Viral determinants of cellular tropism. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Viral determinants of cellular tropism.

Pathobiology. 1992;60(4):225-33. Unique Identifier : AIDSLINE MED/93000467
O'Brien WA; Division of Infectious Diseases, West Los Angeles VA Medical; Center, Calif. 90073.

Abstract: Cells of mononuclear phagocyte lineage are the predominant cell type producing human immunodeficiency virus type 1 (HIV-1) in extravascular tissues; HIV-1 infection of mononuclear phagocytes may be directly related to primary disease manifestations and also appears to contribute to the immune deficiency of AIDS. Whereas peripheral blood lymphocytes are permissive for nearly all strains of HIV-1, only some HIV-1 strains replicate efficiently in mononuclear phagocytes. Recombinant virus strains have been used to identify a 157-amino acid region of gp120 that can confer macrophage tropism. This region is distinct from the principal CD4 binding domain of gp120 and includes the major type-specific neutralizing epitope located in the third hypervariable domain, V3. Quantitative assay of HIV-1-specific DNA by polymerase chain reaction early after infection suggests that HIV-1 strain differences in macrophage tropism are determined at the level of entry. These studies suggest that target cell interactions with gp120 in addition to or in conjunction with the CD4 binding domain are necessary for efficient entry into mononuclear phagocytes.
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY Blood Cells/MICROBIOLOGY Human HIV Infections/*MICROBIOLOGY *HIV-1/PHYSIOLOGY Phagocytes/*MICROBIOLOGY Virus Replication/PHYSIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDacquiredimmunodeficiencysyndrome/microbiologybloodcells/microbiologyhumanhivinfections/KWDmicrobiologyKWDhiv-1/physiologyphagocytes/KWDmicrobiologyvirusreplication/physiologyjournalarticlereviewreview,tutorial
930130
M9311111

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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