espinosa B; Calderon Sandubette E; Medrano Ortega FJ; Andreu Alvarez J; Pavon A; Leal Noval M; Departamento de Medicina Interna, Hospital Universitario Virgen; del Rocio, Sevilla.; We describe the case of a 21-year-old parenterally drug-addict man, who presented an acute and self-limited disease, temporarily associated to seroconversion against the human immunodeficiency virus. During his evolution, the patient developed aseptic meningitis and facial diplegia. Two lymphatic ganglions were histop
[Care for drug addicts in primary care]: Aten Primaria. 1993 Feb 28;11(3):138-40. Unique Identifier : AIDSLINE MED/93200367; Martinez Garcia F; Sebastian S; Martinez Marogna A; OBJECTIVE: 21 drug addicts reasons for attending (RA) primary care clinics were studied. DESIGN: A six-month long prospective study. SITE: An attendance group, as in Insalud s traditional model, from an area of Madrid with a high level of drug use. PARTICIPANTS: Everybody known to be dependent on drugs and who could
[Oligoarthritis as the initial manifestation in human immunodeficiency virus infection (letter)]: Aten Primaria. 1993 Feb 28;11(3):156-7. Unique Identifier : AIDSLINE MED/93200373; Herreros-Calleja A; Camarzana M; Carrillo J; Aylagas A
Cervical neoplasia and cytological manifestations of sexually transmitted diseases in HIV-seropositive prostitutes [letter]: Cytopathology. 1993;4(1):63-4. Unique Identifier : AIDSLINE MED/93200392; Joshi J; Mali B; Bhave G; Wagle U
Lowest dose interleukin-2 immunotherapy [see comments]: Blood. 1993 Mar 15;81(6):1414-23. Unique Identifier : AIDSLINE MED/93200498; Smith KA; Department of Medicine, Dartmouth Medical School, Hanover, NH; 03755-3833.
In vitro infection of human macrophages with human T-cell leukemia virus type 1.: Blood. 1993 Mar 15;81(6):1598-606. Unique Identifier : AIDSLINE MED/93200522; de Revel T; Mabondzo A; Gras G; Delord B; Roques P; Boussin F; Neveux Y; Bahuau M; Fleury HJ; Dormont D; Laboratoire de Neuropathologie experimentale et Neurovirologie,; CRSSA, DSV/DPTE, Commissariat a l'Energie Atomique, Fontenay; aux-Roses, France.; The tropism of the human T-cell leukemia virus type 1 (HTLV-1) for the cells of monocyte-macrophage lineage was evaluated by the coculture of blood monocyte-derived macrophages, with irradiated cells of HTLV-1 producing cell lines MT2 or C91/PL. The susceptibility to HTLV-1 was assessed by the detection of viral DNA u
Human T-cell leukemia virus type II infection frequently goes undetected in contemporary US blood donors.: Blood. 1993 Mar 15;81(6):1641-4. Unique Identifier : AIDSLINE MED/93200528; Hjelle B; Wilson C; Cyrus S; Bradshaw P; Lo J; Schammel C; Wiltbank T; Alexander S; Department of Pathology, University of New Mexico School of; Medicine, Albuquerque 87131.; Serologic screening for human T-cell leukemia virus type I (HTLV-I) infection was begun in US blood banks with the licensure of enzyme-linked immunosorbent assays (ELISA) in December 1988. We examined the donation histories of the first 60 Western blot (WB)-confirmed HTLV-I/II positive donors to one blood center and f
HIV infected pharmacist must have unrestricted job or hospital will lose millions... [news]: Trends Health Care Law Ethics. 1993 Winter;8(1):4. Unique Identifier : AIDSLINE MED/93200718; Stolman CJ
A preparation from bovine colostrum in the treatment of HIV-positive patients with chronic diarrhea.: Clin Investig. 1993 Jan;71(1):42-5. Unique Identifier : AIDSLINE MED/93200737; Plettenberg A; Stoehr A; Stellbrink HJ; Albrecht H; Meigel W; Allgemeines Krankenhaus St. Georg, HIV-Ambulanz, Hamburg.; In a prospective, open, uncontrolled study 25 patients infected with the human immunodeficiency virus with chronic refractory diarrhea and either confirmed cryptosporidiosis (n = 7) or absence of demonstrable pathogenic organisms (n = 18) were treated with a daily oral dose of 10 g of an immunoglobulin preparation fro
Neopterin and opportunistic infections in HIV-infected patients.: Clin Investig. 1993 Jan;71(1):65. Unique Identifier : AIDSLINE MED/93200742; Domingo P; Martinez E; Martinez C; Barrio J; Cadafalch J; Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de; Barcelona, Spain.
