Immunoglobulins in hemophilia: correlation between IgG subclasses, IgE and HIV antibody. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Immunoglobulins in hemophilia: correlation between IgG subclasses, IgE and HIV antibody.

J Clin Lab Immunol. 1990 Apr;31(4):157-60. Unique Identifier : AIDSLINE MED/93021027
Kumar A; Gera R; Kulkarni R; Hogrefe WR; Kaufman DB; Department of Pediatrics and Human Development, Michigan State; University, East Lansing 48824-1317.

Abstract: Twenty-two patients with hemophilia who had received factor VIII concentrate were evaluated. Only 12 of 22 were seropositive for HIV. Elevation of IgG, IgG1, IgM and IgE was not related to HIV seropositivity. Means of IgG1, IgG2, and IgG3 were significantly higher in patients with elevated IgG. Means of IgG2 and IgG3 were significantly lower in patients with elevated (greater than or equal to 251) serum IgM. Seven of the 22 patients demonstrated elevated (greater than or equal to 100) serum IgE; mean serum IgA was significantly lower, though in normal range, in these seven patients. Alterations in serum immunoglobulins in patients with Hemophilia are frequently seen, however, like other immune-dysfunction in these patients, these abnormalities can not be attributed to their HIV status.
Keywords: Adolescence Adult Child Child, Preschool Hemophilia/BLOOD/COMPLICATIONS/*IMMUNOLOGY Human HIV Antibodies/*BLOOD HIV Infections/BLOOD/*COMPLICATIONS/IMMUNOLOGY IgE/*ANALYSIS IgG/ANALYSIS/*CLASSIFICATION IgM/ANALYSIS Lymphocyte Subsets Male JOURNAL ARTICLEKWDadolescenceadultchildchild,preschoolhemophilia/blood/complications/KWDimmunologyhumanhivantibodies/KWDbloodhivinfections/blood/KWDcomplications/immunologyige/KWDanalysisigg/analysis/KWDclassificationigm/analysislymphocytesubsetsmalejournalarticle
930130
M9311177

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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