Cervical carcinoma and the human immunodeficiency virus (HIV) (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Cervical carcinoma and the human immunodeficiency virus (HIV) (Meeting abstract).

International Cervical Cancer Symposium. November 26-30, 1991, Saint Lucia, West Indies, p. 21, 1991.. Unique Identifier : AIDSLINE ICDB/93685946
Fruchter RG; Maiman M; Remy JC; Serur E; Kelly P; State University of New York, Brooklyn, NY

Abstract: Since 1987, we have studied the characteristics and response to therapy of cervical neoplasia in HIV-infected women at a public hospital in Brooklyn, NY. At least one half of HIV-infected women have abnormal cytology and cervical intraepithelial neoplasia (CIN) on biopsy. Of invasive cervical cancer (ICC) patients (pts) under age 51 yr, 25% are HIV-infected, while 10% of pts with CIN are HIV-infected. Compared with HIV-negative ICC pts (n=67), HIV-infected ICC pts (n=16) had more advanced cancer that responded poorly to treatment. Compared with HIV-negative CIN pts (n=120), HIV-infected CIN pts (n=41) had more severe CIN, more extensive lesions and more anogenital warts. CIN persisted after standard treatment in 42% of HIV-infected, but in only 7% of HIV-negative (p less than 0.01). Among ICC pts, Caribbean-born women comprised 8% of the HIV-infected and 55% of the HIV-negative (p less than 0.01). Among CIN pts, Caribbean-born women comprised 29% of the HIV-infected and 54% of HIV-negative. We conclude that HIV-infected women are at high risk for aggressive cervical neoplasia. We recommend regular cytology and periodic colposcopy for HIV-infected women. In communities with high HIV incidence, women with abnormal cytology should be offered HIV counselling. Special therapies must be developed to control both CIN and ICC in HIV-immunodeficient women.
Keywords: Cervix Neoplasms/*COMPLICATIONS/PATHOLOGY/THERAPY Female Human HIV Infections/*COMPLICATIONS New York West Indies/ETHNOLOGY ABSTRACTKWDcervixneoplasms/KWDcomplications/pathology/therapyfemalehumanhivinfections/KWDcomplicationsnewyorkwestindies/ethnologyabstract
930228
M9320885

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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