Human immunodeficiency virus-1 infection among patients with sexually transmitted diseases in Bombay.: Natl Med J India. 1993 Jan-Feb;6(1):11-3. Unique Identifier : AIDSLINE MED/93200889; Kamat HA; Banker DD; Sir Hurkisondas Nurrotumdas Hospital, Maharashtra, India.; BACKGROUND. Patients with sexually transmitted diseases form a particularly vulnerable group for infection with the human immunodeficiency virus (HIV-1), and serological surveillance is a sensitive tool for assessing the prevalence of this disease. METHODS. We carried out a serological survey for the detection of anti
HTLV-1 revisited [letter]: Br J Psychiatry. 1993 Mar;162:426-7. Unique Identifier : AIDSLINE MED/93201217; Daisley H; Hutchinson G; Landeau P
The presence of particles resembling human T-cell leukemia virus type I at ultrastructural examination of lymphomatous cells in a case of T-cell leukemia/lymphoma.: Cancer. 1993 Apr 1;71(7):2227-32. Unique Identifier : AIDSLINE MED/93201432; Vital C; Vital A; Moynet D; Broustet A; de Mascarel A; Bloch B; Guillemain B; Department of Neuropathology, Bordeaux II University, France.; BACKGROUND. Cases of adult T-cell leukemia/lymphoma (ATLL) resulting from human T-cell leukemia virus type I (HTLV-I) have been observed mainly in the southern part of Japan . Recently, the authors performed a second examination of cutaneous, muscle, and nerve biopsy specimens from a
Acquired immune deficiency syndrome-related pulmonary non-Hodgkin lymphoma regressing after zidovudine therapy.: Cancer. 1993 Apr 1;71(7):2332-4. Unique Identifier : AIDSLINE MED/93201447; Baselga J; Krown SE; Telzak EE; Filippa DA; Straus DJ; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, New York 10021.; BACKGROUND. Zidovudine is a thymidine analogue that has been reported to have antiviral and antineoplastic activity in vitro. METHODS. The case of a patient with acquired immune deficiency syndrome (AIDS) and a pulmonary non-Hodgkin lymphoma treated with zidovudine and no other treatment is presented. RESULTS. The pat
Biodistribution and toxicity of photoproducts of merocyanine 540.: Cancer Chemother Pharmacol. 1993;31(6):467-74. Unique Identifier : AIDSLINE MED/93201645; Pervaiz S; Battaglino M; Matthews JL; Gulliya KS; Baylor University Medical Center, Baylor Research Institute,; Dallas, TX 75226.; Light-activated merocyanine 540 (pMC540) has been shown in our earlier studies to be effective against certain types of tumor cells and viruses, including human immunodeficiency virus (HIV-1). To test the potential extracorporeal and systemic use of pMC540, its toxicity was investigated in DBA/2 mice, pigs, and dogs.
Comparative pharmacokinetics of antiviral nucleoside analogues.: Clin Pharmacokinet. 1993 Feb;24(2):101-23. Unique Identifier : AIDSLINE MED/93201832; Morse GD; Shelton MJ; O'Donnell AM; Department of Pharmacy, Erie County Medical Center, State; University of New York, Buffalo.; The recent development of nucleoside analogues with antiviral activity has expanded the small but useful armamentarium for the treatment of certain viral diseases such as the human immunodeficiency virus, cytomegalovirus and others. Their intracellular site of action and need for s
Gastric mucormycosis in a patient with acquired immunodeficiency syndrome [letter]: Gastrointest Endosc. 1993 Jan-Feb;39(1):106-7. Unique Identifier : AIDSLINE MED/93202365; Brullet E; Andreu X; Elias J; Roig J; Cervantes M
Development of a selective and sensitive polymerase chain reaction assay for the detection of Mycoplasma pirum.: FEMS Microbiol Lett. 1993 Feb 1;106(3):327-33. Unique Identifier : AIDSLINE MED/93202458; Grau O; Kovacic R; Griffais R; Montagnier L; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.; A new assay using the polymerase chain reaction to amplify a 173-nucleotide DNA fragment within the 16S ribosomal RNA gene of Mycoplasma pirum has been developed. The assay selectively amplified DNA from all strains of M. pirum tested with a high level of sensitivity, even in a context of human DNA. DNA from other mol
Detection by in situ hybridization of HIV and c-myc RNA in tumour cells of AIDS-related B-cell lymphomas.: Histopathology. 1993 Feb;22(2):151-6. Unique Identifier : AIDSLINE MED/93202605; Prevot S; Raphael M; Fournier JG; Diebold J; Service d'Anatomie et de Cytologie Pathologiques J. Delarue,; Hotel-Dieu, Paris, France.; The incidence of acquired immune deficiency syndrome (AIDS)-related malignant lymphoma has increased since the disease was first described, but its pathogenesis is still not understood. There have been numerous molecular studies addressing the clonality of these proliferations, the presence of Epstein-Barr virus genom
The use of transformed T cell lines for clonal expansion of human B cells from peripheral blood, spleen, and tumor-infiltrating lymphocytes.: Hybridoma. 1993 Feb;12(1):115-25. Unique Identifier : AIDSLINE MED/93202667; Barbuto JA; Verastegui EL; Hersh EM; Arizona Cancer Center, University of Arizona, Tucson 85724.; Human transformed T cell lines were able to induce polyclonal B cell activation and immunoglobulin (Ig) secretion from peripheral blood mononuclear cells, spleen cells and tumor-infiltrating lymphocytes (TIL). Cells from one of the lines tested, MOT, did not require any exogenous stimuli to induce maximal responses an
