The role of monocyte/macrophages and cytokines in the pathogenesis of HIV infection. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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The role of monocyte/macrophages and cytokines in the pathogenesis of HIV infection.

Pathobiology. 1992;60(4):246-51. Unique Identifier : AIDSLINE MED/93000469
Poli G; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Md; 20892.

Abstract: The monocyte/macrophage system, which is characterized by a high degree of heterogeneity, is a target of the human immunodeficiency virus (HIV) in vitro as well as in vivo. Both bone-marrow-derived precursor elements and circulating monocytes are infectable in vitro and have also been found infected in seropositive individuals. However, terminally differentiated macrophages are the most commonly infected cells found in vivo in addition to the CD4+ T lymphocytes. Several immunoregulatory cytokines have been shown to either up-regulate or suppress virus replication/expression in vitro in cells belonging to the monocyte/macrophage lineage by affecting both transcriptional as well as posttranscriptional events. The observation that elevated levels of several of these cytokines are present in HIV-infected individuals suggests that they may play an important role as regulators of virus expression in vivo.
Keywords: Cytokines/*PHYSIOLOGY Human HIV/PHYSIOLOGY HIV Infections/IMMUNOLOGY/*MICROBIOLOGY Macrophages/*MICROBIOLOGY Monocytes/*MICROBIOLOGY Virus Replication/IMMUNOLOGY/PHYSIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDcytokines/KWDphysiologyhumanhiv/physiologyhivinfections/immunology/KWDmicrobiologymacrophages/KWDmicrobiologymonocytes/KWDmicrobiologyvirusreplication/immunology/physiologyjournalarticlereviewreview,tutorial
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Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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