Synthesis and anti-HIV activity of carbovir and related carbocyclic nucleosides. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Synthesis and anti-HIV activity of carbovir and related carbocyclic nucleosides.

Nucleic Acids Symp Ser. 1991;(25):193-4. Unique Identifier : AIDSLINE MED/93065289
Vince R; Department of Medicinal Chemistry, College of Pharmacy,; University of Minnesota, Minneapolis 55455-0343.

Abstract: (+/-) Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir) is an antiretroviral agent which is undergoing preclinical evaluation for the treatment of AIDS. Its hydrolytic stability and its ability to inhibit infectivity and replication of HIV in T-cells at concentrations of approximately 400-fold below toxic concentrations make Carbovir an excellent candidate for development as a potential antiretroviral agent.
Keywords: Antiviral Agents/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Cell Line Dideoxynucleosides/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY Human HIV/*DRUG EFFECTS Molecular Structure Nucleosides/CHEMISTRY/*CHEMICAL SYNTHESIS/PHARMACOLOGY JOURNAL ARTICLEKWDantiviralagents/chemistry/KWDchemicalsynthesis/pharmacologycelllinedideoxynucleosides/chemistry/KWDchemicalsynthesis/pharmacologyhumanhiv/KWDdrugeffectsmolecularstructurenucleosides/chemistry/KWDchemicalsynthesis/pharmacologyjournalarticle
930228
M9320853

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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