Interaction between human immunodeficiency virus and Toxoplasma gondii replication in dually infected monocytoid cells.: Infect Immun. 1993 Apr;61(4):1596-8. Unique Identifier : AIDSLINE MED/93202777; Welker Y; Molina JM; Poirot C; Ferchal F; Decazes JM; Lagrange P; Derouin F; Laboratory of Parasitology, Saint-Louis Hospital, Paris, France.; THP-1 monocytoid cells, either not infected or chronically infected with human immunodeficiency virus type 1 (HIV-1), were challenged with Toxoplasma gondii. Parasitic growth, as assessed by trophozoite counting and measurement of supernatant p30 membrane antigen, was similar in HIV-infected and noninfected THP-1 cell
Israeli AIDS numbers relatively low [news]: Isr J Med Sci. 1993 Jan;29(1):76. Unique Identifier : AIDSLINE MED/93202919
UV irradiation-induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response.: J Biol Chem. 1993 Mar 25;268(9):6734-41. Unique Identifier : AIDSLINE MED/93203277; Kramer M; Sachsenmaier C; Herrlich P; Rahmsdorf HJ; Kernforschungszentrum Karlsruhe, Institut fur Genetik und; Toxikologie, Germany.; UV irradiated cells release into the culture medium factors that induce, when given to nonirradiated cells, the transcription of several UV-inducible genes (collagenase I, human immunodeficiency virus type 1, metallothionein IIA). We identify here the active factors released from UV-treated HeLa cells, as interleukin
Bowenoid changes in Kaposi's sarcoma.: J Dermatol Surg Oncol. 1993 Jan;19(1):21-5. Unique Identifier : AIDSLINE MED/93203500; Cohen PR; Adler-Storthz K; Rapini RP; Department of Dermatology, University of Texas Medical School,; Houston 77030.; BACKGROUND: Previous reports have documented the coexistence of multiple infectious organisms or Kaposi s sarcoma within the same biopsy specimens of mucocutaneous lesions in human immunodeficiency virus- (HIV) infected patients. OBJECTIVE: A 31-year-old black man with the acquired immunodeficiency syndrome (AIDS) who
Colonial morphotype as a determinant of cytokine expression by human monocytes infected with Mycobacterium avium.: J Immunol. 1993 Apr 1;150(7):2945-54. Unique Identifier : AIDSLINE MED/93203614; Shiratsuchi H; Toossi Z; Mettler MA; Ellner JJ; Department of Medicine, Case Western Reserve University School of; Medicine, University Hospitals, Cleveland, OH 44106.; Mycobacterium avium is an intracellular pathogen that causes disseminated infection in patients with AIDS. Colonial morphotype (smooth-transparent (SmT) vs smooth-domed (SmD)) is a key determinant of virulence in mice and the capacity for replication in human monocytes. Some cytokines (IL-1 and IL-6) promote, whereas
Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens.: J Immunol. 1993 Apr 1;150(7):3070-9. Unique Identifier : AIDSLINE MED/93203627; Ho HN; Hultin LE; Mitsuyasu RT; Matud JL; Hausner MA; Bockstoce D; Chou CC; O'Rourke S; Taylor JM; Giorgi JV; Department of Medicine, University of California, Los Angeles; 90024-1745.; CD38, a molecule with multilineage distribution but unknown function, and the MHC class II molecule HLA-DR (DR) have markedly elevated levels of expression on CD8+ cells of HIV-infected people. This study investigated the expression of CD38 and DR Ag on circulating HIV-specific CD8+ CTL in HIV-seropositive subjects. P
Immunization with recombinant BCG-SIV elicits SIV-specific cytotoxic T lymphocytes in rhesus monkeys.: J Immunol. 1993 Apr 1;150(7):3101-7. Unique Identifier : AIDSLINE MED/93203631; Yasutomi Y; Koenig S; Haun SS; Stover CK; Jackson RK; Conard P; Conley AJ; Emini EA; Fuerst TR; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.; Because the transmission of HIV is likely to occur through cell-associated virus, an effective HIV vaccine should be capable of eliciting HIV-specific CTL. We have employed the simian immunodeficiency virus (SIV)/rhesus monkey model to explore the use of the attenuated tuberculosis bacillus, Calmette Guerin bacillus (
Orthostatic hypotension in HIV infection in Africa [letter]: J Infect. 1993 Jan;26(1):103-4. Unique Identifier : AIDSLINE MED/93203633; Colebunders R; Ngimbi K; Ineme I; Izaley L; Bila K
HIV testing among injecting drug users in Glasgow.: J Infect. 1993 Jan;26(1):27-31. Unique Identifier : AIDSLINE MED/93203640; Covell R; Follett E; Coote I; Bloor M; Finlay A; Frischer M; Goldberg D; Green S; Haw S; McKeganey N; University of Glasgow, U.K.; The use of saliva rather than blood for epidemiological studies of HIV prevalence, especially among injecting drug users, has several practical advantages. In a cross-sectional, behavioural and prevalence study among drug users in Glasgow during 1990, salivary samples were therefore obtained by the use of salivettes.
