Other HIV regulatory genes. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Other HIV regulatory genes.

Harvard AIDS Inst Ser; 1:437-71 1991. Unique Identifier : AIDSLINE ICDB/93686280
Anonymous; No affiliation given

Abstract: The human immunosuppressive virus (HIV) and simian immunosuppressive virus (SIV) possess surprisingly complex genomes. In addition to three structural genes, gag, pol and env, which commonly are found in replication-competent retroviruses, HIV-1 has at least six regulatory genes in its genome. Two of these genes, tat and rev, are essential for virus replication. The remaining genes (nef, vif, vpu and vpr) are not required for virus replication, but mutations in these genes alter the replication properties of the virus. Studies of these latter genes are reviewed, including structure and function of human and simian immunosuppressive virus nef proteins (conservation of the nef genes among lentiviruses, cellular localization of nef, expression of myristoylated nef in bacteria, function of HIV and SIV nef proteins and relevance of in vitro and in vivo activities of nef); the vpr protein of HIV-1 (a virion-associated positive regulatory protein); and the nef gene of HIV-1 (recent results).
Keywords: Animal Gene Products, nef/METABOLISM Genes, nef *Genes, Viral Human HIV-1/*GENETICS Macaca Structure-Activity Relationship Virion MONOGRAPHKWDanimalgeneproducts,nef/metabolismgenes,nefKWDgenes,viralhumanhiv-1/KWDgeneticsmacacastructure-activityrelationshipvirionmonograph
930228
M9320881

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1993. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1993. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .