cis and trans regulation of tissue-specific transcription. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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cis and trans regulation of tissue-specific transcription.

J Cell Sci Suppl. 1992;16:21-31. Unique Identifier : AIDSLINE MED/93216854
Engel JD; Beug H; LaVail JH; Zenke MW; Mayo K; Leonard MW; Foley KP; Yang Z; Kornhauser JM; Ko LJ; et al; Department of Biochemistry, Molecular Biology and Cell Biology,; Northwestern University, Evanston, IL 60208-3500.

Abstract: Analysis of both the cis-regulatory sequences which control globin gene switching as well as the trans-acting factors which bind to these sequences to elicit a differential, developmentally regulated response has lent insight into the general mechanisms responsible for tissue-specific gene regulation. We show here that the chicken adult beta-globin gene promoter sequences are intimately involved in competitive interaction with the beta/epsilon-globin enhancer to regulate differentially epsilon- versus beta-globin gene transcription. Secondly, we show that the family of GATA transcription factors directs gene regulation in a variety of discrete cell types, and describe potential cellular target genes for each member of the GATA factor family, as well as potential mechanisms whereby multiple GATA factors expressed in a single cell might be used to elicit differential transcriptional activities.
Keywords: Animal Base Sequence Binding Sites Brain/EMBRYOLOGY Chick Embryo DNA-Binding Proteins/*GENETICS Gene Expression Regulation Genes, Switch Globin/*GENETICS HIV/*GENETICS Mice Molecular Sequence Data Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Transcription Factors/*GENETICS *Transcription, Genetic JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDanimalbasesequencebindingsitesbrain/embryologychickembryodna-bindingproteins/KWDgeneticsgeneexpressionregulationgenes,switchglobin/KWDgeneticshiv/KWDgeneticsmicemolecularsequencedatasupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDtranscriptionfactors/KWDgeneticsKWDtranscription,geneticjournalarticlereviewreview,tutorial
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Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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