Tuberculosis and AIDS: is the white plague up and coming?: J Infect. 1993 Jan;26(1):39-43. Unique Identifier : AIDSLINE MED/93203642; Foley NM; Miller RF; University College and Middlesex School of Medicine, Department; of Medicine, Middlesex Hospital, London, U.K.; We have studied the effect of the HIV epidemic on the incidence of tuberculosis in an inner city area of London which has a high incidence of acquired immunodeficiency syndrome (AIDS). During the period 1985-1991, there was a steady increase in the number of new AIDS cases, whilst the numbers of notifications and labo
Acute and long-term efficacy of antituberculous treatment in HIV-seropositive patients with tuberculosis: a study of 36 cases.: J Infect. 1993 Jan;26(1):45-54. Unique Identifier : AIDSLINE MED/93203643; Schurmann D; Bergmann F; Jautzke G; Fehrenbach J; Mauch H; Ruf B; 2nd Department of Internal Medicine (Department of Infectious; Diseases), Rudolf Virchow University Hospital (Wedding), Free; University of Berlin, Germany.; Thirty-six consecutively observed HIV-seropositive patients with tuberculosis, including 31 patients with AIDS, who received antituberculous treatment, were followed up to evaluate its efficacy. Treatment with standard antituberculous regimens was intended except when an individual s condition required a modified ther
Gastro-intestinal involvement in Mycobacterium avium-intracellulare infection of patients with HIV.: J Infect. 1993 Jan;26(1):55-66. Unique Identifier : AIDSLINE MED/93203644; Hellyer TJ; Brown IN; Taylor MB; Allen BW; Easmon CS; Department of Medical Microbiology, St Mary's Hospital Medical; School, London, U.K.; In a study of 866 faecal specimens from 437 persons, Mycobacterium avium-intracellulare (MAI) was isolated from 14.8% patients with AIDS and 1.3% patients with symptomatic HIV infection but not from any HIV seronegative or asymptomatic HIV seropositive persons. These data support the hypothesis that the gastro-intesti
Helicobacter (Campylobacter) fennelliae-like organisms as an important but occult cause of bacteraemia in a patient with AIDS.: J Infect. 1993 Jan;26(1):97-101. Unique Identifier : AIDSLINE MED/93203654; Kemper CA; Mickelsen P; Morton A; Walton B; Deresinski SC; Department of Medicine, Stanford University School of Medicine,; California 94305.; We describe the isolation and identification of a Helicobacter (Campylobacter)-like organism obtained from the blood of a 32-year-old homosexual man with a 10 months history of AIDS and progressive mucocutaneous Kaposi sarcoma. Fever and bacteremia persisted despite sequential administration of ciprofloxacin and trim
Zidovudine therapy of HIV-associated thrombocytopenia: from MAIDS to AIDS [editorial; comment]: J Lab Clin Med. 1993 Apr;121(4):536-8. Unique Identifier : AIDSLINE MED/93203724; Pomeroy C
Sustained elevation of platelet counts by long-term azidothymidine treatment of immunosuppressed mice [see comments]: J Lab Clin Med. 1993 Apr;121(4):562-9. Unique Identifier : AIDSLINE MED/93203728; Chow FP; Chen RB; Hamburger AW; University of Maryland Cancer Center, Baltimore 21201.; Azidothymidine ( AZT ) has been demonstrated to increase platelet counts in patients suffering from acquired immunodeficiency syndrome (AIDS). However, the ability of long-term AZT treatment to sustain increases in platelet counts is controversial. We h
FDG-PET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS.: J Nucl Med. 1993 Apr;34(4):567-75. Unique Identifier : AIDSLINE MED/93203932; Hoffman JM; Waskin HA; Schifter T; Hanson MW; Gray L; Rosenfeld S; Coleman RE; Department of Radiology, Duke University Medical Center, Durham,; North Carolina 27710.; Structural imaging studies such as CT or MRI are not able to accurately differentiate infectious from malignant cerebral lesions in patients with AIDS. We studied 11 individuals with AIDS and central nervous system (CNS) lesions with 18F-fluoro-2-deoxyglucose (FDG) and positron emission tomography (PET). FDG-PET was a
Hospital sharps disposal system II [letter; comment]: J Occup Med. 1993 Mar;35(3):313-4. Unique Identifier : AIDSLINE MED/93203965; Sokas RK; Moragne-Coon Y; Mohlmann N
Direct detection of HIV-1 RNA in epidermal Langerhans cells of HIV-infected patients.: J Acquir Immune Defic Syndr. 1993 Apr;6(4):329-33. Unique Identifier : AIDSLINE MED/93204009; Giannetti A; Zambruno G; Cimarelli A; Marconi A; Negroni M; Girolomoni G; Bertazzoni U; Clinica Dermatologica, Universita di Modena, Italy.; Human Langerhans cells (LC) are bone marrow-derived, HLA-DR+, CD1a+, and CD4+ dendritic antigen-presenting cells found in stratified squamous epithelia. As other members of the dendritic leukocyte family, to which they belong, LC have been reported as targets for HIV-1 infection. The aim of the present study was to in
