Synthesis and structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential antiretroviral agents. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Synthesis and structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential antiretroviral agents.

Nucleic Acids Symp Ser. 1991;(25):91-2. Unique Identifier : AIDSLINE MED/93065329
Kojima E; Shirasaka T; Machida M; Yoshioka H; Murakami K; Mitsuya H; Research Laboratory of Bioresources, Sanyo-Kokusaku Pulp Co. Ltd,; Iwakuni, Japan.

Abstract: In order to study the structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential anti-retroviral agents, various purine derivatives have been synthesized and tested against rous sarcoma virus (RSV) in chick embryo fibroblast (CEF) cells, and against human immunodeficiency virus (HIV) in human CD4+ T cells (ATH8). Some of the new purine derivatives found to be significant antiretroviral activities. And the correlations of activity between anti-RSV and anti-HIV have shown fairly good values so far.
Keywords: Animal Antiviral Agents/CHEMISTRY/*CHEMICAL SYNTHESIS Cell Line Chick Embryo Dideoxynucleosides/CHEMISTRY/*CHEMICAL SYNTHESIS Human HIV/*DRUG EFFECTS Molecular Structure Sarcoma Viruses, Avian/*DRUG EFFECTS Structure-Activity Relationship JOURNAL ARTICLEKWDanimalantiviralagents/chemistry/KWDchemicalsynthesiscelllinechickembryodideoxynucleosides/chemistry/KWDchemicalsynthesishumanhiv/KWDdrugeffectsmolecularstructuresarcomaviruses,avian/KWDdrugeffectsstructure-activityrelationshipjournalarticle
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M9320848

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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