The synthesis and antiviral activity of some 4'-thio-2'-deoxynucleoside analogues. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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The synthesis and antiviral activity of some 4'-thio-2'-deoxynucleoside analogues.

Nucleic Acids Symp Ser. 1991;(24):1-4. Unique Identifier : AIDSLINE MED/93027283
Dyson MR; Coe PL; Walker RT; School of Chemistry, University of Birmingham, UK.

Abstract: A practical 7-step synthesis of benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside is described and the product has been used in the synthesis of some 4'-thio-2'-deoxynucleosides. These novel nucleoside analogues have potentially useful biological activity and are resistant to phosphorolysis.
Keywords: Animal Antiviral Agents/*CHEMICAL SYNTHESIS/*PHARMACOLOGY Deoxyribonucleosides/*CHEMISTRY/PHARMACOLOGY HIV-1/DRUG EFFECTS Simplexvirus/DRUG EFFECTS Thionucleosides/*CHEMICAL SYNTHESIS/*PHARMACOLOGY Vero Cells Vesicular Stomatitis-Indiana Virus/DRUG EFFECTS JOURNAL ARTICLEKWDanimalantiviralagents/KWDchemicalsynthesis/KWDpharmacologydeoxyribonucleosides/KWDchemistry/pharmacologyhiv-1/drugeffectssimplexvirus/drugeffectsthionucleosides/KWDchemicalsynthesis/KWDpharmacologyverocellsvesicularstomatitis-indianavirus/drugeffectsjournalarticle
930130
M9311135

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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