HIV-1 gp120 and NMDA induce protein kinase C translocation differentially in rat primary neuronal cultures.: J Acquir Immune Defic Syndr. 1993 Apr;6(4):339-43. Unique Identifier : AIDSLINE MED/93204011; Ushijima H; Ando S; Kunisada T; Schroder HC; Klocking HP; Kijjoa A; Muller WE; Division of AIDS Virus, National Institute of Health, Tokyo,; Japan.; Exposure of rat cortical neurons to the human immunodeficiency virus type 1 (HIV-1) coat protein gp120 in vitro causes a rise in the intracellular Ca2+ level and a subsequent translocation of protein kinase C (PKC) from the cytosol to the membrane. Such a translocation persists for at least 2 h, but only in cultures w
Limited proteolytic digestions identify common structural features of HIV-1 Tat proteins expressed during infection from alternatively spliced mRNAs.: J Acquir Immune Defic Syndr. 1993 Apr;6(4):344-52. Unique Identifier : AIDSLINE MED/93204012; Rice AP; Wilson E; Chan F; Division of Molecular Virology, Baylor College of Medicine,; Houston, TX 77030.; Although multiple forms of the HIV-1 Tat protein are synthesized during infection from alternatively spliced mRNAs, only 72 amino acid residues encoded in the first Tat exon are necessary for full transactivation activity. We used limited proteolytic digestions of proteins expressed in vitro to study the structures of
Human monoclonal antibodies to the V3 loop of HIV-1 gp120 mediate variable and distinct effects on binding and viral neutralization by a human monoclonal antibody to the CD4 binding site.: J Acquir Immune Defic Syndr. 1993 Apr;6(4):353-8. Unique Identifier : AIDSLINE MED/93204013; Cavacini LA; Emes CL; Power J; Buchbinder A; Zolla-Pazner S; Posner MR; Department of Medicine, New England Deaconess Hospital, Boston,; MA 02215.; Interactive effects between human monoclonal antibodies specific for the V3 loop (257-D and 447-D) and an epitope within the CD4 binding site (F105) of HIV-1 gp120 were evaluated for neutralization of viral cytopathogenicity and binding to HIV-infected cells. Regardless of antibody pair, only additive effects were obs
Zidovudine therapy of HIV-1 infection during pregnancy: assessment of the effect on the newborns.: J Acquir Immune Defic Syndr. 1993 Apr;6(4):376-9. Unique Identifier : AIDSLINE MED/93204017; Ferrazin A; De Maria A; Gotta C; Mazzarello G; Canessa A; Ciravegna B; Cirillo C; Melica F; Terragna A; First Clinica Malattie Infettive, Universita di Genova, Italia.; Zidovudine (ZDV) administration during pregnancy has been suggested for the prevention of mother-to-child HIV-1 transmission. Reliable levels of the drug have been observed in the fetus and in the newborn. Seven HIV-1-infected pregnant women who declined to have abortions and whose immunological status required antire
Cardiac involvement in human immunodeficiency virus-infected patients.: J Acquir Immune Defic Syndr. 1993 Apr;6(4):380-5. Unique Identifier : AIDSLINE MED/93204018; Fong IW; Howard R; Elzawi A; Simbul M; Chiasson D; Department of Medicine, St. Michael's Hospital, University of; Toronto, Ontario, Canada.; Heart involvement in patients with AIDS has been described in autopsy and clinical series, but the true incidence in HIV-infected patients is not clear. A prospective study was done on 101 unselected HIV-infected patients (71 with AIDS and 30 with pre-AIDS) and 24 healthy controls to assess the prevalence of cardiac a
Unsafe sexual behavior and alcohol use at the event level: results of a national survey.: J Acquir Immune Defic Syndr. 1993 Apr;6(4):393-401. Unique Identifier : AIDSLINE MED/93204020; Temple MT; Leigh BC; Schafer J; Alcohol Research Group, Medical Research Institute of San; Francisco, Berkeley, California.; In recent years, several researchers have suggested that the use of alcohol in conjunction with sexual activity significantly increases the probability that unsafe or risky sexual behavior will occur. However, the majority of studies examining this relationship have utilized general measures of drinking frequency and
The potential for transmission of human immunodeficiency virus through human bites.: J Acquir Immune Defic Syndr. 1993 Apr;6(4):402-6. Unique Identifier : AIDSLINE MED/93204021; Richman KM; Rickman LS; Department of Internal Medicine, University of California, San; Diego Medical Center.; We review the potential for human immunodeficiency virus (HIV) transmission by human bites. HIV may be present in saliva, although infrequently and at low levels. In prospective studies, 13 people bitten by HIV-infected individuals have remained HIV seronegative. Only two cases have been published in which HIV transmi
Prevalence of Toxoplasma infection in a cohort of homosexual men at risk of AIDS and toxoplasmic encephalitis [see comments]: J Acquir Immune Defic Syndr. 1993 Apr;6(4):414-8. Unique Identifier : AIDSLINE MED/93204023; Israelski DM; Chmiel JS; Poggensee L; Phair JP; Remington JS; Department of Medicine, Stanford University School of Medicine,; California.; The purpose of this study was to characterize the epidemiologic, clinical, and laboratory parameters of a cohort of men at risk of AIDS-associated toxoplasmic encephalitis. One hundred seventeen (11%) of the 1,073 participants at the time of enrollment into the Chicago Multicenter AIDS Cohort Study (MACS) were seropos
Low and stable HIV seroprevalence in pregnant women in Shaba province, Zaire.: J Acquir Immune Defic Syndr. 1993 Apr;6(4):419-23. Unique Identifier : AIDSLINE MED/93204024; Magazani K; Laleman G; Perriens JH; Kizonde K; Mukendi K; Mpungu M; Badibanga N; Piot P; Centre Regional de Lutte contre le SIDA, Lubumbashi, Zaire.; Sentinel serosurveillance for HIV infection has been carried out in Shaba province, Zaire , among consecutive pregnant women attending antenatal clinics from 1989 to 1991. There were four surveillance sites (three urban and one semiurban), at which a total of 13 surveillance studie
Blood transfusion as a major risk factor for HTLV-I infection among hospitalized children in Gabon (Equatorial Africa).: J Acquir Immune Defic Syndr. 1993 Apr;6(4):424-8. Unique Identifier : AIDSLINE MED/93204025; Delaporte E; Peeters M; Bardy JL; Ville Y; Placca L; Bedjabaga I; Larouze B; Piot P; International Centre for Medical Research, Franceville, Gabon.; To study the risk factors for HTLV-I infection of African infants living in a high seroprevalence area, a survey was conducted among hospitalized children and their mothers in Franceville, southern Gabon . A total of 610 children (6 months to 14 years old) from 555 families and 434 m
Rhodococcus equi infection in HIV-infected patients [letter; comment]: J Acquir Immune Defic Syndr. 1993 Apr;6(4):429-30. Unique Identifier : AIDSLINE MED/93204026; Clotet B; Sirera G; Erice A
The success and failure of condom use by homosexual men in San Francisco [letter]: J Acquir Immune Defic Syndr. 1993 Apr;6(4):430-1. Unique Identifier : AIDSLINE MED/93204027; van Griensvan GJ; Samuel MC; Winklestein W Jr
Living situation of women with AIDS [letter]: J Acquir Immune Defic Syndr. 1993 Apr;6(4):431-2. Unique Identifier : AIDSLINE MED/93204028; Chu SY; Diaz T
Changes in HIV-2 seroprevalence in Cape Verde, west Africa [letter]: J Acquir Immune Defic Syndr. 1993 Apr;6(4):432-3. Unique Identifier : AIDSLINE MED/93204029; Caussy D; Terrinha A; Evans AC; Reis DD; Nunes JF; Blattner WA
AIDS and priorities in the global village [letter; comment]: JAMA. 1993 Apr 7;269(13):1636-7. Unique Identifier : AIDSLINE MED/93204338; Gellert G; Nordenberg DF
Ethics Committee report: American Nurses Association position statement on HIV infection and nursing students.: Ky Nurse. 1993 Jan-Feb;41(1):15. Unique Identifier : AIDSLINE MED/93204504
[Anticardiolipin antibodies in patients infected with the human immunodeficiency virus type 1 (letter; comment)]: Med Clin (Barc). 1993 Mar 6;100(9):357-8. Unique Identifier : AIDSLINE MED/93204561; Coll J; Yazbeck H; Gutierrez J
[Anticardiolipin antibodies in patients infected with the human immunodeficiency virus type 1 (letter; comment)]: Med Clin (Barc). 1993 Mar 6;100(9):358. Unique Identifier : AIDSLINE MED/93204562; Selva A; Ordi J; Castro-Salomo A; Pascual M
Alternative mode of replication of human immunodeficiency virus: a hypothesis.: Med Hypotheses. 1993 Jan;40(1):1-7. Unique Identifier : AIDSLINE MED/93204733; Nandi J; Banerjee K; National Institute of Virology, Pune, India.; For diagnosis of Human Immunodeficiency Virus (HIV) infection by the recently developed Polymerase Chain Reaction (PCR), the two commonly used clinical samples are either the peripheral blood monocytes (PBMC) or the plasma of the infected individuals. In the former instance, DNA is extracted from PBMC. The integrated
The role of reactive oxygen species, antioxidants and phytopharmaceuticals in human immunodeficiency virus activity.: Med Hypotheses. 1993 Feb;40(2):85-92. Unique Identifier : AIDSLINE MED/93204755; Greenspan HC; Currently, several prominent researchers are investigating the role of reactive oxygen and free radicals in the activation of latent HIV in infected individuals. Early clinical applications of free radical scavengers and plant-based antioxidant systems have shown promise of efficacy in altering this process. This manu
A novel antiviral strategy for HIV infection.: Med Hypotheses. 1993 Feb;40(2):93-4. Unique Identifier : AIDSLINE MED/93204756; May BA; The replication of human immunodeficiency virus (HIV) may be modulated in part by host factors such as DNA methylation. Hypermethylation of the HIV provirus may suppress viral replication and play a role in the establishment of latency. HIV seropositive individuals have decreased levels of metabolites involved in meth
Inducing viral immunity without a vaccine--possible use with human immunodeficiency virus.: Med Hypotheses. 1993 Feb;40(2):95-6. Unique Identifier : AIDSLINE MED/93204757; Stone OJ; Induction of allergic contact dermatitis over warts (verrucae vulgaris) causes viral immunity and resolution of the warts in a large percentage of cases. Human immunodeficiency virus could be removed, concentrated, and placed back into the patient s own skin at a site of contact dermatitis.
The cause of AIDS.: Med Hypotheses. 1993 Feb;40(2):97-101. Unique Identifier : AIDSLINE MED/93204758; Erlander SR; There is growing evidence that allogeneic cells, rather than viruses or bacteria are the cause of AIDS. It is proposed here that these allogeneic cells are sperm cells which induce the production of anti-sperm antibodies. Anal sex, genital ulcers and female circumcision allow sperm cells to be absorbed into the body a
Dentists charging patients for AIDS-protection costs [news]: Minn Med. 1993 Mar;76(3):39. Unique Identifier : AIDSLINE MED/93204815
Mechanistic effects of kijimicin on inhibition of human immunodeficiency virus replication.: Mol Cell Biochem. 1993 Feb 17;119(1-2):35-41. Unique Identifier : AIDSLINE MED/93204936; Yamauchi T; Nakamura M; Honma H; Ikeda M; Kawashima K; Ohno T; Department of Microbiology, Jikei University School of Medicine,; Tokyo, Japan.; Kijimicin represents an important type of ionophore compound. In veterinary medicine, it is becoming important as anticoccidiostatic agent and feed supplement. We examined Kijimicin for its HIV inhibitory activity. The compound exhibited concentration-dependent inhibition of HIV replication in primary infected culture
Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen.: Mol Cell Biol. 1993 Apr;13(4):2193-202. Unique Identifier : AIDSLINE GENBANK/M60725; Gatignol A; Buckler C; Jeang KT; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.; TRBP is a human cellular protein that binds the human immunodeficiency virus type 1 TAR RNA. Here, we show that the intact presence of amino acids 247 to 267 in TRBP correlates with its ability to bind RNA. This region contains a lysine- and arginine-rich motif, KKLAKRNAAAKMLLRVHTVPLDAR. A 24-amino-acid synthetic pept
Search for HIV proviral DNA and amplified sequences in the muscle biopsies of patients with HIV polymyositis.: Muscle Nerve. 1993 Apr;16(4):408-13. Unique Identifier : AIDSLINE MED/93205039; Leon-Monzon M; Lamperth L; Dalakas MC; Neuromuscular Diseases Section, National Institute of; Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, Maryland 20892.; We searched for the presence of human immunodeficiency virus (HIV) in fresh-frozen muscle biopsy specimens from 10 patients with HIV-associated polymyositis (HIV-PM) using (a) 35S-labeled HIV-RNA transcript of the virus and in situ hybridization, and (b) polymerase chain reaction and slot-blot hybridization utilizing
Brief report: primary infection with zidovudine-resistant human immunodeficiency virus type 1 [see comments]: N Engl J Med. 1993 Apr 22;328(16):1163-5. Unique Identifier : AIDSLINE MED/93205077; Erice A; Mayers DL; Strike DG; Sannerud KJ; McCutchan FE; Henry K; Balfour HH Jr; Department of Laboratory Medicine, University of Minnesota; Medical School, Minneapolis.
Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection.: N Engl J Med. 1993 Apr 22;328(16):1173-82. Unique Identifier : AIDSLINE MED/93205079; Hollsberg P; Hafler DA; Department of Medicine, Brigham and Women's Hospital, Boston, MA.
A tale of two mutants [editorial; comment]: N Engl J Med. 1993 Apr 22;328(16):1192-3. Unique Identifier : AIDSLINE MED/93205081; Soeiro R
MicroGeneSys drops out of NIH trial for AIDS vaccine [news]: Nature. 1993 Mar 25;362(6418):277. Unique Identifier : AIDSLINE MED/93205100; Macilwain C
Where the AIDS virus hides away [news; comment]: Nature. 1993 Mar 25;362(6418):287. Unique Identifier : AIDSLINE MED/93205108; Maddox J
AIDS. Where has HIV been hiding? [news; comment]: Nature. 1993 Mar 25;362(6418):292-3. Unique Identifier : AIDSLINE MED/93205110; Temin HM; Bolognesi DP
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease [see comments]: Nature. 1993 Mar 25;362(6418):355-8. Unique Identifier : AIDSLINE MED/93205123; Pantaleo G; Graziosi C; Demarest JF; Butini L; Montroni M; Fox CH; Orenstein JM; Kotler DP; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892.; Primary infection with the human immunodeficiency virus (HIV) is generally followed by a burst of viraemia with or without clinical symptoms. This in turn is followed by a prolonged period of clinical latency. During this period there is little, if any, detectable viraemia, the numbers of infected cells in the blood a
Focus on ethics: ANA issues position statements.: Nebr Nurse. 1993 Feb;26(1):21-2. Unique Identifier : AIDSLINE MED/93205156; Barr P; Pinch WJ; Boardman K
Case management: what's it all about? [interview]: Nebr Nurse. 1993 Feb;26(1):30. Unique Identifier : AIDSLINE MED/93205157; Braden B
Paralyzed by bigotry on AIDS [letter; comment]: Nurs Health Care. 1993 Feb;14(2):62. Unique Identifier : AIDSLINE MED/93205231; Barru HJ
From the folks who brought you little red ribbons.: Nurs Health Care. 1993 Feb;14(2):66-7. Unique Identifier : AIDSLINE MED/93205232; Fedor MA
After HIV testing: what's next? [see comments]: Nurs Health Care. 1993 Feb;14(2):92-4. Unique Identifier : AIDSLINE MED/93205236; O'Quinn JL; Hulme P
Salmonella cholerasuis bacteremia and endocarditis in a patient with acquired immunodeficiency syndrome.: N Y State J Med. 1993 Feb;93(2):147-9. Unique Identifier : AIDSLINE MED/93205275; Buff DD; Patel AD; Neches RB; Department of Medicine, St John's Episcopal Hospital, South; Shore, Far Rockaway, NY 11691.
AIDS fraud, finances, and fringes.: N Y State J Med. 1993 Feb;93(2):92-6. Unique Identifier : AIDSLINE MED/93205283; Sampson WI; Oncology Division, Santa Clara Valley Medical Center, San Jose,; California 95128.
Compliance with New York State's do-not-resuscitate law at Memorial Sloan-Kettering Cancer Center. A review of patient deaths.: N Y State J Med. 1993 Mar;93(3):165-8. Unique Identifier : AIDSLINE MED/93205289; Misbin RI; O'Hare D; Lederberg MS; Holland JC; Department of Psychiatry, Memorial Sloan-Kettering Cancer Center,; New York, NY.; We reviewed the case records of 141 patients (134 with cancer and seven with acquired immunodeficiency syndrome) who died at Memorial Sloan-Kettering Cancer Center between July 11 and September 19, 1991. Do-not-resuscitate orders had been written on 115 (85.8%) of the patients with cancer and all of the patients with
The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2R alpha kappa B enhancer include the product of the c-rel proto-oncogene.: Oncogene. 1993 Apr;8(4):867-75. Unique Identifier : AIDSLINE MED/93205400; Crenon I; Beraud C; Simard P; Montagne J; Veschambre P; Jalinot P; Laboratoire de Biologie Moleculaire et Cellulaire, Ecole Normale; Superieure de Lyon, France.; The transactivator HTLV-I Tax activates the promoter of the gene coding for the interleukin 2 alpha-chain receptor (IL-2R alpha) via a kappa B site that can bind several protein species of the rel family. Tax1 strongly activates the enhancer activity of this motif, in both epithelial HeLa and lymphoid Jurkat cells. Th
Delegation of medication.: Pa Nurse. 1993 Mar;48(3):10. Unique Identifier : AIDSLINE MED/93205418; Bering E
[The Anders Jahre Prize for young researchers 1992. HIV/AIDS--an epidemiological challenge]: Nord Med. 1993;108(3):72-5. Unique Identifier : AIDSLINE MED/93205480; Melbye M; Epidemiologisk forskningsenhed, Statens Serum-institut, Kobenhavn; S.; Mads Melbye was awarded the Anders Jahre prize for young scientists in 1992 for his research into epidemiological infections. His pioneering work, which has elucidated the manner in which HIV and AIDS are transmitted